A new two-parameter formula for the rotational spectra of well deformed nuclei isproposed. The formula is deduced from experimental level systematics and alternatively fromnuclear hydrodynamics. Comparisons with a gre...A new two-parameter formula for the rotational spectra of well deformed nuclei isproposed. The formula is deduced from experimental level systematics and alternatively fromnuclear hydrodynamics. Comparisons with a great number of rotational spectra of even-even nu-clei in rare-earth and actinides region show that the formula is the best one among all two-pa-rameter formulas. It is pointed out that this formula can be applied to the spin assignment forsuperdeformed band.展开更多
The two-parameter formulae, i.e. the nuclear softness formula and the power index formula, have been used to obtain the band head spin （I0） of the triaxial superdeformed （SD） bands in ^163Lu（1,2,3,4）, ^164Lu（1,...The two-parameter formulae, i.e. the nuclear softness formula and the power index formula, have been used to obtain the band head spin （I0） of the triaxial superdeformed （SD） bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3）, in the A - 160 mass region. The least squares fitting approach is used. The values of the root mean square （RMS） deviation among the computed and the measured experimental transition energies are obtained by calculating the model parameters. Whenever accurate spins are available, superb agreement is shown between the determined and the measured experimental transition energies. In comparison to the power index formula, the values of band head spin （I0） of the triaxial SD bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3） obtained by the nuclear softness formula are closer to the experimental data. The lowest RMS deviation is also achieved by the nuclear softness formula. Hence, the nuclear softness formula works well for obtaining the band head spin （I0） for the triaxial SD bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3） in the A-160 mass region. The dynamic moment of inertia against hω is also studied.展开更多
Transcritical and supercritical fluids widely exist in aerospace propulsion systems,such as the coolant flow in the regenerative cooling channels of scramjet engines.To numerically simulate the coolant flow,we must ad...Transcritical and supercritical fluids widely exist in aerospace propulsion systems,such as the coolant flow in the regenerative cooling channels of scramjet engines.To numerically simulate the coolant flow,we must address the challenges in solving Riemann problems(RPs)for real fluids under complex flow conditions.In this study,an exact numerical solution for the one-dimensional RP of two-parameter fluids is developed.Due to the comprehensive resolution of fluid thermodynamics,the proposed solution framework is suitable for all forms of the two-parameter equation of state(EoS).The pressure splitting method is introduced to enable parallel calculation of RPs across multiple grid points.Theoretical analysis demonstrates the isentropic nature of weak waves in two-parameter fluids,ensuring that the same mathematical properties as ideal gas could be applied in Newton's iteration.A series of numerical cases validate the effectiveness of the proposed method.A comparative analysis is conducted on the exact Riemann solutions for the real fluid EoS,the ideal gas EoS,and the improved ideal gas EoS under supercritical and transcritical conditions.The results indicate that the improved one produces smaller errors in the calculation of momentum and energy fluxes.展开更多
BACKGROUND Perimenopausal women are prone to anxiety and depression due to fluctuating hormone levels,which significantly impair their quality of life.The current treatments have certain limitations.In traditional Chi...BACKGROUND Perimenopausal women are prone to anxiety and depression due to fluctuating hormone levels,which significantly impair their quality of life.The current treatments have certain limitations.In traditional Chinese medicine,liver-soothing formulas are commonly prescribed for mood-related disorders,but their overall efficacy in perimenopausal anxiety and depression remains uncertain and requires verification through meta-analysis.AIM To provide evidence-based support for clinical decision-making and research,a meta-analysis was conducted to evaluate the effectiveness of liver-soothing formulas in treating perimenopausal anxiety and depression.METHODS Relevant studies published up to April 2025 were retrieved from ClinicalTrials.gov,PubMed,Web of Science,EMBASE,and the Cochrane Library.Eligible studies were screened according to predefined inclusion and exclusion criteria.Data were extracted and analyzed using the Stata 12.0 software.RESULTS After searching and screening,12 articles involving 1798 patients(922 in the treatment group and 876 in the control group)were included in the analysis.Meta-analysis showed that the standardized scores for anxiety[standardized mean difference(SMD)=-0.71,95%confidence interval(95%CI):-1.06 to-0.36]and depression(SMD=-0.67,95%CI:-1.06 to-0.27)of the treatment group were lower than those of the control group.Subgroup analysis results revealed that for anxiety,liver-soothing formulas used alone(SMD=-0.34,95%CI:-0.50 to-0.18)or in combination(SMD=-0.88,95%CI:-1.43 to-0.34)both significantly reduced scores compared with the control group.For depression,monotherapy of liversoothing formulas showed no significant statistical difference between the treatment and control groups(SMD=-0.47,95%CI:-1.11 to 0.17),whereas combination therapy produced significantly lower standardized scale scores in the treatment group than in the control group,with a statistically significant difference(SMD=-0.83,95%CI:-1.39 to-0.28).Regarding Greene scores,no statistically significant difference was observed with monotherapy(SMD=0.87,95%CI:-0.32 to 2.06),whereas combination therapy had significantly lower Greene scores(SMD=-0.24,95%CI:-0.44 to-0.04).No statistically significant difference was found between the groups in the occurrence of adverse reactions(odds ratio=0.90,95%CI:0.57-1.43).However,liver-soothing formulas did not affect estrogen levels in perimenopausal women.CONCLUSION Compared with placebo,conventional Western medicine,or other interventions,the monotherapy of liver-soothing formulas demonstrates superior efficacy in treating perimenopausal anxiety.When used as an adjuvant,they exert a synergistic effect in alleviating negative emotions and improving overall perimenopausal symptoms.展开更多
