We present a catalog including 11 204 spectra of 10436 early-type emission-line stars from LAMOST DR2, among which 9752 early-type emission-line spectra are newly discovered. For these early- type emissionqine stars, ...We present a catalog including 11 204 spectra of 10436 early-type emission-line stars from LAMOST DR2, among which 9752 early-type emission-line spectra are newly discovered. For these early- type emissionqine stars, we discuss the morphological and physical properties of their low-resolution spectra. In this spectral sample, the Hα emission profiles display a wide variety of shapes. Based on the Hα line profiles, these spectra are categorized into five distinct classes： single-peak emission, single-peak emission in absorption, double-peak emission, double-peak emission in absorption, and P-Cygni profiles. To better understand what causes the Hc~ line profiles, we divide these objects into four types from the perspective of physical classification, which include classical Be stars, Herbig Ae/Be stars, close binaries and spectra contaminated by H n regions. The majority of Herbig Ae/Be stars and classical Be stars are identified and separated using a （H-K, K-W1） color-color diagram. We also discuss 31 binary systems that are listed in the SIMBAD on-line catalog and identify 3600 spectra contaminated by HⅡ regions after cross-matching with positions in the Dubout-Crillon catalog. A statistical analysis of line profiles versus classifications is then conducted in order to understand the distribution of Hc~ profiles for each type in our sample. Finally, we also provide a table of 172 spectra with Fen emission lines and roughly calculate stellar wind velocities for seven spectra with P-Cygni profiles.展开更多
Many methods are proposed to deal with the type synthesis of parallel kinematic mechanisms（PKMs）, but most of them are less intuitive to some extent. Thus, to propose a concise and intuitive type synthesis method fo...Many methods are proposed to deal with the type synthesis of parallel kinematic mechanisms（PKMs）, but most of them are less intuitive to some extent. Thus, to propose a concise and intuitive type synthesis method for engineering application is a very challenging issue, which should be further studied in the field. Grassmann line geometry, which can investigate the dimensions of spatial line-clusters in a concise way, is taken as the mathematic foundation. Atlas method is introduced to visually describe the degrees of freedom（DOFs） and constraints of a mechanism, and the dual rule is brought in to realize the mutual conversion of the freedom-space and constraint-space. Consequently, a systematic method based on Grassmann line geometry and Atlas method is generated and the entire type synthesis process is presented. Three type 4-DOF PKMs, i.e., 1T3R, 2T2R and 3T1R（T： translational DOF; R： rotational DOF）, are classified according to the different combinations of the translational DOFs and rotational DOFs. The type synthesis of 4-DOF PKMs is carried out and the possible configurations are thoroughly investigated. Some new PKMs with useful functions are generated during this procedure. The type synthesis method based on Grassmann line geometry and Atlas method is intuitive and concise, and can reduce the complexity of the PKMs＇ type synthesis. Moreover, this method can provide theoretical guidance for other PKMs＇ type synthesis and engineering application. A novel type synthesis method is proposed, which solves the existing methods＇ problems in terms of complicated, not intuitive and unsuitable for practical application.展开更多
To enhance the yield potential of an elite indica rice cultivar,an introgression(BC_3-derived) line of IR64,YTH288,was developed using a new-plant-type cultivar,IR66215-44-2-3,as a donor parent.YTH288 has agronomicall...To enhance the yield potential of an elite indica rice cultivar,an introgression(BC_3-derived) line of IR64,YTH288,was developed using a new-plant-type cultivar,IR66215-44-2-3,as a donor parent.YTH288 has agronomically valuable characteristics such as large panicles,few unproductive tillers,and large leaves inherited from NPT.To identify the genetic basis of these traits,we used 167 F_2 plants derived from a cross between IR64 and YTH288 to conduct QTL analysis for five agronomic traits:days to heading(DTH),culm length(CL),flag leaf length(FLL),flag leaf width(FLW),and filled spikelet number per panicle(FSN).Six putative QTL were detected:four on chromosome4(for CL,FLL,FLW,and FSN) and two on chromosome 2(for DTH and FLL).All QTL with the IR66215-44-2-3 allele,except that for FLL on chromosome 2,had positive effects on each trait.To confirm the effects of these putative QTL,we developed NILs with the IR64 genetic background by marker-assisted selection.We observed significant differences in several