In 2011, Berinde and Borcut [6] introduced the notion of tripled fixed point in partially ordered metric spaces. In our paper, we give some new tripled fixed point theorems by using a generalization of Meir-Keeler con...In 2011, Berinde and Borcut [6] introduced the notion of tripled fixed point in partially ordered metric spaces. In our paper, we give some new tripled fixed point theorems by using a generalization of Meir-Keeler contraction：展开更多
According to'Report on Market Demand Forecast and Investment Strategy Analysis of China Power Lithium Battery Industry'of the Qianzhan Industry Institute,currently lithium demand is mainly concentrated in mobi...According to'Report on Market Demand Forecast and Investment Strategy Analysis of China Power Lithium Battery Industry'of the Qianzhan Industry Institute,currently lithium demand is mainly concentrated in mobile battery and glass,lubricating oil markets,whose percentage is up to 85%,market share of electric vehicle and ESS energy backup展开更多
BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive di...BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive disorders.Accurate assessment and precise treatment are essential in initial intensive therapy.AIM To investigate the efficacy and safety of a vonoprazan(VPZ)-based triple regimen for first-line eradication of H.pylori in China.METHODS This multicenter noninferior randomized controlled trial(June 2022 to November 2023)involved 524 H.pyloripositive patients across 19 centers in Shandong,China.Participants were randomized to 14-day esomeprazole/bismuth/amoxicillin/clarithromycin(EBAC),14-day VPZ/amoxicillin/clarithromycin(VACa),or 10-day VPZ/amoxicillin/clarithromycin(VACb)-all administered twice daily.Primary outcomes(eradication rates)were assessed via intention-to-treat(ITT)and per-protocol(PP)analyses.Secondary endpoints included adverse events and adherence.Noninferiority testing andχ^(2)tests were used for statistical comparisons.RESULTS A total of 524 patients participated in this study.In ITT analysis,the eradication rates of the EBAC,VACa,and VACb groups were 72.6%(127/175),88.0%(154/175),and 83.3%(145/174),respectively(P=0.001).The difference in the eradication rate between the EBAC and VPCa groups was 15.4%[95%confidence interval(CI):7.3-23.6,P<0.001],and that between the EBAC and VACb groups was 10.8%(95%CI:2.1-19.4,P=0.018).In PP analysis,the eradication rates of the EBAC,VACa,and VACb groups were 81.4%(127/156),93.9%(154/164),and 90.6%(145/160),respectively(P=0.001).There was no significant difference in the incidence of adverse reactions among the three groups,which were 36.6%,33.8%and 29.6%,respectively(P=0.50).CONCLUSION VPZ-based triple therapies demonstrate noninferiority to 14-day bismuth-containing regimens,with the 10-day regimen showing comparable efficacy and similar adverse event rates.展开更多
Soil moisture(SM)is a critical variable in terrestrial ecosystems,especially in arid and semi-arid areas where water sources are limited.Despite its importance,understanding the spatiotemporal variations and influenci...Soil moisture(SM)is a critical variable in terrestrial ecosystems,especially in arid and semi-arid areas where water sources are limited.Despite its importance,understanding the spatiotemporal variations and influencing factors of SM in these areas remains insufficient.This study investigated the spatiotemporal variations and influencing factors of SM in arid and semi-arid areas of China by utilizing the extended triple collation(ETC),Mann-Kendall test,Theil-Sen estimator,ridge regression analysis,and other relevant methods.The following findings were obtained:(1)at the pixel scale,the long-term monthly SM data from the European Space Agency Climate Change Initiative(ESA CCI)exhibited the highest correlation coefficient of 0.794 and the lowest root mean square error(RMSE)of 0.014 m^(3)/m^(3);(2)from 2000 to 2022,the study area experienced significant increase in annual average SM,with a rate of 0.408×10^(-3)m^(3)/(m^(3)•a).Moreover,higher altitudes showed a notable upward trend,with SM increasing rates at 0.210×10^(-3)m^(3)/(m^(3)•a)between 1000 and 2000 m,0.530×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m,and 0.760×10^(-3)m^(3)/(m^(3)•a)at altitudes above 4000 m;(3)land surface temperature(LST),root zone soil moisture(RSM)(10-40 cm depth),and normalized difference vegetation index(NDVI)were identified as the primary factors influencing annual average SM,which accounted for 34.37%,24.16%,and 22.64%relative contributions,respectively;and(4)absolute contribution of LST was more significant in subareas at higher altitudes,with average absolute contributions of 0.800×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m and 0.500×10^(-2) m^(3)/(m^(3)•a)above 4000 m.This study reveals the spatiotemporal variations and main influencing factors of SM in Chinese arid and semi-arid areas,highlighting the more pronounced absolute contribution of LST to SM in high-altitude areas,providing valuable insights for ecological research and water resource management in these areas.展开更多
