In this paper, we first define a doubly transitive resolvable idempotent quasigroup （DTRIQ）, and show that aDTRIQ of order v exists if and only ifv ≡0（mod3） and v ≠ 2（mod4）. Then we use DTRIQ to present a trip...In this paper, we first define a doubly transitive resolvable idempotent quasigroup （DTRIQ）, and show that aDTRIQ of order v exists if and only ifv ≡0（mod3） and v ≠ 2（mod4）. Then we use DTRIQ to present a tripling construction for large sets of resolvable directed triple systems, which improves an earlier version of tripling construction by Kang （J. Combin. Designs, 4 （1996）, 301-321）. As an application, we obtain an LRDTS（4·3^n） for any integer n ≥ 1, which provides an infinite family of even orders.展开更多
The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of ris...The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices.展开更多
The optimization of microstructure represents a significant methodology for enhancing coercivity(Hcj).This paper concentrates on optimizing the microstructure of magnets through the manipulation of the composition of ...The optimization of microstructure represents a significant methodology for enhancing coercivity(Hcj).This paper concentrates on optimizing the microstructure of magnets through the manipulation of the composition of low-melting-point and high-melting-point elements,thereby achieving the objective of augmenting the comprehensive magnetic properties of magnets.The present study is concerned with the microstructure of magnets comprising three distinct Ga and B contents,and the associated changes in their magnetic properties.The findings indicate that when the Ga content is 0.5 wt%and the B content is 0.88 wt%,the coercivity of the magnets is markedly enhanced.This is evidenced by an increase in coercivity from 8.51 to 14.83 kOe,representing a 74.26%rise.Concurrently,the residual magnetization strength of the magnet remains unaltered.This finding provides a crucial foundation for optimizing the overall magnetic properties of the magnets.The microstructural analysis indicates that a reduction in B content coupled with an increase in Ga content leads to the melting of sharp angles on the surface of the main-phase grains,facilitated by low-melting-point rare-earth-rich phases.This process results in the migration of Fe from the grain boundaries(GBs)to the triple junction phases(TJPs),while Nd migrates from the TJPs to the GBs.This migration results in a reduction in the agglomeration of rare-earth-rich elements within the TJPs,thereby increasing the Nd content in the GBs.This increase enhances the wettability of the GBs,while the reduction of Fe content in this phase mitigates the exchange-coupling effect between the main-phase GBs.Consequently,the GBs become more smooth,more homogeneous and more continuous,which ultimately results in an enhancement of the coercivity of the magnets.展开更多
We propose a novel cooling protocol within a triple-Laguerre-Gaussian cavity optomechanical system,which is designed to suppress the thermal vibrations of a rotating mirror to reach its quantum ground state.The system...We propose a novel cooling protocol within a triple-Laguerre-Gaussian cavity optomechanical system,which is designed to suppress the thermal vibrations of a rotating mirror to reach its quantum ground state.The system incorporates two auxiliary cavities and an atomic ensemble coupled to a Laguerre-Gaussian rotational cavity.By carefully selecting system parameters,the cooling process of the rotating mirror is significantly enhanced,while the heating process is effectively suppressed,enabling efficient ground-state cooling even in the unresolved sideband regime.Compared to previous works,our scheme reduces the stringent restrictions on auxiliary systems,making it more experimentally feasible under broader parameter conditions.These findings provide a robust approach for achieving ground-state cooling in mechanical resonators.展开更多
OBJECTIVE:To identify the antitumor effects of Gualou Beimu Yin(瓜蒌贝母饮,GLBMY)in triple-negative breast cancer(TNBC)and to explore the underlying mechanisms.METHODS:A mouse model of breast cancer was established an...OBJECTIVE:To identify the antitumor effects of Gualou Beimu Yin(瓜蒌贝母饮,GLBMY)in triple-negative breast cancer(TNBC)and to explore the underlying mechanisms.METHODS:A mouse model of breast cancer was established and treated with GLBMY.Freeze-dried GLBMY powder was used to treat MDA-MB-231 and BT549 cells to assess the therapeutic efficacy of GLBMY against TNBC.Network pharmacology,transcriptomics and metabolomics were employed to identify the potential mechanism of GLBMY in TNBC treatment.Finally,the main regulating genes and proteins in the enriched pathways were validated by Quantitative real-time polymerase chain reaction(q PCR)and Western blotting analysis to confirm its mechanism.RESULTS:GLBMY can inhibit the growth of TNBC through apoptosis and necroptosis pathways and inhibit TNBC lung metastasis by inhibiting epithelialmesenchymal transition(EMT).Network pharmacology has elucidated the most important active ingredients(tubeimoside I,emodin,cucurbitacin,and ursolic acid)and the most critical targets[interleukin-6(IL6),signal transducer and activator of transcription 3(STAT3),mitogen-activated protein kinase 3(MAPK3)]of GLBMY in treating TNBC.RNA-seq revealed that GLBMY affected the nuclear factor kappa-light-chain-enhancer of activated B cells,rat sarcoma virus,and MAPK signalling pathways.Metabolomics revealed that the metabolites mainly affected by GLBMY were L-(+)-lactic acid,isocitric acid,benzoic acid and indoxyl sulfate.Subsequent experiments demonstrated that GLBMY can inhibit EMT in TNBC through the MAPK/ERK pathway and inhibit the proliferation and progression of TNBC through the IL6-STAT signalling pathway.CONCLUSIONS:We confirmed that GLBMY inhibits the development and metastasis of TNBC through the MAPK/Erk and IL6-STAT signalling pathways.GLBMY shows promise as a long-term supplementary or alternative therapy for TNBC,offering new insights for TNBC treatment.展开更多