agronomic traits between IR64 and NILs that carried these QTL on chromosomes2 and 4.Additionally,four IR64-NILs carrying chromosomal segments derived from different NPT varieties on the long arm of chromosome 4 exhibited similar pleiotropic To enhance the yield potential of an elite indica rice cultivar, an introgression(BC3-derived) line of IR64, YTH288, was developed using a new-plant-type cultivar,IR66215-44-2-3, as a donor parent. YTH288 has agronomically valuable characteristics such as large panicles, few unproductive tillers, and large leaves inherited from NPT.To identify the genetic basis of these traits, we used 167 F2 plants derived from a cross between IR64 and YTH288 to conduct QTL analysis for five agronomic traits: days to heading(DTH), culm length(CL), flag leaf length(FLL), flag leaf width(FLW), and filled spikelet number per panicle(FSN). Six putative QTL were detected: four on chromosome4(for CL, FLL, FLW, and FSN) and two on chromosome 2(for DTH and FLL). All QTL with the IR66215-44-2-3 allele, except that for FLL on chromosome 2, had positive effects on each trait. To confirm the effects of these putative QTL, we developed NILs with the IR64 genetic background by marker-assisted selection. We observed significant differences in several agronomic traits between IR64 and NILs that carried these QTL on chromosomes2 and 4. Additionally, four IR64-NILs carrying chromosomal segments derived from different NPT varieties on the long arm of chromosome 4 exhibited similar pleiotropiceffects for unique agronomic traits. These NILs can be used as research materials for studying each trait and as breeding materials for yield improvement of indica rice cultivars.展开更多
The effects of Sonic hedgehog(Shh) signaling pathway activation on S-type neuroblastoma(NB) cell lines and its role in NB tumorigenesis were investigated.Immunohistochemistry was used to detect the expression of Shh p...The effects of Sonic hedgehog(Shh) signaling pathway activation on S-type neuroblastoma(NB) cell lines and its role in NB tumorigenesis were investigated.Immunohistochemistry was used to detect the expression of Shh pathway components— Patched1(PTCH1) and Gli1 in 40 human primary NB samples.Western blotting and RT-PCR were used to examine the protein expression and mRNA levels of PTCH1 and Gli1 in three kinds of S-type NB cell lines(SK-N-AS,SK-N-SH and SHEP1),respectively.Exogenous Shh was administrated to activate Shh signaling pathway while cyclopamine was used as a selective antagonist of Shh pathway.S-type NB cell lines were treated with different concentrations of Shh or/and cyclopamine for different durations.Cell viability was measured by using MTT method.Apoptosis rate and cell cycle were assayed by flow cytometry.The xenograft experiments were used to evaluate the role of Shh pathway in tumor growth in immunodeficient mice.High-level expression of PTCH1 and Gli1 was detected in both NB samples and S-type NB cell lines.Cyclopamine decreased the survival rate of the three cell lines while Shh increased it,and the inhibition effects of cyclopamine could be partially reversed by shh pre-treatment.Cyclopamine induced the cell apoptosis and the cell cycle arrest in G0/G1 phase,while Shh induced the reverse effects and could partially prevent effects of cyclopamine.Cyclopamine could also inhibit the growth of NB in vivo.Our studies revealed that activation of the Shh pathway is important for survival and proliferation of S-type NB cells in vivo and in vitro through affecting cell apoptosis and cell cycle,suggesting a new therapeutic approach to NB.展开更多
Various kinds of Riemann boundary value problems (BVPs) for analytic functions on closed curves or on open arc, doubly periodic Riemann BVPs, doubly quasi-periodic Riemann BVPs, and BVPs for polyanalytic functions hav...Various kinds of Riemann boundary value problems (BVPs) for analytic functions on closed curves or on open arc, doubly periodic Riemann BVPs, doubly quasi-periodic Riemann BVPs, and BVPs for polyanalytic functions have been widely investigated in [1-8]. The main ap- proach is to use the decomposition of polyanalytic functions and their generalization to transform the boundary value problems to their corresponding boundary value problems for analytic functions. Recently, inverse Riemann BVPs for generalized analytic functions or bianalytic functions have been investigated in [9-12]. In this paper, we consider a kind of Riemann BVP of non-normal type on the infinite straight line and discuss the solvable conditions and the general solution for it.展开更多
