The Early Paleocene to Middle Eocene Apollonia Formation in the BED‒9 field has been particularly interesting for unconventional hydrocarbon exploration since its discovery in 2006.However,the multiscale compositional...The Early Paleocene to Middle Eocene Apollonia Formation in the BED‒9 field has been particularly interesting for unconventional hydrocarbon exploration since its discovery in 2006.However,the multiscale compositional and diagenetic inconsistencies present challenges for its characterization.This study aims to evaluate the petrophysical properties of the Apollonia Formation to locate the sweet-spot intervals.Moreover,it seeks to investigate reservoir rock types(RRTs),depositional settings,and the impact of diagenesis on reservoir quality.The findings of this study are as follows.1)The Apollonia A5 and C1 units are identified as"sweet-spot"intervals.Their effective porosity ranges from 18%to 35%,average permeability varies from 0.1 to 2.0 mD,and water saturation falls between 40%and 50%,indicating good reservoir quality.2)High-order eustatic sea-level changes and repetitive climatic change cycles significantly influence the alternating carbonate productivity and dilution cycles.Five distinct RRTs are classified,denoting a gradational facies change from clean,argillaceous,and carbonaceous chalky limestone to marl and interbedded shale intervals.3)Interpreting the electro-facies responses,collated with microfacies variations and faunal content,deepens our understanding of the depositional environment,which extends from the inner to outer-shelf setting.4)The diagenetic processes have a dual impact that enhances and diminishes the reservoir quality.Finally,the gap in evaluating the petrophysical characteristics of all the Apollonia members has been addressed based on integrating the petrophysical and facies analysis for A,B,and C members.The Apollonia Formation has unique characteristics as an unconventional hydrocarbon resource.展开更多
Objective The aim of this case-control study was to explore the association between serum uric acid to high density lipoprotein cholesterol ratio(UHR) and the risk of nonalcoholic fatty liver disease(NAFLD) in Chinese...Objective The aim of this case-control study was to explore the association between serum uric acid to high density lipoprotein cholesterol ratio(UHR) and the risk of nonalcoholic fatty liver disease(NAFLD) in Chinese adults.Methods A total of 636 patients with NAFLD and 754 controls were enrolled from the Affiliated Hospital of Qingdao University, China, between January and December 2016. All patients completed a comprehensive questionnaire survey and underwent abdominal ultrasound examination and a blood test. NAFLD was diagnosed using ultrasonography after other etiologies were excluded. Logistic regression and restricted cubic spline model were conducted to evaluate the relationship of UHR with NAFLD risk.Results The multivariable adjusted odds ratio(95% confidence interval, CI) for NAFLD in the highest versus lowest quartile of UHR was 3.888(2.324–6.504). In analyses stratified by sex and age, we observed significant and positive associations between UHR and the risk of NAFLD in each subgroup. In analyses stratified by body mass index(BMI), a significant and positive association was found only in individuals with a BMI of ≥ 24 kg/m2. Our dose-response analysis indicated a linear positive correlation between UHR and the risk of NAFLD.Conclusion UHR is positively associated with the risk of NAFLD and may serve as an innovative and noninvasive marker for identifying individuals at risk of NAFLD.展开更多
