The extraction of entity relationship triples is very important to build a knowledge graph(KG),meanwhile,various entity relationship extraction algorithms are mostly based on data-driven,especially for the current pop...The extraction of entity relationship triples is very important to build a knowledge graph(KG),meanwhile,various entity relationship extraction algorithms are mostly based on data-driven,especially for the current popular deep learning algorithms.Therefore,obtaining a large number of accurate triples is the key to build a good KG as well as train a good entity relationship extraction algorithm.Because of business requirements,this KG’s application field is determined and the experts’opinions also must be satisfied.Considering these factors we adopt the top-down method which refers to determining the data schema firstly,then filling the specific data according to the schema.The design of data schema is the top-level design of KG,and determining the data schema according to the characteristics of KG is equivalent to determining the scope of data’s collection and the mode of data’s organization.This method is generally suitable for the construction of domain KG.This article proposes a fast and efficient method to extract the topdown type KG’s triples in social media with the help of structured data in the information box on the right side of the related encyclopedia webpage.At the same time,based on the obtained triples,a data labeling method is proposed to obtain sufficiently high-quality training data,using in various Natural Language Processing(NLP)information extraction algorithms’training.展开更多
Let A be an abelian category,and(X,Z,Y)be a complete hereditary cotorsion triple.We introduce the definition of n-Y-cotilting subcategories of A,and give a characterization of n-Y-cotilting subcategories,which is simi...Let A be an abelian category,and(X,Z,Y)be a complete hereditary cotorsion triple.We introduce the definition of n-Y-cotilting subcategories of A,and give a characterization of n-Y-cotilting subcategories,which is similar to Bazzoni characterization of n-cotilting modules.As an application,we prove that if GP is n-GI-cotilting over a virtually Gorenstein ring R,then R is an n-Gorenstein ring,where GP denotes the subcategory of Gorenstein projective R-modules and GI denotes the subcategory of Gorenstein injective R-modules.Furthermore,we investigate n-costar subcategories over arbitrary ring R,and the relationship between n-Icotilting subcategories with respect to cotorsion triple(P,R-Mod,I)and n-costar subcategories,where P denotes the subcategory of projective left R-modules and I denotes the subcategory of injective left R-modules.展开更多
Continuing our study of spectral triples on quantum domains,we look at unbounded invariant and covariant derivations in the quantum annulus.In particular,we investigate whether such derivations can be implemented by o...Continuing our study of spectral triples on quantum domains,we look at unbounded invariant and covariant derivations in the quantum annulus.In particular,we investigate whether such derivations can be implemented by operators with compact parametrices,a necessary condition in the definition of a spectral triple.展开更多
The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of ris...The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices.展开更多
Let P-3 （n） be the number of overpartition triples of n. By elementary series manipulations, we establish some congruences for P-3（n） modulo small powers of 2, such as P-3（16n＋14）≡0 （mod 32）, P-3（8n＋7）≡0...Let P-3 （n） be the number of overpartition triples of n. By elementary series manipulations, we establish some congruences for P-3（n） modulo small powers of 2, such as P-3（16n＋14）≡0 （mod 32）, P-3（8n＋7）≡0 （mod 64）.We also find many arithmetic properties for P-3（n） modulo 7, 9 and 11, involving the following infinite families of Ramanujan-type congruences： for any integers α≥1 and n ≥ 0, we have展开更多
