Tuberculosis(TB)is a prominent infectious disease globally that imposes a substantial health burden.Genital TB(GTB),an extrapulmonary manifestation,leads to complications such as tubal adhesions,blockage,and diminishe...Tuberculosis(TB)is a prominent infectious disease globally that imposes a substantial health burden.Genital TB(GTB),an extrapulmonary manifestation,leads to complications such as tubal adhesions,blockage,and diminished ovarian function,culminating in infertility,and is recognized as a prevalent cause of infertility in nations with high-burden TB.In regions with low TB rates,infertility and active TB during pregnancy have been reported to be most common among female immigrants from countries with high-burden TB.In the context of TB,pregnant women often exhibit exacerbated symptoms after in vitro fertilization-embryo transfer(IVF-ET),heightening the risk of dissemination.Miliary pulmonary TB and tuberculous meningitis pose a serious threat to maternal and fetal health.This article integrates recent epidemiological data and clinical research findings,delineating the impact of TB on infertility and assisted reproduction and particularly focusing on the diagnosis and treatment of GTB,underscored by the imperative of TB screening before IVF-ET.Our objective is to increase awareness among respiratory and reproductive health professionals,promoting multidisciplinary management to enhance clinical vigilance.This approach seeks to provide patients with judicious reproductive plans and scientifically rigorous pregnancy management,thereby mitigating adverse pregnancy outcomes related to TB activity.展开更多
Background：Screening on multidrug-resistant tuberculosis （MDR-TB） has been limited to the serious TB subpopulations excluding the new TB patients.This study aimed to examine MDR-TB burden among the new TB patients....Background：Screening on multidrug-resistant tuberculosis （MDR-TB） has been limited to the serious TB subpopulations excluding the new TB patients.This study aimed to examine MDR-TB burden among the new TB patients.Methods：We conducted a study in Zhejiang Province during 2009-2013 to screen for MDR-TB patients among the low MDR-TB risk patients and five subpopulations of high MDR-TB risk patients.The number,prevalence,and trend of MDR-TB were compared while the logistic regression model was used to examine risk factors related to MDR-TB.Results：A total of 200 and 791 MDR-TB cases were,respectively,identified from the 9830 new TB cases and 2372 high-risk suspects who took MDR-TB screening from 2009 to 2013.The MDR-TB rates went down in both of the new TB patients and five MDR-TB high-risk groups over the study time,but the percentage of MDR-TB patients identified from the new TB patients in all diagnosed MDR-TB cases kept stable from 28.3% in 2011 to 27.0% in 2012 to 26.0% in 2013.Conclusions：The study indicated that MDR-TB burden among new TB patients was high,thus screening for MDR-TB among the new TB patients should be recommended in China as well as in the similar situation worldwide.展开更多
基金supported by Capital’s Funds for Health Improvement and Research(No.2022-2G-40910)Cohort Projects of Peking University Third Hospital(No.BYSYDL2019005)Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2022014).
文摘Tuberculosis(TB)is a prominent infectious disease globally that imposes a substantial health burden.Genital TB(GTB),an extrapulmonary manifestation,leads to complications such as tubal adhesions,blockage,and diminished ovarian function,culminating in infertility,and is recognized as a prevalent cause of infertility in nations with high-burden TB.In regions with low TB rates,infertility and active TB during pregnancy have been reported to be most common among female immigrants from countries with high-burden TB.In the context of TB,pregnant women often exhibit exacerbated symptoms after in vitro fertilization-embryo transfer(IVF-ET),heightening the risk of dissemination.Miliary pulmonary TB and tuberculous meningitis pose a serious threat to maternal and fetal health.This article integrates recent epidemiological data and clinical research findings,delineating the impact of TB on infertility and assisted reproduction and particularly focusing on the diagnosis and treatment of GTB,underscored by the imperative of TB screening before IVF-ET.Our objective is to increase awareness among respiratory and reproductive health professionals,promoting multidisciplinary management to enhance clinical vigilance.This approach seeks to provide patients with judicious reproductive plans and scientifically rigorous pregnancy management,thereby mitigating adverse pregnancy outcomes related to TB activity.
文摘Background：Screening on multidrug-resistant tuberculosis （MDR-TB） has been limited to the serious TB subpopulations excluding the new TB patients.This study aimed to examine MDR-TB burden among the new TB patients.Methods：We conducted a study in Zhejiang Province during 2009-2013 to screen for MDR-TB patients among the low MDR-TB risk patients and five subpopulations of high MDR-TB risk patients.The number,prevalence,and trend of MDR-TB were compared while the logistic regression model was used to examine risk factors related to MDR-TB.Results：A total of 200 and 791 MDR-TB cases were,respectively,identified from the 9830 new TB cases and 2372 high-risk suspects who took MDR-TB screening from 2009 to 2013.The MDR-TB rates went down in both of the new TB patients and five MDR-TB high-risk groups over the study time,but the percentage of MDR-TB patients identified from the new TB patients in all diagnosed MDR-TB cases kept stable from 28.3% in 2011 to 27.0% in 2012 to 26.0% in 2013.Conclusions：The study indicated that MDR-TB burden among new TB patients was high,thus screening for MDR-TB among the new TB patients should be recommended in China as well as in the similar situation worldwide.
