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Additional Twists of Yarn Produced by System of Compact Spinning with Lattice Apron 被引量:3
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作者 薛文良 魏孟媛 +1 位作者 程隆棣 钱竞芳 《Journal of Donghua University(English Edition)》 EI CAS 2011年第5期507-510,共4页
Based on the flow simulation in the condensing zone of compact spinning with lattice apron and a bead-elastic rod dynamic model of the flexible fiber,trajectories of fibers with different negative pressure are simulat... Based on the flow simulation in the condensing zone of compact spinning with lattice apron and a bead-elastic rod dynamic model of the flexible fiber,trajectories of fibers with different negative pressure are simulated by specially designed Matlab procedure.Then displacement components of fibers at YZ profile under different negative pressure conditions are extracted and compared.The results show that the fibers of different initial positions gradually converge,and are interlaced for position change in yarn cross-section,caused by the airflow in the condensing zone.Finally,compact-spun yarn with different negative pressure and conventional ring spun yarn are produced and their twists are tested.Both the results of simulation and experiments illustrate the existence of additional twists.Also the relationship between additional twists and negative pressure is verified. 展开更多
关键词 compact spinning with lattice apron SIMULATION dynamical model TRAJECTORY additional twists
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Twists and Turns of the Post-1949 Years
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《Contemporary International Relations》 1999年第10期4-4,共1页
Success of the revolution represents but only the first step in a long march. ---Mao Zedong Mao Zedong’s announcement in 1949 that "the Chinese people have stoodup," ended the dark decades of domestic fragm... Success of the revolution represents but only the first step in a long march. ---Mao Zedong Mao Zedong’s announcement in 1949 that "the Chinese people have stoodup," ended the dark decades of domestic fragmentation and foreign subjugation, 展开更多
关键词 twists and Turns of the Post-1949 Years
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Modeling Additional Twists of Yarn Spun by Lateral Compact Spinning with Pneumatic Groove
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作者 Jindan Lyu Longdi Cheng Bugao Xu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2021年第5期737-751,共15页
