In order to reveal the multi-target pharmacological mechanism of Zedoary turmeric oil combined with docetaxel in the treatment of breast cancer,we used network pharmacology and molecular docking.The targets of docetax...In order to reveal the multi-target pharmacological mechanism of Zedoary turmeric oil combined with docetaxel in the treatment of breast cancer,we used network pharmacology and molecular docking.The targets of docetaxel were retrieved from the Swiss Target Prediction database.The active components of Curcuma Zedoary turmeric were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),with criteria set as oral bioavailability OB≥30%and drug-likeness DL≥0.1.Potential targets of these components were subsequently predicted.Breast cancer-related targets were retrieved from the OMIM and GeneCards databases.The Venny tool was used to identify 177 overlapping targets between docetaxel,Zedoary turmeric oil,and breast cancer,followed by protein-protein interaction(PPI)analysis.Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed using the Metascape database.A drug-breast cancer-KEGG pathway target network was constructed using Cytoscape 3.8.0.Molecular docking was employed to verify the binding ability between drugs and core targets.Results showed that the combined treatment may exert anti-breast cancer effects through key targets such as MAPK1,PIK3CA,and HSP90AA1,primarily implicating the biological process of protein phosphorylation and engaging the PI3K-Akt signaling pathway.This study successfully predicted the key targets and enriched pathways of Zedoary turmeric oil combined with docetaxel for breast cancer treatment,providing new insights for further research and development.展开更多
Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the e...Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the effects of TR on the survival of Chinese soft-shelled turtles（SSTs）, Pelodiscus sinensis, under a high ambient temperature. A total of 320 female SSTs were assigned randomly to two diets： basal diet（the control group, n=160） and an interventional diet supplemented with 10% TR（the TR group, n=160）. Our results demonstrated that supplementation of TR increased the SST survival rate by 135.5%, and superoxide dismutase（SOD） activity of SST liver by 112.8%, and decreased the malondialdehyde（MDA） content of SST liver by 36.4%, compared to the control group. The skin of the SST fed TR showed a golden color. High-performance liquid chromatography（HPLC） analysis indicated that the concentrations of curcumin in TR and the skin of the SST fed TR were（1.69±0.30） and（0.14±0.03） μg/g, respectively. Our observation suggests that supplementation of TR increased the survival rate of SST under high ambient temperatures. We speculated that the increased survival rate and tolerance at the high ambient temperature were associated with the anti-oxidation activity of curcumin from TR. Moreover, curcumin in TR could be deposited in SST skin, which made it more favored in the market of China. Our findings provide new knowledge and evidence to effectively reuse TR as a feed additive in animal and aquatic farming.展开更多
To explore the protective effect of extract powder of turmeric on carbon tetrachloride （CCl4）-induced acute hepatic injury, the mice were administrated with extract powder of turmeric with different doses （50, 100,...To explore the protective effect of extract powder of turmeric on carbon tetrachloride （CCl4）-induced acute hepatic injury, the mice were administrated with extract powder of turmeric with different doses （50, 100, 200 mg/kg） for 7 d. Then the mice were treated with 0.12% CCl4 by intraperitoneal injection. The levels of ALT, AST in serum and activities of SOD, CAT, MDA, GSH-Px in liver tissue were detected and the liver lesions were examined. The results showed that the activities of ALT, AST and the level of MDA in extract powder of turmeric group were signif- icantly decreased, and the activities of SOD, CAT, GSH-Px were significantly increased, and liver pathology were improved compared with the injured group （P〈 0.05 or P〈0.01）. It indicated that the extract powder of turmeric had significant protective effect against CCl4 induced acute hepatic injury in mice.展开更多
Metabolic syndrome(MS)involves people with the following risk factors:obesity,hypertension,high glucose level and hyperlipidemia.It can increase the risk of heart disease,stroke and type 2 diabetes mellitus.The preval...Metabolic syndrome(MS)involves people with the following risk factors:obesity,hypertension,high glucose level and hyperlipidemia.It can increase the risk of heart disease,stroke and type 2 diabetes mellitus.The prevalence of MS in the world’s adult population is about 20%–25%.Today,there is much care to use medicinal plants.Turmeric(Curcuma longa)as well as curcumin which is derived from the rhizome of the plant,has been shown beneficial effects on different components of MS.Thus,the purpose of this manuscript was to introduce different in vitro,in vivo and human studies regarding the effect of turmeric and its constituent on MS.Moreover,different mechanisms of action by which this plant overcomes MS have been introduced.Based on studies,turmeric and its bioactive component,curcumin,due to their anti-inflammatory and antioxidant properties,have antidiabetic effects through increasing insulin release,antihyperlipidemic effects by increasing fatty acid uptake,anti-obesity effects by decreasing lipogenesis,and antihypertensive effects by increasing nitric oxide.According to several in vivo,in vitro and human studies,it can be concluded that turmeric or curcumin has important values as a complementary therapy in MS.However,more clinical trials should be done to confirm these effects.展开更多
Gastric ulcer is a common disorder in human at any ages. In this research, the antiulcer activity of wild honey produced by Apis dorsata, alone or in combination with Turmeric Rhizome, was evaluated in healing acute g...Gastric ulcer is a common disorder in human at any ages. In this research, the antiulcer activity of wild honey produced by Apis dorsata, alone or in combination with Turmeric Rhizome, was evaluated in healing acute gastric ulcer. Male Wistar albino rats(150–250 g) were induced ulcers with aspirin at 405 mg/kg BW and ethanol. Antiulcer evaluation was done based on the gastric acidity, numbers and diameter of ulcers, ulcer index, healing ratio, histological examinations, and body weight. The results showed that the groups given honey alone, turmeric alone, and combination of turmeric-honey displayed significant ulcer healing compared to the control group. Ulcers in the group administered with combination of turmeric-wild honey was different significantly from the turmeric alone and wild honey alone groups with increased body weight in that group. The result showed that wild honey(2125 mg/kg BW) had the greatest activity in healing ulcers among other groups. The combination of turmeric-wild honey had a good activity in healing ulcers and increased the body weight of the group.展开更多
The current study is aimed to explore the sustainable dyeing approach of silk fabric with turmeric powder using tannin as mordant extracted from tamarind seed coat. For that, tamarind seed coat tannin was extracted an...The current study is aimed to explore the sustainable dyeing approach of silk fabric with turmeric powder using tannin as mordant extracted from tamarind seed coat. For that, tamarind seed coat tannin was extracted and applied as natural mordant alone and in combination with metal mordant namely copper sulphate for dyeing silk fabric with the extract of turmeric powder. Dyeing parameters such as temperature, time and mordant concentration were varying for optimizing the process. The color strength, color coordinates, color fastness to wash, perspiration, water and rubbing were evaluated for examining dyeing performance. Firstly, tannin was extracted from tamarind seed coat and applying on the silk fabric at 95°C temperature for 45 min by varying concentration. Among them 15 g/l shows better results. Some samples were mordanted with both 15 g/l extracted tannin and 0.5% copper sulphate solution. The mordanted samples were dyed with turmeric dye by varying the time and temperature. By analyzing the test results, the sample mordanted with extracted tannin showed high color strength and good fastness properties dyeing at 80°C for 60 min. The application of 0.5% copper sulphate mordant enhanced sustainable wash fastness properties.展开更多