In this paper,we obtain some tripled common random fixed point and tripled random fixed point theorems with several generalized Lipschitz constants in such spaces.We consider the obtained assertions without the assump...In this paper,we obtain some tripled common random fixed point and tripled random fixed point theorems with several generalized Lipschitz constants in such spaces.We consider the obtained assertions without the assumption of normality of cones.The presented results generalize some coupled common fixed point theorems in the existing literature.展开更多
In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algeb...In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algebra is a sum of a derivation and an antiderivation.As its applications,Jordan triple derivations on triangular algebras are characterized.展开更多
Let f,g and h be three distinct primitive holomorphic cusp forms of even integral weights k_(1),k_(2)and k_(3)for the full modular groupΓ=SL(2,Z),and denote byλ_(f)(n),λ_(g)(n),λ_(h)(n)the corresponding normalized...Let f,g and h be three distinct primitive holomorphic cusp forms of even integral weights k_(1),k_(2)and k_(3)for the full modular groupΓ=SL(2,Z),and denote byλ_(f)(n),λ_(g)(n),λ_(h)(n)the corresponding normalized Fourier coefficients,respectively.In this paper,we investigate the correlations of triple sums associated to these Fourier coefficientsλ_(f)(n),λ_(g)(n),λ_(h)(n)over certain polynomials,and obtain some power-saving asymptotic estimates which beat the trivial bounds.展开更多
A new triple melting method with hot extrusion process for GH4710 alloy ingots has been developed to overcome the difficulty in deformation of GH4710 alloy prepared by the casting and forging process.The as-extruded G...A new triple melting method with hot extrusion process for GH4710 alloy ingots has been developed to overcome the difficulty in deformation of GH4710 alloy prepared by the casting and forging process.The as-extruded GH4710 alloy was analyzed through the isothermal compression experiment and metallographic analysis.The viscoelastic stress characteristics and dynamic recrystallization(DRX)behavior of the as-extruded GH4710 alloy were investigated during deformation at temperatures ranging from 1050℃ to 1120℃ and strain rates ranging from 0.01 s^(−1) to 5.00 s^(−1).The true stress-true strain curves,average grain size,and DRX volume fraction were also obtained under various deformation conditions.Prediction models for DRX volume fraction and grain size of the as-extruded GH4710 alloy were established using the statistical regression method.The model was implanted into the Derform-3D software,and numerical simulation of the microstructure evolution of GH4710 alloy was conducted.Firstly,the isothermal compression simulations were conducted using the finite element method to verify the accuracy of prediction model.Subsequently,the prediction model was applied to perform an optimization analysis of the forging process for a turbine disk with a diameter of 300 mm.Results show a strong correlation between the simulated results and the actual microstructure of the turbine disk forged through the optimal process parameters.The optimal process parameters are deformation temperature of 1100℃ and forging speed of 0.2 mm/s.This established DRX prediction model can serve as a fundamental reference for understanding the microstructural evolution during the hot deformation process of as-extruded GH4710 alloy.展开更多
The sparsity of ground gauges poses a significant challenge for evaluating and merging satellite-based and reanalysis-based precipitation datasets in lake regions.While the standard triple collocation(TC)method offers...The sparsity of ground gauges poses a significant challenge for evaluating and merging satellite-based and reanalysis-based precipitation datasets in lake regions.While the standard triple collocation(TC)method offers a solution without access to ground-based observations,it fails to address rain/no-rain classification and its suitability for assessing and merging lake precipitation has not been explored.This study combines categorical triple collocation(CTC)with standard TC to create an integrated framework(CTC-TC)tailored to evaluate and merge global gridded precipitation products(GPPs).We assess the efficacy of CTC-TC using six GPPs(ERA5-Land,SM2 RAIN-ASCAT,IMERG-Early,IMERG-Late,GSMaPMVK,and PERSIANN-CCS)across the five largest freshwater lakes in China.CTC-TC effectively captures the spatial patterns of metrics for all GPPs,and precisely estimates the correlation coefficient and root mean square error for satellite-based datasets apart from SM2 RAIN-ASCAT,but overestimates the classification accuracy indicator V for all GPPs.Regarding multi-source fusion,CTC-TC leverages the strengths of individual products of triplets,resulting in significant improvements in the critical success index(CSI)by over 11.9%and the modified Kling-Gupta efficiency(KGE')by more than 13.3%.Compared to baseline models,including standard TC,simple model averaging,one outlier removal,and Bayesian model averaging,CTC-TC achieves gains in CSI and KGE'of no less than 24.7%and 3.6%,respectively.In conclusion,the CTC-TC framework offers a thorough evaluation and efficient fusion of GPPs,addressing both categorical and continuous accuracy in data-scarce regions such as lakes.展开更多
