BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Resear...BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.展开更多
A pattern is used to describe best practices and principles. Patterns have been used successfully in architecture and in software design. We propose to apply the pattern method to XML-based security engineering. Organ...A pattern is used to describe best practices and principles. Patterns have been used successfully in architecture and in software design. We propose to apply the pattern method to XML-based security engineering. Organized collections of interrelated patterns (called pattern languages) can embody whole bodies of knowledge on specific topics. We will discuss patterns and security pattern, pattern languages and the requirements of the pattern languages proposing its essential requirement (the template), and lays the groundwork for our future development of a true XML-based security pattern language.展开更多
The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled p...The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed.展开更多
The preparation of red,green,and blue quantum dot(QD)pixelated arrays with high precision,resolution,and brightness poses a significant challenge on the development of advanced micro-displays for virtual,augmented,and...The preparation of red,green,and blue quantum dot(QD)pixelated arrays with high precision,resolution,and brightness poses a significant challenge on the development of advanced micro-displays for virtual,augmented,and mixed reality applications.Alongside the controlled synthesis of high-performance QDs,a reliable QD patterning technology is crucial in overcoming this challenge.Among the various methods available,photolithography-based patterning technologies show great potentials in producing ultra-fine QD patterns at micron scale.This review article presents the recent advancements in the field of QD patterning using photolithography techniques and explores their applications in micro-display technology.Firstly,we discuss QD patterning through photolithography techniques employing photoresist(PR),which falls into two categories:PRassisted photolithography and photolithography of QDPR.Subsequently,direct photolithography techniques based on photo-induced crosslinking of photosensitive groups and photo-induced ligand cleavage mechanisms are thoroughly reviewed.Meanwhile,we assess the performance of QD arrays fabricated using these photolithography techniques and their integration into QD light emitting diode display devices as well as color conversionbased micro light emitting diode display devices.Lastly,we summarize the most recent developments in this field and outline future prospects.展开更多
To more accurately describe the coal damage and fracture evolution law during liquid nitrogen(LN_(2))fracturing under true triaxial stress,a thermal-hydraulic-mechanical-damage(THMD)coupling model for LN_(2) fracturin...To more accurately describe the coal damage and fracture evolution law during liquid nitrogen(LN_(2))fracturing under true triaxial stress,a thermal-hydraulic-mechanical-damage(THMD)coupling model for LN_(2) fracturing coal was developed,considering the coal heterogeneity and thermophysical parameters of nitrogen.The accuracy and applicability of model were verified by comparing with LN_(2) injection pre-cooling and fracturing experimental data.The effects of different pre-cooling times and horizontal stress ratios on coal damage evolution,permeability,temperature distribution,and fracture characteristics were analyzed.The results show that the permeability and damage of the coal increase exponentially,while the temperature decreases exponentially during the fracturing process.As the pre-cooling time increases,the damage range of the coal expands,and the fracture propagation becomes more pronounced.The initiation pressure and rupture pressure decrease and tend to stabilize with longer precooling times.As the horizontal stress ratio increases,fractures preferentially extend along the direction of maximum horizontal principal stress,leading to a significant decrease in both initiation and rupture pressures.At a horizontal stress ratio of 3,the initiation pressure drops by 48.07%,and the rupture pressure decreases by 41.36%.The results provide a theoretical basis for optimizing LN_(2) fracturing techniques and improving coal seam modification.展开更多
The Hengduan Mountains,situated on the southeastern edge of the Qinghai-Tibet Plateau,are the longest and widest north-south-oriented mountain range in China,exerting a significant influence on the ecological and geog...The Hengduan Mountains,situated on the southeastern edge of the Qinghai-Tibet Plateau,are the longest and widest north-south-oriented mountain range in China,exerting a significant influence on the ecological and geographical pattern.Understanding the topographic and geomorphological characteristics of the Hengduan Mountains is fundamental and crucial for research in related fields such as ecology,geography,and sustainability.In this study,Digital Elevation Model(DEM)data were utilized to extract and analyze the topography and geomorphology(TG)pattern.TG maps have been developed to quantitatively classify the TG types in the Hengduan Mountains by combining the five factors of elevation,slope,aspect,relief and landform.The spatial distribution and quantitative characteristics of these factors were mapped and investigated using geographic information systems.The results revealed that:(1)The Hengduan Mountains exhibit an elongated north-south distribution,with an average elevation of approximately 3746 m,an average slope of around 25°,and an average relief of about 266 m.(2)The Hengduan Mountains display significant elevation differences,with an overall high elevation,characterized by a trend of lower elevation in the east and higher elevation in the west,as well as irregular orientations of various aspects.(3)The 19 landform types were identified,the landform types of the Hengduan Mountains are primarily composed of low-relief high-mountains(42.0618%),low-relief mid-mountains(22.4624%),and high-elevation hills(20.5839%).The results of the study can provide data and information support for the ecology,environmental protection and sustainable development of the Hengduan Mountains.展开更多