Stacking velocity V_（C2）,vertical velocity ratio γ_0,effective velocity ratio γ_（eff）,and anisotropic parameter x_（eff） are correlated in the PS-converted-wave（PS-wave） anisotropic prestack Kirchhoff time mi...Stacking velocity V_（C2）,vertical velocity ratio γ_0,effective velocity ratio γ_（eff）,and anisotropic parameter x_（eff） are correlated in the PS-converted-wave（PS-wave） anisotropic prestack Kirchhoff time migration（PKTM） velocity model and are thus difficult to independently determine.We extended the simplified two-parameter（stacking velocity V_（C2） and anisotropic parameter k_（eff）） moveout equation from stacking velocity analysis to PKTM velocity model updating and formed a new four-parameter（stacking velocity V_（C2）,vertical velocity ratio γ_0,effective velocity ratio γ_（eff）,and anisotropic parameter k_（eff）） PS-wave anisotropic PKTM velocity model updating and process flow based on the simplified twoparameter moveout equation.In the proposed method,first,the PS-wave two-parameter stacking velocity is analyzed to obtain the anisotropic PKTM initial velocity and anisotropic parameters;then,the velocity and anisotropic parameters are corrected by analyzing the residual moveout on common imaging point gathers after prestack time migration.The vertical velocity ratio γ_0 of the prestack time migration velocity model is obtained with an appropriate method utilizing the P- and PS-wave stacked sections after level calibration.The initial effective velocity ratio γ_（eff） is calculated using the Thomsen（1999） equation in combination with the P-wave velocity analysis;ultimately,the final velocity model of the effective velocity ratio γ_（eff） is obtained by percentage scanning migration.This method simplifies the PS-wave parameter estimation in high-quality imaging,reduces the uncertainty of multiparameter estimations,and obtains good imaging results in practice.展开更多
In this paper, we consider a general form of the increments for a two-parameter Wiener process. Both the Csorgo-Revesz's increments and a class of the lag increments are the special cases of this general form of i...In this paper, we consider a general form of the increments for a two-parameter Wiener process. Both the Csorgo-Revesz's increments and a class of the lag increments are the special cases of this general form of increments. Our results imply the theorem that have been given by Csorgo and Revesz (1978), and some of their conditions are removed.展开更多
The main objective of this study is to investigate the buckling analysis of CCSs reinforced by CNTs subjected to combined loading of hydrostatic pressure and axial compression resting on the twoparameter elastic found...The main objective of this study is to investigate the buckling analysis of CCSs reinforced by CNTs subjected to combined loading of hydrostatic pressure and axial compression resting on the twoparameter elastic foundation(T-P-EF).It is one of the first attempts to derive the governing equations of the CCSs reinforced with CNTs,based on a generalized first-order shear deformation shell theory(FSDST)which includes shell-foundation interaction.By adopting the extended mixing rule,the effective material properties of CCSs reinforced by CNTs with linear distributions are approximated by introducing some efficiency parameters.Three carbon nanotube distribution in the matrix,i.e.uniform distribution(U)and V and X-types linear distribution are taken into account.The stability equations are solved by using the Galerkin procedure to determine the combined buckling loads(CBLs)of the structure selected here.The numerical illustrations cover CBLs characteristics of CCSs reinforced by CNTs in the presence of the T-P-EF.Finally,a parametric study is carried out to study the influences of the foundation parameters,the volume fraction of carbon nanotubes and the types of reinforcement on the CBLs.展开更多
<div style="text-align:justify;"> The ellipse and the superellipse are both planar closed curves with a double axis of symmetry. Here we show the isoconcentration contour of the simplified two-dimensio...<div style="text-align:justify;"> The ellipse and the superellipse are both planar closed curves with a double axis of symmetry. Here we show the isoconcentration contour of the simplified two-dimensional advection-diffusion equation from a stable line source in the center of a wide river. A new two-parameter heteromorphic elliptic equation with a single axis of symmetry is defined. The values of heights, at the point of the maximum width and that of the centroid of the heteromorphic ellipse, are derived through mathematical analysis. Taking the compression coefficient <em>θ </em>= <em>b/a =</em><em></em><span></span> 1 as the criterion, the shape classification of H-type, Standard-type and W-type for heteromorphic ellipse have been given. The area formula, the perimeter theorem, and the radius of curvature of heteromorphic ellipses, and the geometric properties of the rotating body are subsequently proposed. An illustrative analysis shows that the inner contour curve of a heteromorphic elliptic tunnel has obvious advantages over the multiple- arc splicing cross section. This work demonstrates that the heteromorphic ellipses have extensive prospects of application in all categories of tunnels, liquid transport tanks, aircraft and submarines, bridges, buildings, furniture, and crafts. </div>展开更多
This paper proves a new theorem on the relationship between optical field Wigner function＇s two-parameter Radon transform and optical Fresnel transform of the field, i.e., when an input field ψ （x＇） propagates th...This paper proves a new theorem on the relationship between optical field Wigner function＇s two-parameter Radon transform and optical Fresnel transform of the field, i.e., when an input field ψ （x＇） propagates through an optical [D （-B） （-C） A] system, the energy density of the output field is equal to the Radon transform of the Wigner function of the input field, where the Radon transform parameters are D, B. It prove this theorem in both spatial-domain and frequency-domain, in the latter case the Radon transform parameters are A, C.展开更多