目的:探讨血尿酸/高密度脂蛋白胆固醇比值(UHR)与糖尿病性视网膜病变(DR)的相关性。方法:选择2023年3月~2024年3月于北华大学附属医院内分泌科住院的2型糖尿病患者共98例作为研究对象,收集临床资料及生化结果,计算BMI、UHR、甘油三酯/...目的:探讨血尿酸/高密度脂蛋白胆固醇比值(UHR)与糖尿病性视网膜病变(DR)的相关性。方法:选择2023年3月~2024年3月于北华大学附属医院内分泌科住院的2型糖尿病患者共98例作为研究对象,收集临床资料及生化结果,计算BMI、UHR、甘油三酯/高密度脂蛋白胆固醇比值(TG/HDL-C)等结果;对单纯2型糖尿病组(T2DM) 34例2型糖尿病性视网膜病变组(DR) 64例变量行差异性分析;logistic回归分析筛选DR高危因素并绘制受试者工作特征曲线(ROC曲线)。结果:与T2DM组比较,DR组病程、血尿酸(SUA)、UHR、甘油三酯(TG)、TG/HDL-C水平升高(p pp p p p Objective: to investigate the correlation between blood uric acid/high-density lipoprotein cholesterol ratio (UHR) and diabetic retinopathy (DR). Methods: A total of 98 patients with type 2 diabetes mellitus who were hospitalized in the Department of Endocrinology of Beihua University Hospital from March 2023 to March 2024 were selected as the study subjects. Clinical data and biochemical results were collected, and the results of BMI, UHR, and triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C) were calculated;for the 34 cases of type 2 diabetes mellitus in the type 2 diabetes mellitus group (T2DM) alone and the 64 cases in the diabetic retinopathy group (DR), the differences in variables were analyzed. Retinopathy group (DR) 64 cases were analyzed;logistic regression analysis was performed to screen the risk factors of DR and to draw the working characteristic curve (ROC curve) of the subjects. Results: Compared with the T2DM group, the DR group had increased disease duration, blood uric acid (SUA), UHR, triglyceride (TG), and TG/HDL-C levels (p p p p p p < 0.05). Conclusion: UHR, SUA, TG, and TG/HDL-C are all risk factors for the development of DR, with UHR having the greatest predictive value for the development of DR.展开更多
Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclero...Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods In this single-center,retrospective cross-sectional study,379 patients with T2DM were enrolled and categorized into two groups:259 T2DM patients with CAS(T2DM-CAS)and 120 T2DM patients without CAS(T2DM-WCAS).Carotid intima‒media thickness(CIMT)and carotid atheromatous plaques(CAPs)were assessed via Doppler ultrasound.UHR values were compared between the groups,and receiver operating characteristic(ROC)curve analysis was employed to evaluate their diagnostic performance.Results The UHR was significantly greater in the T2DM-CAS group than in the T2DM-WCAS group(P<0.001).Multivariate logistic regression analysis identified the UHR as an independent risk factor for T2DM-CAS(P<0.001).The area under the ROC curve(AUC)for UHR to detect CAS was 0.750,with an optimal cut-off value of 0.35.Conclusion The UHR is an independent risk factor for CAS in patients with T2DM and may serve as a valuable biomarker for predicting CAS in this population.展开更多
文摘The Early Paleocene to Middle Eocene Apollonia Formation in the BED‒9 field has been particularly interesting for unconventional hydrocarbon exploration since its discovery in 2006.However,the multiscale compositional and diagenetic inconsistencies present challenges for its characterization.This study aims to evaluate the petrophysical properties of the Apollonia Formation to locate the sweet-spot intervals.Moreover,it seeks to investigate reservoir rock types(RRTs),depositional settings,and the impact of diagenesis on reservoir quality.The findings of this study are as follows.1)The Apollonia A5 and C1 units are identified as"sweet-spot"intervals.Their effective porosity ranges from 18%to 35%,average permeability varies from 0.1 to 2.0 mD,and water saturation falls between 40%and 50%,indicating good reservoir quality.2)High-order eustatic sea-level changes and repetitive climatic change cycles significantly influence the alternating carbonate productivity and dilution cycles.Five distinct RRTs are classified,denoting a gradational facies change from clean,argillaceous,and carbonaceous chalky limestone to marl and interbedded shale intervals.3)Interpreting the electro-facies responses,collated with microfacies variations and faunal content,deepens our understanding of the depositional environment,which extends from the inner to outer-shelf setting.4)The diagenetic processes have a dual impact that enhances and diminishes the reservoir quality.Finally,the gap in evaluating the petrophysical characteristics of all the Apollonia members has been addressed based on integrating the petrophysical and facies analysis for A,B,and C members.The Apollonia Formation has unique characteristics as an unconventional hydrocarbon resource.