In this work, an algorithm based on method of lines coupled with radial basis functions namely meshless method of lines (MMOL) is presented for the numerical solution of Kawahara, modified Kawahara and KdV Kawahara eq...In this work, an algorithm based on method of lines coupled with radial basis functions namely meshless method of lines (MMOL) is presented for the numerical solution of Kawahara, modified Kawahara and KdV Kawahara equations. The motion of a single solitary wave, interaction of two and three solitons and the phenomena of wave generation is discussed. The results are compared with the exact solution and with the results in the relevant literature to show the efficiency of the method.展开更多
Numerical simulation was used to estimate the temperature field within a poured concrete,mono-layer freezing-shaft lining.The affects from various factors were investigated.The maximum temperature within the lining in...Numerical simulation was used to estimate the temperature field within a poured concrete,mono-layer freezing-shaft lining.The affects from various factors were investigated.The maximum temperature within the lining increases as the lining thickness increases,decreases as the soil-side wall temperature decreases,decreases as the air temperature inside the shaft decreases and decreases as the air velocity inside the shaft increases.The compression speed of an insulating foam layer affects the maximum temperature difference between the interior and the sidewalls.The maximum temperature difference between the interior and the sidewalls approaches or exceeds the maximum allowable for the curing of poured concrete structures.Attention should be paid to the question of the lining cracking during the curing period.The temperature gradient in the vertical direction may be minimized by preventing air contact against the steel connection board supporting the base of the freshly poured section.展开更多
A cold-cathode Penning Ion Gauge(PIG) type ion source as the internal ion source of an 11 MeV cyclotron is designed and tested at Institute of Fluid Physics.The design considerations and some testings are presented.Ex...A cold-cathode Penning Ion Gauge(PIG) type ion source as the internal ion source of an 11 MeV cyclotron is designed and tested at Institute of Fluid Physics.The design considerations and some testings are presented.Experimental results of Balmer-line-Emission show that the discharge characteristic,which is mainly determined by gas-flow rate,is not very sensitive to arc current and magnetic field in the operation ranges of the cyclotron.The arc power decreases and ascends while the gas-flow rate goes up from 0.5 SCCM to 20 SCCM.By improving the sealing design and reducing the machine tolerance of the source,the minimum power consumption reduces from 9 SCCM to 4 SCCM,thus having better energy efficiency and benefiting for the pumping system.Preliminary DC extractions show that H–microampere current ranges from several tens to hundreds under different operation conditions.Some problems during the experiments and future plan are discussed in the end.展开更多
Towards line speed and accurateness on-line content popularity monitoring on Content Centric Networking(CCN) routers, we propose a three-stage scheme based on Bloom filters and hash tables for differentiated traffic. ...Towards line speed and accurateness on-line content popularity monitoring on Content Centric Networking(CCN) routers, we propose a three-stage scheme based on Bloom filters and hash tables for differentiated traffic. At the first stage, we decide whether to deliver the content to the next stage depending on traffic types. The second stage consisting of Standard Bloom filters(SBF) and Counting Bloom filters(CBF) identifies the popular content. Meanwhile, a scalable sliding time window based monitoring scheme for different traffic types is proposed to implement frequent and real-time updates by the change of popularities. Hash tables according with sliding window are used to record the popularity at the third stage. Simulation results reveal that this method reaches a 40 Gbps processing speed at lower error probability with less memory, and it is more sensitive to the change of popularity. Additionally, the architecture which can be implemented in CCN router is flexible and scalable.展开更多
运用我国2016-2018年三个冬半年(10月至次年3月)地面2515个站的天气现象观测资料,对ECMWF(European Centre for Medium-Range Weather Forecasts)的降水相态预报产品(PTYPE)(分为雨、雨夹雪、雪和冻雨四类)进行了系统性的检验评估,包括...运用我国2016-2018年三个冬半年(10月至次年3月)地面2515个站的天气现象观测资料,对ECMWF(European Centre for Medium-Range Weather Forecasts)的降水相态预报产品(PTYPE)(分为雨、雨夹雪、雪和冻雨四类)进行了系统性的检验评估,包括细网格确定性模式预报产品和集合预报系统概率预报产品。结果显示,ECMWF的确定性预报产品对四类降水相态的正确率普遍达到90%以上,对降雨和降雪的TS评分也较高,冻雨次之,雨夹雪的TS评分较低,预报能力有限。确定性模式对我国雨雪分界线的预报,普遍存在短期位置略偏南、中期随时效延长越来越偏北的误差特点,且对雨夹雪的预报范围明显偏小,对冻雨的预报范围明显偏大。集合预报系统从概率的角度一定程度上弥补了确定性模式的上述误差。对概率预报的检验结果显示,集合预报系统降雨概率普遍偏低,降雪概率短期偏高、中期偏低,而雨夹雪和冻雨概率普遍偏低,但是都有一定的预报技巧。集合预报系统相对于确定性模式的优势,降雨体现在较小花费损失比事件的预报上,降雪体现在较大花费损失比事件的预报上。对雨夹雪和冻雨,相对于确定性模式,集合预报系统体现出了显著的优势,尤其是冻雨,集合预报系统的优势更加明显。展开更多