The n-power two-parameter universal equation for rotational spectra which we deduced recently is appliedto the description of the rotational bands of several diatomic and tetra-atomic molecules. Excellent agreement wi...The n-power two-parameter universal equation for rotational spectra which we deduced recently is appliedto the description of the rotational bands of several diatomic and tetra-atomic molecules. Excellent agreement withexperimental data can be obtained with small n values. The relation between our equation and the famous Dunhamformula is discussed.展开更多
Two fundamental solutions for bending problem of Reissner's plates on twoparameter foundation are derived by means of Fouier integral transformation of generalized function in this paper.On the basis of virtual wo...Two fundamental solutions for bending problem of Reissner's plates on twoparameter foundation are derived by means of Fouier integral transformation of generalized function in this paper.On the basis of virtual work principles, three boundary integral equations which fit for arbitrary shapes, loads and boundary conditions of thick plates are presented according to Hu Haichang's theory about Reissner's plates. It provides the fundamental theories for the application of BEM. A numerical example is given for clamped, simply supported and free boundary conditions. The results obtained are satisfactory as compared with the analytical methods.展开更多
The empirical Bayes test problem is considered for scale parameter of twoparameter exponential distribution under type-II censored data.By using wavelets estimation method,the EB test function is constructed,of which ...The empirical Bayes test problem is considered for scale parameter of twoparameter exponential distribution under type-II censored data.By using wavelets estimation method,the EB test function is constructed,of which the asymptotic optimality and convergence rates are obtained.Finally,an example concerning the main result is given.展开更多
We investigate the dynamics of entanglement for a two-parameter class of states in a hybrid qubit-qutrit system under the influence of various dissipative channels. Our results show that entanglement sudden death （ES...We investigate the dynamics of entanglement for a two-parameter class of states in a hybrid qubit-qutrit system under the influence of various dissipative channels. Our results show that entanglement sudden death （ESD） is a general phenomenon and it usually takes place in a qubit-qutrit system interacting with various noisy channels, not only the ease with dephasing and depolarizing channels observed by others. ESD can only be avoided for some initially entangled states under some particular noisy channels. Moreover, the environment affects the entanglement and the coherence of the system in very different ways.展开更多
This paper presents an enhanced version of the standard shooting method that enables problems with two unknown parameters to be solved.A novel approach is applied to the analysis of the natural vibrations of Euler-Ber...This paper presents an enhanced version of the standard shooting method that enables problems with two unknown parameters to be solved.A novel approach is applied to the analysis of the natural vibrations of Euler-Bernoulli beams.The proposed algorithm,named as two-parameter multiple shooting method,is a new powerful numerical tool for calculating the natural frequencies and modes of multi-segment prismatic and non-prismatic beams with different boundary conditions.The impact of the axial force and additional point masses is also taken into account.Due to the fact that the method is based directly on the fourth-order ordinary differential equation,the structures do not have to be divided into many small elements to obtain an accurate enough solution,even though the geometry is very complex.To verify the proposed method,three different examples are considered,i.e.,a three-segment non-prismatic beam,a prismatic column subject to non-uniformly distributed compressive loads,and a two-segment beam with an additional point mass.Numerical analyses are carried out with the software MATHEMATICA.The results are compared with the solutions computed by the commercial finite element program SOFiSTiK.Good agreement is achieved,which confirms the correctness and high effectiveness of the formulated algorithm.展开更多
The two-parameter exponential distribution is proposed to be an underlying model,and prediction bounds for future observations are obtained by using Bayesian approach.Prediction intervals are derived for unobserved li...The two-parameter exponential distribution is proposed to be an underlying model,and prediction bounds for future observations are obtained by using Bayesian approach.Prediction intervals are derived for unobserved lifetimes in one-sample prediction and two-sample prediction based on type Ⅱ doubly censored samples.A numerical example is given to illustrate the procedures,prediction intervals are investigated via Monte Carlo method,and the accuracy of prediction intervals is presented.展开更多
Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi...Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets.展开更多