基金supported by the Natural Science Foundation of China[No.81703206,No.81973015]Science and Technology Program of Qingdao[No.19-6-1-52-nsh]。
文摘Objective The aim of this case-control study was to explore the association between serum uric acid to high density lipoprotein cholesterol ratio(UHR) and the risk of nonalcoholic fatty liver disease(NAFLD) in Chinese adults.Methods A total of 636 patients with NAFLD and 754 controls were enrolled from the Affiliated Hospital of Qingdao University, China, between January and December 2016. All patients completed a comprehensive questionnaire survey and underwent abdominal ultrasound examination and a blood test. NAFLD was diagnosed using ultrasonography after other etiologies were excluded. Logistic regression and restricted cubic spline model were conducted to evaluate the relationship of UHR with NAFLD risk.Results The multivariable adjusted odds ratio(95% confidence interval, CI) for NAFLD in the highest versus lowest quartile of UHR was 3.888(2.324–6.504). In analyses stratified by sex and age, we observed significant and positive associations between UHR and the risk of NAFLD in each subgroup. In analyses stratified by body mass index(BMI), a significant and positive association was found only in individuals with a BMI of ≥ 24 kg/m2. Our dose-response analysis indicated a linear positive correlation between UHR and the risk of NAFLD.Conclusion UHR is positively associated with the risk of NAFLD and may serve as an innovative and noninvasive marker for identifying individuals at risk of NAFLD.
文摘目的:探讨血尿酸/高密度脂蛋白胆固醇比值(UHR)与糖尿病性视网膜病变(DR)的相关性。方法:选择2023年3月~2024年3月于北华大学附属医院内分泌科住院的2型糖尿病患者共98例作为研究对象,收集临床资料及生化结果,计算BMI、UHR、甘油三酯/高密度脂蛋白胆固醇比值(TG/HDL-C)等结果;对单纯2型糖尿病组(T2DM) 34例2型糖尿病性视网膜病变组(DR) 64例变量行差异性分析;logistic回归分析筛选DR高危因素并绘制受试者工作特征曲线(ROC曲线)。结果:与T2DM组比较,DR组病程、血尿酸(SUA)、UHR、甘油三酯(TG)、TG/HDL-C水平升高(p pp p p p Objective: to investigate the correlation between blood uric acid/high-density lipoprotein cholesterol ratio (UHR) and diabetic retinopathy (DR). Methods: A total of 98 patients with type 2 diabetes mellitus who were hospitalized in the Department of Endocrinology of Beihua University Hospital from March 2023 to March 2024 were selected as the study subjects. Clinical data and biochemical results were collected, and the results of BMI, UHR, and triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C) were calculated;for the 34 cases of type 2 diabetes mellitus in the type 2 diabetes mellitus group (T2DM) alone and the 64 cases in the diabetic retinopathy group (DR), the differences in variables were analyzed. Retinopathy group (DR) 64 cases were analyzed;logistic regression analysis was performed to screen the risk factors of DR and to draw the working characteristic curve (ROC curve) of the subjects. Results: Compared with the T2DM group, the DR group had increased disease duration, blood uric acid (SUA), UHR, triglyceride (TG), and TG/HDL-C levels (p p p p p p < 0.05). Conclusion: UHR, SUA, TG, and TG/HDL-C are all risk factors for the development of DR, with UHR having the greatest predictive value for the development of DR.
基金supported by the National Natural Science Foundation of China(Grant No.82070862 and 82370840)the National Key R&D Program of China(Grant No.2020YFC2008900).
文摘Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods In this single-center,retrospective cross-sectional study,379 patients with T2DM were enrolled and categorized into two groups:259 T2DM patients with CAS(T2DM-CAS)and 120 T2DM patients without CAS(T2DM-WCAS).Carotid intima‒media thickness(CIMT)and carotid atheromatous plaques(CAPs)were assessed via Doppler ultrasound.UHR values were compared between the groups,and receiver operating characteristic(ROC)curve analysis was employed to evaluate their diagnostic performance.Results The UHR was significantly greater in the T2DM-CAS group than in the T2DM-WCAS group(P<0.001).Multivariate logistic regression analysis identified the UHR as an independent risk factor for T2DM-CAS(P<0.001).The area under the ROC curve(AUC)for UHR to detect CAS was 0.750,with an optimal cut-off value of 0.35.Conclusion The UHR is an independent risk factor for CAS in patients with T2DM and may serve as a valuable biomarker for predicting CAS in this population.