A hydraulic model test for ￢-type groynes (with “￢” shape) was conducted to analyze the flow characteristics around these groynes. The results of the model tests are expected to be used as fundamental information ...A hydraulic model test for ￢-type groynes (with “￢” shape) was conducted to analyze the flow characteristics around these groynes. The results of the model tests are expected to be used as fundamental information in designing the ￢-type groyne constructed in the field. Main hydraulic factors such as velocity and thalweg line changes in the main channel and separation area were analyzed in this study. The thalweg line is a stream line where the maximum velocity occurs, whereas the separation area is the boundary between the main flow and the recirculation zone. Model tests with 5 different arm lengths of the ￢-type groynes were conducted by changing the velocity. The LSPIV (Large-Scale Particle Image Velocimetry) technique was used to measure and analyze flow variation around the ￢-type groynes. The velocity in the main channel measured to be increased by 1.5 times. The velocity variation on groyne arm length is little. The width of the thalweg lines (TCL) was changed to 55 - 57% of the channel width. The Froude number did not affect the thalweg line (TCL) and separation line (Sh) changes, however.展开更多
A plant expression vector containing a chimeric Bt29K gene coding for the activated Cry1Ac protein and the arrowhead proteinase inhibitior gene API B were introduced into the cotton cultivar Jihe321 mediated ...A plant expression vector containing a chimeric Bt29K gene coding for the activated Cry1Ac protein and the arrowhead proteinase inhibitior gene API B were introduced into the cotton cultivar Jihe321 mediated by Agrobactertium tumefaciens. Based on the results of kanamycin resistant testing, PCR detection for both foreign genes and insect bioassay using Heliethis armigera , nine transgenic homozygous cotton lines with insect resistance of more than 90% and better agronomic traits were bred through six generations from the original transgenic plants. Results from insect bioassay and sequence analysis of the PCR products of plants from some homozygous lines indicated that the chimeric Bt29K gene was stably inherited in these transgenic cotton lines. The main agronomic characters of these homozygous cotton lines, such as boll productivity and fibre strength, were better than that of the original cotton cv. Jihe321.展开更多
The article deals with the prduction lines in log yard by investigating the utilizationof machines in forest areas,presents the methods and rules of differentiating the log productionlines and also summarizes the form...The article deals with the prduction lines in log yard by investigating the utilizationof machines in forest areas,presents the methods and rules of differentiating the log productionlines and also summarizes the formation and development of three kinds of log production lines innortbeast forest areas of China.It gives different combination types of log production lines andtheir applications, so it is significant for us to evaluate and standardize the log Production lines.展开更多
Objective: To replace the peripheral venous puncture for blood sampling with taking blood samples extracorporally from arterial line before predilution during RCA-CRRT performed. Methods: A new type of double-lumen fe...Objective: To replace the peripheral venous puncture for blood sampling with taking blood samples extracorporally from arterial line before predilution during RCA-CRRT performed. Methods: A new type of double-lumen femoral catheter was used instead of the current tubes. The new type of double-lumen tube had a greater distance from the inner venous ports to the inner arterial ports than current tubes. The minimum distance from the venous port to the arterial port was greatly lengthened. Replacement solution contained citrate, zero Ca<sup>2+</sup>, zero bicarbonate, low Na<sup>+</sup>. Blood samples were synchronously collected from the arterial line before the infusion of citrate replacement fluid and from the peripheral vein. The iCa concentration data of two groups were analyzed to observe the difference between iCa concentration levels in the arterial line and in peripheral vein;the anticoagulant effect of RCA and possible complications were observed, such as bleeding, clottings and hypocalcaemia. Results: 28 times of RCA-CRRT were performed on17 AKI and CRF patients with active bleeding or at the high risk of bleeding;336 blood samples were collected. Statistics showed that the difference of iCa concentration between arterial line group and the peripheral vein group was not significant (P = 0.9), there is a high degree of similarity between the iCa concentration of arterial line blood and the peripheral venous blood. None of the patients developed citrate toxicity or metabolic alkalosis. None induced bleeding, or bleeding aggravated. No obvious clotting occurred. Systemic calcium concentration was achieved in the ideal range. Conclusion: In clinical practice, the data of iCa concentration from arterial line can be used to replace that from peripheral vein when the new type of double-lumen femoral catheter is placed in femoral vein. RCA-CRRT therapy is safe and effective.展开更多