OBJECTIVE:To investigate the effect and mechanism of Yishen Tongluo formula(益肾通络方,YSTLF)in streptozotocin-induced diabetic kidney disease mice(DKD)mice.METHODS:Thirty Institute of Cancer Research mice(specific pa...OBJECTIVE:To investigate the effect and mechanism of Yishen Tongluo formula(益肾通络方,YSTLF)in streptozotocin-induced diabetic kidney disease mice(DKD)mice.METHODS:Thirty Institute of Cancer Research mice(specific pathogen free,SPF grade)were divided into five groups(n=6 per group):control,DKD model,DKD model with YSTLF(4.9 g/kg),DKD model with YSTLF(9.8 g/kg),and DKD model with captopril.DKD was induced through a single intraperitoneal injection of streptozotocin(150 mg/kg).Body weight,fasting blood glucose and urine C-peptide levels were measured to assess metabolic regulation by YSTLF.Renal function was evaluated using indicators of glomerular and tubular health.Liver function was assessed by measuring aspartate aminotransferase and alanine aminotransferase levels.Renal pathological changes were examined using hematoxylin/eosin staining and transmission electron microscopy.Inflammatory and apoptosis-related factors were analyzed through enzyme-linked immunosorbent assay,immunohistochemistry,and Western blot analysis.RESULTS:In DKD mice,fasting blood glucose,Cpeptide,24-hour urine protein(UP)levels,and renal damage were elevated,accompanied by increased inflammation and apoptosis.YSTLF significantly reduced 24-hour UP and C-peptide levels and improved kidney and liver function in DKD mice.YSTLF also mitigated glomerular hypertrophy,basement membrane thickening,and podocyte foot process effacement.It upregulated the expression of the podocyte marker podocalyxin.Furthermore,YSTLF alleviated inflammation and apoptosis,likely by reducing the overexpression of monocyte chemoattractant protein(MCP-1),Bax,and Caspase-3 in the kidneys of DKD mice.CONCLUSIONS:These findings suggest that YSTLF ameliorates kidney injury by modulating the expression of inflammatory cytokine MCP-1 and the Bax/Caspase-3 apoptosis pathway,providing a potential therapeutic approach for DKD.展开更多
Objective The study of medicine formulas is a core component of traditional Chinese medicine(TCM),yet traditional learning methods often lack interactivity and contextual understanding,making it challenging for beginn...Objective The study of medicine formulas is a core component of traditional Chinese medicine(TCM),yet traditional learning methods often lack interactivity and contextual understanding,making it challenging for beginners to grasp the intricate composition rules of formulas.To address this gap,we introduce Formula-S,a situated visualization method for TCM formula learning in augmented reality(AR)and evaluate its performance.This study aims to evaluate the effectiveness of Formula-S in enhancing TCM formula learning for beginners by comparing it with traditional text-based formula learning and web-based visualization.Methods Formula-S is an interactive AR tool designed for TCM formula learning,featuring three modes(3D,Web,and Table).The dataset included TCM formulas and herb properties extracted from authoritative references,including textbook and the SymMap database.In Formula-S,the hierarchical visualization of the formulas as herbal medicine compositions,is linked to the multidimensional herb attribute visualization and embedded in the real world,where real herb samples are presented.To evaluate its effectiveness,a controlled study(n=30)was conducted.Participants who had no formal TCM knowledge were tasked with herbal medicine identification,formula composition,and recognition.In the study,participants interacted with the AR tool through HoloLens 2.Data were collected on both task performance(accuracy and response time)and user experience,with a focus on task efficiency,accuracy,and user preference across the different learning modes.Results The situated visualization method of Formula-S had comparable accuracy to other methods but shorter response time for herbal formula learning tasks.Regarding user experience,our new approach demonstrated the highest system usability and lowest task load,effectively reducing cognitive load and allowing users to complete tasks with greater ease and efficiency.Participants reported that Formula-S enhanced their learning experience through its intuitive interface and immersive AR environment,suggesting this approach offers usability advantages for TCM education.Conclusions The situated visualization method in Formula-S offers more efficient and accurate searching capabilities compared to traditional and web-based methods.Additionally,it provides superior contextual understanding of TCM formulas,making it a promising new solution for TCM learning.展开更多
Traditional Chinese medicine formula(TCMF)represents a fundamental component of Chinese medical practice,incorporating medical knowledge and practices from both Han Chinese and various ethnic minorities,while providin...Traditional Chinese medicine formula(TCMF)represents a fundamental component of Chinese medical practice,incorporating medical knowledge and practices from both Han Chinese and various ethnic minorities,while providing comprehensive insights into health and disease.The foundation of TCMF lies in its holistic approach,manifested through herbal compatibility theory,which has emerged from extensive clinical experience and evolved into a highly refined knowledge system.Within this framework,Chinese herbal medicines exhibit intricated characteristics,including multi-component interactions,diverse target sites,and varied biological pathways.These complexities pose significant challenges for understanding their molecular mechanisms.Contemporary advances in artificial intelligence(AI)are reshaping research in traditional Chinese medicine(TCM),offering immense potential to transform our understanding of the molecular mechanisms underlying TCMFs.This review explores the application of AI in uncovering these mechanisms,highlighting its role in compound absorption,distribution,metabolism,and excretion(ADME)prediction,molecular target identification,compound and target synergy recognition,pharmacological mechanisms exploration,and herbal formula optimization.Furthermore,the review discusses the challenges and opportunities in AI-assisted research on TCMF molecular mechanisms,promoting the modernization and globalization of TCM.展开更多
基金The project supported by the National Natural Scicnce Foundation of China CCAST (World Lab)
文摘A new two-parameter formula for the rotational spectra of well deformed nuclei isproposed. The formula is deduced from experimental level systematics and alternatively fromnuclear hydrodynamics. Comparisons with a great number of rotational spectra of even-even nu-clei in rare-earth and actinides region show that the formula is the best one among all two-pa-rameter formulas. It is pointed out that this formula can be applied to the spin assignment forsuperdeformed band.