The observations of fully-charm tetraquark states in the LHCb,CMS,and ATLAS experiments suggested the existence of hadronic molecules of two-charmonium states,which may also imply bound states in the threecharmonium s...The observations of fully-charm tetraquark states in the LHCb,CMS,and ATLAS experiments suggested the existence of hadronic molecules of two-charmonium states,which may also imply bound states in the threecharmonium systems.In this work,we study the possible bound states in the triple-ηcand triple-J/ψsystems with J^(PC)=0^(-+)and 1^(--),respectively.In quantum chromodynamics sum rules,we calculate the two-point correlation functions and spectral functions up to the dimension-four gluon condensate.We use the iterative dispersion relation approach to deal with the five-loop banana integrals,which significantly improves computational efficiency.Our results show that the masses of triple-ηcand triple-J/ψstates lie below the corresponding mass thresholds,supporting the existence of such three-body bound states.展开更多
Let R be a commutative ring with unity and T be a triangular algebra over R.Let a sequence G={G_n}_(n∈N)of nonlinear mappings G_n:T→T associated with nonlinear Lie triple higher derivations∆={δ_n}_(n∈N)by local ac...Let R be a commutative ring with unity and T be a triangular algebra over R.Let a sequence G={G_n}_(n∈N)of nonlinear mappings G_n:T→T associated with nonlinear Lie triple higher derivations∆={δ_n}_(n∈N)by local actions be a generalized Lie triple higher derivation by local actions satisfying Gn([[x,y],z])=Σ_(i+j+k=n)[[Gi(x),δj(y)],δk(z)]for all x,y,z∈T with xyz=0.Under some mild conditions on T,we prove in this paper that every nonlinear generalized Lie triple higher derivation by local actions on triangular algebras is proper.As an application we shall give a characterization of nonlinear generalized Lie triple higher derivations by local actions on upper triangular matrix algebras and nest algebras,respectively.At the same time,it also improves some interesting conclusions,such as[J.Algebra Appl.22(3),2023,Paper No.2350059],[Axioms,11,2022,1–16].展开更多
Objective:To evaluate the efficacy rate of rebamipide combined with triple therapy in the treatment of senile peptic gastric ulcers.Methods:A cohort of 68 elderly patients diagnosed with peptic gastric ulcers was enro...Objective:To evaluate the efficacy rate of rebamipide combined with triple therapy in the treatment of senile peptic gastric ulcers.Methods:A cohort of 68 elderly patients diagnosed with peptic gastric ulcers was enrolled in this study between January 2022 and December 2024.Using the envelope method for randomization,the patients were divided into two equal groups:a control group administered standard triple therapy and an observation group that received the same triple therapy supplemented with rebamipide.The clinical efficacy,gastric mucosal morphology(mucosal thickness,gland density,active inflammatory cell infiltration,chronic inflammatory cell infiltration),and pepsinogen I/II were compared between the two groups.Results:The total effective rate in the observation group was significantly higher than that in the control group,with a statistically significant difference(p<0.05).After treatment,the scores of all items in both groups were significantly lower than those before treatment,and the scores in the observation group were significantly lower than those in the control group,with statistically significant differences(p<0.05).After treatment,the ratios in both groups were significantly higher than those before treatment,and the ratio in the observation group was significantly higher than that in the control group,with statistically significant differences(p<0.05).Conclusion:Rebamipide combined with triple therapy can significantly improve the treatment efficacy of senile peptic gastric ulcers,effectively improve the histological status of the gastric mucosa,and promote the recovery of gastric mucosal function,with superior efficacy compared to triple therapy alone.展开更多
Triple-negative breast cancer(TNBC)represents an aggressive breast cancer subtype with poor prognosis and limited targeted treatment options.This investigation examined the anticancer potential of Caerulomycin A(Cae A...Triple-negative breast cancer(TNBC)represents an aggressive breast cancer subtype with poor prognosis and limited targeted treatment options.This investigation examined the anticancer potential of Caerulomycin A(Cae A),a natural compound derived from marine actinomycetes,against TNBC.Cae A demonstrated selective inhibition of viability and proliferation in TNBC cell lines,including 4T1,MDA-MB-231,and MDA-MB-468,through apoptosis induction.Mechanistic analyses revealed that the compound induced sustained endoplasmic reticulum(ER)stress and subsequent upregulation of C/EBP homologous protein(CHOP)expression,resulting in mitochondrial damage-mediated apoptosis.Inhibition