The properties of gelatin microspheres Zedoary turmeric oil(GMS-ZT)in vitro release werestudied by the continuous flow system(CFS),which could simulate the actual state in vivo.The effects ofsterilization.different fl...The properties of gelatin microspheres Zedoary turmeric oil(GMS-ZT)in vitro release werestudied by the continuous flow system(CFS),which could simulate the actual state in vivo.The effects ofsterilization.different flow rates,release medium.the amount of formaldehyde,the duration of cross-linking and thesize of microspheres on the drug release were investigated.The results showed that these factors except thesterilization had influences on drug release and the drug release from the microspheres was slow.Eighty percent ofthe drug released after 12 h,and the release profiles in vitro could be described by the first-order dynamic model,anddrug release was controlled by the matrix erosion and diffusion.展开更多
Background: Facial redness is multifactorial in nature and may be a sign of many different conditions,including rosacea, photo damage and flushing. Herbal medicines have been used for thousands of years to treat a var...Background: Facial redness is multifactorial in nature and may be a sign of many different conditions,including rosacea, photo damage and flushing. Herbal medicines have been used for thousands of years to treat a variety of dermatological conditions. Turmeric(Curcuma longa) and its constituents have been shown to mediate dilation and constriction of peripheral arterioles and have demonstrated anti-oxidant,anti-inflammatory and wound-healing properties.Objective: To investigate the effects of turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness.Design, setting, participants, and interventions: This was a prospective, double-blind, randomized pilot study. Thirty-three healthy participants were recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017. Thirty participants were enrolled, and28 participants completed the study. The enrolled participants were randomized to receive one of three interventions(placebo, turmeric or polyherbal combination tablets) and were told to take the intervention tablets by mouth twice daily for 4 weeks. Facial redness was assessed at baseline and 4 weeks after intervention by clinical grading and by image-based analysis.Main outcome measures: The primary outcome measure was image-based facial quantification of redness using a research camera and software analysis system. The investigators performed an intention-to-treat analysis by including all subjects who were enrolled in the trial and received any study intervention.Differences were considered statistically significant after accounting for multiple comparisons. Effect sizes for clinical grading were calculated with a Hedges' g where indicated.Results: Twenty-eight participants completed the study and there were no reported adverse events.Based on clinical grading, facial redness intensity and distribution down trended in the polyherbal combination group after 4 weeks(P = 0.1). Under photographic image analysis, the polyherbal combination group had a significant decrease in redness of 40% compared to baseline(P = 0.03). The placebo and turmeric groups had no statistically significant changes in image analysis-based facial redness.Conclusion: Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo. Overall, our findings suggested further investigations into the effects of turmeric and polyherbal formulations in skin conditions associated with facial redness would be warranted.Trial registration: ClinicalTrials.gov identifier: NCT03065504.展开更多
A plant fermentation was carried out by Yeast and Lactobaccilli against fermented black turmeric, Kaempferia parviflora (FBT). These materials were proved by as safe in animal safety experiment. We tried to investigat...A plant fermentation was carried out by Yeast and Lactobaccilli against fermented black turmeric, Kaempferia parviflora (FBT). These materials were proved by as safe in animal safety experiment. We tried to investigate changes of immune-competent cells that commonly utilized FBT, including after administration of immno-suppressed animals, the effects by FBT on the regulated effect on the cells were evaluated. Our results showed that FBT augmented the level of lymphocytes in number, while FBT regulated the level of granulocytes in both number and function. In our clinical study with 20 healthy volunteers, granulocyte and lymphocyte ratio suggesting their constitution as neutral in peripheral blood were increased significantly 30 days after the administration of FBT in rodents, and compromised host was prepared with cancer chemotherapeutic agent (Mytomycin-C). Our observations showed against intracellular parasite, and that FBT augmented intercellular pathogen through humoral immunity. We discussed the significance and mechanism of FBT on the level of leukocyte subsets in number and function that were considered to be potential indicators for the activation of the compromised host. We also proposed an idea that FBT exhibited tonic effects via activating complement components. The evidences were shown by immune-electrophoretic method. Moreover, we tried to access further to the anti-oxidative activities of this FBT. This modification brought to the significant lift up for antibody producing cells and anti-oxidative activity for phagocytic cells.展开更多
BACKGROUND Inflammatory bowel disease(IBD) is a complex chronic IBD that is closely associated with risk factors such as environment, diet, medications and lifestyle that may influence the host microbiome or immune re...BACKGROUND Inflammatory bowel disease(IBD) is a complex chronic IBD that is closely associated with risk factors such as environment, diet, medications and lifestyle that may influence the host microbiome or immune response to antigens. At present, with the increasing incidence of IBD worldwide, it is of great significance to further study the pathogenesis of IBD and seek new therapeutic targets. Traditional Chinese medicine(TCM) treatment of diseases is characterized by multiple approaches and multiple targets and has a long history of clinical application in China. The mechanism underlying the effect of zedoary turmerictrisomes on inducing mucosal healing in IBD is not clear.AIM To explore the effective components and potential mechanism of zedoary turmeric-trisomes in the treatment of IBD with intestinal fibrosis using network pharmacology and molecular docking techniques.METHODS The chemical constituents and targets of Rhizoma zedoary and Rhizoma sanarum were screened using the TCMSP database. The GeneCards database was searched to identify targets associated with intestinal fibrosis in IBD. The intersection of chemical component targets and disease targets was obtained using the Venny 2.1 online analysis platform, and the common targets were imported into the STRING 11.0 database to construct a protein interaction regulatory network. A “zedoary turmeric-trisomes-chemical composition-target-disease” network diagram was subsequently constructed using Cytoscape 3.7.2 software, and the topological properties of the network were analyzed using the “Network Analysis” plug-in. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses of the common targets were performed using the DAVID 6.8 database to elucidate the mechanism of zedoary turmeric-trisomes in the treatment of IBD. Subsequently, molecular docking of the compounds and targets with the highest intermediate values in the “zedoary turmeric-trisomes-chemical composition-target-disease” network was performed using Sybyl-x 2.1.1 software.RESULTS A total of 5 chemical components with 60 targets were identified, as well as 3153 targets related to IBD and 44 common targets. The protein-protein interaction network showed that the core therapeutic targets included JUN, MAPK14, CASP3, AR, and PTGS2. The GO enrichment analysis identified 759 items, and the KEGG enrichment analysis yielded 52 items, including the cancer pathway, neuroactive ligand-receptor interaction, hepatitis B, and the calcium signaling pathway, reflecting the complex biological processes of the multicomponent, multitarget and multipathway treatment of diseases with zedoary turmeric-trisomes. Molecular docking showed that the compound bonded with the target through hydrogen bond interactions and exhibited good docking activity.CONCLUSION This study identified the potential mechanism of action of zedoary turmeric-trisomes in the treatment of inflammatory bowel fibrosis using network pharmacology and molecular docking technology, providing a scientific basis for further expansion of their clinical use.展开更多