Clarifying the mechanisms that control the evolution of territorial space patterns is essential for regulating and optimizing the geographical structure and processes related to sustainable development.Using the Guang...Clarifying the mechanisms that control the evolution of territorial space patterns is essential for regulating and optimizing the geographical structure and processes related to sustainable development.Using the Guangdong and Guangxi sections of the Pearl River Basin as examples,the transfer-matrix method and standard deviation ellipse model were applied to characterize the evolution of territorial space patterns from 1990 to 2020.A trend surface analysis and the Theil index were used to analyze regional differences in the evolution process,and geodetectors were used to identify the underlying mechanisms of the changes.There were three key results.(1)In these critical areas of the Pearl River Basin,agricultural and ecological spaces have rapidly declined due to urban expansion,with transfers between these spaces dominating the evolution of territorial space patterns.Spatial pattern changes in the Guangdong section were more intense than in the Guangxi section.(2)Regional differences in urban space have decreased,whereas differences in agricultural and ecological spaces have intensified.Driven by socio-economic growth,the cross-regional transfers of territorial space have created a“high in the east,while low in the west”inter-regional difference,and a“high in the south,while low in the north”intra-regional difference shaped by natural conditions.The regional differences in space patterns were greater in Guangdong than in Guangxi.(3)The evolution of watershed territorial space patterns resulted from scale changes,locational shifts,structural reorganizations,and directional changes driven by multiple factors.Natural environment,social life,economic development,and policy factors played foundational,leading,key driving,and guiding roles,respectively.Additionally,the regional differences in the evolution of watershed territorial space patterns originated from the differential transmission of the influence of various factors affecting spatial evolution.Enhancing urban space efficiency,restructuring agricultural space,and optimizing ecological space are key strategies for building a complementary and synergistic territorial space pattern in the basin.展开更多
The real-time monitoring of fracture propagation during hydraulic fracturing is crucial for obtaining a deeper understanding of fracture morphology and optimizing hydraulic fracture designs.Accurate measurements of ke...The real-time monitoring of fracture propagation during hydraulic fracturing is crucial for obtaining a deeper understanding of fracture morphology and optimizing hydraulic fracture designs.Accurate measurements of key fracture parameters,such as the fracture height and width,are particularly important to ensure efficient oilfield development and precise fracture diagnosis.This study utilized the optical frequency domain reflectometer(OFDR)technique in physical simulation experiments to monitor fractures during indoor true triaxial hydraulic fracturing experiments.The results indicate that the distributed fiber optic strain monitoring technology can efficiently capture the initiation and expansion of fractures.In horizontal well monitoring,the fiber strain waterfall plot can be used to interpret the fracture width,initiation location,and expansion speed.The fiber response can be divided into three stages:strain contraction convergence,strain band formation,and postshutdown strain rate reversal.When the fracture does not contact the fiber,a dual peak strain phenomenon occurs in the fiber and gradually converges as the fracture approaches.During vertical well monitoring in adjacent wells,within the effective monitoring range of the fiber,the axial strain produced by the fiber can represent the fracture height with an accuracy of 95.6%relative to the actual fracture height.This study provides a new perspective on real-time fracture monitoring.The response patterns of fiber-induced strain due to fractures can help us better understand and assess the dynamic fracture behavior,offering significant value for the optimization of oilfield development and fracture diagnostic techniques.展开更多
Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examine...Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examined.In this study,we apply two widely-used objective methods,the self-organizing map(SOM)and K-means clustering analysis,to derive ozone-favorable SWPs at four Chinese megacities in 2015-2022.We find that the two algorithms are largely consistent in recognizing dominant ozone-favorable SWPs for four Chinese megacities.In the case of classifying six SWPs,the derived circulation fields are highly similar with a spatial correlation of 0.99 between the two methods,and the difference in themean frequency of each SWP is less than 7%.The six dominant ozone-favorable SWPs in Guangzhou are all characterized by anomaly higher radiation and temperature,lower cloud cover,relative humidity,and wind speed,and stronger subsidence compared to climatology mean.We find that during 2015-2022,the occurrence of ozone-favorable SWPs days increases significantly at a rate of 3.2 days/year,faster than the increases in the ozone exceedance days(3.0 days/year).The interannual variability between the occurrence of ozone-favorable SWPs and ozone exceedance days are generally consistent with a temporal correlation coefficient of 0.6.In particular,the significant increase in ozone-favorable SWPs in 2022,especially the Subtropical High type which typically occurs in September,is consistent with a long-lasting ozone pollution episode in Guangzhou during September 2022.Our results thus reveal that enhanced frequency of ozone-favorable SWPs plays an important role in the observed 2015-2022 ozone increase in Guangzhou.展开更多
