This study proposes a two-color laser-induced fluorescence (LIF) technique for measuring the temperature distribution of an airflow by spraying a mist of a fluorescent dye. The mist is generated by using propylene gly...This study proposes a two-color laser-induced fluorescence (LIF) technique for measuring the temperature distribution of an airflow by spraying a mist of a fluorescent dye. The mist is generated by using propylene glycol, the vapor pressure of which is much lower than that of water, as the solvent of the fluorescent dyes. A supersonic moisture chamber is used as the atomizer for seeding the tracer particles to be visualized. The proposed technique is applied to the measurement of the temperature distribution in a thermal vertical buoyant plume. The proposed two-color LIF thermometry is found to be very effective for the study of such a thermal structure, and it is well suited for measuring the temperature field of an airflow.展开更多
为了快速识别市场中的劣质食用油,提出了一种结合激光诱导荧光(laser-induced fluorescence,LIF)技术与偏最小二乘判别分析(partial least squares-discriminant analysis,PLS-DA)的高品质食用油掺伪鉴别方法。首先利用实验室搭建的LIF...为了快速识别市场中的劣质食用油,提出了一种结合激光诱导荧光(laser-induced fluorescence,LIF)技术与偏最小二乘判别分析(partial least squares-discriminant analysis,PLS-DA)的高品质食用油掺伪鉴别方法。首先利用实验室搭建的LIF系统采集了橄榄油、芝麻油和花生油及其掺伪样本的荧光光谱数据;然后基于PLS-DA方法分别为橄榄油、芝麻油和花生油构建了掺伪鉴别模型;最后通过预测集对模型性能进行了评估。结果表明,PLS-DA模型能够准确捕捉掺伪样本与真实样本荧光光谱之间的差异性特征,在实验所得数据验证下,达到了100%的分类准确率。该方法可实现对掺伪食用油的高精度鉴别,为食品安全监管提供了科学的鉴别手段。展开更多
由于传统的互补金属-氧化物-半导体(Complementary Metal Oxide Semiconductor,CMOS)神经元电路与生物学的契合性较差且电路复杂,提出了一种基于忆阻器的多端口输入的泄露-整合-激发(Leaky-Integrate-Fire,LIF)神经元电路。该电路由运...由于传统的互补金属-氧化物-半导体(Complementary Metal Oxide Semiconductor,CMOS)神经元电路与生物学的契合性较差且电路复杂,提出了一种基于忆阻器的多端口输入的泄露-整合-激发(Leaky-Integrate-Fire,LIF)神经元电路。该电路由运放、逻辑门等器件以及忆阻器构成,主要分为信号叠加模块和神经元信号产生模块。通过施加多个双尖峰脉冲信号并调节输入信号的数量和频率,模拟了生物神经元受到的不同程度刺激。研究发现施加到神经元上信号的数量和频率达到一定的值,神经元电路才会输出电压信号,这与生物体中只有受到一定程度的刺激时才会做出反应的现象是一致的。进一步,调节该电路中神经元信号产生模块的阈值电压大小,研究发现输入相同的信号,只有当电路的阈值电压较低时,神经元电路才能输出电压信号,这与生物中不同部位受到相同的刺激,神经元兴奋程度越高,越容易做出反应的现象一致。由此,该文所提出的LIF神经元电路不仅解决了传统电路输入信号单一、输入信号波形与生物信号波形差异大等问题,而且能模拟生物神经元的兴奋程度,这为人工神经网络的设计提供理论依据。展开更多
Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effec...Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits.The present study seeks to answer these questions through in vitro and in vivo investigations.Results Excessive lipid deposition and lower melatonin levels in the uterus are detrimental to endometrial receptivity and embryo implantation in high backfat thickness sows.In cells treated with melatonin,the MT2/PI3K/LIF axis played a role in reducing lipid accumulation in porcine endometrial epithelium cells and improved endometrial receptivity.Furthermore,we found a reduction of lipids in the uterus after eight weeks of intraperitoneal administration of melatonin to HFD mice.Notably,melatonin treatment caused a significant reduction in the deposition of endometrial collagen,an increase in the number of glands,and repair of the pinopode structure,ultimately improving endometrial receptivity,promoting embryo implantation,and increasing the number of litter size of mice.Conclusions Collectively,the finding reveals the harmful effects of high backfat thickness sows on embryo implantation and highlight the role of melatonin and the MT2/PI3K/LIF axis in improving endometrial receptivity by enhancing metabolism and reducing the levels of uterine lipids in obese animals.展开更多
The spatiotemporal distribution of soot concentration in aero-engine combustor is important for assessing its combustion performance.Here,we report experimental measurements of soot concentration in terms of Soot Volu...The spatiotemporal distribution of soot concentration in aero-engine combustor is important for assessing its combustion performance.Here,we report experimental measurements of soot concentration in terms of Soot Volume Fraction(SVF)and its spatiotemporal distribution in a single-sector dual-swirl aero-engine combustor using Two-Color Laser-Induced Incandescence(2C-LII).It is shown that soot predominantly forms in the symmetrical vortices of the primary combustion zone,exhibiting a V-type distribution with higher concentration in the lower half of the zone than the upper half,with a small amount distributed in the secondary recirculation zone.Soot emissions at the combustor outlet are relatively low under three typical operating conditions by LII experiments,which is aligned with Smoke Number(SN)from gas analysis.The effect of inlet air temperature on SVF distribution and dynamics in the primary combustion zone is studied,which suggests