of ER stress or CHOP expression knockdown reversed mitochondrial damage and apoptosis,highlighting the essential role of ER stress and CHOP in Cae A's anti-tumor mechanism.Both oxygen consumption rate(OCR)and extracellular acidification rate(ECAR)decreased in TNBC cells following Cae A treatment,indicating reduced mitochondrial respiratory and glycolytic capacities.This diminished energy metabolism potentially triggers ER stress and subsequent apoptosis.Furthermore,Cae A exhibited significant anti-tumor effects in the 4T1 tumor model in vivo without apparent toxicity.The compound also effectively inhibited human TNBC organoid growth.These results indicate that Cae A may serve as a potential therapeutic agent for TNBC,with its efficacy likely mediated through the disruption of glucose metabolism and the induction of ER stress-associated apoptosis.展开更多
OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple n...OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple negative breast cancer(TNBC).METHODS:A total of 60 patients diagnosed with TNBC and depression were enrolled and randomly assigned to either the control group(receiving routine tumor treatment and duloxetine)or the treatment group(receiving the TCM in addition to routine treatment).RESULTS:Both treatment and control groups showed a reduction in depressive symptoms and improved daily living abilities after treatment.However,the treatment group demonstrated significantly better outcomes compared to the control group.Furthermore,the levels of dopamine and serotonin in the serum increased in both groups after 8 weeks of treatment,while the treatment group exhibited superior results.CONCLUSIONS:This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression,which was verified by the increase in serum levels of dopamine and serotonin,suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM.展开更多
This paper investigates the optimization of data sampling and target labeling techniques to enhance algorithmic trading strategies in cryptocurrency markets,focusing on Bitcoin(BTC)and Ethereum(ETH).Traditional data s...This paper investigates the optimization of data sampling and target labeling techniques to enhance algorithmic trading strategies in cryptocurrency markets,focusing on Bitcoin(BTC)and Ethereum(ETH).Traditional data sampling methods,such as time bars,often fail to capture the nuances of the continuously active and highly volatile cryptocurrency market and force traders to wait for arbitrary points in time.To address this,we propose an alternative approach using information-driven sampling methods,including the CUSUM filter,range bars,volume bars,and dollar bars,and evaluate their performance using tick-level data from January 2018 to June 2023.Additionally,we introduce the Triple Barrier method for target labeling,which offers a solution tailored for algorithmic trading as opposed to the widely used next-bar prediction.We empirically assess the effectiveness of these data sampling and labeling methods to craft profitable trading strategies.The results demonstrate that the innovative combination of CUSUM-filtered data with Triple Barrier labeling outperforms traditional time bars and next-bar prediction,achieving consistently positive trading performance even after accounting for transaction costs.Moreover,our system enables making trading decisions at any point in time on the basis of market conditions,providing an advantage over traditional methods that rely on fixed time intervals.Furthermore,the paper contributes to the ongoing debate on the applicability of Transformer models to time series classification in the context of algorithmic trading by evaluating various Transformer architectures—including the vanilla Transformer encoder,FEDformer,and Autoformer—alongside other deep learning architectures and classical machine learning models,revealing insights into their relative performance.展开更多
The global burden of Helicobacter pylori infection continues to drive the need for effective,well-tolerated,and regionally adaptable eradication regimens.Recently Han et al presented compelling results from a multicen...The global burden of Helicobacter pylori infection continues to drive the need for effective,well-tolerated,and regionally adaptable eradication regimens.Recently Han et al presented compelling results from a multicenter randomized controlled trial in China,demonstrating the non-inferiority and potential superiority of vonoprazan(VPZ)-based triple therapy over the standard 14-day bismuth quad-ruple regimen.Both the 10-day and 14-day VPZ-amoxicillin-clarithromycin regi-mens achieved eradication rates exceeding 90%per protocol,with similar or fewer adverse events,suggesting improved patient tolerability.This study reinforces the potential of VPZ to overcome the limitations of proton pump inhibitor-based regimens,particularly in populations with CYP2C19 polymorphisms and increa-sing clarithromycin resistance.These findings also lend support to shortened trea-tment durations,which could enhance adherence and reduce antimicrobial expo-sure.These data highlight an important shift in the therapeutic landscape,positio-ning VPZ as a strong candidate for first-line empirical therapies.However,broa-der implementation requires careful consideration of local resistance patterns,drug accessibility,and pharmacoeconomic implications.展开更多