An experiment was carried out at the Agroforestry and Environment Research Farm, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh, during April, 2014 to January 2015. The experiment was la...An experiment was carried out at the Agroforestry and Environment Research Farm, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh, during April, 2014 to January 2015. The experiment was laid out in two factors Randomized Complete Block Design (RCBD) with three replications. Among the two factors, one factor like A was two production systems: S1 = Mango + Turmeric and S2 = Turmeric (sole crop);another factor like B was three turmeric variety: V1 = BARI Holud-1, V2 = BARI Holud-2 and V3 = BARI Holud-3. So, the treatment combinations were: S1V1 = Mango + BARI Holud-1, S1V2 = Mango + BARI Holud-2, S1V3 = Mango + BARI Holud-3, S2V1 = sole cropping of BARI Holud-1, S2V2 = sole cropping of BARI Holud-2 and S2V3 = sole cropping of BARI Holud-3. The result of the experiment revealed that interaction effect of production systems and variety was found significant on plant height, number of leaf per plant, length of leaf blade, breadth of leaf blade, number of finger per rhizome, fresh and dry yield per hectare. The higher fresh yield of turmeric (34.75 t/ha) and dry yield (6.10 t/ha) was found from S1V1 treatment (Mango + BARI Holud-1). Whereas the lowest fresh yield (33.41 t/ha) and dry yield (4.93 t/ha) was found from S2V2 treatment (sole cropping of BARI Holud-2). However, the suitability of the cultivation of different turmeric variety under mango based agroforestry systems may be ranked as S1V1 > S2V1 > S1V3 > S2V3 > S1V2 > S2V2. Finally it may be concluded that, BARI Holud-1 would be the best variety to be grown under mango based agroforestry.展开更多
Spices have been used for centuries for food preservation, flavors, and medicinal properties. Research suggests that garlic, turmeric, and ginger contain potent antioxidants that may prevent and/or delay chronic disea...Spices have been used for centuries for food preservation, flavors, and medicinal properties. Research suggests that garlic, turmeric, and ginger contain potent antioxidants that may prevent and/or delay chronic diseases such as cancer, diabetes, and heart disease. Heat treatment of spices may potentially increase antioxidative activity by modifying the inherent chemical structure of potent antioxidative compounds within spices. The purpose of this study was to determine the impact of thermal treatment of garlic, ginger, and turmeric on total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferric reducing antioxidant potential (FRAP), trolox activity (TEAC), lipase, a-amylase, and a-glucosidase inhibition. Conventional stovetop heating of selected spices was performed followed by methanolic and aqueous extractions (1 - 5 minutes;70°C - 130°C). Overall methanolic extracts had higher phytochemical, antioxidative, and anti-diabetic potential. However, aqueous garlic extracts exhibited higher phytochemical and antioxidative potential over methanolic garlic extracts. The highest TPC for aqueous garlic extracts was observed at 1 minute (14.11 mg GAE/g) while methanolic garlic extracts at 1 minute were significantly lower (1.72 mg GAE/g). Methanolic turmeric extracts had highest TPC at 5 minutes (28.55 mg GAE/g). Time and temperature influenced antioxidant activity in the spices. Turmeric and ginger (methanolic extracts) resulted in higher percent inhibition of DPPH radical with an increase in time (5 minute) turmeric (86.9%) and ginger (79.09%) at 7.9 mg/mL concentration. The results of this study revealed both solvent and time for thermal treatment of spices influenced antioxidative potential as determined using DPPH and FRAP assays. Therefore, the use of thermal application on spices presents promise in potentiating the antioxidant content and thereby their potential health promoting properties. Spices are utilized in the U.S. food industry and increasing their use as a natural antioxidant preservative and flavoring agent may have beneficial impact in food product development.展开更多
Profitable turmeric (Curcuma longa L.) production requires adequate nutrients. We have investigated the effect of inoculation with arbus cular mycorrhizal fungi (AMF) on growth, nutrient uptake, yield and curcumin pro...Profitable turmeric (Curcuma longa L.) production requires adequate nutrients. We have investigated the effect of inoculation with arbus cular mycorrhizal fungi (AMF) on growth, nutrient uptake, yield and curcumin production of turmeric under field and glasshouse conditions. Although AMF inoculation slightly increased plant height, leaf number and shoot N content, no statistical differences were observed in vegetative growth parameters, biomass production, nutrient uptake and curcumin content compared to control plants under field conditions. It was difficult to determine the exact effect of inoculated AMF on turmeric growth because of indigenous AMF. On the other hand, turmeric showed better response to AMF inoculation under greenhouse conditions. AMF inoculation resulted in higher biomass production and nutrient uptake of turmeric. Moreover the concen tration of curcumin, contained in the rhizome of turmeric, increased in AMF treatment. These results indicate that AMF inoculation has beneficial effects on turmeric growth and curcumin production. AMF inoculation to turmeric field would be effective when indigenous soil populations of AMF are low or native AMF are no longer effective.展开更多
The structural and magnetic properties of the synthesized pure and functionalized CoFe2O4magnetic nanoparticles(NPs) are studied by analyzing the results from the x-ray diffraction(XRD), transmission electron microsco...The structural and magnetic properties of the synthesized pure and functionalized CoFe2O4magnetic nanoparticles(NPs) are studied by analyzing the results from the x-ray diffraction(XRD), transmission electron microscopy(TEM), FT–IR spectroscopy, thermogravimetry(TG), and vibrating sample magnetometer(VSM). To extract the structure and lattice parameters from the XRD analysis results, we first apply the pseudo-Voigt model function to the experimental data obtained from XRD analysis and then the Rietveld algorithm is used in order to optimize the model function to estimate the true intensity values. Our simulated intensities are in good agreement with the experimental peaks, therefore, all structural parameters such as crystallite size and lattice constant are achieved through this simulation. Magnetic analysis reveals that the synthesized functionalized NPs have a saturation magnetization almost equal to that of pure nanoparticles(PNPs). It is also found that the presence of the turmeric causes a small reduction in coercivity of the functionalized NPs in comparison with PNP. Our TGA and FTIR results show that the turmeric is bonded very well to the surface of the NPs. So it can be inferred that a nancomposite(NC) powder of turmeric and nanoparticles is produced. As an application, the anti-arsenic characteristic of turmeric makes the synthesized functionalized NPs or NC powder a good candidate for arsenic removal from polluted industrial waste water.展开更多
Objective: To study gap junction intercellular communication (GJIC), H ras oncogene expression and ras oncogene product (P 21 ras protein) expression in four human solid tumor cell lines, W1-38,CACO 2,A549 and...Objective: To study gap junction intercellular communication (GJIC), H ras oncogene expression and ras oncogene product (P 21 ras protein) expression in four human solid tumor cell lines, W1-38,CACO 2,A549 and PaCa, and the effects of four compounds, Salvia miltiorrhiza derivative (SMD), d Limonene, Turmeric derivative I (TD I) and Turmeric derivative II (TD II), on them. Methods: The abilities of the four solid tumor cell lines to transfer dye to adjacent cells were examined by the scrape loading/dye transfer technique, and the H ras oncogene expression by Northern blotting and P 21 ras protein expression by Western blotting. Results: The results showed the loss of intercellular coupling in PaCa cells, slight GJIC in A549 and CACO 2 cells, and a good GJIC in W1-38 cells. The four compounds could improve the GJIC of PaCa to different extents. The amount of total and membrane associated P 21 ras in PaCa cells were decreased after treatment with SMD, d Limonene and TD I (2.5 μg/ml) for 48 h. Concomitantly, the growth of PaCa cells decreased in soft agar and had enhanced GJIC. The relative potency was found to be:d Limonene>SMD >TD I=TD II. There was no significant effect of the four compounds on H ras oncogene expression. Conclusion: It was suggested that there was an excellent correlation between loss of Lucifer Yellow dye transfer and ras gene mutation rate in the four solid tumor cell lines (ras gene mutation rate inversely correlated with average cell number coupled, r=0.98) i.e., the high ras gene mutation was closely correlated with loss of GJIC in these malignant human tumor cells; The antitumor effect of the monoterpene d Limonene and the phenol compound, SMD, might be related to inhibition of P 21 ras membrane association and enhancement of GJIC, whilst that of the others may be by a different mechanism; The inhibition of P 21 ras membrane association was directly related to the enhancement of gap junction intercellular com munication.展开更多