that the SVF level in the primary combustion zone monotonically increases with the temperature.Meanwhile,the SVF distribution becomes more symmetrical as the inlet temperature increases,although the overall SVF level in the lower half of the zone is still higher.We also investigate the influence of the inlet air pressure on the SVF distribution at the combustor outlet.The soot concentration at the combustor outlet increases with inlet pressure,mainly distributed irregularly across both sides and the center.On both sides,the distribution is continuous,while the center exhibits dot-like and linear patterns.Numerical simulations correlated SVF distribution with the flow field in the primary combustion zone,qualitatively explaining the observed SVF distribution behavior.These results under various conditions can provide valuable insights for improving the performance of this specific combustor and designing high-temperature-rise combustors in the future.展开更多
Therapeutic antibodies of targeting the programmed cell death protein 1(PD-1)/programmed death-ligand 1(PD-L1)pathway are used in hepatocellular carcinoma(HCC)treatment,but are limited by low response rates and immune...Therapeutic antibodies of targeting the programmed cell death protein 1(PD-1)/programmed death-ligand 1(PD-L1)pathway are used in hepatocellular carcinoma(HCC)treatment,but are limited by low response rates and immune-related toxicity[1].Searching for treatment approaches to combine with PD-1/PD-L1 blockade may potentially enhance the efficacy of PD-1/PD-L1 blockade and reduce its side effects.展开更多
The widespread application of solid-state polymer electrolytes(SPEs)is impeded due to their limited ionic conductivity,narrow electrochemical window and lithium dendrite problem.In this work,Mg-metal-organic framework...The widespread application of solid-state polymer electrolytes(SPEs)is impeded due to their limited ionic conductivity,narrow electrochemical window and lithium dendrite problem.In this work,Mg-metal-organic frameworks(MOF)is incorporated into a polyethylene oxide(PEO)-based polymer solid electrolyte,leading to the insitu formation of LiF and other compounds at the electrolyte interface.This modification significantly improves lithium-ion transport capabilities and regulates lithium deposition behavior,suppressing the formation of lithium dendrites.展开更多
文摘This study proposes a two-color laser-induced fluorescence (LIF) technique for measuring the temperature distribution of an airflow by spraying a mist of a fluorescent dye. The mist is generated by using propylene glycol, the vapor pressure of which is much lower than that of water, as the solvent of the fluorescent dyes. A supersonic moisture chamber is used as the atomizer for seeding the tracer particles to be visualized. The proposed technique is applied to the measurement of the temperature distribution in a thermal vertical buoyant plume. The proposed two-color LIF thermometry is found to be very effective for the study of such a thermal structure, and it is well suited for measuring the temperature field of an airflow.
文摘为了快速识别市场中的劣质食用油,提出了一种结合激光诱导荧光(laser-induced fluorescence,LIF)技术与偏最小二乘判别分析(partial least squares-discriminant analysis,PLS-DA)的高品质食用油掺伪鉴别方法。首先利用实验室搭建的LIF系统采集了橄榄油、芝麻油和花生油及其掺伪样本的荧光光谱数据;然后基于PLS-DA方法分别为橄榄油、芝麻油和花生油构建了掺伪鉴别模型;最后通过预测集对模型性能进行了评估。结果表明,PLS-DA模型能够准确捕捉掺伪样本与真实样本荧光光谱之间的差异性特征,在实验所得数据验证下,达到了100%的分类准确率。该方法可实现对掺伪食用油的高精度鉴别,为食品安全监管提供了科学的鉴别手段。
文摘由于传统的互补金属-氧化物-半导体(Complementary Metal Oxide Semiconductor,CMOS)神经元电路与生物学的契合性较差且电路复杂,提出了一种基于忆阻器的多端口输入的泄露-整合-激发(Leaky-Integrate-Fire,LIF)神经元电路。该电路由运放、逻辑门等器件以及忆阻器构成,主要分为信号叠加模块和神经元信号产生模块。通过施加多个双尖峰脉冲信号并调节输入信号的数量和频率,模拟了生物神经元受到的不同程度刺激。研究发现施加到神经元上信号的数量和频率达到一定的值,神经元电路才会输出电压信号,这与生物体中只有受到一定程度的刺激时才会做出反应的现象是一致的。进一步,调节该电路中神经元信号产生模块的阈值电压大小,研究发现输入相同的信号,只有当电路的阈值电压较低时,神经元电路才能输出电压信号,这与生物中不同部位受到相同的刺激,神经元兴奋程度越高,越容易做出反应的现象一致。由此,该文所提出的LIF神经元电路不仅解决了传统电路输入信号单一、输入信号波形与生物信号波形差异大等问题,而且能模拟生物神经元的兴奋程度,这为人工神经网络的设计提供理论依据。
基金supported by the China Agriculture Research System(CARS-35-PIG)the National Natural Science Foundation of China(32272847,U22A20516)+1 种基金the National Key Research and Development Program of China(No.2021YFF1000602)the Key Research and Development Program of Shaanxi Province(No.2022ZDLNY01–04)。