The optimization of microstructure represents a significant methodology for enhancing coercivity(Hcj).This paper concentrates on optimizing the microstructure of magnets through the manipulation of the composition of ...The optimization of microstructure represents a significant methodology for enhancing coercivity(Hcj).This paper concentrates on optimizing the microstructure of magnets through the manipulation of the composition of low-melting-point and high-melting-point elements,thereby achieving the objective of augmenting the comprehensive magnetic properties of magnets.The present study is concerned with the microstructure of magnets comprising three distinct Ga and B contents,and the associated changes in their magnetic properties.The findings indicate that when the Ga content is 0.5 wt%and the B content is 0.88 wt%,the coercivity of the magnets is markedly enhanced.This is evidenced by an increase in coercivity from 8.51 to 14.83 kOe,representing a 74.26%rise.Concurrently,the residual magnetization strength of the magnet remains unaltered.This finding provides a crucial foundation for optimizing the overall magnetic properties of the magnets.The microstructural analysis indicates that a reduction in B content coupled with an increase in Ga content leads to the melting of sharp angles on the surface of the main-phase grains,facilitated by low-melting-point rare-earth-rich phases.This process results in the migration of Fe from the grain boundaries(GBs)to the triple junction phases(TJPs),while Nd migrates from the TJPs to the GBs.This migration results in a reduction in the agglomeration of rare-earth-rich elements within the TJPs,thereby increasing the Nd content in the GBs.This increase enhances the wettability of the GBs,while the reduction of Fe content in this phase mitigates the exchange-coupling effect between the main-phase GBs.Consequently,the GBs become more smooth,more homogeneous and more continuous,which ultimately results in an enhancement of the coercivity of the magnets.展开更多
We propose a novel cooling protocol within a triple-Laguerre-Gaussian cavity optomechanical system,which is designed to suppress the thermal vibrations of a rotating mirror to reach its quantum ground state.The system...We propose a novel cooling protocol within a triple-Laguerre-Gaussian cavity optomechanical system,which is designed to suppress the thermal vibrations of a rotating mirror to reach its quantum ground state.The system incorporates two auxiliary cavities and an atomic ensemble coupled to a Laguerre-Gaussian rotational cavity.By carefully selecting system parameters,the cooling process of the rotating mirror is significantly enhanced,while the heating process is effectively suppressed,enabling efficient ground-state cooling even in the unresolved sideband regime.Compared to previous works,our scheme reduces the stringent restrictions on auxiliary systems,making it more experimentally feasible under broader parameter conditions.These findings provide a robust approach for achieving ground-state cooling in mechanical resonators.展开更多
OBJECTIVE:To identify the antitumor effects of Gualou Beimu Yin(瓜蒌贝母饮,GLBMY)in triple-negative breast cancer(TNBC)and to explore the underlying mechanisms.METHODS:A mouse model of breast cancer was established an...OBJECTIVE:To identify the antitumor effects of Gualou Beimu Yin(瓜蒌贝母饮,GLBMY)in triple-negative breast cancer(TNBC)and to explore the underlying mechanisms.METHODS:A mouse model of breast cancer was established and treated with GLBMY.Freeze-dried GLBMY powder was used to treat MDA-MB-231 and BT549 cells to assess the therapeutic efficacy of GLBMY against TNBC.Network pharmacology,transcriptomics and metabolomics were employed to identify the potential mechanism of GLBMY in TNBC treatment.Finally,the main regulating genes and proteins in the enriched pathways were validated by Quantitative real-time polymerase chain reaction(q PCR)and Western blotting analysis to confirm its mechanism.RESULTS:GLBMY can inhibit the growth of TNBC through apoptosis and necroptosis pathways and inhibit TNBC lung metastasis by inhibiting epithelialmesenchymal transition(EMT).Network pharmacology has elucidated the most important active ingredients(tubeimoside I,emodin,cucurbitacin,and ursolic acid)and the most critical targets[interleukin-6(IL6),signal transducer and activator of transcription 3(STAT3),mitogen-activated protein kinase 3(MAPK3)]of GLBMY in treating TNBC.RNA-seq revealed that GLBMY affected the nuclear factor kappa-light-chain-enhancer of activated B cells,rat sarcoma virus,and MAPK signalling pathways.Metabolomics revealed that the metabolites mainly affected by GLBMY were L-(+)-lactic acid,isocitric acid,benzoic acid and indoxyl sulfate.Subsequent experiments demonstrated that GLBMY can inhibit EMT in TNBC through the MAPK/ERK pathway and inhibit the proliferation and progression of TNBC through the IL6-STAT signalling pathway.CONCLUSIONS:We confirmed that GLBMY inhibits the development and metastasis of TNBC through the MAPK/Erk and IL6-STAT signalling pathways.GLBMY shows promise as a long-term supplementary or alternative therapy for TNBC,offering new insights for TNBC treatment.展开更多