A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states...A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states.The experimental results indicate that the dip angle of structural plane(θ)and the intermediate principal stress(σ2)have an important influence on the peak strength,cracking mode,and rockburst severity.The peak strength exhibits a first increase and then decrease as a function ofσ2 for a constantθ.However,whenσ2 is constant,the maximum peak strength is obtained atθof 90°,and the minimum peak strength is obtained atθof 30°or 45°.For the case of an inclined structural plane,the crack type at the tips of structural plane transforms from a mix of wing and anti-wing cracks to wing cracks with an increase inσ2,while the crack type around the tips of structural plane is always anti-wing cracks for the vertical structural plane,accompanied by a series of tensile cracks besides.The specimens with structural plane do not undergo slabbing failure regardless ofθ,and always exhibit composite tensile-shear failure whatever theσ2 value is.With an increase inσ2 andθ,the intensity of the rockburst is consistent with the tendency of the peak strength.By analyzing the relationship between the cohesion(c),internal friction angle(φ),andθin sandstone specimens,we incorporateθinto the true triaxial unloading strength criterion,and propose a modified linear Mogi-Coulomb criterion.Moreover,the crack propagation mechanism at the tips of structural plane,and closure degree of the structural plane under true triaxial unloading conditions are also discussed and summarized.This study provides theoretical guidance for stability assessment of surrounding rocks containing geological structures in deep complex stress environments.展开更多
In the era of the digital economy,digital trade has demonstrated strong vitality,becoming a crucial driving force for the highquality development of national and regional economies.However,understanding the resilience...In the era of the digital economy,digital trade has demonstrated strong vitality,becoming a crucial driving force for the highquality development of national and regional economies.However,understanding the resilience of digital trade in the face of external crises is an important topic.Taking the backdrop of Sino-US trade friction,this paper constructs a resilience index system for digital trade.It utilizes entropy method,kernel density estimation,and ArcGIS mapping to calculate and visually analyze the resilience of China’s digital trade from 2017 to 2021.Additionally,a Tobit model is constructed to explore the main influencing factors of digital trade resilience patterns.The research findings indicate:1)temporally,during the period of Sino-US trade friction,China’s digital trade resilience shows an overall upward trend,but there are regional differences in resilience levels across the country,with a severe polarization phenomenon.2)Spatially,high resilience is observed in the eastern and central regions of China,while the western and northeastern regions exhibit low resilience.3)From a dimensional perspective,the resistance of digital trade resilience displays a spatial distribution of high values in the east and low values in the west.The recovery force is aggregated along coastal areas,and the renewal force tends to aggregate along the eastern coastline.4)Factors such as economic scale,industrial structure,urbanization rate,government fiscal expenditure,and technological talents significantly promote the enhancement of digital trade resilience.This study reveals the dynamic characteristics and influencing factors of digital trade resilience in responding to external shocks,providing theoretical basis and policy suggestions for enhancing digital trade resilience,and promoting high-quality economic development in China.展开更多
A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,conf...A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,confocal laser microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,transmission electron microscopy,and electrochemical analysis,are employed to characterize MAO coatings at different stages of preparation.MAO has MgO,hydroxyapatite,Ca_(3)(PO_(4))_(2),and Mg2SiO4 phases.Its microstructure of the coating is characterized by"multiple breakdowns,pores within pores",and"repaired blind pores".The porosity and the uniformity of MAO coating first declines in the constant voltage mode,then augments while the discharge phenomenon takes place,and finally decreases in the repair stage.These analyses reveal a four-stage growth pattern for MAO coatings:anodic oxidation stage,micro-arc oxidation stage,breakdown stage,and repairing stage.During anodic oxidation and MAO stages,inward growth prevails,while the breakdown stage sees outward and accelerated growth.Simultaneous inward and outward growth in the repair stage results in a denser,more uniform coating with increased thickness and improved corrosion resistance.展开更多
The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious materials.Consequently,the true triaxial compressio...The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious materials.Consequently,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of aggregates.The mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically analyzed.The results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,respectively.However,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the aggregates.Theσ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite trend.Theε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse aggregates.With increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.展开更多
The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set inco...The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents.展开更多
The transport of suspended particulate matter is a crucial aspect of studies on sediment source-to-sink processes.However,research on its transport patterns in high-erosion areas of low-latitude seas remains limited.T...The transport of suspended particulate matter is a crucial aspect of studies on sediment source-to-sink processes.However,research on its transport patterns in high-erosion areas of low-latitude seas remains limited.To elucidate modern land-sea interaction processes controlled by the monsoon climate,this study investigates the seasonal transport patterns and control mechanisms of suspended particulate matter in the western Sunda Shelf.Results reveal significant seasonal variations in the spatial distribution of suspended particulate matter concentrations,with elevated levels observed during autumn compared with spring.These differences are directly attributed to the East Asian monsoon,including seasonal monsoon precipitation and the associated transport dynamics.During the northeast monsoon,the Malay Peninsula serves as a primary source for the western sea area,with terrestrial materials from its rivers transported to the northern Gulf of Thailand.This transport pattern shifts to an S-shaped,clockwise circulation during upwelling events.Conversely,in the southwest monsoon,rivers in the northern Gulf of Thailand become the predominant sources for the Sunda Shelf,with terrestrial materials carried by clockwise currents toward the eastern Malay Peninsula.When upwelling occurs off the southern Indochina Peninsula,one branch heads toward the South China Sea and the other toward the southern tip of the Malay Peninsula.The seasonal variation in material sources is further supported by the distribution of clay minerals and the discrimination results of rare earth element proxies,including(La/Sm)UCC-(Gd/Yb)UCCand(La/Yb)UCC-(Gd/Yb)UCC,in surface sediments from the Sunda Shelf and surrounding marine areas.展开更多