We propose a simple scheme to generate x-type four-charge entangled states by using SQUID-based charge qubits capacitively coupled to a transmission line resonator （TLR）. The coupling between the superconducting qub...We propose a simple scheme to generate x-type four-charge entangled states by using SQUID-based charge qubits capacitively coupled to a transmission line resonator （TLR）. The coupling between the superconducting qubit and the TLR can be effectively controlled by properly adjusting the control parameters of the charge qubit. The experimental feasibility of our scheme is also shown.展开更多
基金supported by the National Key Basic Research Program of China (Grant No. 2014CB845700)the National Natural Science Foundation of China (Grant Nos. 11390371 and 11233004)The Guo Shou Jing Telescope (the Large Sky Area Multi-Object Fiber Spectroscopic Telescope, LAMOST) is a National Major Scientific Project built by the Chinese Academy of Sciences. Funding for the project has been provided by the National Development and Reform Commission
文摘We present a catalog including 11 204 spectra of 10436 early-type emission-line stars from LAMOST DR2, among which 9752 early-type emission-line spectra are newly discovered. For these early- type emissionqine stars, we discuss the morphological and physical properties of their low-resolution spectra. In this spectral sample, the Hα emission profiles display a wide variety of shapes. Based on the Hα line profiles, these spectra are categorized into five distinct classes： single-peak emission, single-peak emission in absorption, double-peak emission, double-peak emission in absorption, and P-Cygni profiles. To better understand what causes the Hc~ line profiles, we divide these objects into four types from the perspective of physical classification, which include classical Be stars, Herbig Ae/Be stars, close binaries and spectra contaminated by H n regions. The majority of Herbig Ae/Be stars and classical Be stars are identified and separated using a （H-K, K-W1） color-color diagram. We also discuss 31 binary systems that are listed in the SIMBAD on-line catalog and identify 3600 spectra contaminated by HⅡ regions after cross-matching with positions in the Dubout-Crillon catalog. A statistical analysis of line profiles versus classifications is then conducted in order to understand the distribution of Hc~ profiles for each type in our sample. Finally, we also provide a table of 172 spectra with Fen emission lines and roughly calculate stellar wind velocities for seven spectra with P-Cygni profiles.
基金supported by National Natural Science Foundation of China(Grant No.51135008)National Basic Research Program of China(973 Program,Grant No.2013CB035400)China Postdoctoral Science Foundation(Grant Nos.2012M520256,2013T60107)
文摘Many methods are proposed to deal with the type synthesis of parallel kinematic mechanisms（PKMs）, but most of them are less intuitive to some extent. Thus, to propose a concise and intuitive type synthesis method for engineering application is a very challenging issue, which should be further studied in the field. Grassmann line geometry, which can investigate the dimensions of spatial line-clusters in a concise way, is taken as the mathematic foundation. Atlas method is introduced to visually describe the degrees of freedom（DOFs） and constraints of a mechanism, and the dual rule is brought in to realize the mutual conversion of the freedom-space and constraint-space. Consequently, a systematic method based on Grassmann line geometry and Atlas method is generated and the entire type synthesis process is presented. Three type 4-DOF PKMs, i.e., 1T3R, 2T2R and 3T1R（T： translational DOF; R： rotational DOF）, are classified according to the different combinations of the translational DOFs and rotational DOFs. The type synthesis of 4-DOF PKMs is carried out and the possible configurations are thoroughly investigated. Some new PKMs with useful functions are generated during this procedure. The type synthesis method based on Grassmann line geometry and Atlas method is intuitive and concise, and can reduce the complexity of the PKMs＇ type synthesis. Moreover, this method can provide theoretical guidance for other PKMs＇ type synthesis and engineering application. A novel type synthesis method is proposed, which solves the existing methods＇ problems in terms of complicated, not intuitive and unsuitable for practical application.
