Mitochondria contain over 1000 types of proteins,most of which are imported from the cytosol1.This import process is intricate and energy-dependent,in which mitochondrial energy deficits and oxidative stress pose sign...Mitochondria contain over 1000 types of proteins,most of which are imported from the cytosol1.This import process is intricate and energy-dependent,in which mitochondrial energy deficits and oxidative stress pose significant threats to the import efficiency.When the import is compromised,it can initiate mitochondrial import stress,potentially triggering the integrated stress response(ISR).Persistent ISR may escalate into broader cellular stress2,3.Under normal conditions,the body maintains mitochondrial and cellular equilibrium through intricate stress response pathways.展开更多
基金supported by the National Natural Science Foundation of China(project 32271220)to Jianping Ye.
文摘Mitochondria contain over 1000 types of proteins,most of which are imported from the cytosol1.This import process is intricate and energy-dependent,in which mitochondrial energy deficits and oxidative stress pose significant threats to the import efficiency.When the import is compromised,it can initiate mitochondrial import stress,potentially triggering the integrated stress response(ISR).Persistent ISR may escalate into broader cellular stress2,3.Under normal conditions,the body maintains mitochondrial and cellular equilibrium through intricate stress response pathways.