Gastric cancer(GC)represents a significant global health burden due to its high morbidity and mortality.Specific behaviors of GC sub-types,distinct dissem-ination patterns,and associated risk-factors remain poorly und...Gastric cancer(GC)represents a significant global health burden due to its high morbidity and mortality.Specific behaviors of GC sub-types,distinct dissem-ination patterns,and associated risk-factors remain poorly understood.This editorial highlights several key prognostic factors,including pathological staging and vascular invasion,that impact GC.It examines a recent study’s investigation of differential metastatic lymph nodes distribution and survival in upper and lower GC sub-types,focusing on histological characterization,pathophysiology,usage of neoadjuvant chemotherapy,and additional predictive determinants.We assess the statistical robustness and clinical applicability of the findings,un-derscoring the importance of treating GC as a heterogeneous disease and em-phasizing how tailored surgical approaches informed by lymph node distribution can optimize tumor detection while minimizing unnecessary interventions.The study’s large cohort,multi-center design,and strict inclusion criteria strengthen its validity in guiding surgical planning and risk-stratification.However,inte-grating genetic and molecular data is critical for refining models and broadening applicability.Additionally,recurrence-metrics and infection-related factors,such as Helicobacter pylori and Epstein-Barr virus,absent in the original study,remain vital for directing future research.By bridging metastatic patterns with pros-pective methodologies and inclusion of diverse populations,this editorial pro-vides a framework for advancing early detection and personalized GC care.展开更多
BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have ...BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no research.AIM To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic intervention.METHODS A cross-sectional survey was disseminated among ophthalmologists all over India.The survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up patterns.RESULTS A total of 180 ophthalmologists responded to the survey.Most practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was advised.The most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid surgeries.Sixty-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease patients.CONCLUSION Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular conditions.Many ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract surgery.Eyelid conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.展开更多
Chaoshan drawnwork handkerchief design exhibits self-similarity and fractal characteristics due to their grid-based structure,overall symmetry,and the way local motifs reflect the whole pattern.To explore the potentia...Chaoshan drawnwork handkerchief design exhibits self-similarity and fractal characteristics due to their grid-based structure,overall symmetry,and the way local motifs reflect the whole pattern.To explore the potential of fractals in traditional textile design,a fractal-based generative framework was proposed for efficiently creating drawnwork patterns suitable for practical handicraft production.The research was initiated with an analysis of the structural composition of center,skeleton,and filler motifs extracted from a pattern sample library.Based on this hierarchical classification,the box-counting method was employed to calculate their respective fractal dimensions.Building on fractal art theory,generative algorithms,and studies on the application of Ultra Fractal,a Chaoshan drawnwork fractal design model was established.Using this model,51 drawnwork fractal patterns and 153 handkerchief patterns were generated.These patterns were subsequently applied in real-world production to validate the feasibility and value of fractal techniques in textile design.展开更多
Background: Diabetes Mellitus (DM) is a growing health issue in Bangladesh, with significant complications affecting the quality of life (QoL). This study aims to assess long-term complications, treatment patterns, an...Background: Diabetes Mellitus (DM) is a growing health issue in Bangladesh, with significant complications affecting the quality of life (QoL). This study aims to assess long-term complications, treatment patterns, and QoL of diabetic patients during COVID-19. Methods: A cross-sectional study was conducted on 385 diabetic patients (aged 18-80) from tertiary hospitals in Dhaka and Mymensingh between May and October 2022. Data were collected via a semi-structured questionnaire on sociodemographics, complications, treatment patterns, and QoL (SF-12 scale). Chi-square tests, ANOVA, and linear regression were used for inferential analysis. Results: The sample predominantly included middle-aged males (41 - 55 years) with type 2 diabetes. Diabetic retinopathy (34.5%), polyneuropathy (32.2%), and hypertension (52.3%) were the most common complications. Oral medications were used by 59.7% of patients, with 29.1% on insulin. Chi-square analysis showed a significant association between treatment adherence and complications (p β = 0.45, p Conclusion: Complications in diabetic patients significantly affect QoL in Bangladesh. Treatment adherence, especially with oral medications, positively impacts QoL. There is a need for improved access to diabetes care to manage complications and enhance the overall well-being of diabetic patients.展开更多
文摘BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.
基金"China National Science Foundation"under grant No: 2001AA412010
文摘A pattern is used to describe best practices and principles. Patterns have been used successfully in architecture and in software design. We propose to apply the pattern method to XML-based security engineering. Organized collections of interrelated patterns (called pattern languages) can embody whole bodies of knowledge on specific topics. We will discuss patterns and security pattern, pattern languages and the requirements of the pattern languages proposing its essential requirement (the template), and lays the groundwork for our future development of a true XML-based security pattern language.