文摘The two-parameter formulae, i.e. the nuclear softness formula and the power index formula, have been used to obtain the band head spin （I0） of the triaxial superdeformed （SD） bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3）, in the A - 160 mass region. The least squares fitting approach is used. The values of the root mean square （RMS） deviation among the computed and the measured experimental transition energies are obtained by calculating the model parameters. Whenever accurate spins are available, superb agreement is shown between the determined and the measured experimental transition energies. In comparison to the power index formula, the values of band head spin （I0） of the triaxial SD bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3） obtained by the nuclear softness formula are closer to the experimental data. The lowest RMS deviation is also achieved by the nuclear softness formula. Hence, the nuclear softness formula works well for obtaining the band head spin （I0） for the triaxial SD bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3） in the A-160 mass region. The dynamic moment of inertia against hω is also studied.
基金Project supported by the National Natural Science Foundation of China(No.12525202)。
文摘Transcritical and supercritical fluids widely exist in aerospace propulsion systems,such as the coolant flow in the regenerative cooling channels of scramjet engines.To numerically simulate the coolant flow,we must address the challenges in solving Riemann problems(RPs)for real fluids under complex flow conditions.In this study,an exact numerical solution for the one-dimensional RP of two-parameter fluids is developed.Due to the comprehensive resolution of fluid thermodynamics,the proposed solution framework is suitable for all forms of the two-parameter equation of state(EoS).The pressure splitting method is introduced to enable parallel calculation of RPs across multiple grid points.Theoretical analysis demonstrates the isentropic nature of weak waves in two-parameter fluids,ensuring that the same mathematical properties as ideal gas could be applied in Newton's iteration.A series of numerical cases validate the effectiveness of the proposed method.A comparative analysis is conducted on the exact Riemann solutions for the real fluid EoS,the ideal gas EoS,and the improved ideal gas EoS under supercritical and transcritical conditions.The results indicate that the improved one produces smaller errors in the calculation of momentum and energy fluxes.
文摘BACKGROUND Perimenopausal women are prone to anxiety and depression due to fluctuating hormone levels,which significantly impair their quality of life.The current treatments have certain limitations.In traditional Chinese medicine,liver-soothing formulas are commonly prescribed for mood-related disorders,but their overall efficacy in perimenopausal anxiety and depression remains uncertain and requires verification through meta-analysis.AIM To provide evidence-based support for clinical decision-making and research,a meta-analysis was conducted to evaluate the effectiveness of liver-soothing formulas in treating perimenopausal anxiety and depression.METHODS Relevant studies published up to April 2025 were retrieved from ClinicalTrials.gov,PubMed,Web of Science,EMBASE,and the Cochrane Library.Eligible studies were screened according to predefined inclusion and exclusion criteria.Data were extracted and analyzed using the Stata 12.0 software.RESULTS After searching and screening,12 articles involving 1798 patients(922 in the treatment group and 876 in the control group)were included in the analysis.Meta-analysis showed that the standardized scores for anxiety[standardized mean difference(SMD)=-0.71,95%confidence interval(95%CI):-1.06 to-0.36]and depression(SMD=-0.67,95%CI:-1.06 to-0.27)of the treatment group were lower than those of the control group.Subgroup analysis results revealed that for anxiety,liver-soothing formulas used alone(SMD=-0.34,95%CI:-0.50 to-0.18)or in combination(SMD=-0.88,95%CI:-1.43 to-0.34)both significantly reduced scores compared with the control group.For depression,monotherapy of liversoothing formulas showed no significant statistical difference between the treatment and control groups(SMD=-0.47,95%CI:-1.11 to 0.17),whereas combination therapy produced significantly lower standardized scale scores in the treatment group than in the control group,with a statistically significant difference(SMD=-0.83,95%CI:-1.39 to-0.28).Regarding Greene scores,no statistically significant difference was observed with monotherapy(SMD=0.87,95%CI:-0.32 to 2.06),whereas combination therapy had significantly lower Greene scores(SMD=-0.24,95%CI:-0.44 to-0.04).No statistically significant difference was found between the groups in the occurrence of adverse reactions(odds ratio=0.90,95%CI:0.57-1.43).However,liver-soothing formulas did not affect estrogen levels in perimenopausal women.CONCLUSION Compared with placebo,conventional Western medicine,or other interventions,the monotherapy of liver-soothing formulas demonstrates superior efficacy in treating perimenopausal anxiety.When used as an adjuvant,they exert a synergistic effect in alleviating negative emotions and improving overall perimenopausal symptoms.