As an important index to measure the degree of entanglement in quantum systems,concurrence plays an important role in practical research.In this paper,we study the concurrence between two qubits in triangular triple q...As an important index to measure the degree of entanglement in quantum systems,concurrence plays an important role in practical research.In this paper,we study the concurrence between two qubits in triangular triple quantum dot structure.Through calculation and simulation,it is found that concurrence is mainly affected by the interdot coupling strength t,Coulomb interactionU,temperature T,and electrode coupling G.Through comparative studies with parallel triple quantum dot structures,we demonstrate that the triangular geometry exhibits significantly enhanced concurrence under identical conditions.In addition,under the condition that concurrence exceeds 0.9,the functional relationship between t and U is obtained through simulation,which provides theoretical support for quantum dot regulation under high entanglement.Finally,we demonstrate the feasibility of implementing a three-qubit quantum gate,using the Toffoli gate as a representative example,under the condition that the triangular triple quantum dot system maintains high entanglement.展开更多
The landscape of breast cancer treatment has undergone a transformative shift with the integration of immunotherapy.Historically considered a“cold”tumor with limited immunogenicity,breast cancer management was domin...The landscape of breast cancer treatment has undergone a transformative shift with the integration of immunotherapy.Historically considered a“cold”tumor with limited immunogenicity,breast cancer management was dominated by surgery,chemotherapy,radiotherapy,and targeted therapies1.However,the advent of immune checkpoint inhibitors(ICIs)has challenged this paradigm,opening a new frontier.The initial breakthrough in triple-negative breast cancer(TNBC)demonstrated that a subset of patients could derive profound and durable clinical benefit from pembrolizumab and atezolizumab2,3.Today,precision immunotherapy aims to identify the patients most likely to respond,to convert immunologically silent tumors into responsive tumors,and to strategically combine immunotherapies with other modalities to overcome resistance.This evolution from empirical application to biomarker-driven strategies marks the critical juncture at which we stand,transitioning promising clinical trial data into refined,effective,and accessible clinical practice4.Recent key clinical studies on breast cancer immunotherapy are summarized in Table 1.展开更多
The hydrological system in Central Asia is highly sensitive to global climate change,significantly affecting water supply and energy production.In Tajikistan,the Vakhsh River—one of the main tributaries of the Amu Da...The hydrological system in Central Asia is highly sensitive to global climate change,significantly affecting water supply and energy production.In Tajikistan,the Vakhsh River—one of the main tributaries of the Amu Darya—plays a key role in the region’s hydropower and irrigation.However,research on long-term hydrological changes in its two top large basins—the Surkhob and Khingov river basins—remains limited.Therefore,this study analyzed long-term climate and hydrological changes in the Vakhsh River,including its main tributaries—the Surkhob and Khingov rivers—which are vital for the water resource management in Tajikistan and even in Central Asia.Using long-term hydrometeorological observations,the change trends of temperature(1933–2020),precipitation(1970–2020),and runoff(1940–2018)were examined to assess the impact of climate change on the regional water resources.The analysis revealed the occurrence of significant warming and a spatially uneven increase in precipitation.The temperature changes across three climatic periods(1933–1960,1960–1990,and 1990–2020)indicated that there was a transition from baseline level to accelerated warming.The precipitation showed a 2.99 mm/a increase in the Khingov River Basin and a 2.80 mm/a increase in the Surkhob River Basin during 1970–2020.Moreover,there was a gradual shift toward wetter conditions in recent decades.Despite the relatively stable annual mean runoff,seasonal redistribution occurred,with increased runoff in spring and reduced runoff in summer,due to the compensation of glacier melting.Moreover,this study forecasted runoff change during 2019–2040 using the exponential triple smoothing(ETS)method and revealed the occurrence of alternating wet and dry phases,emphasizing the sensitivity of the Vakhsh River Basin’s hydrological system to climate change and the necessity of adaptive water resource management in mountainous regions of Central Asia.Therefore,this study can provide evidence-based insights that are critical for future water resources planning,climate-resilient hydropower development,and regional adaptation strategies in climate-vulnerable basins in Central Asia.展开更多
BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive di...BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive disorders.Accurate assessment and precise treatment are essential in initial intensive therapy.AIM To investigate the efficacy and safety of a vonoprazan(VPZ)-based triple regimen for first-line eradication of H.pylori in China.METHODS This multicenter noninferior randomized controlled trial(June 2022 to November 2023)involved 524 H.pyloripositive patients across 19 centers in Shandong,China.Participants were randomized to 14-day esomeprazole/bismuth/amoxicillin/clarithromycin(EBAC),14-day VPZ/amoxicillin/clarithromycin(VACa),or 10-day VPZ/amoxicillin/clarithromycin(VACb)-all administered twice daily.Primary outcomes(eradication rates)were assessed via intention-to-treat(ITT)and per-protocol(PP)analyses.Secondary endpoints included adverse events and adherence.Noninferiority testing andχ^(2)tests were used for statistical comparisons.RESULTS A total of 524 patients participated in this study.In ITT analysis,the eradication rates of the EBAC,VACa,and VACb groups were 72.6%(127/175),88.0%(154/175),and 83.3%(145/174),respectively(P=0.001).The difference in the eradication rate between the EBAC and VPCa groups was 15.4%[95%confidence interval(CI):7.3-23.6,P<0.001],and that between the EBAC and VACb groups was 10.8%(95%CI:2.1-19.4,P=0.018).In PP analysis,the eradication rates of the EBAC,VACa,and VACb groups were 81.4%(127/156),93.9%(154/164),and 90.6%(145/160),respectively(P=0.001).There was no significant difference in the incidence of adverse reactions among the three groups,which were 36.6%,33.8%and 29.6%,respectively(P=0.50).CONCLUSION VPZ-based triple therapies demonstrate noninferiority to 14-day bismuth-containing regimens,with the 10-day regimen showing comparable efficacy and similar adverse event rates.展开更多
Soil moisture(SM)is a critical variable in terrestrial ecosystems,especially in arid and semi-arid areas where water sources are limited.Despite its importance,understanding the spatiotemporal variations and influenci...Soil moisture(SM)is a critical variable in terrestrial ecosystems,especially in arid and semi-arid areas where water sources are limited.Despite its importance,understanding the spatiotemporal variations and influencing factors of SM in these areas remains insufficient.This study investigated the spatiotemporal variations and influencing factors of SM in arid and semi-arid areas of China by utilizing the extended triple collation(ETC),Mann-Kendall test,Theil-Sen estimator,ridge regression analysis,and other relevant methods.The following findings were obtained:(1)at the pixel scale,the long-term monthly SM data from the European Space Agency Climate Change Initiative(ESA CCI)exhibited the highest correlation coefficient of 0.794 and the lowest root mean square error(RMSE)of 0.014 m^(3)/m^(3);(2)from 2000 to 2022,the study area experienced significant increase in annual average SM,with a rate of 0.408×10^(-3)m^(3)/(m^(3)•a).Moreover,higher altitudes showed a notable upward trend,with SM increasing rates at 0.210×10^(-3)m^(3)/(m^(3)•a)between 1000 and 2000 m,0.530×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m,and 0.760×10^(-3)m^(3)/(m^(3)•a)at altitudes above 4000 m;(3)land surface temperature(LST),root zone soil moisture(RSM)(10-40 cm depth),and normalized difference vegetation index(NDVI)were identified as the primary factors influencing annual average SM,which accounted for 34.37%,24.16%,and 22.64%relative contributions,respectively;and(4)absolute contribution of LST was more significant in subareas at higher altitudes,with average absolute contributions of 0.800×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m and 0.500×10^(-2) m^(3)/(m^(3)•a)above 4000 m.This study reveals the spatiotemporal variations and main influencing factors of SM in Chinese arid and semi-arid areas,highlighting the more pronounced absolute contribution of LST to SM in high-altitude areas,providing valuable insights for ecological research and water resource management in these areas.展开更多
OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple n...OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple negative breast cancer(TNBC).METHODS:A total of 60 patients diagnosed with TNBC and depression were enrolled and randomly assigned to either the control group(receiving routine tumor treatment and duloxetine)or the treatment group(receiving the TCM in addition to routine treatment).RESULTS:Both treatment and control groups showed a reduction in depressive symptoms and improved daily living abilities after treatment.However,the treatment group demonstrated significantly better outcomes compared to the control group.Furthermore,the levels of dopamine and serotonin in the serum increased in both groups after 8 weeks of treatment,while the treatment group exhibited superior results.CONCLUSIONS:This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression,which was verified by the increase in serum levels of dopamine and serotonin,suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM.展开更多