基金supported by Fund of State Key Laboratory of IPOC(BUPT)(No.IPOC2021ZT16),China.
文摘The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed.
基金supported by the National Natural Science Foundation of China(62374142,12175189 and 11904302)External Cooperation Program of Fujian(2022I0004)+1 种基金Fundamental Research Funds for the Central Universities(20720190005 and 20720220085)Major Science and Technology Project of Xiamen in China(3502Z20191015).
文摘The preparation of red,green,and blue quantum dot(QD)pixelated arrays with high precision,resolution,and brightness poses a significant challenge on the development of advanced micro-displays for virtual,augmented,and mixed reality applications.Alongside the controlled synthesis of high-performance QDs,a reliable QD patterning technology is crucial in overcoming this challenge.Among the various methods available,photolithography-based patterning technologies show great potentials in producing ultra-fine QD patterns at micron scale.This review article presents the recent advancements in the field of QD patterning using photolithography techniques and explores their applications in micro-display technology.Firstly,we discuss QD patterning through photolithography techniques employing photoresist(PR),which falls into two categories:PRassisted photolithography and photolithography of QDPR.Subsequently,direct photolithography techniques based on photo-induced crosslinking of photosensitive groups and photo-induced ligand cleavage mechanisms are thoroughly reviewed.Meanwhile,we assess the performance of QD arrays fabricated using these photolithography techniques and their integration into QD light emitting diode display devices as well as color conversionbased micro light emitting diode display devices.Lastly,we summarize the most recent developments in this field and outline future prospects.
基金financially supported by the National Natural Science Foundation of China(Nos.51874236 and 52174207)Shaanxi Science and Technology Innovation Team(No.2022TD02)Henan University of Science and Technology PhD Funded Projects(No.B2025-9)。
文摘To more accurately describe the coal damage and fracture evolution law during liquid nitrogen(LN_(2))fracturing under true triaxial stress,a thermal-hydraulic-mechanical-damage(THMD)coupling model for LN_(2) fracturing coal was developed,considering the coal heterogeneity and thermophysical parameters of nitrogen.The accuracy and applicability of model were verified by comparing with LN_(2) injection pre-cooling and fracturing experimental data.The effects of different pre-cooling times and horizontal stress ratios on coal damage evolution,permeability,temperature distribution,and fracture characteristics were analyzed.The results show that the permeability and damage of the coal increase exponentially,while the temperature decreases exponentially during the fracturing process.As the pre-cooling time increases,the damage range of the coal expands,and the fracture propagation becomes more pronounced.The initiation pressure and rupture pressure decrease and tend to stabilize with longer precooling times.As the horizontal stress ratio increases,fractures preferentially extend along the direction of maximum horizontal principal stress,leading to a significant decrease in both initiation and rupture pressures.At a horizontal stress ratio of 3,the initiation pressure drops by 48.07%,and the rupture pressure decreases by 41.36%.The results provide a theoretical basis for optimizing LN_(2) fracturing techniques and improving coal seam modification.
基金funded by the Yunnan Provincial Basic Research Joint Special Fund Project(2019FH001(-052))Cangshan Mountain Synthetic Scientific Expeditions Fund.
文摘The Hengduan Mountains,situated on the southeastern edge of the Qinghai-Tibet Plateau,are the longest and widest north-south-oriented mountain range in China,exerting a significant influence on the ecological and geographical pattern.Understanding the topographic and geomorphological characteristics of the Hengduan Mountains is fundamental and crucial for research in related fields such as ecology,geography,and sustainability.In this study,Digital Elevation Model(DEM)data were utilized to extract and analyze the topography and geomorphology(TG)pattern.TG maps have been developed to quantitatively classify the TG types in the Hengduan Mountains by combining the five factors of elevation,slope,aspect,relief and landform.The spatial distribution and quantitative characteristics of these factors were mapped and investigated using geographic information systems.The results revealed that:(1)The Hengduan Mountains exhibit an elongated north-south distribution,with an average elevation of approximately 3746 m,an average slope of around 25°,and an average relief of about 266 m.(2)The Hengduan Mountains display significant elevation differences,with an overall high elevation,characterized by a trend of lower elevation in the east and higher elevation in the west,as well as irregular orientations of various aspects.(3)The 19 landform types were identified,the landform types of the Hengduan Mountains are primarily composed of low-relief high-mountains(42.0618%),low-relief mid-mountains(22.4624%),and high-elevation hills(20.5839%).The results of the study can provide data and information support for the ecology,environmental protection and sustainable development of the Hengduan Mountains.
