In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This...In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This article considers subgroup analysis methods for longitudinal data containing multiple covariates and biomarkers.We divide subgroups based on whether a linear combination of these biomarkers exceeds a predetermined threshold,and assess the heterogeneity of treatment effects across subgroups using the interaction between subgroups and exposure variables.Quantile regression is used to better characterize the global distribution of the response variable and sparsity penalties are imposed to achieve variable selection of covariates and biomarkers.The effectiveness of our proposed methodology for both variable selection and parameter estimation is verified through random simulations.Finally,we demonstrate the application of this method by analyzing data from the PA.3 trial,further illustrating the practicality of the method proposed in this paper.展开更多
Copula functions have been widely used in stochastic simulation and prediction of streamflow.However,existing models are usually limited to single two-dimensional or three-dimensional copulas with the same bivariate b...Copula functions have been widely used in stochastic simulation and prediction of streamflow.However,existing models are usually limited to single two-dimensional or three-dimensional copulas with the same bivariate block for all months.To address this limitation,this study developed a mixed D-vine copula-based conditional quantile model that can capture temporal correlations.This model can generate streamflow by selecting different historical streamflow variables as the conditions for different months and by exploiting the conditional quantile functions of streamflows in different months with mixed D-vine copulas.The up-to-down sequential method,which couples the maximum weight approach with the Akaike information criteria and the maximum likelihood approach,was used to determine the structures of multivariate Dvine copulas.The developed model was used in a case study to synthesize the monthly streamflow at the Tangnaihai hydrological station,the inflow control station of the Longyangxia Reservoir in the Yellow River Basin.The results showed that the developed model outperformed the commonly used bivariate copula model in terms of the performance in simulating the seasonality and interannual variability of streamflow.This model provides useful information for water-related natural hazard risk assessment and integrated water resources management and utilization.展开更多
In this paper, we propose the double-penalized quantile regression estimators in partially linear models. An iterative algorithm is proposed for solving the proposed optimization problem. Some numerical examples illus...In this paper, we propose the double-penalized quantile regression estimators in partially linear models. An iterative algorithm is proposed for solving the proposed optimization problem. Some numerical examples illustrate that the finite sample performances of proposed method perform better than the least squares based method with regard to the non-causal selection rate (NSR) and the median of model error (MME) when the error distribution is heavy-tail. Finally, we apply the proposed methodology to analyze the ragweed pollen level dataset.展开更多
The composite quantile regression should provide estimation efficiency gain over a single quantile regression. In this paper, we extend composite quantile regression to nonparametric model with random censored data. T...The composite quantile regression should provide estimation efficiency gain over a single quantile regression. In this paper, we extend composite quantile regression to nonparametric model with random censored data. The asymptotic normality of the proposed estimator is established. The proposed methods are applied to the lung cancer data. Extensive simulations are reported, showing that the proposed method works well in practical settings.展开更多
In this paper,we consider testing the hypothesis concerning the means of two independent semicontinuous distributions whose observations are zero-inflated,characterized by a sizable number of zeros and positive observ...In this paper,we consider testing the hypothesis concerning the means of two independent semicontinuous distributions whose observations are zero-inflated,characterized by a sizable number of zeros and positive observations from a continuous distribution.The continuous parts of the two semicontinuous distributions are assumed to follow a density ratio model.A new two-part test is developed for this kind of data.The proposed test takes the sum of one test for equality of proportions of zero values and one conditional test for the continuous distribution.The test is proved to follow a 2 distribution with two degrees of freedom.Simulation studies show that the proposed test controls the type I error rates at the desired level,and is competitive to,and most of the time more powerful than two popular tests.A real data example from a dietary intervention study is used to illustrate the usefulness of the proposed test.展开更多
In this paper, three smoothed empirical log-likelihood ratio functions for the parameters of nonlinear models with missing response are suggested. Under some regular conditions, the corresponding Wilks phenomena are o...In this paper, three smoothed empirical log-likelihood ratio functions for the parameters of nonlinear models with missing response are suggested. Under some regular conditions, the corresponding Wilks phenomena are obtained and the confidence regions for the parameter can be constructed easily.展开更多
基金Supported by the Natural Science Foundation of Fujian Province(2022J011177,2024J01903)the Key Project of Fujian Provincial Education Department(JZ230054)。
文摘In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This article considers subgroup analysis methods for longitudinal data containing multiple covariates and biomarkers.We divide subgroups based on whether a linear combination of these biomarkers exceeds a predetermined threshold,and assess the heterogeneity of treatment effects across subgroups using the interaction between subgroups and exposure variables.Quantile regression is used to better characterize the global distribution of the response variable and sparsity penalties are imposed to achieve variable selection of covariates and biomarkers.The effectiveness of our proposed methodology for both variable selection and parameter estimation is verified through random simulations.Finally,we demonstrate the application of this method by analyzing data from the PA.3 trial,further illustrating the practicality of the method proposed in this paper.