基金supported by Università degli Studi di Padermo,Local Project R.S.ex 60\char37
文摘In 2011, Berinde and Borcut [6] introduced the notion of tripled fixed point in partially ordered metric spaces. In our paper, we give some new tripled fixed point theorems by using a generalization of Meir-Keeler contraction：
文摘According to'Report on Market Demand Forecast and Investment Strategy Analysis of China Power Lithium Battery Industry'of the Qianzhan Industry Institute,currently lithium demand is mainly concentrated in mobile battery and glass,lubricating oil markets,whose percentage is up to 85%,market share of electric vehicle and ESS energy backup
基金Supported by Qilu Health Outstanding Young Talent Cultivation Project,No.QDFY-3839。
文摘BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive disorders.Accurate assessment and precise treatment are essential in initial intensive therapy.AIM To investigate the efficacy and safety of a vonoprazan(VPZ)-based triple regimen for first-line eradication of H.pylori in China.METHODS This multicenter noninferior randomized controlled trial(June 2022 to November 2023)involved 524 H.pyloripositive patients across 19 centers in Shandong,China.Participants were randomized to 14-day esomeprazole/bismuth/amoxicillin/clarithromycin(EBAC),14-day VPZ/amoxicillin/clarithromycin(VACa),or 10-day VPZ/amoxicillin/clarithromycin(VACb)-all administered twice daily.Primary outcomes(eradication rates)were assessed via intention-to-treat(ITT)and per-protocol(PP)analyses.Secondary endpoints included adverse events and adherence.Noninferiority testing andχ^(2)tests were used for statistical comparisons.RESULTS A total of 524 patients participated in this study.In ITT analysis,the eradication rates of the EBAC,VACa,and VACb groups were 72.6%(127/175),88.0%(154/175),and 83.3%(145/174),respectively(P=0.001).The difference in the eradication rate between the EBAC and VPCa groups was 15.4%[95%confidence interval(CI):7.3-23.6,P<0.001],and that between the EBAC and VACb groups was 10.8%(95%CI:2.1-19.4,P=0.018).In PP analysis,the eradication rates of the EBAC,VACa,and VACb groups were 81.4%(127/156),93.9%(154/164),and 90.6%(145/160),respectively(P=0.001).There was no significant difference in the incidence of adverse reactions among the three groups,which were 36.6%,33.8%and 29.6%,respectively(P=0.50).CONCLUSION VPZ-based triple therapies demonstrate noninferiority to 14-day bismuth-containing regimens,with the 10-day regimen showing comparable efficacy and similar adverse event rates.
基金supported by the Natural Science Foundation of Henan Province(252300421290)the National Natural Science Foundation of China(41771438)+1 种基金the Program for Innovative Research Team(in Science and Technology)of Henan University(22IRTSTHN010)the Postgraduate Education Reform and Quality Improvement Project of Henan Province(HNYJS2020JD14).
文摘Soil moisture(SM)is a critical variable in terrestrial ecosystems,especially in arid and semi-arid areas where water sources are limited.Despite its importance,understanding the spatiotemporal variations and influencing factors of SM in these areas remains insufficient.This study investigated the spatiotemporal variations and influencing factors of SM in arid and semi-arid areas of China by utilizing the extended triple collation(ETC),Mann-Kendall test,Theil-Sen estimator,ridge regression analysis,and other relevant methods.The following findings were obtained:(1)at the pixel scale,the long-term monthly SM data from the European Space Agency Climate Change Initiative(ESA CCI)exhibited the highest correlation coefficient of 0.794 and the lowest root mean square error(RMSE)of 0.014 m^(3)/m^(3);(2)from 2000 to 2022,the study area experienced significant increase in annual average SM,with a rate of 0.408×10^(-3)m^(3)/(m^(3)•a).Moreover,higher altitudes showed a notable upward trend,with SM increasing rates at 0.210×10^(-3)m^(3)/(m^(3)•a)between 1000 and 2000 m,0.530×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m,and 0.760×10^(-3)m^(3)/(m^(3)•a)at altitudes above 4000 m;(3)land surface temperature(LST),root zone soil moisture(RSM)(10-40 cm depth),and normalized difference vegetation index(NDVI)were identified as the primary factors influencing annual average SM,which accounted for 34.37%,24.16%,and 22.64%relative contributions,respectively;and(4)absolute contribution of LST was more significant in subareas at higher altitudes,with average absolute contributions of 0.800×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m and 0.500×10^(-2) m^(3)/(m^(3)•a)above 4000 m.This study reveals the spatiotemporal variations and main influencing factors of SM in Chinese arid and semi-arid areas,highlighting the more pronounced absolute contribution of LST to SM in high-altitude areas,providing valuable insights for ecological research and water resource management in these areas.