Compact spinning with pneumatic grooves is a spinning process to gather fibers by blended actions of airflow and mechanical forces.Modified from the ring spinning system,the lateral compact spinning with pneumatic gro... Compact spinning with pneumatic grooves is a spinning process to gather fibers by blended actions of airflow and mechanical forces.Modified from the ring spinning system,the lateral compact spinning with pneumatic grooves can improve yarn appearance and properties due to generated additional twists.In this study,we investigated additional twists of the lateral compact spinning with pneumatic grooves via a finite element(FE)method.An elastic thin rod was used to model a fiber to simulate its dynamic deformation in the three-dimensional space,and the space bar unit was used to simplify the fiber model for the dynamic analysis.The stiffness equation of the elastic rod element and the dynamic equation of the rigid body mass element were derived from the differential equation of the elastic thin rod.In the analysis of the nonlinear geometric displacement of the space elastic thin rod unit,the large deformation problem was solved with the stepwise loading successive approximation.The simulation results explained the mechanism of generating additional twists,and the experiment results proved the existence of additional twists.The study demonstrated that the FE model is effective for predicting additional twists of fiber bundles in the agglomeration zone,and for simulating the fiber motion in the compact spinning with pneumatic grooves. 展开更多
关键词 Compact spinning additional twist finite element dynamic analysis
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Dehn Twists and Products of Mapping Classes of Riemann Surfaces with One Puncture
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作者 Chaohui ZHANG 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2011年第6期885-894,共10页
Let S be a Riemann surface that contains one puncture x. Let be the collection of simple closed geodesics on S, and let denote the set of mapping classes on S isotopic to the identity on S U {x}. Denote by tc the ... Let S be a Riemann surface that contains one puncture x. Let be the collection of simple closed geodesics on S, and let denote the set of mapping classes on S isotopic to the identity on S U {x}. Denote by tc the positive Dehn twist about a curve c ∈ . In this paper, the author studies the products of forms (tb^-m o t^na) o f^k, where a, b ∈ and f ∈ . It is easy to see that if a = b or a, b are boundary components of an x-punctured cylinder on S, then one may find an element f ∈ such that the sequence (tb^-m o t^na) ofk contains infinitely many powers of Dehn twists. The author shows that the converse statement remains true, that is, if the sequence (tb^-m o t^na) o f^k contains infinitely many powers of Dehn twists, then a, b must be the boundary components of an x-punctured cylinder on S and f is a power of the spin map tb^-1 o ta. 展开更多