基金National Social Science Foundation Program,No.22VRC163National Natural Science Foundation of China,No.42061043+1 种基金Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX24_1008Innovation Project of Guangxi Graduate Education,No.YCSW2024473。
文摘Clarifying the mechanisms that control the evolution of territorial space patterns is essential for regulating and optimizing the geographical structure and processes related to sustainable development.Using the Guangdong and Guangxi sections of the Pearl River Basin as examples,the transfer-matrix method and standard deviation ellipse model were applied to characterize the evolution of territorial space patterns from 1990 to 2020.A trend surface analysis and the Theil index were used to analyze regional differences in the evolution process,and geodetectors were used to identify the underlying mechanisms of the changes.There were three key results.(1)In these critical areas of the Pearl River Basin,agricultural and ecological spaces have rapidly declined due to urban expansion,with transfers between these spaces dominating the evolution of territorial space patterns.Spatial pattern changes in the Guangdong section were more intense than in the Guangxi section.(2)Regional differences in urban space have decreased,whereas differences in agricultural and ecological spaces have intensified.Driven by socio-economic growth,the cross-regional transfers of territorial space have created a“high in the east,while low in the west”inter-regional difference,and a“high in the south,while low in the north”intra-regional difference shaped by natural conditions.The regional differences in space patterns were greater in Guangdong than in Guangxi.(3)The evolution of watershed territorial space patterns resulted from scale changes,locational shifts,structural reorganizations,and directional changes driven by multiple factors.Natural environment,social life,economic development,and policy factors played foundational,leading,key driving,and guiding roles,respectively.Additionally,the regional differences in the evolution of watershed territorial space patterns originated from the differential transmission of the influence of various factors affecting spatial evolution.Enhancing urban space efficiency,restructuring agricultural space,and optimizing ecological space are key strategies for building a complementary and synergistic territorial space pattern in the basin.
基金supported by the National Natural Science Foundation of China(Grant No.52104060)the Natural Science Foundation of Shandong Province,China(Grant No.ZR2021QE015).
文摘The real-time monitoring of fracture propagation during hydraulic fracturing is crucial for obtaining a deeper understanding of fracture morphology and optimizing hydraulic fracture designs.Accurate measurements of key fracture parameters,such as the fracture height and width,are particularly important to ensure efficient oilfield development and precise fracture diagnosis.This study utilized the optical frequency domain reflectometer(OFDR)technique in physical simulation experiments to monitor fractures during indoor true triaxial hydraulic fracturing experiments.The results indicate that the distributed fiber optic strain monitoring technology can efficiently capture the initiation and expansion of fractures.In horizontal well monitoring,the fiber strain waterfall plot can be used to interpret the fracture width,initiation location,and expansion speed.The fiber response can be divided into three stages:strain contraction convergence,strain band formation,and postshutdown strain rate reversal.When the fracture does not contact the fiber,a dual peak strain phenomenon occurs in the fiber and gradually converges as the fracture approaches.During vertical well monitoring in adjacent wells,within the effective monitoring range of the fiber,the axial strain produced by the fiber can represent the fracture height with an accuracy of 95.6%relative to the actual fracture height.This study provides a new perspective on real-time fracture monitoring.The response patterns of fiber-induced strain due to fractures can help us better understand and assess the dynamic fracture behavior,offering significant value for the optimization of oilfield development and fracture diagnostic techniques.
基金supported by the Guangdong Basic and Applied Basic Research project (No.2020B0301030004)the Key-Area Research and Development Program of Guangdong Province (No.2020B1111360003)+1 种基金the National Natural Science Foundation of China (No.42105103)the Guangdong Basic and Applied Basic Research Foundation (No.2022A1515011554).
文摘Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examined.In this study,we apply two widely-used objective methods,the self-organizing map(SOM)and K-means clustering analysis,to derive ozone-favorable SWPs at four Chinese megacities in 2015-2022.We find that the two algorithms are largely consistent in recognizing dominant ozone-favorable SWPs for four Chinese megacities.In the case of classifying six SWPs,the derived circulation fields are highly similar with a spatial correlation of 0.99 between the two methods,and the difference in themean frequency of each SWP is less than 7%.The six dominant ozone-favorable SWPs in Guangzhou are all characterized by anomaly higher radiation and temperature,lower cloud cover,relative humidity,and wind speed,and stronger subsidence compared to climatology mean.We find that during 2015-2022,the occurrence of ozone-favorable SWPs days increases significantly at a rate of 3.2 days/year,faster than the increases in the ozone exceedance days(3.0 days/year).The interannual variability between the occurrence of ozone-favorable SWPs and ozone exceedance days are generally consistent with a temporal correlation coefficient of 0.6.In particular,the significant increase in ozone-favorable SWPs in 2022,especially the Subtropical High type which typically occurs in September,is consistent with a long-lasting ozone pollution episode in Guangzhou during September 2022.Our results thus reveal that enhanced frequency of ozone-favorable SWPs plays an important role in the observed 2015-2022 ozone increase in Guangzhou.
基金supports from the National Natural Science Foundation of China (Grant Nos.52004143 and 52374095)the open fund for the Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines (Grant No.SKLMRDPC21KF06).
