RNA molecules play diverse and essential roles in cellular processes beyond their wellknown functions in gene expression and regulation.While ribosomal RNAs(rRNAs)have long been recognized as structural components of ...RNA molecules play diverse and essential roles in cellular processes beyond their wellknown functions in gene expression and regulation.While ribosomal RNAs(rRNAs)have long been recognized as structural components of ribosomes,recent research has highlighted the importance of a distinct group of RNAs which directly compose the structures or organelles in mammalian cells.We refer to these as‘organelle formation RNAs’.Specifically,the discovery of tubulin-associated lncRNA(TubAR),the first identified cytoskeleton-forming RNA,has expanded our understanding of RNA functionality;we now recognize‘organelle formation RNAs’not only as regulatory molecules but also as direct structural components within cellular subunits.Other‘organelle formation RNAs’include paraspeckle-forming RNAs,nuclear speckle-forming RNAs,and nucleolus-forming RNAs.Various RNAs contribute to the formation of distinct cellular structures,while also participating in intricate intermolecular interactions.Understanding these molecules not only uncovers their fundamental roles in cellular physiology but also suggests potential applications in the treatment of related diseases.By examining the latest advancements and methodologies in organelle formation RNA research,this review provides a comprehensive overview of the intricate mechanisms of these RNAs and future directions in the field.展开更多
基金supported by National Natural Science Foundation of China(32400436 to XLL and 32170557 to XW)Anhui Provincial Key Research and Development Project(2022e07020020 to XW)+1 种基金Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM(2023IHM01034 to XW)Anhui Postdoctoral Scientific Research Program Foundation(2024C879 to XLL).
文摘RNA molecules play diverse and essential roles in cellular processes beyond their wellknown functions in gene expression and regulation.While ribosomal RNAs(rRNAs)have long been recognized as structural components of ribosomes,recent research has highlighted the importance of a distinct group of RNAs which directly compose the structures or organelles in mammalian cells.We refer to these as‘organelle formation RNAs’.Specifically,the discovery of tubulin-associated lncRNA(TubAR),the first identified cytoskeleton-forming RNA,has expanded our understanding of RNA functionality;we now recognize‘organelle formation RNAs’not only as regulatory molecules but also as direct structural components within cellular subunits.Other‘organelle formation RNAs’include paraspeckle-forming RNAs,nuclear speckle-forming RNAs,and nucleolus-forming RNAs.Various RNAs contribute to the formation of distinct cellular structures,while also participating in intricate intermolecular interactions.Understanding these molecules not only uncovers their fundamental roles in cellular physiology but also suggests potential applications in the treatment of related diseases.By examining the latest advancements and methodologies in organelle formation RNA research,this review provides a comprehensive overview of the intricate mechanisms of these RNAs and future directions in the field.