关键词 Riemann surfaces Simple closed geodesics Dehn twists PRODUCTS Bers isomorphisms
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Fractional Dehn twists and modular invariants
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作者 Xiao-Lei Liu 《Science China Mathematics》 SCIE CSCD 2021年第8期1735-1744,共10页
In this paper, we establish a relationship between fractional Dehn twist coefficients of Riemann surface automorphisms and modular invariants of holomorphic families of algebraic curves. Specially, we give a character... In this paper, we establish a relationship between fractional Dehn twist coefficients of Riemann surface automorphisms and modular invariants of holomorphic families of algebraic curves. Specially, we give a characterization of pseudo-periodic maps with nontrivial fractional Dehn twist coefficients. We also obtain some uniform lower bounds of non-zero fractional Dehn twist coefficients. 展开更多
关键词 fractional Dehn twists pseudo-periodic maps modular invariants families of curves
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IgA肾病患者血清Twist水平与疾病进展关系研究
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作者 杨晓霞 贾卿 于艳 《陕西医学杂志》 2026年第1期43-47,52,共6页
目的:探讨转录因子Twist水平在IgA肾病(IgAN)患者血清中的表达水平及其与IgAN进展的关系。方法:用酶联免疫吸附测定(ELISA)法对前瞻性收集的86例IgAN患者的血清Twist水平进行检测,并平均随访38个月研究血清Twist水平与IgAN患者预后的关... 目的:探讨转录因子Twist水平在IgA肾病(IgAN)患者血清中的表达水平及其与IgAN进展的关系。方法:用酶联免疫吸附测定(ELISA)法对前瞻性收集的86例IgAN患者的血清Twist水平进行检测,并平均随访38个月研究血清Twist水平与IgAN患者预后的关系。结果:研究发现IgAN组血清Twist浓度明显高于健康对照组[540.5(323.1~583.2)pg/ml与220.2(204.8~257.6)pg/ml,P<0.001]。血清Twist表达水平与IgAN患者的Lee氏分级有明显的相关性,病理分级更高的Lee氏Ⅳ-Ⅴ级患者血清Twist的表达水平显著高于Lee氏Ⅰ-Ⅱ级(P<0.001)。同时做了Spearman相关性分析发现血清Twist的表达水平与IgAN患者的估算肾小球滤过率(eGFR)呈明显负相关(r=-0.429,P<0.001),与肌酐、尿素氮、肾间质纤维化的比例呈正相关(r=0.346,P<0.001;r=0.254,P=0.003;r=0.388,P<0.001),但在24 h尿蛋白定量、性别、年龄并没有发现明显的相关性(均P>0.05)。K-M生存曲线分析表明血清中较高水平的Twist与较低的肾脏存活率相关。Cox风险比例回归模型评估发现高浓度的血清Twist水平为IgAN独立的预后因子(HR=7.40,P<0.001)。结论:血清中高表达的Twist与IgA患者的肾脏不良预后相关,表明Twist可能是IgAN进展的一个血清生物学指标。 展开更多
关键词 IGA肾病 TWIST 血清 肾间质纤维化 终末期肾脏病 预后
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Extreme central L-values of almost prime quadratic twists of elliptic curves 被引量:1
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作者 Shenghao Hua Bingrong Huang 《Science China Mathematics》 SCIE CSCD 2023年第12期2755-2766,共12页