Turmeric is a spice widely used to enhance the taste and color of certain meats. We investigated the antioxidant capacities of turmeric ethanol soaking extracts by utilizing the scavenging properties of hydroxyl radic...Turmeric is a spice widely used to enhance the taste and color of certain meats. We investigated the antioxidant capacities of turmeric ethanol soaking extracts by utilizing the scavenging properties of hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl（DPPH） free radical. The results showed that the optimum extraction parameters were： extraction time 4 h, sample-solvent ratio 1：84.12, solvent 72.34% ethanol solution, and water bath temperature 81.3 ℃. The optimum ethanol soaking extraction parameters were： extraction time 4 h, sample-solvent ratio 1：90.74, solvent 80.46% ethanol solution, water bath temperature 88.2 ℃. With these parameters, the hydroxyl radical scavenging rate and the DPPH free radical clearance of crude extracts from turmeric can reach about 93.78% and 40.69%, respectively. These results indicate that ethanol soaking extraction may be a useful method for extracting antioxidants from turmeric.展开更多
The analytical description of the trap signature in the charge conduction process of turmeric dye-based organic semiconductor has been presented in this study.An analytical explanation of the built-in potential Ⅴx-Ⅴ...The analytical description of the trap signature in the charge conduction process of turmeric dye-based organic semiconductor has been presented in this study.An analytical explanation of the built-in potential Ⅴx-Ⅴ graph that emphasizes the presence of trapping states has been provided.Differential analysis of current-voltage(Ⅰ-Ⅴ)characteristics has also been conducted to verify the trap signature of the carrier in the device.The non-monotonous decrement of the G(Ⅴ)-Ⅴ plot verifies the trap signature.The values of trap energy(Et)and trap factor(θ)have been derived from the logarithmic Ⅰ-Ⅴ relationship.From the analysis of the semilogarithmic Ⅰ-Ⅴ plot,the barrier height(ϕbi)of the device has also been determined.The overallⅠ-Ⅴcurve has been taken into account to examine the Richardson-Schottky and Poole-Frenkel effects on the trap-assisted charge conduction process.From the results of the experiment,the Schottky effect has been observed to be effective,which leads to a bulk-limited charge conduction process.展开更多
Objective:The aim of this study was to use network pharmacology to predict the targets and related signaling pathways of turmeric in the treatment of liver cancer.Methods:The active ingredients of turmeric turmeric an...Objective:The aim of this study was to use network pharmacology to predict the targets and related signaling pathways of turmeric in the treatment of liver cancer.Methods:The active ingredients of turmeric turmeric and their corresponding targets were screened and collected through the traditional Chinese medicine components and systematic Chinese medicine pharmacology database and analysis platform(TCMSP)database.Through the online human Mendelian network(OMIM),the human genome annotation database(Genecards)and the GAD database,the targets related to liver cancer were collected and compared with the targets corresponding to the drug components,the common parts were screened out to obtain the potential target genes that overlap between turmeric and liver cancer.Cytoscape was used to construct the"compound-target"action network,and the protein interaction(PPI)network was constructed through STRING software to screen the key components and key targets of turmeric for the treatment of liver cancer,and the GO enrichment and KEGG enrichment analysis were conducted on the key targets to analyze their potential mechanism of action.Results:There were 15 active components and 45 target genes in the treatment of liver cancer with turmeric turmeric,and the drug-component-target-disease network showed that the key genes mainly included:MAPK1,MAPK3,AKT1,JUN,RELA,BCL2,CASP8,ESR1,ADRB2,etc.GO functional enrichment showed that biological processes and functions were concentrated in cofactor binding,phosphatase binding,amide binding,g-protein-coupled amide receptor activity,antioxidant activity,steroid activity,nuclear receptor activity,transcription factor activity,direct ligand regulation of sequence-specific DNA binding,and steroid hormone receptor activity.KEGG functional enrichment showed that the enriched pathways mainly included hepatitis b,human immunodeficiency virus 1 infection,apoptosis,hepatitis c and some cancer signaling pathways.Conclusion:The role of turmeric in the treatment of liver cancer may be realized through the above molecular mechanism,providing theoretical evidence for subsequent studies and clinical applications.展开更多
From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span s...From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span style="font-family:Verdana;">Curcuma</span></i> <i><span style="font-family:Verdana;">longa</span></i><span style="font-family:Verdana;"> (Turmeric) is an Indian rhizomatous medicinal herb from the Zingiberaceae family that is common and widely available across the globe. The components of Turmeric are curcumin, demethoxycurcumin and bisdemethoxycurcumin and these are collectively known as curcuminoids. Curcumin, the active ingredient of Turmeric is generally investigated by the scientific community for its wide range of antioxidant activity, anti-Inflammatory properties and anti-cancer activity, anti-metabolic syndrome activities, neuroprotective activity, antimicrobial </span><span style="font-family:Verdana;">effects, anti-arthritis effects, anti-viral effects, anti-asthma and anti-diabetic effects, anti-obesity, cardio and liver toxicity protection activity, anti-depression and anxiety activities.</span><span style="font-family:Verdana;"> Turmeric has been widely used as a typical household treatment for cough, sore throat, respiratory ailments and could be an effective immunity booster against SARS-CoV-2 therapy during the ongoing pandemic situation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, turmeric and its constituents have the potential for the development of modern medicine for the treatment of various diseases. So in this review, we describe the various metabolic roles of curcumin and activities for the benefit of human health.展开更多
Fifteen turmeric genotypes from the germplasm held at National Root Crops Research Institute Umudike, Nigeria, were evaluated during the season of 2012-2013 at four locations-Jos （8.3833°N, 7.1833°E, 1,200 ...Fifteen turmeric genotypes from the germplasm held at National Root Crops Research Institute Umudike, Nigeria, were evaluated during the season of 2012-2013 at four locations-Jos （8.3833°N, 7.1833°E, 1,200 m a.s.l.）, Otobi （7.11667°N and 8.08333°E）, Umudike （5.4758°N, 7.5489°E） and Igbariam （6.4°N and 6.93333°E）-in order to select high yielding and stable turmeric cultivars with good quality for release in Nigeria. At each location, the experiment was laid out in randomized complete block design （RCBD） in three replications. Plot size was 9 m2. Data were collected on sprout count, plant height, number of tillers, number of leaves, main pseudo stem girth, rhizome number and weight. Analysis of variance was carried out on the combined data using GenStat Discovery Edition software. Results based on the combined data from four locations indicate that turmeric genotypes did not vary in percentage emergence and number of leaves. However, they varied in height, main pseudo stem girth, tillering, number and yield of fresh rhizomes. The effect of location on all attributes was significant （P 〈 0.05） with Jos location giving consistently the least values for all attributes thus suggesting that this location may not be suitable for the commercial production of turmeric. Genotype by environment interaction for most attributes was not significant indicating that the genotypes responded the same way across the locations. Ten genotypes, viz., UT39, UT44, UT46, UT58, UT50, UTI4, UT41, UT6, UT38 and UT35, are identified as promising and require further evaluation as pre-condition for nomination for official release to farmers.展开更多
基金supported by Key Cultivation Project of Qiqihar Academy of Medical Sciences(No.2022-ZDPY-003).