基金supported by the Important National Science&Technology Specific Projects(No.2011ZX05019-003)the New Method and Technology Research Project of Geophysical Exploration of CNPC(No.2014A-3612)
文摘Stacking velocity V_（C2）,vertical velocity ratio γ_0,effective velocity ratio γ_（eff）,and anisotropic parameter x_（eff） are correlated in the PS-converted-wave（PS-wave） anisotropic prestack Kirchhoff time migration（PKTM） velocity model and are thus difficult to independently determine.We extended the simplified two-parameter（stacking velocity V_（C2） and anisotropic parameter k_（eff）） moveout equation from stacking velocity analysis to PKTM velocity model updating and formed a new four-parameter（stacking velocity V_（C2）,vertical velocity ratio γ_0,effective velocity ratio γ_（eff）,and anisotropic parameter k_（eff）） PS-wave anisotropic PKTM velocity model updating and process flow based on the simplified twoparameter moveout equation.In the proposed method,first,the PS-wave two-parameter stacking velocity is analyzed to obtain the anisotropic PKTM initial velocity and anisotropic parameters;then,the velocity and anisotropic parameters are corrected by analyzing the residual moveout on common imaging point gathers after prestack time migration.The vertical velocity ratio γ_0 of the prestack time migration velocity model is obtained with an appropriate method utilizing the P- and PS-wave stacked sections after level calibration.The initial effective velocity ratio γ_（eff） is calculated using the Thomsen（1999） equation in combination with the P-wave velocity analysis;ultimately,the final velocity model of the effective velocity ratio γ_（eff） is obtained by percentage scanning migration.This method simplifies the PS-wave parameter estimation in high-quality imaging,reduces the uncertainty of multiparameter estimations,and obtains good imaging results in practice.
基金Supported by the National Natural Science Foundation of ChinaZhejiang Province Natural Science Fund
文摘In this paper, we consider a general form of the increments for a two-parameter Wiener process. Both the Csorgo-Revesz's increments and a class of the lag increments are the special cases of this general form of increments. Our results imply the theorem that have been given by Csorgo and Revesz (1978), and some of their conditions are removed.
文摘The main objective of this study is to investigate the buckling analysis of CCSs reinforced by CNTs subjected to combined loading of hydrostatic pressure and axial compression resting on the twoparameter elastic foundation(T-P-EF).It is one of the first attempts to derive the governing equations of the CCSs reinforced with CNTs,based on a generalized first-order shear deformation shell theory(FSDST)which includes shell-foundation interaction.By adopting the extended mixing rule,the effective material properties of CCSs reinforced by CNTs with linear distributions are approximated by introducing some efficiency parameters.Three carbon nanotube distribution in the matrix,i.e.uniform distribution(U)and V and X-types linear distribution are taken into account.The stability equations are solved by using the Galerkin procedure to determine the combined buckling loads(CBLs)of the structure selected here.The numerical illustrations cover CBLs characteristics of CCSs reinforced by CNTs in the presence of the T-P-EF.Finally,a parametric study is carried out to study the influences of the foundation parameters,the volume fraction of carbon nanotubes and the types of reinforcement on the CBLs.
文摘<div style="text-align:justify;"> The ellipse and the superellipse are both planar closed curves with a double axis of symmetry. Here we show the isoconcentration contour of the simplified two-dimensional advection-diffusion equation from a stable line source in the center of a wide river. A new two-parameter heteromorphic elliptic equation with a single axis of symmetry is defined. The values of heights, at the point of the maximum width and that of the centroid of the heteromorphic ellipse, are derived through mathematical analysis. Taking the compression coefficient <em>θ </em>= <em>b/a =</em><em></em><span></span> 1 as the criterion, the shape classification of H-type, Standard-type and W-type for heteromorphic ellipse have been given. The area formula, the perimeter theorem, and the radius of curvature of heteromorphic ellipses, and the geometric properties of the rotating body are subsequently proposed. An illustrative analysis shows that the inner contour curve of a heteromorphic elliptic tunnel has obvious advantages over the multiple- arc splicing cross section. This work demonstrates that the heteromorphic ellipses have extensive prospects of application in all categories of tunnels, liquid transport tanks, aircraft and submarines, bridges, buildings, furniture, and crafts. </div>
基金supported by the National Natural Science Foundation of China (Grant Nos 10775097 and 10874174)
文摘This paper proves a new theorem on the relationship between optical field Wigner function＇s two-parameter Radon transform and optical Fresnel transform of the field, i.e., when an input field ψ （x＇） propagates through an optical [D （-B） （-C） A] system, the energy density of the output field is equal to the Radon transform of the Wigner function of the input field, where the Radon transform parameters are D, B. It prove this theorem in both spatial-domain and frequency-domain, in the latter case the Radon transform parameters are A, C.