As an important index to measure the degree of entanglement in quantum systems,concurrence plays an important role in practical research.In this paper,we study the concurrence between two qubits in triangular triple q...As an important index to measure the degree of entanglement in quantum systems,concurrence plays an important role in practical research.In this paper,we study the concurrence between two qubits in triangular triple quantum dot structure.Through calculation and simulation,it is found that concurrence is mainly affected by the interdot coupling strength t,Coulomb interactionU,temperature T,and electrode coupling G.Through comparative studies with parallel triple quantum dot structures,we demonstrate that the triangular geometry exhibits significantly enhanced concurrence under identical conditions.In addition,under the condition that concurrence exceeds 0.9,the functional relationship between t and U is obtained through simulation,which provides theoretical support for quantum dot regulation under high entanglement.Finally,we demonstrate the feasibility of implementing a three-qubit quantum gate,using the Toffoli gate as a representative example,under the condition that the triangular triple quantum dot system maintains high entanglement.展开更多
The landscape of breast cancer treatment has undergone a transformative shift with the integration of immunotherapy.Historically considered a“cold”tumor with limited immunogenicity,breast cancer management was domin...The landscape of breast cancer treatment has undergone a transformative shift with the integration of immunotherapy.Historically considered a“cold”tumor with limited immunogenicity,breast cancer management was dominated by surgery,chemotherapy,radiotherapy,and targeted therapies1.However,the advent of immune checkpoint inhibitors(ICIs)has challenged this paradigm,opening a new frontier.The initial breakthrough in triple-negative breast cancer(TNBC)demonstrated that a subset of patients could derive profound and durable clinical benefit from pembrolizumab and atezolizumab2,3.Today,precision immunotherapy aims to identify the patients most likely to respond,to convert immunologically silent tumors into responsive tumors,and to strategically combine immunotherapies with other modalities to overcome resistance.This evolution from empirical application to biomarker-driven strategies marks the critical juncture at which we stand,transitioning promising clinical trial data into refined,effective,and accessible clinical practice4.Recent key clinical studies on breast cancer immunotherapy are summarized in Table 1.展开更多
The hydrological system in Central Asia is highly sensitive to global climate change,significantly affecting water supply and energy production.In Tajikistan,the Vakhsh River—one of the main tributaries of the Amu Da...The hydrological system in Central Asia is highly sensitive to global climate change,significantly affecting water supply and energy production.In Tajikistan,the Vakhsh River—one of the main tributaries of the Amu Darya—plays a key role in the region’s hydropower and irrigation.However,research on long-term hydrological changes in its two top large basins—the Surkhob and Khingov river basins—remains limited.Therefore,this study analyzed long-term climate and hydrological changes in the Vakhsh River,including its main tributaries—the Surkhob and Khingov rivers—which are vital for the water resource management in Tajikistan and even in Central Asia.Using long-term hydrometeorological observations,the change trends of temperature(1933–2020),precipitation(1970–2020),and runoff(1940–2018)were examined to assess the