基金supported by the Foundation of Education Ministry,Hubei Province,China(Q20122203)
文摘In this paper,we obtain some tripled common random fixed point and tripled random fixed point theorems with several generalized Lipschitz constants in such spaces.We consider the obtained assertions without the assumption of normality of cones.The presented results generalize some coupled common fixed point theorems in the existing literature.
基金Supported by Basic Research Foundation of Yunnan Education Department(Nos.2020J0748,2021J0635)Talent Project Foundation of Yunnan Provincial Science and Technology Department(No.202105AC160089)NSF of Yunnan Province(No.202101BA070001198).
文摘In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algebra is a sum of a derivation and an antiderivation.As its applications,Jordan triple derivations on triangular algebras are characterized.
基金Supported in part by NSFC(Nos.12401011,12201214)National Key Research and Development Program of China(No.2021YFA1000700)+3 种基金Shaanxi Fundamental Science Research Project for Mathematics and Physics(No.23JSQ053)Science and Technology Program for Youth New Star of Shaanxi Province(No.2025ZC-KJXX-29)Natural Science Basic Research Program of Shaanxi Province(No.2025JC-YBQN-091)Scientific Research Foundation for Young Talents of WNU(No.2024XJ-QNRC-01)。
文摘Let f,g and h be three distinct primitive holomorphic cusp forms of even integral weights k_(1),k_(2)and k_(3)for the full modular groupΓ=SL(2,Z),and denote byλ_(f)(n),λ_(g)(n),λ_(h)(n)the corresponding normalized Fourier coefficients,respectively.In this paper,we investigate the correlations of triple sums associated to these Fourier coefficientsλ_(f)(n),λ_(g)(n),λ_(h)(n)over certain polynomials,and obtain some power-saving asymptotic estimates which beat the trivial bounds.
基金Key Field Research Foundation of Beijing Institute of Aeronautical Materials(KJSC192309)。
文摘A new triple melting method with hot extrusion process for GH4710 alloy ingots has been developed to overcome the difficulty in deformation of GH4710 alloy prepared by the casting and forging process.The as-extruded GH4710 alloy was analyzed through the isothermal compression experiment and metallographic analysis.The viscoelastic stress characteristics and dynamic recrystallization(DRX)behavior of the as-extruded GH4710 alloy were investigated during deformation at temperatures ranging from 1050℃ to 1120℃ and strain rates ranging from 0.01 s^(−1) to 5.00 s^(−1).The true stress-true strain curves,average grain size,and DRX volume fraction were also obtained under various deformation conditions.Prediction models for DRX volume fraction and grain size of the as-extruded GH4710 alloy were established using the statistical regression method.The model was implanted into the Derform-3D software,and numerical simulation of the microstructure evolution of GH4710 alloy was conducted.Firstly,the isothermal compression simulations were conducted using the finite element method to verify the accuracy of prediction model.Subsequently,the prediction model was applied to perform an optimization analysis of the forging process for a turbine disk with a diameter of 300 mm.Results show a strong correlation between the simulated results and the actual microstructure of the turbine disk forged through the optimal process parameters.The optimal process parameters are deformation temperature of 1100℃ and forging speed of 0.2 mm/s.This established DRX prediction model can serve as a fundamental reference for understanding the microstructural evolution during the hot deformation process of as-extruded GH4710 alloy.
基金National Key R&D Program of China,No.2022YFC3202802National Natural Science Foundation of China,No.52009081,No.52121006,No.52279071Special Funded Project for Basic Scientific Research Operation Expenses of the Central Public Welfare Scientific Research Institutes of China,No.Y524017。
文摘The sparsity of ground gauges poses a significant challenge for evaluating and merging satellite-based and reanalysis-based precipitation datasets in lake regions.While the standard triple collocation(TC)method offers a solution without access to ground-based observations,it fails to address rain/no-rain classification and its suitability for assessing and merging lake precipitation has not been explored.This study combines categorical triple collocation(CTC)with standard TC to create an integrated framework(CTC-TC)tailored to evaluate and merge global gridded precipitation products(GPPs).We assess the efficacy of CTC-TC using six GPPs(ERA5-Land,SM2 RAIN-ASCAT,IMERG-Early,IMERG-Late,GSMaPMVK,and PERSIANN-CCS)across the five largest freshwater lakes in China.CTC-TC effectively captures the spatial patterns of metrics for all GPPs,and precisely estimates the correlation coefficient and root mean square error for satellite-based datasets apart from SM2 RAIN-ASCAT,but overestimates the classification accuracy indicator V for all GPPs.Regarding multi-source fusion,CTC-TC leverages the strengths of individual products of triplets,resulting in significant improvements in the critical success index(CSI)by over 11.9%and the modified Kling-Gupta efficiency(KGE')by more than 13.3%.Compared to baseline models,including standard TC,simple model averaging,one outlier removal,and Bayesian model averaging,CTC-TC achieves gains in CSI and KGE'of no less than 24.7%and 3.6%,respectively.In conclusion,the CTC-TC framework offers a thorough evaluation and efficient fusion of GPPs,addressing both categorical and continuous accuracy in data-scarce regions such as lakes.