In this paper,we prove the extreme values of L-functions at the central point for almost prime quadratic twists of an elliptic curve.As an application,we get the extreme values for the Tate-Shafarevich groups in the q... In this paper,we prove the extreme values of L-functions at the central point for almost prime quadratic twists of an elliptic curve.As an application,we get the extreme values for the Tate-Shafarevich groups in the quadratic twist family of an elliptic curve under the Birch and Swinnerton-Dyer conjecture. 展开更多
关键词 extreme value quadratic twist central L-value elliptic curve almost prime
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Pseudo-Anosov Mapping Classes and Their Representations by Products of Two Dehn Twists 被引量:1
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作者 Chaohui ZHANG 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2009年第3期281-292,共12页
Let S be a Riemann surface of analytically finite type (p, n) with 3p-3+n 〉 0. Let a ∈ S and S = S - {a}. In this article, the author studies those pseudo-Anosov maps on S that are isotopic to the identity on S a... Let S be a Riemann surface of analytically finite type (p, n) with 3p-3+n 〉 0. Let a ∈ S and S = S - {a}. In this article, the author studies those pseudo-Anosov maps on S that are isotopic to the identity on S and can be represented by products of Dehn twists. It is also proved that for any pseudo-Anosov map f of S isotopic to the identity on S, there are infinitely many pseudo-Anosov maps F on S - {b} = S - {a, b}, where b is a point on S, such that F is isotopic to f on S as b is filled in. 展开更多
关键词 Riemann surface Pseudo-Anosov map Dehn twist Teichmullerspace Bers fiber space
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尿脱落细胞蜡块在尿路上皮癌TWIST1基因甲基化检测中的应用 被引量:1
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作者 张继伟 谭艳佳 《临床与实验病理学杂志》 北大核心 2025年第5期685-687,共3页
目的探讨尿脱落细胞蜡块用于TWIST1基因甲基化检测的临床价值,及用于尿路上皮癌早期筛查的可行性。方法收集22例泌尿系统肿瘤患者术前尿液样本,其中5例用于比较尿脱落细胞和细胞蜡块检测TWIST1基因甲基化结果。结果尿脱落细胞和细胞蜡... 目的探讨尿脱落细胞蜡块用于TWIST1基因甲基化检测的临床价值,及用于尿路上皮癌早期筛查的可行性。方法收集22例泌尿系统肿瘤患者术前尿液样本,其中5例用于比较尿脱落细胞和细胞蜡块检测TWIST1基因甲基化结果。结果尿脱落细胞和细胞蜡块检测TWIST1基因甲基化结果一致性为100%,同时TWIST1和内标基因GAPDH扩增曲线的Ct值之间差异无统计学意义。以病理诊断结果为“金标准”,尿脱落细胞学检查诊断尿路上皮癌的一致性为50.00%,细胞蜡块TWIST1基因甲基化检测的一致性为81.82%。结论尿脱落细胞蜡块可以用于包括膀胱癌在内的尿路上皮癌早期筛查的TWIST1基因甲基化检测。 展开更多
关键词 膀胱癌 尿路上皮癌 细胞蜡块 TWIST1基因
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TPT1-AS1靶向miR-324/TWIST1轴调控上皮性卵巢癌细胞侵袭、迁移及血管生成的分子机制
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作者 王爱萍 戚莹莹 《细胞与分子免疫学杂志》 北大核心 2025年第6期536-543,共8页