文摘Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits.The present study seeks to answer these questions through in vitro and in vivo investigations.Results Excessive lipid deposition and lower melatonin levels in the uterus are detrimental to endometrial receptivity and embryo implantation in high backfat thickness sows.In cells treated with melatonin,the MT2/PI3K/LIF axis played a role in reducing lipid accumulation in porcine endometrial epithelium cells and improved endometrial receptivity.Furthermore,we found a reduction of lipids in the uterus after eight weeks of intraperitoneal administration of melatonin to HFD mice.Notably,melatonin treatment caused a significant reduction in the deposition of endometrial collagen,an increase in the number of glands,and repair of the pinopode structure,ultimately improving endometrial receptivity,promoting embryo implantation,and increasing the number of litter size of mice.Conclusions Collectively,the finding reveals the harmful effects of high backfat thickness sows on embryo implantation and highlight the role of melatonin and the MT2/PI3K/LIF axis in improving endometrial receptivity by enhancing metabolism and reducing the levels of uterine lipids in obese animals.
基金support of the National Science and Technology Major Project of China(No.J2019-V-0005-0096)the National Key Research and Development Program of China(No.2020YFA0405700).
文摘The spatiotemporal distribution of soot concentration in aero-engine combustor is important for assessing its combustion performance.Here,we report experimental measurements of soot concentration in terms of Soot Volume Fraction(SVF)and its spatiotemporal distribution in a single-sector dual-swirl aero-engine combustor using Two-Color Laser-Induced Incandescence(2C-LII).It is shown that soot predominantly forms in the symmetrical vortices of the primary combustion zone,exhibiting a V-type distribution with higher concentration in the lower half of the zone than the upper half,with a small amount distributed in the secondary recirculation zone.Soot emissions at the combustor outlet are relatively low under three typical operating conditions by LII experiments,which is aligned with Smoke Number(SN)from gas analysis.The effect of inlet air temperature on SVF distribution and dynamics in the primary combustion zone is studied,which suggests that the SVF level in the primary combustion zone monotonically increases with the temperature.Meanwhile,the SVF distribution becomes more symmetrical as the inlet temperature increases,although the overall SVF level in the lower half of the zone is still higher.We also investigate the influence of the inlet air pressure on the SVF distribution at the combustor outlet.The soot concentration at the combustor outlet increases with inlet pressure,mainly distributed irregularly across both sides and the center.On both sides,the distribution is continuous,while the center exhibits dot-like and linear patterns.Numerical simulations correlated SVF distribution with the flow field in the primary combustion zone,qualitatively explaining the observed SVF distribution behavior.These results under various conditions can provide valuable insights for improving the performance of this specific combustor and designing high-temperature-rise combustors in the future.
基金National Natural Science Foundation of China(Grant Nos.:82274154,82304792)Natural Science Foundation of Tianjin Municipality(GrantNos.:23JCzXJC00150+1 种基金23JCJQjC00040)China Postdoctoral Science Foundation(Grant Nos.:2023M732627,2024T170657).
文摘Therapeutic antibodies of targeting the programmed cell death protein 1(PD-1)/programmed death-ligand 1(PD-L1)pathway are used in hepatocellular carcinoma(HCC)treatment,but are limited by low response rates and immune-related toxicity[1].Searching for treatment approaches to combine with PD-1/PD-L1 blockade may potentially enhance the efficacy of PD-1/PD-L1 blockade and reduce its side effects.
基金supported by the National Natural Science Foundation of China(Nos.52374302 and 51874099)the Natural Science Foundation of Fujian Province’s Key Project(No.2021J02031)+1 种基金support from the open fund from Academy of Carbon Neutrality of Fujian Normal University(No.TZH_(2)022-06)We also thank the Undergraduate Training Programs for Innovation and Entrepreneurship(No.cxx1-2024363)。
文摘The widespread application of solid-state polymer electrolytes(SPEs)is impeded due to their limited ionic conductivity,narrow electrochemical window and lithium dendrite problem.In this work,Mg-metal-organic frameworks(MOF)is incorporated into a polyethylene oxide(PEO)-based polymer solid electrolyte,leading to the insitu formation of LiF and other compounds at the electrolyte interface.This modification significantly improves lithium-ion transport capabilities and regulates lithium deposition behavior,suppressing the formation of lithium dendrites.