基金supported by the National Natural Science Foundation of China(Grant No.12175318)the Natural Science Foundation of Guangdong Province of China(Grant No.2023A1515011704)。
文摘The observations of fully-charm tetraquark states in the LHCb,CMS,and ATLAS experiments suggested the existence of hadronic molecules of two-charmonium states,which may also imply bound states in the threecharmonium systems.In this work,we study the possible bound states in the triple-ηcand triple-J/ψsystems with J^(PC)=0^(-+)and 1^(--),respectively.In quantum chromodynamics sum rules,we calculate the two-point correlation functions and spectral functions up to the dimension-four gluon condensate.We use the iterative dispersion relation approach to deal with the five-loop banana integrals,which significantly improves computational efficiency.Our results show that the masses of triple-ηcand triple-J/ψstates lie below the corresponding mass thresholds,supporting the existence of such three-body bound states.
基金Supported by Open Research Fund of Hubei Key Laboratory of Mathematical Sciences(Central China Normal University)the Natural Science Foundation of Anhui Province(Grant No.2008085QA01)the University Natural Science Research Project of Anhui Province(Grant No.KJ2019A0107)。
文摘Let R be a commutative ring with unity and T be a triangular algebra over R.Let a sequence G={G_n}_(n∈N)of nonlinear mappings G_n:T→T associated with nonlinear Lie triple higher derivations∆={δ_n}_(n∈N)by local actions be a generalized Lie triple higher derivation by local actions satisfying Gn([[x,y],z])=Σ_(i+j+k=n)[[Gi(x),δj(y)],δk(z)]for all x,y,z∈T with xyz=0.Under some mild conditions on T,we prove in this paper that every nonlinear generalized Lie triple higher derivation by local actions on triangular algebras is proper.As an application we shall give a characterization of nonlinear generalized Lie triple higher derivations by local actions on upper triangular matrix algebras and nest algebras,respectively.At the same time,it also improves some interesting conclusions,such as[J.Algebra Appl.22(3),2023,Paper No.2350059],[Axioms,11,2022,1–16].
文摘Objective:To evaluate the efficacy rate of rebamipide combined with triple therapy in the treatment of senile peptic gastric ulcers.Methods:A cohort of 68 elderly patients diagnosed with peptic gastric ulcers was enrolled in this study between January 2022 and December 2024.Using the envelope method for randomization,the patients were divided into two equal groups:a control group administered standard triple therapy and an observation group that received the same triple therapy supplemented with rebamipide.The clinical efficacy,gastric mucosal morphology(mucosal thickness,gland density,active inflammatory cell infiltration,chronic inflammatory cell infiltration),and pepsinogen I/II were compared between the two groups.Results:The total effective rate in the observation group was significantly higher than that in the control group,with a statistically significant difference(p<0.05).After treatment,the scores of all items in both groups were significantly lower than those before treatment,and the scores in the observation group were significantly lower than those in the control group,with statistically significant differences(p<0.05).After treatment,the ratios in both groups were significantly higher than those before treatment,and the ratio in the observation group was significantly higher than that in the control group,with statistically significant differences(p<0.05).Conclusion:Rebamipide combined with triple therapy can significantly improve the treatment efficacy of senile peptic gastric ulcers,effectively improve the histological status of the gastric mucosa,and promote the recovery of gastric mucosal function,with superior efficacy compared to triple therapy alone.