目的探究肿瘤蛋白翻译调控1反义RNA1(TPT1-AS1)靶向miR-324/核转录因子扭曲相关蛋白1(TWIST1)轴调控上皮性卵巢癌(EOC)细胞的增殖、侵袭、迁移及血管生成从而影响卵巢癌(OC)发展的作用机制。方法实时定量PCR检测29例OC灶及癌旁组织样本... 目的探究肿瘤蛋白翻译调控1反义RNA1(TPT1-AS1)靶向miR-324/核转录因子扭曲相关蛋白1(TWIST1)轴调控上皮性卵巢癌(EOC)细胞的增殖、侵袭、迁移及血管生成从而影响卵巢癌(OC)发展的作用机制。方法实时定量PCR检测29例OC灶及癌旁组织样本中TPT1-AS1和miR-324的表达;构建“TPT1-AS1过表达”与“miRNA324敲除”的两种OC细胞模型,并采用CCK-8、Transwell TM和划痕试验法检测细胞增殖、侵袭和迁移能力;Western blot法检测TWIST1、上皮钙黏蛋白(E-cadherin)、波形蛋白(Vimentin)、血管内皮生长因子A(VEGF-A)的蛋白表达;荧光原位杂交实验、RNA下拉实验验证TPT1-AS1与miR-324之间的相互作用;免疫组织化学染色法检测、Targetscan生物信息学分析验证miR-324的表达对上皮-间质转化(EMT)过程及血管生成有负调控作用。结果TPT1-AS1在OC组织中的表达水平显著高于癌旁组织,而miR-324的表达水平在OC组织中则显著低于癌旁组织。在TPT1-AS1过表达的人卵巢癌细胞株SKOV3细胞中,miR-324的表达水平明显下降,TPT1-AS1与miR-324呈显著负相关。实验还发现,TPT1-AS1与miR-324在OC细胞中共同表达,并且二者之间存在直接结合关系。下调miR-324显著促进了SKOV3细胞的增殖、侵袭和迁移能力。进一步研究发现miR-324与EMT关键转录因子TWIST13′-UTR端有结合位点,抑制miR-324表达可以上调TWIST1的转录水平,从而导致E-cadherin蛋白表达的下降和Vimentin蛋白表达的上升。此外,miR-324下调时,VEGF-A蛋白表达水平上升。结论本研究揭示了TPT1-AS1通过负调控miR-324/TWIST1轴促进EOC细胞增殖、侵袭、迁移以及血管生成,从而促进OC的发展,这些发现为OC的诊断和治疗提供了新的潜在靶点。 展开更多
关键词 卵巢癌(OC) 上皮-间质转化(EMT) TWIST1 miR-324 血管生成
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lncRNA SNHG12通过miR-409-3p/TWIST1轴调节急性髓系白血病细胞的增殖、迁移和侵袭 被引量:2
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作者 赵海歌 王静 +1 位作者 肖梦瑶 崔雯萱 《医学研究与战创伤救治》 北大核心 2025年第2期135-142,共8页
目的探讨lncRNA SNHG12是否可通过miR-409-3p/TWIST1轴调节急性髓系白血病(AML)细胞的增殖、迁移和侵袭。方法用q RT-PCR检测47例急性髓系白血病患者和47例非血液系统肿瘤性疾病患者骨髓单个核细胞中SNHG12、miR-409-3p和TWIST1 mRNA的... 目的探讨lncRNA SNHG12是否可通过miR-409-3p/TWIST1轴调节急性髓系白血病(AML)细胞的增殖、迁移和侵袭。方法用q RT-PCR检测47例急性髓系白血病患者和47例非血液系统肿瘤性疾病患者骨髓单个核细胞中SNHG12、miR-409-3p和TWIST1 mRNA的表达水平;然后将HL-60细胞分为对照组、sh-NC组、sh-SNHG12组、sh-SNHG12+inhibitor NC组、sh-SNHG12+miR-409-3p inhibitor组、sh-SNHG12+oe-NC组、sh-SNHG12+oe-TWIST1组;用q RT-PCR检测各组细胞SNHG12、miR-409-3p和TWIST1 mRNA表达水平;CCK-8检测细胞增殖;Transwell实验检测细胞迁移和侵袭;流式细胞术检测细胞凋亡;Western blot检测细胞中TWIST1、CyclinD1、Ki67、Cleaved-caspase-3、MMP-9蛋白表达量。双荧光素酶报告基因实验检测miR-409-3p与SNHG12和TWIST1的靶向关系。结果AML患者骨髓单个核细胞和建株AML细胞中SNHG12和TWIST1 mRNA表达显著升高,miR-409-3p表达显著降低(P<0.05);下调SNHG12表达显著降低HL-60细胞中SNHG12和TWIST1 mRNA表达、A_(450)(24、48 h)值、细胞迁移和侵袭个数、TWIST1、CyclinD1、Ki67、MMP-9蛋白表达,提高凋亡率、miR-409-3p和Cleaved-caspase-3蛋白表达(P<0.05);下调miR-409-3p表达或上调TWIST1表达均可减弱下调SNHG12对HL-60细胞的抑制作用(P<0.05)。结论干扰SNHG12表达可提高miR-409-3p表达抑制TWIST1,进而抑制AML细胞增殖、迁移和侵袭。 展开更多
关键词 lncRNA SNHG12 miR-409-3p/TWIST1轴 急性髓系白血病 细胞
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USP8调控TWIST1对卵巢癌细胞上皮间质转化的影响
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作者 杨贺 蔡娱飞 +6 位作者 马奎丽 周影 李文会 鄢杰 陈雨 马溯阳 马哲 《海南医学》 2025年第6期761-766,共6页