Accurately forecasting the triple point(TP)path is essential for analyzing blast loads and assessing the destructive effectiveness of the height of burst explosion.Empirical models that describe the TP path under norm...Accurately forecasting the triple point(TP)path is essential for analyzing blast loads and assessing the destructive effectiveness of the height of burst explosion.Empirical models that describe the TP path under normal temperature and pressure environments are commonly employed;however,in certain configurations,such as at high-altitudes(HAs),the environment may involve low temperature and pressure conditions.The present study develops a theoretical prediction model for the TP path under reduced pressure and temperature conditions,utilizing the image bursts method,reflected polar analysis,and dimensional analysis.The model's accuracy is evaluated through numerical simulations and experimental data.Results indicate that the prediction model effectively evaluates the TP path under diminished temperature and pressure conditions,with most predictions falling within a±15%deviation.It was found that the TP height increases with altitude.As the altitude rises from 0 m to 10,000 m,the average TP height increases by 61.7%,87.9%,109.0%,and 134.3%for the scaled height of burst of 1.5 m,2.0 m,2.5 m,and 3.0 m,respectively.Moreover,the variation in TP height under HA environments closely mirrors that observed under corresponding reduced pressure conditions.In HA environments,only the effect of low-pressure conditions on the TP path needs to be considered,as the environmental lowtemperature has a minimal effect.展开更多
In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algeb...In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algebra is a sum of a derivation and an antiderivation.As its applications,Jordan triple derivations on triangular algebras are characterized.展开更多
Let f,g and h be three distinct primitive holomorphic cusp forms of even integral weights k_(1),k_(2)and k_(3)for the full modular groupΓ=SL(2,Z),and denote byλ_(f)(n),λ_(g)(n),λ_(h)(n)the corresponding normalized...Let f,g and h be three distinct primitive holomorphic cusp forms of even integral weights k_(1),k_(2)and k_(3)for the full modular groupΓ=SL(2,Z),and denote byλ_(f)(n),λ_(g)(n),λ_(h)(n)the corresponding normalized Fourier coefficients,respectively.In this paper,we investigate the correlations of triple sums associated to these Fourier coefficientsλ_(f)(n),λ_(g)(n),λ_(h)(n)over certain polynomials,and obtain some power-saving asymptotic estimates which beat the trivial bounds.展开更多
A new triple melting method with hot extrusion process for GH4710 alloy ingots has been developed to overcome the difficulty in deformation of GH4710 alloy prepared by the casting and forging process.The as-extruded G...A new triple melting method with hot extrusion process for GH4710 alloy ingots has been developed to overcome the difficulty in deformation of GH4710 alloy prepared by the casting and forging process.The as-extruded GH4710 alloy was analyzed through the isothermal compression experiment and metallographic analysis.The viscoelastic stress characteristics and dynamic recrystallization(DRX)behavior of the as-extruded GH4710 alloy were investigated during deformation at temperatures ranging from 1050℃ to 1120℃ and strain rates ranging from 0.01 s^(−1) to 5.00 s^(−1).The true stress-true strain curves,average grain size,and DRX volume fraction were also obtained under various deformation conditions.Prediction models for DRX volume fraction and grain size of the as-extruded GH4710 alloy were established using the statistical regression method.The model was implanted into the Derform-3D software,and numerical simulation of the microstructure evolution of GH4710 alloy was conducted.Firstly,the isothermal compression simulations were conducted using the finite element method to verify the accuracy of prediction model.Subsequently,the prediction model was applied to perform an optimization analysis of the forging process for a turbine disk with a diameter of 300 mm.Results show a strong correlation between the simulated results and the actual microstructure of the turbine disk forged through the optimal process parameters.The optimal process parameters are deformation temperature of 1100℃ and forging speed of 0.2 mm/s.This established DRX prediction model can serve as a fundamental reference for understanding the microstructural evolution during the hot deformation process of as-extruded GH4710 alloy.展开更多
文摘In this paper, we first define a doubly transitive resolvable idempotent quasigroup （DTRIQ）, and show that aDTRIQ of order v exists if and only ifv ≡0（mod3） and v ≠ 2（mod4）. Then we use DTRIQ to present a tripling construction for large sets of resolvable directed triple systems, which improves an earlier version of tripling construction by Kang （J. Combin. Designs, 4 （1996）, 301-321）. As an application, we obtain an LRDTS（4·3^n） for any integer n ≥ 1, which provides an infinite family of even orders.
