Natural products have garnered significant attention due to their exceptional industrial and medicinal value.Glycosylation,a crucial structural modification in these products,is typically mediated by uridine diphospha...Natural products have garnered significant attention due to their exceptional industrial and medicinal value.Glycosylation,a crucial structural modification in these products,is typically mediated by uridine diphosphate-dependent glycosyltransferases(UGTs).These enzymes not only enhance the physicochemical properties of natural products but also markedly increase their biological activity.This review provides an in-depth exploration of the characteristic features of UGTs and their diverse applications in the glycosylation modification of natural products,encompassing terpenoids,flavonoids,alkaloids,phenolic acids,and amide compounds.Special emphasis has been placed on the latest strategies in UGTs’protein engineering and high-throughput screening methods,which provides insights into the study of UGTs’protein engineering and facilitate their application in the fields of food and medicine.展开更多
基金supported by the National Natural Science Foundation of China(No.32172192)the Zhejiang Provincial Natural Science Foundation of China(No.ZCLQ24C2001).
文摘Natural products have garnered significant attention due to their exceptional industrial and medicinal value.Glycosylation,a crucial structural modification in these products,is typically mediated by uridine diphosphate-dependent glycosyltransferases(UGTs).These enzymes not only enhance the physicochemical properties of natural products but also markedly increase their biological activity.This review provides an in-depth exploration of the characteristic features of UGTs and their diverse applications in the glycosylation modification of natural products,encompassing terpenoids,flavonoids,alkaloids,phenolic acids,and amide compounds.Special emphasis has been placed on the latest strategies in UGTs’protein engineering and high-throughput screening methods,which provides insights into the study of UGTs’protein engineering and facilitate their application in the fields of food and medicine.