impact of climate change on the regional water resources.The analysis revealed the occurrence of significant warming and a spatially uneven increase in precipitation.The temperature changes across three climatic periods(1933–1960,1960–1990,and 1990–2020)indicated that there was a transition from baseline level to accelerated warming.The precipitation showed a 2.99 mm/a increase in the Khingov River Basin and a 2.80 mm/a increase in the Surkhob River Basin during 1970–2020.Moreover,there was a gradual shift toward wetter conditions in recent decades.Despite the relatively stable annual mean runoff,seasonal redistribution occurred,with increased runoff in spring and reduced runoff in summer,due to the compensation of glacier melting.Moreover,this study forecasted runoff change during 2019–2040 using the exponential triple smoothing(ETS)method and revealed the occurrence of alternating wet and dry phases,emphasizing the sensitivity of the Vakhsh River Basin’s hydrological system to climate change and the necessity of adaptive water resource management in mountainous regions of Central Asia.Therefore,this study can provide evidence-based insights that are critical for future water resources planning,climate-resilient hydropower development,and regional adaptation strategies in climate-vulnerable basins in Central Asia.展开更多
Ⅰ. INTRODUCTIONA triple system S<sub>λ</sub>（2, 3, v）is an ordered pair （V,）, where Vis a v-set, is a collection of 3-subsets （called triples ） of V such that each pair of distinct dements of V is ...Ⅰ. INTRODUCTIONA triple system S<sub>λ</sub>（2, 3, v）is an ordered pair （V,）, where Vis a v-set, is a collection of 3-subsets （called triples ） of V such that each pair of distinct dements of V is contained in exactly λ triples. An S<sub>2</sub>（2, 3, v）is called a twofold triple system.展开更多
In this paper, we give some decompositions of triples of Zp^n or Z3p^n into cyclic triple systems. New constructions of difference families are given. Some infinite classes of simple cyclic triple systems are obtained...In this paper, we give some decompositions of triples of Zp^n or Z3p^n into cyclic triple systems. New constructions of difference families are given. Some infinite classes of simple cyclic triple systems are obtained from these decompositions.展开更多
We revise the notion of von Neumann regularity in JB^＊-triples by finding a new characterisation in terms of the range of the quadratic operator Q（a）. We introduce the quadratic conorm of an element a in a JB^＊-tr...We revise the notion of von Neumann regularity in JB^＊-triples by finding a new characterisation in terms of the range of the quadratic operator Q（a）. We introduce the quadratic conorm of an element a in a JB^＊-triple as the minimum reduced modulus of the mapping Q（a）. It is shown that the quadratic conorm of a coincides with the infimum of the squares of the points in the triple spectrum of a. It is established that a contractive bijection between JBW^＊-triples is a triple isomorphism if, and only if, it preserves quadratic conorms. The continuity of the quadratic conorm and the generalized inverse are discussed. Some applications to C^＊-algebras and von Neumann algebras are also studied.展开更多
Semantic Web has emerged to make web content machine-readable,and with the rapid increase in the number of web pages,its importance has increased.Resource description framework(RDF)is a special data graph format where...Semantic Web has emerged to make web content machine-readable,and with the rapid increase in the number of web pages,its importance has increased.Resource description framework(RDF)is a special data graph format where Semantic Web data are stored and it can be queried by SPARQL query language.The challenge is to find the optimal query order that results in the shortest period of time.In this paper,the discrete Artificial Bee Colony(dABCSPARQL)algorithm is proposed,based on a novel heuristic approach,namely reordering SPARQL queries.The processing time of queries with different shapes and sizes is minimized using the dABCSPARQL algorithm.The performance of the proposed method is evaluated on chain,star,cyclic,and chain-star queries of different sizes from the Lehigh University Benchmark(LUBM)dataset.The results obtained by the proposed method are compared with those of ARQ(a SPARQL processor for Jena)query engine,the Ant System,the Elitist Ant System,and MAX-MIN Ant System algorithms.The experiments demonstrate that the proposed method significantly reduces the processing time,and in most queries,the reduction rate is higher compared with other optimization methods.展开更多