文摘The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices.
基金Project supported by the National Key Research and Development Program of China(2022YFB3503302)the Major Projects in Inner Mongolia Autonomous Region(20212D0035)the High-quality Development Special Funds Program Ministry of Industry Technology(TC220H06G)。
文摘The optimization of microstructure represents a significant methodology for enhancing coercivity(Hcj).This paper concentrates on optimizing the microstructure of magnets through the manipulation of the composition of low-melting-point and high-melting-point elements,thereby achieving the objective of augmenting the comprehensive magnetic properties of magnets.The present study is concerned with the microstructure of magnets comprising three distinct Ga and B contents,and the associated changes in their magnetic properties.The findings indicate that when the Ga content is 0.5 wt%and the B content is 0.88 wt%,the coercivity of the magnets is markedly enhanced.This is evidenced by an increase in coercivity from 8.51 to 14.83 kOe,representing a 74.26%rise.Concurrently,the residual magnetization strength of the magnet remains unaltered.This finding provides a crucial foundation for optimizing the overall magnetic properties of the magnets.The microstructural analysis indicates that a reduction in B content coupled with an increase in Ga content leads to the melting of sharp angles on the surface of the main-phase grains,facilitated by low-melting-point rare-earth-rich phases.This process results in the migration of Fe from the grain boundaries(GBs)to the triple junction phases(TJPs),while Nd migrates from the TJPs to the GBs.This migration results in a reduction in the agglomeration of rare-earth-rich elements within the TJPs,thereby increasing the Nd content in the GBs.This increase enhances the wettability of the GBs,while the reduction of Fe content in this phase mitigates the exchange-coupling effect between the main-phase GBs.Consequently,the GBs become more smooth,more homogeneous and more continuous,which ultimately results in an enhancement of the coercivity of the magnets.
基金Project supported by the National Natural Science Foundation of China(Grant No.62471180)。
文摘We propose a novel cooling protocol within a triple-Laguerre-Gaussian cavity optomechanical system,which is designed to suppress the thermal vibrations of a rotating mirror to reach its quantum ground state.The system incorporates two auxiliary cavities and an atomic ensemble coupled to a Laguerre-Gaussian rotational cavity.By carefully selecting system parameters,the cooling process of the rotating mirror is significantly enhanced,while the heating process is effectively suppressed,enabling efficient ground-state cooling even in the unresolved sideband regime.Compared to previous works,our scheme reduces the stringent restrictions on auxiliary systems,making it more experimentally feasible under broader parameter conditions.These findings provide a robust approach for achieving ground-state cooling in mechanical resonators.
基金Supported by the National Natural Science Foundation of China:Study on Mechanism of Transdifferentiation of Hepatocellular Carcinoma Cells Induced by Huoxue Ruanjian Traditional Chinese Medicine (No. 82174103)。
文摘OBJECTIVE:To identify the antitumor effects of Gualou Beimu Yin(瓜蒌贝母饮,GLBMY)in triple-negative breast cancer(TNBC)and to explore the underlying mechanisms.METHODS:A mouse model of breast cancer was established and treated with GLBMY.Freeze-dried GLBMY powder was used to treat MDA-MB-231 and BT549 cells to assess the therapeutic efficacy of GLBMY against TNBC.Network pharmacology,transcriptomics and metabolomics were employed to identify the potential mechanism of GLBMY in TNBC treatment.Finally,the main regulating genes and proteins in the enriched pathways were validated by Quantitative real-time polymerase chain reaction(q PCR)and Western blotting analysis to confirm its mechanism.RESULTS:GLBMY can inhibit the growth of TNBC through apoptosis and necroptosis pathways and inhibit TNBC lung metastasis by inhibiting epithelialmesenchymal transition(EMT).Network pharmacology has elucidated the most important active ingredients(tubeimoside I,emodin,cucurbitacin,and ursolic acid)and the most critical targets[interleukin-6(IL6),signal transducer and activator of transcription 3(STAT3),mitogen-activated protein kinase 3(MAPK3)]of GLBMY in treating TNBC.RNA-seq revealed that GLBMY affected the nuclear factor kappa-light-chain-enhancer of activated B cells,rat sarcoma virus,and MAPK signalling pathways.Metabolomics revealed that the metabolites mainly affected by GLBMY were L-(+)-lactic acid,isocitric acid,benzoic acid and indoxyl sulfate.Subsequent experiments demonstrated that GLBMY can inhibit EMT in TNBC through the MAPK/ERK pathway and inhibit the proliferation and progression of TNBC through the IL6-STAT signalling pathway.CONCLUSIONS:We confirmed that GLBMY inhibits the development and metastasis of TNBC through the MAPK/Erk and IL6-STAT signalling pathways.GLBMY shows promise as a long-term supplementary or alternative therapy for TNBC,offering new insights for TNBC treatment.
