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Multifocal neuroendocrine cell hyperplasia accompanied by tumorlet formation and pulmonary sclerosing pneumocytoma:A case report 被引量:1
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作者 Xiao-Yu Han Yuan-Yuan Wang +4 位作者 Hong-Quan Wei Guang-Zhao Yang Jian Wang Yu-Zhu Jia Wei-Qun Ao 《World Journal of Clinical Cases》 SCIE 2020年第16期3583-3590,共8页
BACKGROUND Pulmonary tumorlets are nodular hyperplastic neuroendocrine cells(NECs)that extend beyond the basement membrane.They often coexist with other lung diseases such as fibrosis and bronchiectasis,but rarely acc... BACKGROUND Pulmonary tumorlets are nodular hyperplastic neuroendocrine cells(NECs)that extend beyond the basement membrane.They often coexist with other lung diseases such as fibrosis and bronchiectasis,but rarely accompanied by pulmonary sclerosing pneumocytoma(PSP),which has not been reported in the literature.CASE SUMMARY A 54-year-old woman was admitted to the hospital because she had symptoms of bloody sputum for more than 4 mo and hemoptysis for 1 wk.Computed tomography images showed atrophy accompanied by infections in the middle lobe of her right lung.Moreover,numerous nodules were identified in the middle lobe of the right lung.The patient underwent thoracoscopic pneumonectomy of the middle lobe of the right lung,and the resected mass was pathologically confirmed to have bronchiectasis,multifocal NEC hyperplasia accompanied by tumorlet,and PSP.CONCLUSION Our report presents a rare clinical case of bronchiectasis complicated with multifocal NEC hyperplasia,tumorlet,and PSP. 展开更多
关键词 Neuroendocrine cell hyperplasia tumorlet formation Pulmonary sclerosing pneumocytoma Pulmonary tumor
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直径小于2cm的胃肠道间质瘤是肿瘤还是瘤样病变 被引量:6
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作者 陈林莺 任彩虹 +1 位作者 陈祥娜 张声 《中国肿瘤临床》 CAS CSCD 北大核心 2012年第18期1349-1353,共5页
目的:分析直径≤2 cm的胃肠道间质瘤(small-GIST)病变遗传学特征,探讨GIST发生发展的可能机制,方法:收集福建医科大学附属第一医院病理科2008年1月至2010年12月间71例GIST病例,进行免疫组化染色和石蜡切片DNA抽提,PCR扩增-直接测序,分析... 目的:分析直径≤2 cm的胃肠道间质瘤(small-GIST)病变遗传学特征,探讨GIST发生发展的可能机制,方法:收集福建医科大学附属第一医院病理科2008年1月至2010年12月间71例GIST病例,进行免疫组化染色和石蜡切片DNA抽提,PCR扩增-直接测序,分析small-GIST的临床病理学特征,比较small-GIST和临床显著性(overt)GIST中C-kit基因的突变状态结果:small-GIST患者平均年龄62.2岁,86.7%(13/15)伴有原发器官或邻近器官的恶性上皮性肿瘤。GIST平均直径0.88 cm,显微镜下观察多数瘤结节位于胃壁浆肌层,与周围肌组织境界不清,细胞形态以梭形细胞为主,除2例为中等细胞密度以外,其余细胞密度均较低,肿瘤细胞形态温和,核较细长,呈波浪状,核端空泡易见。间质玻璃样变性明显,尤以肿瘤中央区显著。瘤结节旁可见增生的Cajal细胞,形态与瘤结节相似,CD117和CD34免疫组化染色瘤细胞和增生的Cajal细胞均强阳性表达。9例(60%)small-GIST存在C-kit基因突变,其中exon11突变6例,exon9突变1例,exon 13突变2例small-GIST C-kit基因总体突变率低于overt-GIST,但差异无统计学意义(P>0.05)。结论:发生在胃的直径小于2 cm的胃肠道间质瘤更多为惰性自限性增生性病变,C-kit基因突变可能是CIST发生的早期事件。 展开更多
关键词 small/overt-GIST 临床病理特征 基因突变 瘤样病变
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