Jordan D-bialgebras were introduced by Zhelyabin.In this paper,we use a new approach to study Jordan D-bialgebras by a new notion of the dual representation of the regular representation of a Jordan algebra.Motivated ...Jordan D-bialgebras were introduced by Zhelyabin.In this paper,we use a new approach to study Jordan D-bialgebras by a new notion of the dual representation of the regular representation of a Jordan algebra.Motivated by the essential connection between Lie bialgebras and Manin triples,we give an explicit proof of the equivalence between Jordan D-bialgebras and a class of special Jordan-Manin triples called double constructions of pseudo-euclidean Jordan algebras.We also show that a Jordan D-bialgebra leads to the Jordan Yang-Baxter equation under the coboundary condition and an antisymmetric nondegenerate solution of the Jordan Yang-Baxter equation corresponds to an antisymmetric bilinear form,which we call a Jordan symplectic form on Jordan algebras.Furthermore,there exists a new algebra structure called pre-Jordan algebra on Jordan algebras with a Jordan symplectic form.展开更多
文摘The extraction of entity relationship triples is very important to build a knowledge graph(KG),meanwhile,various entity relationship extraction algorithms are mostly based on data-driven,especially for the current popular deep learning algorithms.Therefore,obtaining a large number of accurate triples is the key to build a good KG as well as train a good entity relationship extraction algorithm.Because of business requirements,this KG’s application field is determined and the experts’opinions also must be satisfied.Considering these factors we adopt the top-down method which refers to determining the data schema firstly,then filling the specific data according to the schema.The design of data schema is the top-level design of KG,and determining the data schema according to the characteristics of KG is equivalent to determining the scope of data’s collection and the mode of data’s organization.This method is generally suitable for the construction of domain KG.This article proposes a fast and efficient method to extract the topdown type KG’s triples in social media with the help of structured data in the information box on the right side of the related encyclopedia webpage.At the same time,based on the obtained triples,a data labeling method is proposed to obtain sufficiently high-quality training data,using in various Natural Language Processing(NLP)information extraction algorithms’training.
基金Supported by Research Project in Institutions of Higher Learning in Gansu Province(Grant No.2019B-224)Innovation Fund Project of Colleges and Universities in Gansu Province(Grant No.2020A-277)。
文摘Let A be an abelian category,and(X,Z,Y)be a complete hereditary cotorsion triple.We introduce the definition of n-Y-cotilting subcategories of A,and give a characterization of n-Y-cotilting subcategories,which is similar to Bazzoni characterization of n-cotilting modules.As an application,we prove that if GP is n-GI-cotilting over a virtually Gorenstein ring R,then R is an n-Gorenstein ring,where GP denotes the subcategory of Gorenstein projective R-modules and GI denotes the subcategory of Gorenstein injective R-modules.Furthermore,we investigate n-costar subcategories over arbitrary ring R,and the relationship between n-Icotilting subcategories with respect to cotorsion triple(P,R-Mod,I)and n-costar subcategories,where P denotes the subcategory of projective left R-modules and I denotes the subcategory of injective left R-modules.
文摘Continuing our study of spectral triples on quantum domains,we look at unbounded invariant and covariant derivations in the quantum annulus.In particular,we investigate whether such derivations can be implemented by operators with compact parametrices,a necessary condition in the definition of a spectral triple.
文摘The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices.