文摘As an important index to measure the degree of entanglement in quantum systems,concurrence plays an important role in practical research.In this paper,we study the concurrence between two qubits in triangular triple quantum dot structure.Through calculation and simulation,it is found that concurrence is mainly affected by the interdot coupling strength t,Coulomb interactionU,temperature T,and electrode coupling G.Through comparative studies with parallel triple quantum dot structures,we demonstrate that the triangular geometry exhibits significantly enhanced concurrence under identical conditions.In addition,under the condition that concurrence exceeds 0.9,the functional relationship between t and U is obtained through simulation,which provides theoretical support for quantum dot regulation under high entanglement.Finally,we demonstrate the feasibility of implementing a three-qubit quantum gate,using the Toffoli gate as a representative example,under the condition that the triangular triple quantum dot system maintains high entanglement.
基金supported by the Non-communicable Chronic Diseases National Science and Technology Major Project(Grant No.2025ZD0544003).
文摘The landscape of breast cancer treatment has undergone a transformative shift with the integration of immunotherapy.Historically considered a“cold”tumor with limited immunogenicity,breast cancer management was dominated by surgery,chemotherapy,radiotherapy,and targeted therapies1.However,the advent of immune checkpoint inhibitors(ICIs)has challenged this paradigm,opening a new frontier.The initial breakthrough in triple-negative breast cancer(TNBC)demonstrated that a subset of patients could derive profound and durable clinical benefit from pembrolizumab and atezolizumab2,3.Today,precision immunotherapy aims to identify the patients most likely to respond,to convert immunologically silent tumors into responsive tumors,and to strategically combine immunotherapies with other modalities to overcome resistance.This evolution from empirical application to biomarker-driven strategies marks the critical juncture at which we stand,transitioning promising clinical trial data into refined,effective,and accessible clinical practice4.Recent key clinical studies on breast cancer immunotherapy are summarized in Table 1.
基金supported by the National Natural Science Foundation of China(W2412135).
文摘The hydrological system in Central Asia is highly sensitive to global climate change,significantly affecting water supply and energy production.In Tajikistan,the Vakhsh River—one of the main tributaries of the Amu Darya—plays a key role in the region’s hydropower and irrigation.However,research on long-term hydrological changes in its two top large basins—the Surkhob and Khingov river basins—remains limited.Therefore,this study analyzed long-term climate and hydrological changes in the Vakhsh River,including its main tributaries—the Surkhob and Khingov rivers—which are vital for the water resource management in Tajikistan and even in Central Asia.Using long-term hydrometeorological observations,the change trends of temperature(1933–2020),precipitation(1970–2020),and runoff(1940–2018)were examined to assess the impact of climate change on the regional water resources.The analysis revealed the occurrence of significant warming and a spatially uneven increase in precipitation.The temperature changes across three climatic periods(1933–1960,1960–1990,and 1990–2020)indicated that there was a transition from baseline level to accelerated warming.The precipitation showed a 2.99 mm/a increase in the Khingov River Basin and a 2.80 mm/a increase in the Surkhob River Basin during 1970–2020.Moreover,there was a gradual shift toward wetter conditions in recent decades.Despite the relatively stable annual mean runoff,seasonal redistribution occurred,with increased runoff in spring and reduced runoff in summer,due to the compensation of glacier melting.Moreover,this study forecasted runoff change during 2019–2040 using the exponential triple smoothing(ETS)method and revealed the occurrence of alternating wet and dry phases,emphasizing the sensitivity of the Vakhsh River Basin’s hydrological system to climate change and the necessity of adaptive water resource management in mountainous regions of Central Asia.Therefore,this study can provide evidence-based insights that are critical for future water resources planning,climate-resilient hydropower development,and regional adaptation strategies in climate-vulnerable basins in Central Asia.
