The retroviral vector （RCAS） has been widely used in avian system to study development and diseases, but is not suitable for mammals which do not produce the retrovirus receptor TVA. In this review, we trace the cur...The retroviral vector （RCAS） has been widely used in avian system to study development and diseases, but is not suitable for mammals which do not produce the retrovirus receptor TVA. In this review, we trace the current uses of RCAS-TVA approach in mammalian system with improved strategies, including generation of tv-a transgenic mice, use of soluble TVA receptor and retroviral receptor-ligand fusion proteins, improvement of RCAS vectors, and compare a series of mammalian models in variant studies of gene function, development, oncogenesis and gene therapy. All those studies demonstrate that the RCAS-TVA based mammalian models are powerful tools for understanding the mechanisms and target treating of human diseases.展开更多
The technique of imaging a target with a complicated motion using an Inverse Synthetic Aperture Radar(ISAR) system is an effective tool in the field of radar signal processing. After the translational compensation, th...The technique of imaging a target with a complicated motion using an Inverse Synthetic Aperture Radar(ISAR) system is an effective tool in the field of radar signal processing. After the translational compensation, the received signal reflected from the target can take the form of a multi-component Polynomial Phase Signal(m-PPS), and the high quality ISAR image can be provided via the combination between the estimated parameters of the m-PPS and the Range Instantaneous-Doppler technique(RID). For a target with a high maneuvrability, the occurrence of scatterers Migration Through Resolution Cell(MTRC), caused by the rotational movement could be appearing. That is why the variation in the amplitude of the echo during the time of observation cannot be neglected. The purpose of this study is the parameters estimation of the m-PPS signal with order three in the case of the Time Varying Amplitude(TVA). The Improved-version of the Product High-order Ambiguity Function(IPHAF) with TVA is proposed to improve the quality of the ISAR image compared with traditional techniques based on a constant amplitude;the experimental outcomes confirm that the new IPHAF-TVA method presented in this study is an effective technique to make the ISAR image very clear.展开更多
文摘The retroviral vector （RCAS） has been widely used in avian system to study development and diseases, but is not suitable for mammals which do not produce the retrovirus receptor TVA. In this review, we trace the current uses of RCAS-TVA approach in mammalian system with improved strategies, including generation of tv-a transgenic mice, use of soluble TVA receptor and retroviral receptor-ligand fusion proteins, improvement of RCAS vectors, and compare a series of mammalian models in variant studies of gene function, development, oncogenesis and gene therapy. All those studies demonstrate that the RCAS-TVA based mammalian models are powerful tools for understanding the mechanisms and target treating of human diseases.
基金supported in part by the National Natural Science Foundation of China (No. 61871146)。
文摘The technique of imaging a target with a complicated motion using an Inverse Synthetic Aperture Radar(ISAR) system is an effective tool in the field of radar signal processing. After the translational compensation, the received signal reflected from the target can take the form of a multi-component Polynomial Phase Signal(m-PPS), and the high quality ISAR image can be provided via the combination between the estimated parameters of the m-PPS and the Range Instantaneous-Doppler technique(RID). For a target with a high maneuvrability, the occurrence of scatterers Migration Through Resolution Cell(MTRC), caused by the rotational movement could be appearing. That is why the variation in the amplitude of the echo during the time of observation cannot be neglected. The purpose of this study is the parameters estimation of the m-PPS signal with order three in the case of the Time Varying Amplitude(TVA). The Improved-version of the Product High-order Ambiguity Function(IPHAF) with TVA is proposed to improve the quality of the ISAR image compared with traditional techniques based on a constant amplitude;the experimental outcomes confirm that the new IPHAF-TVA method presented in this study is an effective technique to make the ISAR image very clear.