文摘Let P-3 （n） be the number of overpartition triples of n. By elementary series manipulations, we establish some congruences for P-3（n） modulo small powers of 2, such as P-3（16n＋14）≡0 （mod 32）, P-3（8n＋7）≡0 （mod 64）.We also find many arithmetic properties for P-3（n） modulo 7, 9 and 11, involving the following infinite families of Ramanujan-type congruences： for any integers α≥1 and n ≥ 0, we have
基金Project supported by the National Key Research and Development Program of China(2022YFB3503302)the Major Projects in Inner Mongolia Autonomous Region(20212D0035)the High-quality Development Special Funds Program Ministry of Industry Technology(TC220H06G)。
文摘The optimization of microstructure represents a significant methodology for enhancing coercivity(Hcj).This paper concentrates on optimizing the microstructure of magnets through the manipulation of the composition of low-melting-point and high-melting-point elements,thereby achieving the objective of augmenting the comprehensive magnetic properties of magnets.The present study is concerned with the microstructure of magnets comprising three distinct Ga and B contents,and the associated changes in their magnetic properties.The findings indicate that when the Ga content is 0.5 wt%and the B content is 0.88 wt%,the coercivity of the magnets is markedly enhanced.This is evidenced by an increase in coercivity from 8.51 to 14.83 kOe,representing a 74.26%rise.Concurrently,the residual magnetization strength of the magnet remains unaltered.This finding provides a crucial foundation for optimizing the overall magnetic properties of the magnets.The microstructural analysis indicates that a reduction in B content coupled with an increase in Ga content leads to the melting of sharp angles on the surface of the main-phase grains,facilitated by low-melting-point rare-earth-rich phases.This process results in the migration of Fe from the grain boundaries(GBs)to the triple junction phases(TJPs),while Nd migrates from the TJPs to the GBs.This migration results in a reduction in the agglomeration of rare-earth-rich elements within the TJPs,thereby increasing the Nd content in the GBs.This increase enhances the wettability of the GBs,while the reduction of Fe content in this phase mitigates the exchange-coupling effect between the main-phase GBs.Consequently,the GBs become more smooth,more homogeneous and more continuous,which ultimately results in an enhancement of the coercivity of the magnets.
基金Project supported by the National Natural Science Foundation of China(Grant No.62471180)。
文摘We propose a novel cooling protocol within a triple-Laguerre-Gaussian cavity optomechanical system,which is designed to suppress the thermal vibrations of a rotating mirror to reach its quantum ground state.The system incorporates two auxiliary cavities and an atomic ensemble coupled to a Laguerre-Gaussian rotational cavity.By carefully selecting system parameters,the cooling process of the rotating mirror is significantly enhanced,while the heating process is effectively suppressed,enabling efficient ground-state cooling even in the unresolved sideband regime.Compared to previous works,our scheme reduces the stringent restrictions on auxiliary systems,making it more experimentally feasible under broader parameter conditions.These findings provide a robust approach for achieving ground-state cooling in mechanical resonators.
基金Supported by the National Natural Science Foundation of China:Study on Mechanism of Transdifferentiation of Hepatocellular Carcinoma Cells Induced by Huoxue Ruanjian Traditional Chinese Medicine (No. 82174103)。
文摘OBJECTIVE:To identify the antitumor effects of Gualou Beimu Yin(瓜蒌贝母饮,GLBMY)in triple-negative breast cancer(TNBC)and to explore the underlying mechanisms.METHODS:A mouse model of breast cancer was established and treated with GLBMY.Freeze-dried GLBMY powder was used to treat MDA-MB-231 and BT549 cells to assess the therapeutic efficacy of GLBMY against TNBC.Network pharmacology,transcriptomics and metabolomics were employed to identify the potential mechanism of GLBMY in TNBC treatment.Finally,the main regulating genes and proteins in the enriched pathways were validated by Quantitative real-time polymerase chain reaction(q PCR)and Western blotting analysis to confirm its mechanism.RESULTS:GLBMY can inhibit the growth of TNBC through apoptosis and necroptosis pathways and inhibit TNBC lung metastasis by inhibiting epithelialmesenchymal transition(EMT).Network pharmacology has elucidated the most important active ingredients(tubeimoside I,emodin,cucurbitacin,and ursolic acid)and the most critical targets[interleukin-6(IL6),signal transducer and activator of transcription 3(STAT3),mitogen-activated protein kinase 3(MAPK3)]of GLBMY in treating TNBC.RNA-seq revealed that GLBMY affected the nuclear factor kappa-light-chain-enhancer of activated B cells,rat sarcoma virus,and MAPK signalling pathways.Metabolomics revealed that the metabolites mainly affected by GLBMY were L-(+)-lactic acid,isocitric acid,benzoic acid and indoxyl sulfate.Subsequent experiments demonstrated that GLBMY can inhibit EMT in TNBC through the MAPK/ERK pathway and inhibit the proliferation and progression of TNBC through the IL6-STAT signalling pathway.CONCLUSIONS:We confirmed that GLBMY inhibits the development and metastasis of TNBC through the MAPK/Erk and IL6-STAT signalling pathways.GLBMY shows promise as a long-term supplementary or alternative therapy for TNBC,offering new insights for TNBC treatment.