基金supported by the Science and Education Integration Project by the Innovation and Entrepreneurship Office of Nanjing University(No.0214-1480608207)Jiangsu Provincial Research Hospital(No.YJXYY202204)。
文摘Triple-negative breast cancer(TNBC)represents an aggressive breast cancer subtype with poor prognosis and limited targeted treatment options.This investigation examined the anticancer potential of Caerulomycin A(Cae A),a natural compound derived from marine actinomycetes,against TNBC.Cae A demonstrated selective inhibition of viability and proliferation in TNBC cell lines,including 4T1,MDA-MB-231,and MDA-MB-468,through apoptosis induction.Mechanistic analyses revealed that the compound induced sustained endoplasmic reticulum(ER)stress and subsequent upregulation of C/EBP homologous protein(CHOP)expression,resulting in mitochondrial damage-mediated apoptosis.Inhibition of ER stress or CHOP expression knockdown reversed mitochondrial damage and apoptosis,highlighting the essential role of ER stress and CHOP in Cae A's anti-tumor mechanism.Both oxygen consumption rate(OCR)and extracellular acidification rate(ECAR)decreased in TNBC cells following Cae A treatment,indicating reduced mitochondrial respiratory and glycolytic capacities.This diminished energy metabolism potentially triggers ER stress and subsequent apoptosis.Furthermore,Cae A exhibited significant anti-tumor effects in the 4T1 tumor model in vivo without apparent toxicity.The compound also effectively inhibited human TNBC organoid growth.These results indicate that Cae A may serve as a potential therapeutic agent for TNBC,with its efficacy likely mediated through the disruption of glucose metabolism and the induction of ER stress-associated apoptosis.
文摘OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple negative breast cancer(TNBC).METHODS:A total of 60 patients diagnosed with TNBC and depression were enrolled and randomly assigned to either the control group(receiving routine tumor treatment and duloxetine)or the treatment group(receiving the TCM in addition to routine treatment).RESULTS:Both treatment and control groups showed a reduction in depressive symptoms and improved daily living abilities after treatment.However,the treatment group demonstrated significantly better outcomes compared to the control group.Furthermore,the levels of dopamine and serotonin in the serum increased in both groups after 8 weeks of treatment,while the treatment group exhibited superior results.CONCLUSIONS:This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression,which was verified by the increase in serum levels of dopamine and serotonin,suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM.
基金support of the University of Warsaw under’New Ideas 3B’competition in POB Ⅲ implemented under the’Excellence Initiative-Research University’Programme.
文摘This paper investigates the optimization of data sampling and target labeling techniques to enhance algorithmic trading strategies in cryptocurrency markets,focusing on Bitcoin(BTC)and Ethereum(ETH).Traditional data sampling methods,such as time bars,often fail to capture the nuances of the continuously active and highly volatile cryptocurrency market and force traders to wait for arbitrary points in time.To address this,we propose an alternative approach using information-driven sampling methods,including the CUSUM filter,range bars,volume bars,and dollar bars,and evaluate their performance using tick-level data from January 2018 to June 2023.Additionally,we introduce the Triple Barrier method for target labeling,which offers a solution tailored for algorithmic trading as opposed to the widely used next-bar prediction.We empirically assess the effectiveness of these data sampling and labeling methods to craft profitable trading strategies.The results demonstrate that the innovative combination of CUSUM-filtered data with Triple Barrier labeling outperforms traditional time bars and next-bar prediction,achieving consistently positive trading performance even after accounting for transaction costs.Moreover,our system enables making trading decisions at any point in time on the basis of market conditions,providing an advantage over traditional methods that rely on fixed time intervals.Furthermore,the paper contributes to the ongoing debate on the applicability of Transformer models to time series classification in the context of algorithmic trading by evaluating various Transformer architectures—including the vanilla Transformer encoder,FEDformer,and Autoformer—alongside other deep learning architectures and classical machine learning models,revealing insights into their relative performance.
基金Supported by Ministry of Science and Higher Education of the Russian Federation,No.FGMF-2025-0003.
文摘The global burden of Helicobacter pylori infection continues to drive the need for effective,well-tolerated,and regionally adaptable eradication regimens.Recently Han et al presented compelling results from a multicenter randomized controlled trial in China,demonstrating the non-inferiority and potential superiority of vonoprazan(VPZ)-based triple therapy over the standard 14-day bismuth quad-ruple regimen.Both the 10-day and 14-day VPZ-amoxicillin-clarithromycin regi-mens achieved eradication rates exceeding 90%per protocol,with similar or fewer adverse events,suggesting improved patient tolerability.This study reinforces the potential of VPZ to overcome the limitations of proton pump inhibitor-based regimens,particularly in populations with CYP2C19 polymorphisms and increa-sing clarithromycin resistance.These findings also lend support to shortened trea-tment durations,which could enhance adherence and reduce antimicrobial expo-sure.These data highlight an important shift in the therapeutic landscape,positio-ning VPZ as a strong candidate for first-line empirical therapies.However,broa-der implementation requires careful consideration of local resistance patterns,drug accessibility,and pharmacoeconomic implications.