文摘In order to reveal the multi-target pharmacological mechanism of Zedoary turmeric oil combined with docetaxel in the treatment of breast cancer,we used network pharmacology and molecular docking.The targets of docetaxel were retrieved from the Swiss Target Prediction database.The active components of Curcuma Zedoary turmeric were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),with criteria set as oral bioavailability OB≥30%and drug-likeness DL≥0.1.Potential targets of these components were subsequently predicted.Breast cancer-related targets were retrieved from the OMIM and GeneCards databases.The Venny tool was used to identify 177 overlapping targets between docetaxel,Zedoary turmeric oil,and breast cancer,followed by protein-protein interaction(PPI)analysis.Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed using the Metascape database.A drug-breast cancer-KEGG pathway target network was constructed using Cytoscape 3.8.0.Molecular docking was employed to verify the binding ability between drugs and core targets.Results showed that the combined treatment may exert anti-breast cancer effects through key targets such as MAPK1,PIK3CA,and HSP90AA1,primarily implicating the biological process of protein phosphorylation and engaging the PI3K-Akt signaling pathway.This study successfully predicted the key targets and enriched pathways of Zedoary turmeric oil combined with docetaxel for breast cancer treatment,providing new insights for further research and development.
基金Project supported by the National Natural Science Foundation of China(No.31271848)the Foundation of Fuli Institute of Food Science of Zhejiang University(No.KY201404),China
文摘Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the effects of TR on the survival of Chinese soft-shelled turtles（SSTs）, Pelodiscus sinensis, under a high ambient temperature. A total of 320 female SSTs were assigned randomly to two diets： basal diet（the control group, n=160） and an interventional diet supplemented with 10% TR（the TR group, n=160）. Our results demonstrated that supplementation of TR increased the SST survival rate by 135.5%, and superoxide dismutase（SOD） activity of SST liver by 112.8%, and decreased the malondialdehyde（MDA） content of SST liver by 36.4%, compared to the control group. The skin of the SST fed TR showed a golden color. High-performance liquid chromatography（HPLC） analysis indicated that the concentrations of curcumin in TR and the skin of the SST fed TR were（1.69±0.30） and（0.14±0.03） μg/g, respectively. Our observation suggests that supplementation of TR increased the survival rate of SST under high ambient temperatures. We speculated that the increased survival rate and tolerance at the high ambient temperature were associated with the anti-oxidation activity of curcumin from TR. Moreover, curcumin in TR could be deposited in SST skin, which made it more favored in the market of China. Our findings provide new knowledge and evidence to effectively reuse TR as a feed additive in animal and aquatic farming.
基金Supported by the Scientific and Technological Innovation Project of Wuhan Academy of Agricultural Science&Technology(CX201417)~~
文摘To explore the protective effect of extract powder of turmeric on carbon tetrachloride （CCl4）-induced acute hepatic injury, the mice were administrated with extract powder of turmeric with different doses （50, 100, 200 mg/kg） for 7 d. Then the mice were treated with 0.12% CCl4 by intraperitoneal injection. The levels of ALT, AST in serum and activities of SOD, CAT, MDA, GSH-Px in liver tissue were detected and the liver lesions were examined. The results showed that the activities of ALT, AST and the level of MDA in extract powder of turmeric group were signif- icantly decreased, and the activities of SOD, CAT, GSH-Px were significantly increased, and liver pathology were improved compared with the injured group （P〈 0.05 or P〈0.01）. It indicated that the extract powder of turmeric had significant protective effect against CCl4 induced acute hepatic injury in mice.
文摘Metabolic syndrome(MS)involves people with the following risk factors:obesity,hypertension,high glucose level and hyperlipidemia.It can increase the risk of heart disease,stroke and type 2 diabetes mellitus.The prevalence of MS in the world’s adult population is about 20%–25%.Today,there is much care to use medicinal plants.Turmeric(Curcuma longa)as well as curcumin which is derived from the rhizome of the plant,has been shown beneficial effects on different components of MS.Thus,the purpose of this manuscript was to introduce different in vitro,in vivo and human studies regarding the effect of turmeric and its constituent on MS.Moreover,different mechanisms of action by which this plant overcomes MS have been introduced.Based on studies,turmeric and its bioactive component,curcumin,due to their anti-inflammatory and antioxidant properties,have antidiabetic effects through increasing insulin release,antihyperlipidemic effects by increasing fatty acid uptake,anti-obesity effects by decreasing lipogenesis,and antihypertensive effects by increasing nitric oxide.According to several in vivo,in vitro and human studies,it can be concluded that turmeric or curcumin has important values as a complementary therapy in MS.However,more clinical trials should be done to confirm these effects.
文摘Gastric ulcer is a common disorder in human at any ages. In this research, the antiulcer activity of wild honey produced by Apis dorsata, alone or in combination with Turmeric Rhizome, was evaluated in healing acute gastric ulcer. Male Wistar albino rats(150–250 g) were induced ulcers with aspirin at 405 mg/kg BW and ethanol. Antiulcer evaluation was done based on the gastric acidity, numbers and diameter of ulcers, ulcer index, healing ratio, histological examinations, and body weight. The results showed that the groups given honey alone, turmeric alone, and combination of turmeric-honey displayed significant ulcer healing compared to the control group. Ulcers in the group administered with combination of turmeric-wild honey was different significantly from the turmeric alone and wild honey alone groups with increased body weight in that group. The result showed that wild honey(2125 mg/kg BW) had the greatest activity in healing ulcers among other groups. The combination of turmeric-wild honey had a good activity in healing ulcers and increased the body weight of the group.