基金the results obtained from phases Ⅲ , Ⅳ, Ⅴ, and Ⅵ of the IRRI – Japan Collaborative Research Project, which was supported by the Ministry of Foreign Affairs and the Ministry of Agriculture, Forestry and Fisheries of Japan
文摘To enhance the yield potential of an elite indica rice cultivar,an introgression(BC_3-derived) line of IR64,YTH288,was developed using a new-plant-type cultivar,IR66215-44-2-3,as a donor parent.YTH288 has agronomically valuable characteristics such as large panicles,few unproductive tillers,and large leaves inherited from NPT.To identify the genetic basis of these traits,we used 167 F_2 plants derived from a cross between IR64 and YTH288 to conduct QTL analysis for five agronomic traits:days to heading(DTH),culm length(CL),flag leaf length(FLL),flag leaf width(FLW),and filled spikelet number per panicle(FSN).Six putative QTL were detected:four on chromosome4(for CL,FLL,FLW,and FSN) and two on chromosome 2(for DTH and FLL).All QTL with the IR66215-44-2-3 allele,except that for FLL on chromosome 2,had positive effects on each trait.To confirm the effects of these putative QTL,we developed NILs with the IR64 genetic background by marker-assisted selection.We observed significant differences in several agronomic traits between IR64 and NILs that carried these QTL on chromosomes2 and 4.Additionally,four IR64-NILs carrying chromosomal segments derived from different NPT varieties on the long arm of chromosome 4 exhibited similar pleiotropic To enhance the yield potential of an elite indica rice cultivar, an introgression(BC3-derived) line of IR64, YTH288, was developed using a new-plant-type cultivar,IR66215-44-2-3, as a donor parent. YTH288 has agronomically valuable characteristics such as large panicles, few unproductive tillers, and large leaves inherited from NPT.To identify the genetic basis of these traits, we used 167 F2 plants derived from a cross between IR64 and YTH288 to conduct QTL analysis for five agronomic traits: days to heading(DTH), culm length(CL), flag leaf length(FLL), flag leaf width(FLW), and filled spikelet number per panicle(FSN). Six putative QTL were detected: four on chromosome4(for CL, FLL, FLW, and FSN) and two on chromosome 2(for DTH and FLL). All QTL with the IR66215-44-2-3 allele, except that for FLL on chromosome 2, had positive effects on each trait. To confirm the effects of these putative QTL, we developed NILs with the IR64 genetic background by marker-assisted selection. We observed significant differences in several agronomic traits between IR64 and NILs that carried these QTL on chromosomes2 and 4. Additionally, four IR64-NILs carrying chromosomal segments derived from different NPT varieties on the long arm of chromosome 4 exhibited similar pleiotropiceffects for unique agronomic traits. These NILs can be used as research materials for studying each trait and as breeding materials for yield improvement of indica rice cultivars.
基金supported by a grant from the National Natural Sciences Foundation of China (No.30600189)
文摘The effects of Sonic hedgehog(Shh) signaling pathway activation on S-type neuroblastoma(NB) cell lines and its role in NB tumorigenesis were investigated.Immunohistochemistry was used to detect the expression of Shh pathway components— Patched1(PTCH1) and Gli1 in 40 human primary NB samples.Western blotting and RT-PCR were used to examine the protein expression and mRNA levels of PTCH1 and Gli1 in three kinds of S-type NB cell lines(SK-N-AS,SK-N-SH and SHEP1),respectively.Exogenous Shh was administrated to activate Shh signaling pathway while cyclopamine was used as a selective antagonist of Shh pathway.S-type NB cell lines were treated with different concentrations of Shh or/and cyclopamine for different durations.Cell viability was measured by using MTT method.Apoptosis rate and cell cycle were assayed by flow cytometry.The xenograft experiments were used to evaluate the role of Shh pathway in tumor growth in immunodeficient mice.High-level expression of PTCH1 and Gli1 was detected in both NB samples and S-type NB cell lines.Cyclopamine decreased the survival rate of the three cell lines while Shh increased it,and the inhibition effects of cyclopamine could be partially reversed by shh pre-treatment.Cyclopamine induced the cell apoptosis and the cell cycle arrest in G0/G1 phase,while Shh induced the reverse effects and could partially prevent effects of cyclopamine.Cyclopamine could also inhibit the growth of NB in vivo.Our studies revealed that activation of the Shh pathway is important for survival and proliferation of S-type NB cells in vivo and in vitro through affecting cell apoptosis and cell cycle,suggesting a new therapeutic approach to NB.
文摘Various kinds of Riemann boundary value problems (BVPs) for analytic functions on closed curves or on open arc, doubly periodic Riemann BVPs, doubly quasi-periodic Riemann BVPs, and BVPs for polyanalytic functions have been widely investigated in [1-8]. The main ap- proach is to use the decomposition of polyanalytic functions and their generalization to transform the boundary value problems to their corresponding boundary value problems for analytic functions. Recently, inverse Riemann BVPs for generalized analytic functions or bianalytic functions have been investigated in [9-12]. In this paper, we consider a kind of Riemann BVP of non-normal type on the infinite straight line and discuss the solvable conditions and the general solution for it.