目的探究USP8调控TWIST1对卵巢癌细胞上皮间质转化的影响。方法将卵巢癌OVCAR3细胞和SKOV3细胞均随机分为si NC实验组、si USP8实验组和si TWIST1实验组。采用细胞集落实验分析OVCAR3和SKOV3细胞的增殖能力;采用Transwell实验方法分析OV... 目的探究USP8调控TWIST1对卵巢癌细胞上皮间质转化的影响。方法将卵巢癌OVCAR3细胞和SKOV3细胞均随机分为si NC实验组、si USP8实验组和si TWIST1实验组。采用细胞集落实验分析OVCAR3和SKOV3细胞的增殖能力;采用Transwell实验方法分析OVCAR3和SKOV3细胞的侵袭能力;采用细胞划痕实验分析OVCAR3和SKOV3细胞的迁移能力;采用蛋白免疫印迹方法分析N-cadherin、Vimentin、USP8与TWIST1蛋白的表达。结果抑制USP8表达后,细胞集落实验显示,si USP8以及si TWIST1实验组的OVCAR3和SKOV3细胞增殖能力下降,差异均有统计学意义(P<0.05);Transwell实验显示,si USP8以及si TWIST1实验组的OVCAR3和SKOV3细胞侵袭数量下降,差异均有统计学意义(P<0.05);细胞划痕实验显示,si USP8以及si TWIST1实验组的OVCAR3和SKOV3细胞迁移率下降,差异均有统计学意义(P<0.05);蛋白免疫印迹实验结果显示,si USP8以及si TWIST1实验组的N-cadherin、Vimentin蛋白表达水平下降,si USP8实验组的USP8、TWIST1蛋白表达水平下降,差异均有统计学意义(P<0.05)。结论抑制USP8表达后,OVCAR3和SKOV3细胞的上皮间质转化过程受到抑制,该机制与USP8调节TWIST1密切相关。 展开更多
关键词 USP8 TWIST1 增殖 卵巢癌 侵袭 迁移 上皮间质转化 SIRNA
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炎症微环境下miR-210调控Twist1对牙周膜干细胞成骨分化的影响
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作者 郑兴 何家才 《实用口腔医学杂志》 北大核心 2025年第1期21-25,共5页
目的:研究炎症微环境下微小RNA(miR)-210调控Twist1对牙周膜干细胞(PDLSCs)成骨分化的影响。方法:培养PDLSCs,分为对照组、炎症组、miR-阴性对照(NC)组、炎症+miR-NC组、炎症+miR-210组、miR-NC+NC质粒组、炎症+miR-NC+NC质粒组、炎症+m... 目的:研究炎症微环境下微小RNA(miR)-210调控Twist1对牙周膜干细胞(PDLSCs)成骨分化的影响。方法:培养PDLSCs,分为对照组、炎症组、miR-阴性对照(NC)组、炎症+miR-NC组、炎症+miR-210组、miR-NC+NC质粒组、炎症+miR-NC+NC质粒组、炎症+miR-210+NC质粒组、炎症+miR-210+Twist1质粒组,各炎症组均采用10μg/L肿瘤坏死因子-α处理的方式建立炎症微环境,采用脂质体转染miR序列或质粒。处理24 h后检测miR-210和Twist1的表达水平;成骨诱导分化2周后检测茜素红染色的A590水平及Runt相关转录因子2(Runx2)、骨钙素(OCN)的表达水平。结果:炎症组的miR-210表达水平低于对照组,Twist1表达水平高于对照组(P<0.05);炎症+miR-NC组的miR-210表达水平及成骨诱导后的A590水平、Runx2及OCN表达水平均低于miR-NC组,Twist1表达水平高于miR-NC组(P<0.05);炎症+miR-210组的miR-210表达水平及成骨诱导后的A590水平、Runx2及OCN表达水平均高于炎症+miR-NC组,Twist1表达水平低于炎症+miR-NC组(P<0.05);miR-210组的Twist1表达水平及野生型Twist1报告基因的荧光值均低于miR-NC组(P<0.05);炎症+miR-210+Twist1质粒组的Twist1表达水平高于炎症+miR-210+NC质粒组,成骨诱导后的A590水平、Runx2及OCN表达水平均低于炎症+miR-210+NC质粒组(P<0.05)。结论:炎症微环境下miR-210表达降低,进而增加Twist1表达并抑制PDLSCs成骨分化。 展开更多
关键词 牙周炎 牙周膜干细胞 MIR-210 TWIST1 成骨分化
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一种基于TwIST稀疏正则化的冲击载荷识别方法
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作者 袁哲锋 缪炳荣 +3 位作者 张盈 金月皓 尹兆珂 胡天棋 《机械制造与自动化》 2025年第3期126-131,共6页
针对冲击载荷识别精度低的问题,提出一种基于稀疏正则化和两步迭代收缩阈值算法(TwIST)的冲击载荷识别方法。该方法采用稀疏正则化方法构建冲击载荷识别模型,使用TwIST算法迭代求解冲击载荷。通过铝合金梁冲击载荷识别试验对该方法进行... 针对冲击载荷识别精度低的问题,提出一种基于稀疏正则化和两步迭代收缩阈值算法(TwIST)的冲击载荷识别方法。该方法采用稀疏正则化方法构建冲击载荷识别模型,使用TwIST算法迭代求解冲击载荷。通过铝合金梁冲击载荷识别试验对该方法进行验证。结果表明:在单源、多源冲击载荷两种工况中,TwIST稀疏正则化方法能够准确识别冲击载荷,与传统的Tikhonov正则化方法相比,该方法的识别准确性、稳定性和抗噪性更优。 展开更多
关键词 冲击载荷识别 稀疏正则化 TWIST 逆问题
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Retraction:Swainsonine inhibits invasion and the EMT process in esophageal carcinoma cells by targeting twist1
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作者 《Oncology Research》 2025年第5期1253-1253,共1页
The published article titled“Swainsonine inhibits invasion and the EMT process in esophageal carcinoma cells by targeting twist1”has been retracted from Oncology Research,Vol.26,No.8,2018,pp.1207–1213.