文摘The n-power two-parameter universal equation for rotational spectra which we deduced recently is appliedto the description of the rotational bands of several diatomic and tetra-atomic molecules. Excellent agreement withexperimental data can be obtained with small n values. The relation between our equation and the famous Dunhamformula is discussed.
文摘Two fundamental solutions for bending problem of Reissner's plates on twoparameter foundation are derived by means of Fouier integral transformation of generalized function in this paper.On the basis of virtual work principles, three boundary integral equations which fit for arbitrary shapes, loads and boundary conditions of thick plates are presented according to Hu Haichang's theory about Reissner's plates. It provides the fundamental theories for the application of BEM. A numerical example is given for clamped, simply supported and free boundary conditions. The results obtained are satisfactory as compared with the analytical methods.
基金Supported by the NNSF of China（70471057）Supported by the Natural Science Foundation of the Education Department of Shannxi Province（03JK065）
文摘The empirical Bayes test problem is considered for scale parameter of twoparameter exponential distribution under type-II censored data.By using wavelets estimation method,the EB test function is constructed,of which the asymptotic optimality and convergence rates are obtained.Finally,an example concerning the main result is given.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 10974020 and 11174039,NCET-11-0031the Fundamental Research Funds for the Central Universities
文摘We investigate the dynamics of entanglement for a two-parameter class of states in a hybrid qubit-qutrit system under the influence of various dissipative channels. Our results show that entanglement sudden death （ESD） is a general phenomenon and it usually takes place in a qubit-qutrit system interacting with various noisy channels, not only the ease with dephasing and depolarizing channels observed by others. ESD can only be avoided for some initially entangled states under some particular noisy channels. Moreover, the environment affects the entanglement and the coherence of the system in very different ways.
文摘This paper presents an enhanced version of the standard shooting method that enables problems with two unknown parameters to be solved.A novel approach is applied to the analysis of the natural vibrations of Euler-Bernoulli beams.The proposed algorithm,named as two-parameter multiple shooting method,is a new powerful numerical tool for calculating the natural frequencies and modes of multi-segment prismatic and non-prismatic beams with different boundary conditions.The impact of the axial force and additional point masses is also taken into account.Due to the fact that the method is based directly on the fourth-order ordinary differential equation,the structures do not have to be divided into many small elements to obtain an accurate enough solution,even though the geometry is very complex.To verify the proposed method,three different examples are considered,i.e.,a three-segment non-prismatic beam,a prismatic column subject to non-uniformly distributed compressive loads,and a two-segment beam with an additional point mass.Numerical analyses are carried out with the software MATHEMATICA.The results are compared with the solutions computed by the commercial finite element program SOFiSTiK.Good agreement is achieved,which confirms the correctness and high effectiveness of the formulated algorithm.
文摘The two-parameter exponential distribution is proposed to be an underlying model,and prediction bounds for future observations are obtained by using Bayesian approach.Prediction intervals are derived for unobserved lifetimes in one-sample prediction and two-sample prediction based on type Ⅱ doubly censored samples.A numerical example is given to illustrate the procedures,prediction intervals are investigated via Monte Carlo method,and the accuracy of prediction intervals is presented.
基金supported by the National Key Research and Development Project(2022YFC3400700)the City-School Cooperation Project of the Fuyang Science and Technology Special Fund undertaken by Fuyang Normal University(SXHZ2020007)+1 种基金the Basic Research Program of Shenzhen Municipal Government(JCYJ20200109114242138)the Special Commissioner for Rural Science and Technology of Guangdong Province(KTP20210345).
文摘Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets.