基金supported by the National Natural Science Foundation of China(Grant No.52109010)the Postdoctoral Science Foundation of China(Grant No.2021M701047)the China National Postdoctoral Program for Innovative Talents(Grant No.BX20200113).
文摘Copula functions have been widely used in stochastic simulation and prediction of streamflow.However,existing models are usually limited to single two-dimensional or three-dimensional copulas with the same bivariate block for all months.To address this limitation,this study developed a mixed D-vine copula-based conditional quantile model that can capture temporal correlations.This model can generate streamflow by selecting different historical streamflow variables as the conditions for different months and by exploiting the conditional quantile functions of streamflows in different months with mixed D-vine copulas.The up-to-down sequential method,which couples the maximum weight approach with the Akaike information criteria and the maximum likelihood approach,was used to determine the structures of multivariate Dvine copulas.The developed model was used in a case study to synthesize the monthly streamflow at the Tangnaihai hydrological station,the inflow control station of the Longyangxia Reservoir in the Yellow River Basin.The results showed that the developed model outperformed the commonly used bivariate copula model in terms of the performance in simulating the seasonality and interannual variability of streamflow.This model provides useful information for water-related natural hazard risk assessment and integrated water resources management and utilization.
文摘In this paper, we propose the double-penalized quantile regression estimators in partially linear models. An iterative algorithm is proposed for solving the proposed optimization problem. Some numerical examples illustrate that the finite sample performances of proposed method perform better than the least squares based method with regard to the non-causal selection rate (NSR) and the median of model error (MME) when the error distribution is heavy-tail. Finally, we apply the proposed methodology to analyze the ragweed pollen level dataset.
文摘The composite quantile regression should provide estimation efficiency gain over a single quantile regression. In this paper, we extend composite quantile regression to nonparametric model with random censored data. The asymptotic normality of the proposed estimator is established. The proposed methods are applied to the lung cancer data. Extensive simulations are reported, showing that the proposed method works well in practical settings.
基金Supported by the National Natural Science Foundation of China(No.11971433)the First Class Discipline of Zhejiang-A(Zhejiang Gongshang University-Statistics)the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
文摘In this paper,we consider testing the hypothesis concerning the means of two independent semicontinuous distributions whose observations are zero-inflated,characterized by a sizable number of zeros and positive observations from a continuous distribution.The continuous parts of the two semicontinuous distributions are assumed to follow a density ratio model.A new two-part test is developed for this kind of data.The proposed test takes the sum of one test for equality of proportions of zero values and one conditional test for the continuous distribution.The test is proved to follow a 2 distribution with two degrees of freedom.Simulation studies show that the proposed test controls the type I error rates at the desired level,and is competitive to,and most of the time more powerful than two popular tests.A real data example from a dietary intervention study is used to illustrate the usefulness of the proposed test.
文摘In this paper, three smoothed empirical log-likelihood ratio functions for the parameters of nonlinear models with missing response are suggested. Under some regular conditions, the corresponding Wilks phenomena are obtained and the confidence regions for the parameter can be constructed easily.