关键词 SWAINSONINE EMT TWIST targeting twist INVASION esophageal carcinoma esophageal carcinoma cells emt process
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宫颈鳞癌患者癌组织中Twist表达水平及临床特征与预后的关系
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作者 胡美芳 王锦艳 +1 位作者 黄美兴 石曦雯 《吉林医学》 2025年第12期2996-2999,共4页
目的:探讨宫颈鳞癌患者癌组织中Twist表达水平及临床特征与预后的关系。方法:选取2020年3月~2022年12月于广州市中西医结合医院收治的44例宫颈鳞癌患者作为观察组,另选取同时期40例与上述患者年龄相仿的宫颈上皮内瘤病变患者为对照组1,... 目的:探讨宫颈鳞癌患者癌组织中Twist表达水平及临床特征与预后的关系。方法:选取2020年3月~2022年12月于广州市中西医结合医院收治的44例宫颈鳞癌患者作为观察组,另选取同时期40例与上述患者年龄相仿的宫颈上皮内瘤病变患者为对照组1,选取40例正常女性作为对照组2,应用免疫组化对研究对象组织的Twist表达进行检查,比较Twist阳性表达率及其临床特征,对患者进行为期一年半的随访观察,分析Twist表达与预后的关系。结果:观察组Twist阳性表达率显著高于对照组1与对照组2,差异有统计学意义(P<0.05);观察组Twist表达水平与患者临床分期、病理分级、浸润深度、脉管浸润、淋巴转移有相关性(P<0.05);44例宫颈鳞癌患者存活28例,总生存率为63.64%,经过单因素分析,临床分期(Ⅲ~Ⅳ期)、病理分级(G3)、淋巴转移、Twist阳性表达与预后不良具有相关性(P<0.05);多因素分析表明临床分期Ⅲ~Ⅳ期(OR=3.364,95%CI:1.075~10.525)以及Twist表达阳性(OR=4.100,95%CI:1.500~11.206)是患者预后不良的独立危险因素。结论:Twist表达水平是宫颈鳞癌患者的独立预后因素,临床检验Twist对指导患者临床治疗与预后有积极意义。 展开更多
关键词 宫颈鳞癌 Twist表达水平 临床特征 预后
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Preferential fatigue cracking at basal twist grain boundary (BTGB) in bimodal Ti-5Al-4V alloy: Dislocation activities and crack initiation
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作者 Zhihong Wu Hongchao Kou +6 位作者 Jinshan Li Samuel Hémery Tong Li Carlo Franke Nana Chen Frédéric Prima Fan Sun 《Journal of Materials Science & Technology》 2025年第14期281-295,共15页
In recent years,(0001)twist grain boundaries(BTGBs)located in primary α grain clusters were identified as fatigue crack nucleation sites in different Ti alloys.In the present study,crack initiation was investigated i... In recent years,(0001)twist grain boundaries(BTGBs)located in primary α grain clusters were identified as fatigue crack nucleation sites in different Ti alloys.In the present study,crack initiation was investigated in a bimodal Ti-5Al-4 V alloy subjected to low-cycle fatigue and dwell-fatigue loadings at room temperature.The low fraction of primary α grains was not associated with a lack of sensitivity to BTGB cracking.Transmission electron microscopy and electron back-scattered diffraction were used to characterize BTGBs in the initial microstructure.The fatigue mechanisms were then analyzed with a focus on dislocation activity.α_(p) grains adjacent to cracked BTGBs contained a high dislocation density.It was primarily composed of planar slip bands of dislocations.In addition,<c+a>dislocations were noticed in the vicinity of cracked BTGBs.They supposedly pertain to crack tip plasticity during growth,and no evidence of a role of an incoming slip event in crack nucleation was obtained.Also,basal slip bands extending across adjacent grains were found to emerge from BTGBs.This feature provides an easier path for crack extension when growth along the grain boundary becomes difficult owing to a deviation from the basal plane.Atom probe tomography analyses evidenced V and Fe segregation at a grain boundary with a significant deviation from the BTGB configuration.This suggests a possible contribution of local solute segregation to the high cracking resistance of general α_(p)/α_(p) grain boundaries.This work provides new insights into the mechanisms involved in cracking of BTGB in Ti alloys subjected to cyclic loadings. 展开更多