文摘A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states.The experimental results indicate that the dip angle of structural plane(θ)and the intermediate principal stress(σ2)have an important influence on the peak strength,cracking mode,and rockburst severity.The peak strength exhibits a first increase and then decrease as a function ofσ2 for a constantθ.However,whenσ2 is constant,the maximum peak strength is obtained atθof 90°,and the minimum peak strength is obtained atθof 30°or 45°.For the case of an inclined structural plane,the crack type at the tips of structural plane transforms from a mix of wing and anti-wing cracks to wing cracks with an increase inσ2,while the crack type around the tips of structural plane is always anti-wing cracks for the vertical structural plane,accompanied by a series of tensile cracks besides.The specimens with structural plane do not undergo slabbing failure regardless ofθ,and always exhibit composite tensile-shear failure whatever theσ2 value is.With an increase inσ2 andθ,the intensity of the rockburst is consistent with the tendency of the peak strength.By analyzing the relationship between the cohesion(c),internal friction angle(φ),andθin sandstone specimens,we incorporateθinto the true triaxial unloading strength criterion,and propose a modified linear Mogi-Coulomb criterion.Moreover,the crack propagation mechanism at the tips of structural plane,and closure degree of the structural plane under true triaxial unloading conditions are also discussed and summarized.This study provides theoretical guidance for stability assessment of surrounding rocks containing geological structures in deep complex stress environments.
基金Under the auspices of National Natural Science Foundation of China(No.42471205)the General Scientific Research Project of Zhejiang Provincial Department of Education(No.2024JYTYB12)the Philosophy and Social Science Planning Project of Zhejiang Province(No.23NDJC109YB)。
文摘In the era of the digital economy,digital trade has demonstrated strong vitality,becoming a crucial driving force for the highquality development of national and regional economies.However,understanding the resilience of digital trade in the face of external crises is an important topic.Taking the backdrop of Sino-US trade friction,this paper constructs a resilience index system for digital trade.It utilizes entropy method,kernel density estimation,and ArcGIS mapping to calculate and visually analyze the resilience of China’s digital trade from 2017 to 2021.Additionally,a Tobit model is constructed to explore the main influencing factors of digital trade resilience patterns.The research findings indicate:1)temporally,during the period of Sino-US trade friction,China’s digital trade resilience shows an overall upward trend,but there are regional differences in resilience levels across the country,with a severe polarization phenomenon.2)Spatially,high resilience is observed in the eastern and central regions of China,while the western and northeastern regions exhibit low resilience.3)From a dimensional perspective,the resistance of digital trade resilience displays a spatial distribution of high values in the east and low values in the west.The recovery force is aggregated along coastal areas,and the renewal force tends to aggregate along the eastern coastline.4)Factors such as economic scale,industrial structure,urbanization rate,government fiscal expenditure,and technological talents significantly promote the enhancement of digital trade resilience.This study reveals the dynamic characteristics and influencing factors of digital trade resilience in responding to external shocks,providing theoretical basis and policy suggestions for enhancing digital trade resilience,and promoting high-quality economic development in China.
文摘A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,confocal laser microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,transmission electron microscopy,and electrochemical analysis,are employed to characterize MAO coatings at different stages of preparation.MAO has MgO,hydroxyapatite,Ca_(3)(PO_(4))_(2),and Mg2SiO4 phases.Its microstructure of the coating is characterized by"multiple breakdowns,pores within pores",and"repaired blind pores".The porosity and the uniformity of MAO coating first declines in the constant voltage mode,then augments while the discharge phenomenon takes place,and finally decreases in the repair stage.These analyses reveal a four-stage growth pattern for MAO coatings:anodic oxidation stage,micro-arc oxidation stage,breakdown stage,and repairing stage.During anodic oxidation and MAO stages,inward growth prevails,while the breakdown stage sees outward and accelerated growth.Simultaneous inward and outward growth in the repair stage results in a denser,more uniform coating with increased thickness and improved corrosion resistance.
基金financially supported by the National Natural Science Foundation of China(Nos.52174092,51904290,and 52374147)the Natural Science Foundation of Jiangsu Province,China(No.BK20220157)+2 种基金the Fundamental Research Funds for the Central Universities,China(No.2022YCPY0202)the National Key Research and Development Program of China(No.2023YFC3804204)the Major Program of Xinjiang Uygur Autonomous Region S cience and Technology(No.2023A01002)。
文摘The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious materials.Consequently,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of aggregates.The mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically analyzed.The results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,respectively.However,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the aggregates.Theσ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite trend.Theε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse aggregates.With increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.
基金supported by the National Natural Science Foundation of China(No.U21B2062).
文摘The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents.
