Due to their biological interpretability,memristors are widely used to simulate synapses between artificial neural networks.As a type of neural network whose dynamic behavior can be explained,the coupling of resonant ...Due to their biological interpretability,memristors are widely used to simulate synapses between artificial neural networks.As a type of neural network whose dynamic behavior can be explained,the coupling of resonant tunneling diode-based cellular neural networks(RTD-CNNs)with memristors has rarely been reported in the literature.Therefore,this paper designs a coupled RTD-CNN model with memristors(RTD-MCNN),investigating and analyzing the dynamic behavior of the RTD-MCNN.Based on this model,a simple encryption scheme for the protection of digital images in police forensic applications is proposed.The results show that the RTD-MCNN can have two positive Lyapunov exponents,and its output is influenced by the initial values,exhibiting multistability.Furthermore,a set of amplitudes in its output sequence is affected by the internal parameters of the memristor,leading to nonlinear variations.Undoubtedly,the rich dynamic behaviors described above make the RTD-MCNN highly suitable for the design of chaos-based encryption schemes in the field of privacy protection.Encryption tests and security analyses validate the effectiveness of this scheme.展开更多
目的:本研究采用网络药理学与分子对接技术分析当归–川芎药对中的活性成分,探讨其治疗腕管综合征的作用机制。方法:通过筛选中药系统药理学数据库与分析平台(TCMSP)和UniPort数据库获取当归–川芎药对中已发现的主要活性成分及具体的...目的:本研究采用网络药理学与分子对接技术分析当归–川芎药对中的活性成分,探讨其治疗腕管综合征的作用机制。方法:通过筛选中药系统药理学数据库与分析平台(TCMSP)和UniPort数据库获取当归–川芎药对中已发现的主要活性成分及具体的功效靶点,再利用GeneCards和人类孟德尔遗传综合数据库获取腕管综合征的相关靶点。通过Venn网页工具获取药物疾病共同靶点,再在Cytoscape 3.9.1软件中输入相关数据,以绘制当归与川芎药对有效成分及腕管综合征交集靶点网络图。在STRING数据库对交集靶点进行蛋白质–蛋白质相互作用网络分析,然后使用DAVID数据库对交集靶点进行基因本体论(GO)功能富集分析和京都基因与基因组百科全书(KEGG)通路富集分析,用微生信绘制富集分析气泡图。利用AutoDock软件模拟核心蛋白–配体相互作用的分子对接模型,并用PyMOL软件对分子对接结果进行可视化。结果:获取当归、川芎治疗腕管综合征的有效活性成分9个,潜在作用靶点69个。关键作用靶点为丝氨酸/苏氨酸蛋白激酶1(Akt Serine/Threonine Kinase1,AKT1)、表皮生长因子受体(Epidermal Growth Factor Receptor,EGFR)、半胱氨酸蛋白酶(Caspase,CASP)3、热休克蛋白90α家族A类成员1(Heat Shock Protein 90 Alpha Family Class A Member 1,HSP90AA1)、热休克蛋白90α家族B类成员1(Heat Shock Protein 90 Alpha Family Class B Member 1,HSP90AB1)等,主要涉及凋亡过程的负调控通路、磷酸化、胶原蛋白分解代谢过程等。结论:当归–川芎药对通过多通路、多种有效活性成分和多种有效靶点实现对腕管综合征的治疗。展开更多
基金supported by the Scientific Research Fund of Hunan Provincial Education Department(Grant No.24A0248)the National Key Research and Development Program“National Quality Infrastructure System”Special Project(Grant No.2024YFF0617900)the Hefei Minglong Electronic Technology Co.,Ltd.(Grant Nos.2024ZKHX293,2024ZKHX294,and 2024ZKHX295).
文摘Due to their biological interpretability,memristors are widely used to simulate synapses between artificial neural networks.As a type of neural network whose dynamic behavior can be explained,the coupling of resonant tunneling diode-based cellular neural networks(RTD-CNNs)with memristors has rarely been reported in the literature.Therefore,this paper designs a coupled RTD-CNN model with memristors(RTD-MCNN),investigating and analyzing the dynamic behavior of the RTD-MCNN.Based on this model,a simple encryption scheme for the protection of digital images in police forensic applications is proposed.The results show that the RTD-MCNN can have two positive Lyapunov exponents,and its output is influenced by the initial values,exhibiting multistability.Furthermore,a set of amplitudes in its output sequence is affected by the internal parameters of the memristor,leading to nonlinear variations.Undoubtedly,the rich dynamic behaviors described above make the RTD-MCNN highly suitable for the design of chaos-based encryption schemes in the field of privacy protection.Encryption tests and security analyses validate the effectiveness of this scheme.
文摘目的:本研究采用网络药理学与分子对接技术分析当归–川芎药对中的活性成分,探讨其治疗腕管综合征的作用机制。方法:通过筛选中药系统药理学数据库与分析平台(TCMSP)和UniPort数据库获取当归–川芎药对中已发现的主要活性成分及具体的功效靶点,再利用GeneCards和人类孟德尔遗传综合数据库获取腕管综合征的相关靶点。通过Venn网页工具获取药物疾病共同靶点,再在Cytoscape 3.9.1软件中输入相关数据,以绘制当归与川芎药对有效成分及腕管综合征交集靶点网络图。在STRING数据库对交集靶点进行蛋白质–蛋白质相互作用网络分析,然后使用DAVID数据库对交集靶点进行基因本体论(GO)功能富集分析和京都基因与基因组百科全书(KEGG)通路富集分析,用微生信绘制富集分析气泡图。利用AutoDock软件模拟核心蛋白–配体相互作用的分子对接模型,并用PyMOL软件对分子对接结果进行可视化。结果:获取当归、川芎治疗腕管综合征的有效活性成分9个,潜在作用靶点69个。关键作用靶点为丝氨酸/苏氨酸蛋白激酶1(Akt Serine/Threonine Kinase1,AKT1)、表皮生长因子受体(Epidermal Growth Factor Receptor,EGFR)、半胱氨酸蛋白酶(Caspase,CASP)3、热休克蛋白90α家族A类成员1(Heat Shock Protein 90 Alpha Family Class A Member 1,HSP90AA1)、热休克蛋白90α家族B类成员1(Heat Shock Protein 90 Alpha Family Class B Member 1,HSP90AB1)等,主要涉及凋亡过程的负调控通路、磷酸化、胶原蛋白分解代谢过程等。结论:当归–川芎药对通过多通路、多种有效活性成分和多种有效靶点实现对腕管综合征的治疗。