基金Supported by Qilu Health Outstanding Young Talent Cultivation Project,No.QDFY-3839。
文摘BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive disorders.Accurate assessment and precise treatment are essential in initial intensive therapy.AIM To investigate the efficacy and safety of a vonoprazan(VPZ)-based triple regimen for first-line eradication of H.pylori in China.METHODS This multicenter noninferior randomized controlled trial(June 2022 to November 2023)involved 524 H.pyloripositive patients across 19 centers in Shandong,China.Participants were randomized to 14-day esomeprazole/bismuth/amoxicillin/clarithromycin(EBAC),14-day VPZ/amoxicillin/clarithromycin(VACa),or 10-day VPZ/amoxicillin/clarithromycin(VACb)-all administered twice daily.Primary outcomes(eradication rates)were assessed via intention-to-treat(ITT)and per-protocol(PP)analyses.Secondary endpoints included adverse events and adherence.Noninferiority testing andχ^(2)tests were used for statistical comparisons.RESULTS A total of 524 patients participated in this study.In ITT analysis,the eradication rates of the EBAC,VACa,and VACb groups were 72.6%(127/175),88.0%(154/175),and 83.3%(145/174),respectively(P=0.001).The difference in the eradication rate between the EBAC and VPCa groups was 15.4%[95%confidence interval(CI):7.3-23.6,P<0.001],and that between the EBAC and VACb groups was 10.8%(95%CI:2.1-19.4,P=0.018).In PP analysis,the eradication rates of the EBAC,VACa,and VACb groups were 81.4%(127/156),93.9%(154/164),and 90.6%(145/160),respectively(P=0.001).There was no significant difference in the incidence of adverse reactions among the three groups,which were 36.6%,33.8%and 29.6%,respectively(P=0.50).CONCLUSION VPZ-based triple therapies demonstrate noninferiority to 14-day bismuth-containing regimens,with the 10-day regimen showing comparable efficacy and similar adverse event rates.
基金supported by the Natural Science Foundation of Henan Province(252300421290)the National Natural Science Foundation of China(41771438)+1 种基金the Program for Innovative Research Team(in Science and Technology)of Henan University(22IRTSTHN010)the Postgraduate Education Reform and Quality Improvement Project of Henan Province(HNYJS2020JD14).
文摘Soil moisture(SM)is a critical variable in terrestrial ecosystems,especially in arid and semi-arid areas where water sources are limited.Despite its importance,understanding the spatiotemporal variations and influencing factors of SM in these areas remains insufficient.This study investigated the spatiotemporal variations and influencing factors of SM in arid and semi-arid areas of China by utilizing the extended triple collation(ETC),Mann-Kendall test,Theil-Sen estimator,ridge regression analysis,and other relevant methods.The following findings were obtained:(1)at the pixel scale,the long-term monthly SM data from the European Space Agency Climate Change Initiative(ESA CCI)exhibited the highest correlation coefficient of 0.794 and the lowest root mean square error(RMSE)of 0.014 m^(3)/m^(3);(2)from 2000 to 2022,the study area experienced significant increase in annual average SM,with a rate of 0.408×10^(-3)m^(3)/(m^(3)•a).Moreover,higher altitudes showed a notable upward trend,with SM increasing rates at 0.210×10^(-3)m^(3)/(m^(3)•a)between 1000 and 2000 m,0.530×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m,and 0.760×10^(-3)m^(3)/(m^(3)•a)at altitudes above 4000 m;(3)land surface temperature(LST),root zone soil moisture(RSM)(10-40 cm depth),and normalized difference vegetation index(NDVI)were identified as the primary factors influencing annual average SM,which accounted for 34.37%,24.16%,and 22.64%relative contributions,respectively;and(4)absolute contribution of LST was more significant in subareas at higher altitudes,with average absolute contributions of 0.800×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m and 0.500×10^(-2) m^(3)/(m^(3)•a)above 4000 m.This study reveals the spatiotemporal variations and main influencing factors of SM in Chinese arid and semi-arid areas,highlighting the more pronounced absolute contribution of LST to SM in high-altitude areas,providing valuable insights for ecological research and water resource management in these areas.
文摘OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple negative breast cancer(TNBC).METHODS:A total of 60 patients diagnosed with TNBC and depression were enrolled and randomly assigned to either the control group(receiving routine tumor treatment and duloxetine)or the treatment group(receiving the TCM in addition to routine treatment).RESULTS:Both treatment and control groups showed a reduction in depressive symptoms and improved daily living abilities after treatment.However,the treatment group demonstrated significantly better outcomes compared to the control group.Furthermore,the levels of dopamine and serotonin in the serum increased in both groups after 8 weeks of treatment,while the treatment group exhibited superior results.CONCLUSIONS:This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression,which was verified by the increase in serum levels of dopamine and serotonin,suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM.