文摘The current study is aimed to explore the sustainable dyeing approach of silk fabric with turmeric powder using tannin as mordant extracted from tamarind seed coat. For that, tamarind seed coat tannin was extracted and applied as natural mordant alone and in combination with metal mordant namely copper sulphate for dyeing silk fabric with the extract of turmeric powder. Dyeing parameters such as temperature, time and mordant concentration were varying for optimizing the process. The color strength, color coordinates, color fastness to wash, perspiration, water and rubbing were evaluated for examining dyeing performance. Firstly, tannin was extracted from tamarind seed coat and applying on the silk fabric at 95°C temperature for 45 min by varying concentration. Among them 15 g/l shows better results. Some samples were mordanted with both 15 g/l extracted tannin and 0.5% copper sulphate solution. The mordanted samples were dyed with turmeric dye by varying the time and temperature. By analyzing the test results, the sample mordanted with extracted tannin showed high color strength and good fastness properties dyeing at 80°C for 60 min. The application of 0.5% copper sulphate mordant enhanced sustainable wash fastness properties.
文摘The properties of gelatin microspheres Zedoary turmeric oil(GMS-ZT)in vitro release werestudied by the continuous flow system(CFS),which could simulate the actual state in vivo.The effects ofsterilization.different flow rates,release medium.the amount of formaldehyde,the duration of cross-linking and thesize of microspheres on the drug release were investigated.The results showed that these factors except thesterilization had influences on drug release and the drug release from the microspheres was slow.Eighty percent ofthe drug released after 12 h,and the release profiles in vitro could be described by the first-order dynamic model,anddrug release was controlled by the matrix erosion and diffusion.
文摘Background: Facial redness is multifactorial in nature and may be a sign of many different conditions,including rosacea, photo damage and flushing. Herbal medicines have been used for thousands of years to treat a variety of dermatological conditions. Turmeric(Curcuma longa) and its constituents have been shown to mediate dilation and constriction of peripheral arterioles and have demonstrated anti-oxidant,anti-inflammatory and wound-healing properties.Objective: To investigate the effects of turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness.Design, setting, participants, and interventions: This was a prospective, double-blind, randomized pilot study. Thirty-three healthy participants were recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017. Thirty participants were enrolled, and28 participants completed the study. The enrolled participants were randomized to receive one of three interventions(placebo, turmeric or polyherbal combination tablets) and were told to take the intervention tablets by mouth twice daily for 4 weeks. Facial redness was assessed at baseline and 4 weeks after intervention by clinical grading and by image-based analysis.Main outcome measures: The primary outcome measure was image-based facial quantification of redness using a research camera and software analysis system. The investigators performed an intention-to-treat analysis by including all subjects who were enrolled in the trial and received any study intervention.Differences were considered statistically significant after accounting for multiple comparisons. Effect sizes for clinical grading were calculated with a Hedges' g where indicated.Results: Twenty-eight participants completed the study and there were no reported adverse events.Based on clinical grading, facial redness intensity and distribution down trended in the polyherbal combination group after 4 weeks(P = 0.1). Under photographic image analysis, the polyherbal combination group had a significant decrease in redness of 40% compared to baseline(P = 0.03). The placebo and turmeric groups had no statistically significant changes in image analysis-based facial redness.Conclusion: Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo. Overall, our findings suggested further investigations into the effects of turmeric and polyherbal formulations in skin conditions associated with facial redness would be warranted.Trial registration: ClinicalTrials.gov identifier: NCT03065504.
文摘A plant fermentation was carried out by Yeast and Lactobaccilli against fermented black turmeric, Kaempferia parviflora (FBT). These materials were proved by as safe in animal safety experiment. We tried to investigate changes of immune-competent cells that commonly utilized FBT, including after administration of immno-suppressed animals, the effects by FBT on the regulated effect on the cells were evaluated. Our results showed that FBT augmented the level of lymphocytes in number, while FBT regulated the level of granulocytes in both number and function. In our clinical study with 20 healthy volunteers, granulocyte and lymphocyte ratio suggesting their constitution as neutral in peripheral blood were increased significantly 30 days after the administration of FBT in rodents, and compromised host was prepared with cancer chemotherapeutic agent (Mytomycin-C). Our observations showed against intracellular parasite, and that FBT augmented intercellular pathogen through humoral immunity. We discussed the significance and mechanism of FBT on the level of leukocyte subsets in number and function that were considered to be potential indicators for the activation of the compromised host. We also proposed an idea that FBT exhibited tonic effects via activating complement components. The evidences were shown by immune-electrophoretic method. Moreover, we tried to access further to the anti-oxidative activities of this FBT. This modification brought to the significant lift up for antibody producing cells and anti-oxidative activity for phagocytic cells.
基金Supported by General Research of Xi’an Science and Technology Planning Project,No. 2022JH-YBYJ-0265Shaanxi Province Natural Science Basic Research Program-General Project,No:2019JM-580 and 2021SF-314+1 种基金Project of Shaanxi Administration of Traditional Chinese Medicine,No. 2019-ZZ-JC010Shaanxi Provincial Hospital of Traditional Chinese Medicine,No. 2021-07, 2018-04
文摘BACKGROUND Inflammatory bowel disease(IBD) is a complex chronic IBD that is closely associated with risk factors such as environment, diet, medications and lifestyle that may influence the host microbiome or immune response to antigens. At present, with the increasing incidence of IBD worldwide, it is of great significance to further study the pathogenesis of IBD and seek new therapeutic targets. Traditional Chinese medicine(TCM) treatment of diseases is characterized by multiple approaches and multiple targets and has a long history of clinical application in China. The mechanism underlying the effect of zedoary turmerictrisomes on inducing mucosal healing in IBD is not clear.AIM To explore the effective components and potential mechanism of zedoary turmeric-trisomes in the treatment of IBD with intestinal fibrosis using network pharmacology and molecular docking techniques.METHODS The chemical constituents and targets of Rhizoma zedoary and Rhizoma sanarum were screened using the TCMSP database. The GeneCards database was searched to identify targets associated with intestinal fibrosis in IBD. The intersection of chemical component targets and disease targets was obtained using the Venny 2.1 online analysis platform, and the common targets were imported into the STRING 11.0 database to construct a protein interaction regulatory network. A “zedoary turmeric-trisomes-chemical composition-target-disease” network diagram was subsequently constructed using Cytoscape 3.7.2 software, and the topological properties of the network were analyzed using the “Network Analysis” plug-in. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses of the common targets were performed using the DAVID 6.8 database to elucidate the mechanism of zedoary turmeric-trisomes in the treatment of IBD. Subsequently, molecular docking of the compounds and targets with the highest intermediate values in the “zedoary turmeric-trisomes-chemical composition-target-disease” network was performed using Sybyl-x 2.1.1 software.RESULTS A total of 5 chemical components with 60 targets were identified, as well as 3153 targets related to IBD and 44 common targets. The protein-protein interaction network showed that the core therapeutic targets included JUN, MAPK14, CASP3, AR, and PTGS2. The GO enrichment analysis identified 759 items, and the KEGG enrichment analysis yielded 52 items, including the cancer pathway, neuroactive ligand-receptor interaction, hepatitis B, and the calcium signaling pathway, reflecting the complex biological processes of the multicomponent, multitarget and multipathway treatment of diseases with zedoary turmeric-trisomes. Molecular docking showed that the compound bonded with the target through hydrogen bond interactions and exhibited good docking activity.CONCLUSION This study identified the potential mechanism of action of zedoary turmeric-trisomes in the treatment of inflammatory bowel fibrosis using network pharmacology and molecular docking technology, providing a scientific basis for further expansion of their clinical use.