基金the Basic Scientific Fund for National Public Research Institutes of China(No.2023Q03)the National Natural Science Foundation of China(Nos.42476078,42306091)+2 种基金the National Programme on Global Change and Air-Sea Interaction(Nos.GASI-04-HYDZ-02,GASI-02-SCS-CJB01)the China-Malaysia Cooperation Project‘Effect on Variability of Seasonal Monsoon on Sedimentary Process in Peninsular Malaysia Waters’the China-Thailand Cooperation Project‘Research on Vulnerability of Coastal Zone’。
文摘The transport of suspended particulate matter is a crucial aspect of studies on sediment source-to-sink processes.However,research on its transport patterns in high-erosion areas of low-latitude seas remains limited.To elucidate modern land-sea interaction processes controlled by the monsoon climate,this study investigates the seasonal transport patterns and control mechanisms of suspended particulate matter in the western Sunda Shelf.Results reveal significant seasonal variations in the spatial distribution of suspended particulate matter concentrations,with elevated levels observed during autumn compared with spring.These differences are directly attributed to the East Asian monsoon,including seasonal monsoon precipitation and the associated transport dynamics.During the northeast monsoon,the Malay Peninsula serves as a primary source for the western sea area,with terrestrial materials from its rivers transported to the northern Gulf of Thailand.This transport pattern shifts to an S-shaped,clockwise circulation during upwelling events.Conversely,in the southwest monsoon,rivers in the northern Gulf of Thailand become the predominant sources for the Sunda Shelf,with terrestrial materials carried by clockwise currents toward the eastern Malay Peninsula.When upwelling occurs off the southern Indochina Peninsula,one branch heads toward the South China Sea and the other toward the southern tip of the Malay Peninsula.The seasonal variation in material sources is further supported by the distribution of clay minerals and the discrimination results of rare earth element proxies,including(La/Sm)UCC-(Gd/Yb)UCCand(La/Yb)UCC-(Gd/Yb)UCC,in surface sediments from the Sunda Shelf and surrounding marine areas.
文摘Gastric cancer(GC)represents a significant global health burden due to its high morbidity and mortality.Specific behaviors of GC sub-types,distinct dissem-ination patterns,and associated risk-factors remain poorly understood.This editorial highlights several key prognostic factors,including pathological staging and vascular invasion,that impact GC.It examines a recent study’s investigation of differential metastatic lymph nodes distribution and survival in upper and lower GC sub-types,focusing on histological characterization,pathophysiology,usage of neoadjuvant chemotherapy,and additional predictive determinants.We assess the statistical robustness and clinical applicability of the findings,un-derscoring the importance of treating GC as a heterogeneous disease and em-phasizing how tailored surgical approaches informed by lymph node distribution can optimize tumor detection while minimizing unnecessary interventions.The study’s large cohort,multi-center design,and strict inclusion criteria strengthen its validity in guiding surgical planning and risk-stratification.However,inte-grating genetic and molecular data is critical for refining models and broadening applicability.Additionally,recurrence-metrics and infection-related factors,such as Helicobacter pylori and Epstein-Barr virus,absent in the original study,remain vital for directing future research.By bridging metastatic patterns with pros-pective methodologies and inclusion of diverse populations,this editorial pro-vides a framework for advancing early detection and personalized GC care.
文摘BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no research.AIM To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic intervention.METHODS A cross-sectional survey was disseminated among ophthalmologists all over India.The survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up patterns.RESULTS A total of 180 ophthalmologists responded to the survey.Most practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was advised.The most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid surgeries.Sixty-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease patients.CONCLUSION Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular conditions.Many ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract surgery.Eyelid conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.
文摘Chaoshan drawnwork handkerchief design exhibits self-similarity and fractal characteristics due to their grid-based structure,overall symmetry,and the way local motifs reflect the whole pattern.To explore the potential of fractals in traditional textile design,a fractal-based generative framework was proposed for efficiently creating drawnwork patterns suitable for practical handicraft production.The research was initiated with an analysis of the structural composition of center,skeleton,and filler motifs extracted from a pattern sample library.Based on this hierarchical classification,the box-counting method was employed to calculate their respective fractal dimensions.Building on fractal art theory,generative algorithms,and studies on the application of Ultra Fractal,a Chaoshan drawnwork fractal design model was established.Using this model,51 drawnwork fractal patterns and 153 handkerchief patterns were generated.These patterns were subsequently applied in real-world production to validate the feasibility and value of fractal techniques in textile design.
文摘Background: Diabetes Mellitus (DM) is a growing health issue in Bangladesh, with significant complications affecting the quality of life (QoL). This study aims to assess long-term complications, treatment patterns, and QoL of diabetic patients during COVID-19. Methods: A cross-sectional study was conducted on 385 diabetic patients (aged 18-80) from tertiary hospitals in Dhaka and Mymensingh between May and October 2022. Data were collected via a semi-structured questionnaire on sociodemographics, complications, treatment patterns, and QoL (SF-12 scale). Chi-square tests, ANOVA, and linear regression were used for inferential analysis. Results: The sample predominantly included middle-aged males (41 - 55 years) with type 2 diabetes. Diabetic retinopathy (34.5%), polyneuropathy (32.2%), and hypertension (52.3%) were the most common complications. Oral medications were used by 59.7% of patients, with 29.1% on insulin. Chi-square analysis showed a significant association between treatment adherence and complications (p β = 0.45, p Conclusion: Complications in diabetic patients significantly affect QoL in Bangladesh. Treatment adherence, especially with oral medications, positively impacts QoL. There is a need for improved access to diabetes care to manage complications and enhance the overall well-being of diabetic patients.
