Hepatitis B virus(HBV)is a pathogen that infects humans and can lead to the development of liver disease and hepatocellular carcinoma.Currently,however,animal models of HBV infection remain lacking.Similar to humans,t...Hepatitis B virus(HBV)is a pathogen that infects humans and can lead to the development of liver disease and hepatocellular carcinoma.Currently,however,animal models of HBV infection remain lacking.Similar to humans,tree shrews(Tupaia belangeri)can be infected with HBV1,2 and exhibit similar hepatic histopathological changes and hepatocellular carcinoma features as those found in HBV-infected humans.2,3 Sodium taurocholate cotransporting polypeptide is a functional HBV receptor that was recently identified in tree shrews.4 However,the infection rate is usually low in adult animals under natural conditions,and the virus can be eliminated spontaneously over a short period of time.1 Thus,the mechanism related to the weak HBV replication in tree shrews needs to be further explored,although host factors are hypothesized to be major factors affecting HBV infection and persistence.展开更多
文摘Hepatitis B virus(HBV)is a pathogen that infects humans and can lead to the development of liver disease and hepatocellular carcinoma.Currently,however,animal models of HBV infection remain lacking.Similar to humans,tree shrews(Tupaia belangeri)can be infected with HBV1,2 and exhibit similar hepatic histopathological changes and hepatocellular carcinoma features as those found in HBV-infected humans.2,3 Sodium taurocholate cotransporting polypeptide is a functional HBV receptor that was recently identified in tree shrews.4 However,the infection rate is usually low in adult animals under natural conditions,and the virus can be eliminated spontaneously over a short period of time.1 Thus,the mechanism related to the weak HBV replication in tree shrews needs to be further explored,although host factors are hypothesized to be major factors affecting HBV infection and persistence.