文摘An experiment was carried out at the Agroforestry and Environment Research Farm, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh, during April, 2014 to January 2015. The experiment was laid out in two factors Randomized Complete Block Design (RCBD) with three replications. Among the two factors, one factor like A was two production systems: S1 = Mango + Turmeric and S2 = Turmeric (sole crop);another factor like B was three turmeric variety: V1 = BARI Holud-1, V2 = BARI Holud-2 and V3 = BARI Holud-3. So, the treatment combinations were: S1V1 = Mango + BARI Holud-1, S1V2 = Mango + BARI Holud-2, S1V3 = Mango + BARI Holud-3, S2V1 = sole cropping of BARI Holud-1, S2V2 = sole cropping of BARI Holud-2 and S2V3 = sole cropping of BARI Holud-3. The result of the experiment revealed that interaction effect of production systems and variety was found significant on plant height, number of leaf per plant, length of leaf blade, breadth of leaf blade, number of finger per rhizome, fresh and dry yield per hectare. The higher fresh yield of turmeric (34.75 t/ha) and dry yield (6.10 t/ha) was found from S1V1 treatment (Mango + BARI Holud-1). Whereas the lowest fresh yield (33.41 t/ha) and dry yield (4.93 t/ha) was found from S2V2 treatment (sole cropping of BARI Holud-2). However, the suitability of the cultivation of different turmeric variety under mango based agroforestry systems may be ranked as S1V1 > S2V1 > S1V3 > S2V3 > S1V2 > S2V2. Finally it may be concluded that, BARI Holud-1 would be the best variety to be grown under mango based agroforestry.
文摘Spices have been used for centuries for food preservation, flavors, and medicinal properties. Research suggests that garlic, turmeric, and ginger contain potent antioxidants that may prevent and/or delay chronic diseases such as cancer, diabetes, and heart disease. Heat treatment of spices may potentially increase antioxidative activity by modifying the inherent chemical structure of potent antioxidative compounds within spices. The purpose of this study was to determine the impact of thermal treatment of garlic, ginger, and turmeric on total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferric reducing antioxidant potential (FRAP), trolox activity (TEAC), lipase, a-amylase, and a-glucosidase inhibition. Conventional stovetop heating of selected spices was performed followed by methanolic and aqueous extractions (1 - 5 minutes;70°C - 130°C). Overall methanolic extracts had higher phytochemical, antioxidative, and anti-diabetic potential. However, aqueous garlic extracts exhibited higher phytochemical and antioxidative potential over methanolic garlic extracts. The highest TPC for aqueous garlic extracts was observed at 1 minute (14.11 mg GAE/g) while methanolic garlic extracts at 1 minute were significantly lower (1.72 mg GAE/g). Methanolic turmeric extracts had highest TPC at 5 minutes (28.55 mg GAE/g). Time and temperature influenced antioxidant activity in the spices. Turmeric and ginger (methanolic extracts) resulted in higher percent inhibition of DPPH radical with an increase in time (5 minute) turmeric (86.9%) and ginger (79.09%) at 7.9 mg/mL concentration. The results of this study revealed both solvent and time for thermal treatment of spices influenced antioxidative potential as determined using DPPH and FRAP assays. Therefore, the use of thermal application on spices presents promise in potentiating the antioxidant content and thereby their potential health promoting properties. Spices are utilized in the U.S. food industry and increasing their use as a natural antioxidant preservative and flavoring agent may have beneficial impact in food product development.
文摘Profitable turmeric (Curcuma longa L.) production requires adequate nutrients. We have investigated the effect of inoculation with arbus cular mycorrhizal fungi (AMF) on growth, nutrient uptake, yield and curcumin production of turmeric under field and glasshouse conditions. Although AMF inoculation slightly increased plant height, leaf number and shoot N content, no statistical differences were observed in vegetative growth parameters, biomass production, nutrient uptake and curcumin content compared to control plants under field conditions. It was difficult to determine the exact effect of inoculated AMF on turmeric growth because of indigenous AMF. On the other hand, turmeric showed better response to AMF inoculation under greenhouse conditions. AMF inoculation resulted in higher biomass production and nutrient uptake of turmeric. Moreover the concen tration of curcumin, contained in the rhizome of turmeric, increased in AMF treatment. These results indicate that AMF inoculation has beneficial effects on turmeric growth and curcumin production. AMF inoculation to turmeric field would be effective when indigenous soil populations of AMF are low or native AMF are no longer effective.
基金supported by the University of Guilanthe Iran Nanotechnology Initiative Council
文摘The structural and magnetic properties of the synthesized pure and functionalized CoFe2O4magnetic nanoparticles(NPs) are studied by analyzing the results from the x-ray diffraction(XRD), transmission electron microscopy(TEM), FT–IR spectroscopy, thermogravimetry(TG), and vibrating sample magnetometer(VSM). To extract the structure and lattice parameters from the XRD analysis results, we first apply the pseudo-Voigt model function to the experimental data obtained from XRD analysis and then the Rietveld algorithm is used in order to optimize the model function to estimate the true intensity values. Our simulated intensities are in good agreement with the experimental peaks, therefore, all structural parameters such as crystallite size and lattice constant are achieved through this simulation. Magnetic analysis reveals that the synthesized functionalized NPs have a saturation magnetization almost equal to that of pure nanoparticles(PNPs). It is also found that the presence of the turmeric causes a small reduction in coercivity of the functionalized NPs in comparison with PNP. Our TGA and FTIR results show that the turmeric is bonded very well to the surface of the NPs. So it can be inferred that a nancomposite(NC) powder of turmeric and nanoparticles is produced. As an application, the anti-arsenic characteristic of turmeric makes the synthesized functionalized NPs or NC powder a good candidate for arsenic removal from polluted industrial waste water.
文摘Objective: To study gap junction intercellular communication (GJIC), H ras oncogene expression and ras oncogene product (P 21 ras protein) expression in four human solid tumor cell lines, W1-38,CACO 2,A549 and PaCa, and the effects of four compounds, Salvia miltiorrhiza derivative (SMD), d Limonene, Turmeric derivative I (TD I) and Turmeric derivative II (TD II), on them. Methods: The abilities of the four solid tumor cell lines to transfer dye to adjacent cells were examined by the scrape loading/dye transfer technique, and the H ras oncogene expression by Northern blotting and P 21 ras protein expression by Western blotting. Results: The results showed the loss of intercellular coupling in PaCa cells, slight GJIC in A549 and CACO 2 cells, and a good GJIC in W1-38 cells. The four compounds could improve the GJIC of PaCa to different extents. The amount of total and membrane associated P 21 ras in PaCa cells were decreased after treatment with SMD, d Limonene and TD I (2.5 μg/ml) for 48 h. Concomitantly, the growth of PaCa cells decreased in soft agar and had enhanced GJIC. The relative potency was found to be:d Limonene>SMD >TD I=TD II. There was no significant effect of the four compounds on H ras oncogene expression. Conclusion: It was suggested that there was an excellent correlation between loss of Lucifer Yellow dye transfer and ras gene mutation rate in the four solid tumor cell lines (ras gene mutation rate inversely correlated with average cell number coupled, r=0.98) i.e., the high ras gene mutation was closely correlated with loss of GJIC in these malignant human tumor cells; The antitumor effect of the monoterpene d Limonene and the phenol compound, SMD, might be related to inhibition of P 21 ras membrane association and enhancement of GJIC, whilst that of the others may be by a different mechanism; The inhibition of P 21 ras membrane association was directly related to the enhancement of gap junction intercellular com munication.