文摘In this work, an algorithm based on method of lines coupled with radial basis functions namely meshless method of lines (MMOL) is presented for the numerical solution of Kawahara, modified Kawahara and KdV Kawahara equations. The motion of a single solitary wave, interaction of two and three solitons and the phenomena of wave generation is discussed. The results are compared with the exact solution and with the results in the relevant literature to show the efficiency of the method.
基金provided by the Office of National Science and Technology (No.2006BAB16B01)the Physics Program of the Henan Province Education Department (No.2009B 560004)the Doctoral Fund of Henan Polytechnic University (No.648234)
文摘Numerical simulation was used to estimate the temperature field within a poured concrete,mono-layer freezing-shaft lining.The affects from various factors were investigated.The maximum temperature within the lining increases as the lining thickness increases,decreases as the soil-side wall temperature decreases,decreases as the air temperature inside the shaft decreases and decreases as the air velocity inside the shaft increases.The compression speed of an insulating foam layer affects the maximum temperature difference between the interior and the sidewalls.The maximum temperature difference between the interior and the sidewalls approaches or exceeds the maximum allowable for the curing of poured concrete structures.Attention should be paid to the question of the lining cracking during the curing period.The temperature gradient in the vertical direction may be minimized by preventing air contact against the steel connection board supporting the base of the freshly poured section.
基金Supported by Army-Civilian Technology Development of CAEP(No.JM200701)National Natural Science Foundation of China(No.11105130)Science Foundation of CAEP(No.2012B0402056)
文摘A cold-cathode Penning Ion Gauge(PIG) type ion source as the internal ion source of an 11 MeV cyclotron is designed and tested at Institute of Fluid Physics.The design considerations and some testings are presented.Experimental results of Balmer-line-Emission show that the discharge characteristic,which is mainly determined by gas-flow rate,is not very sensitive to arc current and magnetic field in the operation ranges of the cyclotron.The arc power decreases and ascends while the gas-flow rate goes up from 0.5 SCCM to 20 SCCM.By improving the sealing design and reducing the machine tolerance of the source,the minimum power consumption reduces from 9 SCCM to 4 SCCM,thus having better energy efficiency and benefiting for the pumping system.Preliminary DC extractions show that H–microampere current ranges from several tens to hundreds under different operation conditions.Some problems during the experiments and future plan are discussed in the end.
基金supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (Grant No.61521003)the National Basic Research Program of China (2012CB315901, 2013CB329104)+1 种基金the National Natural Science Foundation of China (Grant No. 61372121, 61309019, 61309020)the National HighTech Research & Development Program of China (Grant No. 2015AA016102, 2013AA013505)
文摘Towards line speed and accurateness on-line content popularity monitoring on Content Centric Networking(CCN) routers, we propose a three-stage scheme based on Bloom filters and hash tables for differentiated traffic. At the first stage, we decide whether to deliver the content to the next stage depending on traffic types. The second stage consisting of Standard Bloom filters(SBF) and Counting Bloom filters(CBF) identifies the popular content. Meanwhile, a scalable sliding time window based monitoring scheme for different traffic types is proposed to implement frequent and real-time updates by the change of popularities. Hash tables according with sliding window are used to record the popularity at the third stage. Simulation results reveal that this method reaches a 40 Gbps processing speed at lower error probability with less memory, and it is more sensitive to the change of popularity. Additionally, the architecture which can be implemented in CCN router is flexible and scalable.