基金funding from Anhui Engineering Laboratory of Explosive Materials and Technology Foundation(No.AHBP2022B-04)Natural Science Research Project of Anhui Educational Committee(No.2023AH051221)+1 种基金Anhui Provincial Natural Science Foundation(No.2208085QA26)Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology for the project related to this work.
文摘Accurately forecasting the triple point(TP)path is essential for analyzing blast loads and assessing the destructive effectiveness of the height of burst explosion.Empirical models that describe the TP path under normal temperature and pressure environments are commonly employed;however,in certain configurations,such as at high-altitudes(HAs),the environment may involve low temperature and pressure conditions.The present study develops a theoretical prediction model for the TP path under reduced pressure and temperature conditions,utilizing the image bursts method,reflected polar analysis,and dimensional analysis.The model's accuracy is evaluated through numerical simulations and experimental data.Results indicate that the prediction model effectively evaluates the TP path under diminished temperature and pressure conditions,with most predictions falling within a±15%deviation.It was found that the TP height increases with altitude.As the altitude rises from 0 m to 10,000 m,the average TP height increases by 61.7%,87.9%,109.0%,and 134.3%for the scaled height of burst of 1.5 m,2.0 m,2.5 m,and 3.0 m,respectively.Moreover,the variation in TP height under HA environments closely mirrors that observed under corresponding reduced pressure conditions.In HA environments,only the effect of low-pressure conditions on the TP path needs to be considered,as the environmental lowtemperature has a minimal effect.
基金Supported by Basic Research Foundation of Yunnan Education Department(Nos.2020J0748,2021J0635)Talent Project Foundation of Yunnan Provincial Science and Technology Department(No.202105AC160089)NSF of Yunnan Province(No.202101BA070001198).
文摘In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algebra is a sum of a derivation and an antiderivation.As its applications,Jordan triple derivations on triangular algebras are characterized.
基金Supported in part by NSFC(Nos.12401011,12201214)National Key Research and Development Program of China(No.2021YFA1000700)+3 种基金Shaanxi Fundamental Science Research Project for Mathematics and Physics(No.23JSQ053)Science and Technology Program for Youth New Star of Shaanxi Province(No.2025ZC-KJXX-29)Natural Science Basic Research Program of Shaanxi Province(No.2025JC-YBQN-091)Scientific Research Foundation for Young Talents of WNU(No.2024XJ-QNRC-01)。
文摘Let f,g and h be three distinct primitive holomorphic cusp forms of even integral weights k_(1),k_(2)and k_(3)for the full modular groupΓ=SL(2,Z),and denote byλ_(f)(n),λ_(g)(n),λ_(h)(n)the corresponding normalized Fourier coefficients,respectively.In this paper,we investigate the correlations of triple sums associated to these Fourier coefficientsλ_(f)(n),λ_(g)(n),λ_(h)(n)over certain polynomials,and obtain some power-saving asymptotic estimates which beat the trivial bounds.
基金Key Field Research Foundation of Beijing Institute of Aeronautical Materials(KJSC192309)。
文摘A new triple melting method with hot extrusion process for GH4710 alloy ingots has been developed to overcome the difficulty in deformation of GH4710 alloy prepared by the casting and forging process.The as-extruded GH4710 alloy was analyzed through the isothermal compression experiment and metallographic analysis.The viscoelastic stress characteristics and dynamic recrystallization(DRX)behavior of the as-extruded GH4710 alloy were investigated during deformation at temperatures ranging from 1050℃ to 1120℃ and strain rates ranging from 0.01 s^(−1) to 5.00 s^(−1).The true stress-true strain curves,average grain size,and DRX volume fraction were also obtained under various deformation conditions.Prediction models for DRX volume fraction and grain size of the as-extruded GH4710 alloy were established using the statistical regression method.The model was implanted into the Derform-3D software,and numerical simulation of the microstructure evolution of GH4710 alloy was conducted.Firstly,the isothermal compression simulations were conducted using the finite element method to verify the accuracy of prediction model.Subsequently,the prediction model was applied to perform an optimization analysis of the forging process for a turbine disk with a diameter of 300 mm.Results show a strong correlation between the simulated results and the actual microstructure of the turbine disk forged through the optimal process parameters.The optimal process parameters are deformation temperature of 1100℃ and forging speed of 0.2 mm/s.This established DRX prediction model can serve as a fundamental reference for understanding the microstructural evolution during the hot deformation process of as-extruded GH4710 alloy.