基金Supported by the National Natural Science Foundation of China(31401500)the Natural Science Foundation of Zhejiang Province(LQ13C200005)the Young Academic Team of Zhejiang Shuren University
文摘Turmeric is a spice widely used to enhance the taste and color of certain meats. We investigated the antioxidant capacities of turmeric ethanol soaking extracts by utilizing the scavenging properties of hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl（DPPH） free radical. The results showed that the optimum extraction parameters were： extraction time 4 h, sample-solvent ratio 1：84.12, solvent 72.34% ethanol solution, and water bath temperature 81.3 ℃. The optimum ethanol soaking extraction parameters were： extraction time 4 h, sample-solvent ratio 1：90.74, solvent 80.46% ethanol solution, water bath temperature 88.2 ℃. With these parameters, the hydroxyl radical scavenging rate and the DPPH free radical clearance of crude extracts from turmeric can reach about 93.78% and 40.69%, respectively. These results indicate that ethanol soaking extraction may be a useful method for extracting antioxidants from turmeric.
文摘The analytical description of the trap signature in the charge conduction process of turmeric dye-based organic semiconductor has been presented in this study.An analytical explanation of the built-in potential Ⅴx-Ⅴ graph that emphasizes the presence of trapping states has been provided.Differential analysis of current-voltage(Ⅰ-Ⅴ)characteristics has also been conducted to verify the trap signature of the carrier in the device.The non-monotonous decrement of the G(Ⅴ)-Ⅴ plot verifies the trap signature.The values of trap energy(Et)and trap factor(θ)have been derived from the logarithmic Ⅰ-Ⅴ relationship.From the analysis of the semilogarithmic Ⅰ-Ⅴ plot,the barrier height(ϕbi)of the device has also been determined.The overallⅠ-Ⅴcurve has been taken into account to examine the Richardson-Schottky and Poole-Frenkel effects on the trap-assisted charge conduction process.From the results of the experiment,the Schottky effect has been observed to be effective,which leads to a bulk-limited charge conduction process.
基金CSCO Traditional Chinese Medicine Cancer Research Fund(No.Y-L2018-002)
文摘Objective:The aim of this study was to use network pharmacology to predict the targets and related signaling pathways of turmeric in the treatment of liver cancer.Methods:The active ingredients of turmeric turmeric and their corresponding targets were screened and collected through the traditional Chinese medicine components and systematic Chinese medicine pharmacology database and analysis platform(TCMSP)database.Through the online human Mendelian network(OMIM),the human genome annotation database(Genecards)and the GAD database,the targets related to liver cancer were collected and compared with the targets corresponding to the drug components,the common parts were screened out to obtain the potential target genes that overlap between turmeric and liver cancer.Cytoscape was used to construct the"compound-target"action network,and the protein interaction(PPI)network was constructed through STRING software to screen the key components and key targets of turmeric for the treatment of liver cancer,and the GO enrichment and KEGG enrichment analysis were conducted on the key targets to analyze their potential mechanism of action.Results:There were 15 active components and 45 target genes in the treatment of liver cancer with turmeric turmeric,and the drug-component-target-disease network showed that the key genes mainly included:MAPK1,MAPK3,AKT1,JUN,RELA,BCL2,CASP8,ESR1,ADRB2,etc.GO functional enrichment showed that biological processes and functions were concentrated in cofactor binding,phosphatase binding,amide binding,g-protein-coupled amide receptor activity,antioxidant activity,steroid activity,nuclear receptor activity,transcription factor activity,direct ligand regulation of sequence-specific DNA binding,and steroid hormone receptor activity.KEGG functional enrichment showed that the enriched pathways mainly included hepatitis b,human immunodeficiency virus 1 infection,apoptosis,hepatitis c and some cancer signaling pathways.Conclusion:The role of turmeric in the treatment of liver cancer may be realized through the above molecular mechanism,providing theoretical evidence for subsequent studies and clinical applications.
文摘From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span style="font-family:Verdana;">Curcuma</span></i> <i><span style="font-family:Verdana;">longa</span></i><span style="font-family:Verdana;"> (Turmeric) is an Indian rhizomatous medicinal herb from the Zingiberaceae family that is common and widely available across the globe. The components of Turmeric are curcumin, demethoxycurcumin and bisdemethoxycurcumin and these are collectively known as curcuminoids. Curcumin, the active ingredient of Turmeric is generally investigated by the scientific community for its wide range of antioxidant activity, anti-Inflammatory properties and anti-cancer activity, anti-metabolic syndrome activities, neuroprotective activity, antimicrobial </span><span style="font-family:Verdana;">effects, anti-arthritis effects, anti-viral effects, anti-asthma and anti-diabetic effects, anti-obesity, cardio and liver toxicity protection activity, anti-depression and anxiety activities.</span><span style="font-family:Verdana;"> Turmeric has been widely used as a typical household treatment for cough, sore throat, respiratory ailments and could be an effective immunity booster against SARS-CoV-2 therapy during the ongoing pandemic situation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, turmeric and its constituents have the potential for the development of modern medicine for the treatment of various diseases. So in this review, we describe the various metabolic roles of curcumin and activities for the benefit of human health.
文摘Fifteen turmeric genotypes from the germplasm held at National Root Crops Research Institute Umudike, Nigeria, were evaluated during the season of 2012-2013 at four locations-Jos （8.3833°N, 7.1833°E, 1,200 m a.s.l.）, Otobi （7.11667°N and 8.08333°E）, Umudike （5.4758°N, 7.5489°E） and Igbariam （6.4°N and 6.93333°E）-in order to select high yielding and stable turmeric cultivars with good quality for release in Nigeria. At each location, the experiment was laid out in randomized complete block design （RCBD） in three replications. Plot size was 9 m2. Data were collected on sprout count, plant height, number of tillers, number of leaves, main pseudo stem girth, rhizome number and weight. Analysis of variance was carried out on the combined data using GenStat Discovery Edition software. Results based on the combined data from four locations indicate that turmeric genotypes did not vary in percentage emergence and number of leaves. However, they varied in height, main pseudo stem girth, tillering, number and yield of fresh rhizomes. The effect of location on all attributes was significant （P 〈 0.05） with Jos location giving consistently the least values for all attributes thus suggesting that this location may not be suitable for the commercial production of turmeric. Genotype by environment interaction for most attributes was not significant indicating that the genotypes responded the same way across the locations. Ten genotypes, viz., UT39, UT44, UT46, UT58, UT50, UTI4, UT41, UT6, UT38 and UT35, are identified as promising and require further evaluation as pre-condition for nomination for official release to farmers.