关键词 Low cycle fatigue Titanium alloy Crack initiation Twist boundary Dislocations
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miR-130a-5p靶向Twist1调控卵巢癌增殖与迁移
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作者 徐成博 惠豪斌 +4 位作者 李红希 吴蔚 朱昆维 王东旭 任碧琦 《黑龙江医药科学》 2025年第5期1-5,共5页
目的:明确miR-130a-5p对Twist1(扭曲螺旋转录因子1)的靶向调控作用及对卵巢癌转移的影响。方法:通过基因组测序将与卵巢癌有关的差异基因筛选出来,在临床标本中验证。本研究拟通过过表达miR-130a-5p,采用Transwell, CCK-8(细胞活力检测... 目的:明确miR-130a-5p对Twist1(扭曲螺旋转录因子1)的靶向调控作用及对卵巢癌转移的影响。方法:通过基因组测序将与卵巢癌有关的差异基因筛选出来,在临床标本中验证。本研究拟通过过表达miR-130a-5p,采用Transwell, CCK-8(细胞活力检测方法), Western blot等方法,明确miR-130a-5p对Twist的调控作用。结果:miR-130a-5p是通过生物信息学分析发现的miRNA。miR-130a-5p的表达与肿瘤组织有关,可能会对病人的预后造成影响。miR-130a-5p是前期研究发现的、显著高表达针对卵巢癌的miRNA。研究表明,在抑制卵巢癌细胞增殖和转移方面,miR-130a-5p发挥了一定作用。此外,机制研究表明,卵巢癌组织中Twist1表达显著上调,miR-130a-5p能抑制卵巢癌细胞EMT(上皮间质转化)及干细胞特性。结论:(1)miR-130a-5p是新近发现的在卵巢癌中发挥重要作用的miRNA。(2)miR-130a-5p通过Twist信号通路的调节来抑制卵巢癌的进展。 展开更多
关键词 卵巢癌 TWIST1 miR-130a-5p 增殖 迁移
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Birkhoff Orbits for Twist Homeomorphisms on the High-Dimensional Cylinder
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作者 ZHOU Tong 《Wuhan University Journal of Natural Sciences》 2025年第1期43-48,共6页
It is known that monotone recurrence relations can induce a class of twist homeomorphisms on the high-dimensional cylinder,which is an extension of the class of monotone twist maps on the annulus or two-dimensional cy... It is known that monotone recurrence relations can induce a class of twist homeomorphisms on the high-dimensional cylinder,which is an extension of the class of monotone twist maps on the annulus or two-dimensional cylinder.By constructing a bounded solution of the monotone recurrence relation,the main conclusion in this paper is acquired:The induced homeomorphism has Birkhoff orbits provided there is a compact forward-invariant set.Therefore,it generalizes Angenent's results in low-dimensional cases. 展开更多
关键词 monotone recurrence relation twist homeomorphism high-dimensional cylinder bounded action Birkhoff orbit
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食管癌组织中Cofilin1和Twist1表达与临床病理特征以及预后的关联
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作者 张思慧 孙晓华 《中外医学研究》 2025年第32期56-59,共4页
目的:探讨中丝切蛋白1(Cofilin1)和碱性螺旋-环-螺旋转录因子1(Twist1)在食管癌组织中的表达及其与患者临床病理特征和预后的关系。方法:选取2018年1月—2022年2月南京医科大学附属泰州人民医院收治的68例食管癌患者。检测Cofilin1和Twi... 目的:探讨中丝切蛋白1(Cofilin1)和碱性螺旋-环-螺旋转录因子1(Twist1)在食管癌组织中的表达及其与患者临床病理特征和预后的关系。方法:选取2018年1月—2022年2月南京医科大学附属泰州人民医院收治的68例食管癌患者。检测Cofilin1和Twist1在患者肿瘤组织中的表达,统计临床病理资料,分析蛋白表达与临床病理特征及预后的关系。结果:Cofilin1和Twist1在68例食管癌患者肿瘤组织中的表达与临床分期和淋巴结是否转移相关,差异有统计学意义(P<0.05);与患者的年龄和性别,以及肿瘤的病理分级、分化程度和位置大小等无关,差异无统计学意义(P>0.05)。较高的Cofilin1和Twist1表达水平与患者较短的总生存期密切相关,差异有统计学意义(P<0.05)。结论:Cofilin1和Twist1的阳性表达率在食管癌肿瘤组织中的升高,与临床分期、淋巴结转移和不良预后密切相关。 展开更多
关键词 食管癌 Cofilin1 TWIST1 病理特征 淋巴结转移
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