文摘运用我国2016-2018年三个冬半年(10月至次年3月)地面2515个站的天气现象观测资料,对ECMWF(European Centre for Medium-Range Weather Forecasts)的降水相态预报产品(PTYPE)(分为雨、雨夹雪、雪和冻雨四类)进行了系统性的检验评估,包括细网格确定性模式预报产品和集合预报系统概率预报产品。结果显示,ECMWF的确定性预报产品对四类降水相态的正确率普遍达到90%以上,对降雨和降雪的TS评分也较高,冻雨次之,雨夹雪的TS评分较低,预报能力有限。确定性模式对我国雨雪分界线的预报,普遍存在短期位置略偏南、中期随时效延长越来越偏北的误差特点,且对雨夹雪的预报范围明显偏小,对冻雨的预报范围明显偏大。集合预报系统从概率的角度一定程度上弥补了确定性模式的上述误差。对概率预报的检验结果显示,集合预报系统降雨概率普遍偏低,降雪概率短期偏高、中期偏低,而雨夹雪和冻雨概率普遍偏低,但是都有一定的预报技巧。集合预报系统相对于确定性模式的优势,降雨体现在较小花费损失比事件的预报上,降雪体现在较大花费损失比事件的预报上。对雨夹雪和冻雨,相对于确定性模式,集合预报系统体现出了显著的优势,尤其是冻雨,集合预报系统的优势更加明显。
文摘A hydraulic model test for ￢-type groynes (with “￢” shape) was conducted to analyze the flow characteristics around these groynes. The results of the model tests are expected to be used as fundamental information in designing the ￢-type groyne constructed in the field. Main hydraulic factors such as velocity and thalweg line changes in the main channel and separation area were analyzed in this study. The thalweg line is a stream line where the maximum velocity occurs, whereas the separation area is the boundary between the main flow and the recirculation zone. Model tests with 5 different arm lengths of the ￢-type groynes were conducted by changing the velocity. The LSPIV (Large-Scale Particle Image Velocimetry) technique was used to measure and analyze flow variation around the ￢-type groynes. The velocity in the main channel measured to be increased by 1.5 times. The velocity variation on groyne arm length is little. The width of the thalweg lines (TCL) was changed to 55 - 57% of the channel width. The Froude number did not affect the thalweg line (TCL) and separation line (Sh) changes, however.
文摘A plant expression vector containing a chimeric Bt29K gene coding for the activated Cry1Ac protein and the arrowhead proteinase inhibitior gene API B were introduced into the cotton cultivar Jihe321 mediated by Agrobactertium tumefaciens. Based on the results of kanamycin resistant testing, PCR detection for both foreign genes and insect bioassay using Heliethis armigera , nine transgenic homozygous cotton lines with insect resistance of more than 90% and better agronomic traits were bred through six generations from the original transgenic plants. Results from insect bioassay and sequence analysis of the PCR products of plants from some homozygous lines indicated that the chimeric Bt29K gene was stably inherited in these transgenic cotton lines. The main agronomic characters of these homozygous cotton lines, such as boll productivity and fibre strength, were better than that of the original cotton cv. Jihe321.
文摘The article deals with the prduction lines in log yard by investigating the utilizationof machines in forest areas,presents the methods and rules of differentiating the log productionlines and also summarizes the formation and development of three kinds of log production lines innortbeast forest areas of China.It gives different combination types of log production lines andtheir applications, so it is significant for us to evaluate and standardize the log Production lines.
文摘Objective: To replace the peripheral venous puncture for blood sampling with taking blood samples extracorporally from arterial line before predilution during RCA-CRRT performed. Methods: A new type of double-lumen femoral catheter was used instead of the current tubes. The new type of double-lumen tube had a greater distance from the inner venous ports to the inner arterial ports than current tubes. The minimum distance from the venous port to the arterial port was greatly lengthened. Replacement solution contained citrate, zero Ca<sup>2+</sup>, zero bicarbonate, low Na<sup>+</sup>. Blood samples were synchronously collected from the arterial line before the infusion of citrate replacement fluid and from the peripheral vein. The iCa concentration data of two groups were analyzed to observe the difference between iCa concentration levels in the arterial line and in peripheral vein;the anticoagulant effect of RCA and possible complications were observed, such as bleeding, clottings and hypocalcaemia. Results: 28 times of RCA-CRRT were performed on17 AKI and CRF patients with active bleeding or at the high risk of bleeding;336 blood samples were collected. Statistics showed that the difference of iCa concentration between arterial line group and the peripheral vein group was not significant (P = 0.9), there is a high degree of similarity between the iCa concentration of arterial line blood and the peripheral venous blood. None of the patients developed citrate toxicity or metabolic alkalosis. None induced bleeding, or bleeding aggravated. No obvious clotting occurred. Systemic calcium concentration was achieved in the ideal range. Conclusion: In clinical practice, the data of iCa concentration from arterial line can be used to replace that from peripheral vein when the new type of double-lumen femoral catheter is placed in femoral vein. RCA-CRRT therapy is safe and effective.
基金supported by the National Natural Science Foundations of China (Grant Nos. 10947017/A05 and 11074190)the Science Foundation of the Key Laboratory of Novel Thin Film Solar Cells, China (Grant No. KF200912)the Graduates' Innovative Scientific Research Project of Zhejiang Province, China (Grant No. 2011831)
文摘We propose a simple scheme to generate x-type four-charge entangled states by using SQUID-based charge qubits capacitively coupled to a transmission line resonator （TLR）. The coupling between the superconducting qubit and the TLR can be effectively controlled by properly adjusting the control parameters of the charge qubit. The experimental feasibility of our scheme is also shown.