基金National Key Research and Development Plan:Evidence-Based Evaluation and Therapeutic Mechanism Cooperation Study of Yishen Tongluo Formula for Preventing Diabetes Kidney Disease(Phase 3)(No.2020YFE0201800)Key Science and Technology Projects of Henan Province:Research on Innovative Drug Cooperation of Traditional Chinese Medicine Yishen Tongluo Concentrated Pills(益肾通络浓缩丸)(No.221111520300)+1 种基金Key scientific and technological projects of Henan province:Study on the Pharmacodynamic Mechanism of Yishen Tongluo Formula in Treatment of Diabetes Kidney Disease based on the Interaction Regulation of Protein Phosphorylation and Acylation Modification(No.212102310347)to WU SuhuiNational Natural Science Foundation of China:the Mechanism of Yishen Tongluo Formula Intervention in Diabetic Kidney Disease based on(Yin-Yang-1/Nuclear Factor Erythroid 2-Related Factor 2 Mediated Endothelial Podocyte Interaction Response(No.82474495)to XU Jiangyan。
文摘OBJECTIVE:To investigate the effect and mechanism of Yishen Tongluo formula(益肾通络方,YSTLF)in streptozotocin-induced diabetic kidney disease mice(DKD)mice.METHODS:Thirty Institute of Cancer Research mice(specific pathogen free,SPF grade)were divided into five groups(n=6 per group):control,DKD model,DKD model with YSTLF(4.9 g/kg),DKD model with YSTLF(9.8 g/kg),and DKD model with captopril.DKD was induced through a single intraperitoneal injection of streptozotocin(150 mg/kg).Body weight,fasting blood glucose and urine C-peptide levels were measured to assess metabolic regulation by YSTLF.Renal function was evaluated using indicators of glomerular and tubular health.Liver function was assessed by measuring aspartate aminotransferase and alanine aminotransferase levels.Renal pathological changes were examined using hematoxylin/eosin staining and transmission electron microscopy.Inflammatory and apoptosis-related factors were analyzed through enzyme-linked immunosorbent assay,immunohistochemistry,and Western blot analysis.RESULTS:In DKD mice,fasting blood glucose,Cpeptide,24-hour urine protein(UP)levels,and renal damage were elevated,accompanied by increased inflammation and apoptosis.YSTLF significantly reduced 24-hour UP and C-peptide levels and improved kidney and liver function in DKD mice.YSTLF also mitigated glomerular hypertrophy,basement membrane thickening,and podocyte foot process effacement.It upregulated the expression of the podocyte marker podocalyxin.Furthermore,YSTLF alleviated inflammation and apoptosis,likely by reducing the overexpression of monocyte chemoattractant protein(MCP-1),Bax,and Caspase-3 in the kidneys of DKD mice.CONCLUSIONS:These findings suggest that YSTLF ameliorates kidney injury by modulating the expression of inflammatory cytokine MCP-1 and the Bax/Caspase-3 apoptosis pathway,providing a potential therapeutic approach for DKD.
文摘Objective The study of medicine formulas is a core component of traditional Chinese medicine(TCM),yet traditional learning methods often lack interactivity and contextual understanding,making it challenging for beginners to grasp the intricate composition rules of formulas.To address this gap,we introduce Formula-S,a situated visualization method for TCM formula learning in augmented reality(AR)and evaluate its performance.This study aims to evaluate the effectiveness of Formula-S in enhancing TCM formula learning for beginners by comparing it with traditional text-based formula learning and web-based visualization.Methods Formula-S is an interactive AR tool designed for TCM formula learning,featuring three modes(3D,Web,and Table).The dataset included TCM formulas and herb properties extracted from authoritative references,including textbook and the SymMap database.In Formula-S,the hierarchical visualization of the formulas as herbal medicine compositions,is linked to the multidimensional herb attribute visualization and embedded in the real world,where real herb samples are presented.To evaluate its effectiveness,a controlled study(n=30)was conducted.Participants who had no formal TCM knowledge were tasked with herbal medicine identification,formula composition,and recognition.In the study,participants interacted with the AR tool through HoloLens 2.Data were collected on both task performance(accuracy and response time)and user experience,with a focus on task efficiency,accuracy,and user preference across the different learning modes.Results The situated visualization method of Formula-S had comparable accuracy to other methods but shorter response time for herbal formula learning tasks.Regarding user experience,our new approach demonstrated the highest system usability and lowest task load,effectively reducing cognitive load and allowing users to complete tasks with greater ease and efficiency.Participants reported that Formula-S enhanced their learning experience through its intuitive interface and immersive AR environment,suggesting this approach offers usability advantages for TCM education.Conclusions The situated visualization method in Formula-S offers more efficient and accurate searching capabilities compared to traditional and web-based methods.Additionally,it provides superior contextual understanding of TCM formulas,making it a promising new solution for TCM learning.
基金supported by the National Key R&D Program of China(No.2022YFC3502005)the three-year Action Plan for Shanghai TCM Development and Inheritance Program[No.ZY(2021-2023)-0401]the National Natural Science Foundation of China(No.82104521)。
文摘Traditional Chinese medicine formula(TCMF)represents a fundamental component of Chinese medical practice,incorporating medical knowledge and practices from both Han Chinese and various ethnic minorities,while providing comprehensive insights into health and disease.The foundation of TCMF lies in its holistic approach,manifested through herbal compatibility theory,which has emerged from extensive clinical experience and evolved into a highly refined knowledge system.Within this framework,Chinese herbal medicines exhibit intricated characteristics,including multi-component interactions,diverse target sites,and varied biological pathways.These complexities pose significant challenges for understanding their molecular mechanisms.Contemporary advances in artificial intelligence(AI)are reshaping research in traditional Chinese medicine(TCM),offering immense potential to transform our understanding of the molecular mechanisms underlying TCMFs.This review explores the application of AI in uncovering these mechanisms,highlighting its role in compound absorption,distribution,metabolism,and excretion(ADME)prediction,molecular target identification,compound and target synergy recognition,pharmacological mechanisms exploration,and herbal formula optimization.Furthermore,the review discusses the challenges and opportunities in AI-assisted research on TCMF molecular mechanisms,promoting the modernization and globalization of TCM.