文摘As an important index to measure the degree of entanglement in quantum systems,concurrence plays an important role in practical research.In this paper,we study the concurrence between two qubits in triangular triple quantum dot structure.Through calculation and simulation,it is found that concurrence is mainly affected by the interdot coupling strength t,Coulomb interactionU,temperature T,and electrode coupling G.Through comparative studies with parallel triple quantum dot structures,we demonstrate that the triangular geometry exhibits significantly enhanced concurrence under identical conditions.In addition,under the condition that concurrence exceeds 0.9,the functional relationship between t and U is obtained through simulation,which provides theoretical support for quantum dot regulation under high entanglement.Finally,we demonstrate the feasibility of implementing a three-qubit quantum gate,using the Toffoli gate as a representative example,under the condition that the triangular triple quantum dot system maintains high entanglement.
基金supported by the Non-communicable Chronic Diseases National Science and Technology Major Project(Grant No.2025ZD0544003).
文摘The landscape of breast cancer treatment has undergone a transformative shift with the integration of immunotherapy.Historically considered a“cold”tumor with limited immunogenicity,breast cancer management was dominated by surgery,chemotherapy,radiotherapy,and targeted therapies1.However,the advent of immune checkpoint inhibitors(ICIs)has challenged this paradigm,opening a new frontier.The initial breakthrough in triple-negative breast cancer(TNBC)demonstrated that a subset of patients could derive profound and durable clinical benefit from pembrolizumab and atezolizumab2,3.Today,precision immunotherapy aims to identify the patients most likely to respond,to convert immunologically silent tumors into responsive tumors,and to strategically combine immunotherapies with other modalities to overcome resistance.This evolution from empirical application to biomarker-driven strategies marks the critical juncture at which we stand,transitioning promising clinical trial data into refined,effective,and accessible clinical practice4.Recent key clinical studies on breast cancer immunotherapy are summarized in Table 1.
基金supported by the National Natural Science Foundation of China(W2412135).
文摘The hydrological system in Central Asia is highly sensitive to global climate change,significantly affecting water supply and energy production.In Tajikistan,the Vakhsh River—one of the main tributaries of the Amu Darya—plays a key role in the region’s hydropower and irrigation.However,research on long-term hydrological changes in its two top large basins—the Surkhob and Khingov river basins—remains limited.Therefore,this study analyzed long-term climate and hydrological changes in the Vakhsh River,including its main tributaries—the Surkhob and Khingov rivers—which are vital for the water resource management in Tajikistan and even in Central Asia.Using long-term hydrometeorological observations,the change trends of temperature(1933–2020),precipitation(1970–2020),and runoff(1940–2018)were examined to assess the impact of climate change on the regional water resources.The analysis revealed the occurrence of significant warming and a spatially uneven increase in precipitation.The temperature changes across three climatic periods(1933–1960,1960–1990,and 1990–2020)indicated that there was a transition from baseline level to accelerated warming.The precipitation showed a 2.99 mm/a increase in the Khingov River Basin and a 2.80 mm/a increase in the Surkhob River Basin during 1970–2020.Moreover,there was a gradual shift toward wetter conditions in recent decades.Despite the relatively stable annual mean runoff,seasonal redistribution occurred,with increased runoff in spring and reduced runoff in summer,due to the compensation of glacier melting.Moreover,this study forecasted runoff change during 2019–2040 using the exponential triple smoothing(ETS)method and revealed the occurrence of alternating wet and dry phases,emphasizing the sensitivity of the Vakhsh River Basin’s hydrological system to climate change and the necessity of adaptive water resource management in mountainous regions of Central Asia.Therefore,this study can provide evidence-based insights that are critical for future water resources planning,climate-resilient hydropower development,and regional adaptation strategies in climate-vulnerable basins in Central Asia.
基金Project supported by the National Natural Science Foundation of China.
文摘Ⅰ. INTRODUCTIONA triple system S<sub>λ</sub>（2, 3, v）is an ordered pair （V,）, where Vis a v-set, is a collection of 3-subsets （called triples ） of V such that each pair of distinct dements of V is contained in exactly λ triples. An S<sub>2</sub>（2, 3, v）is called a twofold triple system.
基金supported by National Natural Science Foundation of China(Grant Nos.11071056 and 10971051)supported by Natural Science and Engineering Research Council of Canada(Grant No.239135-06)
文摘In this paper, we give some decompositions of triples of Zp^n or Z3p^n into cyclic triple systems. New constructions of difference families are given. Some infinite classes of simple cyclic triple systems are obtained from these decompositions.
基金I+D MEC Projects No.MTM 2005-02541,MTM 2004-03882Junta de Andalucfa Grants FQM 0199,FQM 0194,FQM 1215the PCI Project No.A/4044/05 of the Spanish AECI
文摘We revise the notion of von Neumann regularity in JB^＊-triples by finding a new characterisation in terms of the range of the quadratic operator Q（a）. We introduce the quadratic conorm of an element a in a JB^＊-triple as the minimum reduced modulus of the mapping Q（a）. It is shown that the quadratic conorm of a coincides with the infimum of the squares of the points in the triple spectrum of a. It is established that a contractive bijection between JBW^＊-triples is a triple isomorphism if, and only if, it preserves quadratic conorms. The continuity of the quadratic conorm and the generalized inverse are discussed. Some applications to C^＊-algebras and von Neumann algebras are also studied.
文摘Semantic Web has emerged to make web content machine-readable,and with the rapid increase in the number of web pages,its importance has increased.Resource description framework(RDF)is a special data graph format where Semantic Web data are stored and it can be queried by SPARQL query language.The challenge is to find the optimal query order that results in the shortest period of time.In this paper,the discrete Artificial Bee Colony(dABCSPARQL)algorithm is proposed,based on a novel heuristic approach,namely reordering SPARQL queries.The processing time of queries with different shapes and sizes is minimized using the dABCSPARQL algorithm.The performance of the proposed method is evaluated on chain,star,cyclic,and chain-star queries of different sizes from the Lehigh University Benchmark(LUBM)dataset.The results obtained by the proposed method are compared with those of ARQ(a SPARQL processor for Jena)query engine,the Ant System,the Elitist Ant System,and MAX-MIN Ant System algorithms.The experiments demonstrate that the proposed method significantly reduces the processing time,and in most queries,the reduction rate is higher compared with other optimization methods.
文摘Jordan D-bialgebras were introduced by Zhelyabin.In this paper,we use a new approach to study Jordan D-bialgebras by a new notion of the dual representation of the regular representation of a Jordan algebra.Motivated by the essential connection between Lie bialgebras and Manin triples,we give an explicit proof of the equivalence between Jordan D-bialgebras and a class of special Jordan-Manin triples called double constructions of pseudo-euclidean Jordan algebras.We also show that a Jordan D-bialgebra leads to the Jordan Yang-Baxter equation under the coboundary condition and an antisymmetric nondegenerate solution of the Jordan Yang-Baxter equation corresponds to an antisymmetric bilinear form,which we call a Jordan symplectic form on Jordan algebras.Furthermore,there exists a new algebra structure called pre-Jordan algebra on Jordan algebras with a Jordan symplectic form.
