Novel trimers of triphenylethylene-coumarin hybrid containing two amino side chains （5a-d and 6a-d） were designed and synthesized by the condensation of 1,3,5-benzenetricarboxylic acid with the varied amino monomeri...Novel trimers of triphenylethylene-coumarin hybrid containing two amino side chains （5a-d and 6a-d） were designed and synthesized by the condensation of 1,3,5-benzenetricarboxylic acid with the varied amino monomeric hybrids catalyzed by HATU and DIPEA at room temperature. The extended trimeric compound 6a （R = piperidinyl） exhibited significant anti-proliferative activity against three cancer cells at IC5o of near 10 μmol/L. UV-vis, fluorescence （lifetime） and thermal denaturation exhibited that 6a had significant interaction with Ct-DNA by the intercalative mode of binding. The order of their anti- proliferative activities was 6（a, d） 〉 5（a, d） and （5-6）a 〉 （5-6）d, respectively, in accordance with that of their DNA binding properties, which suggested that the prolonged linker （six carbons） and piperidinyl ~roun on the side chains are beneficial to DNA binding and the anti-tumor activity.展开更多
The new approaches to construct deep blue aggregation-induced emission （ALE） materials have been explored, which control the conjugation by two different strategies, to make a great step for the commercialization of...The new approaches to construct deep blue aggregation-induced emission （ALE） materials have been explored, which control the conjugation by two different strategies, to make a great step for the commercialization of organic light-emitting diodes. In order to shorten the intramolecular conjugation length, triphenylethylene （tPE） was utilized to construct blue AIEgens as peripheral groups, instead of tetraphenylethylene （TPE）, the famous AIE star molecule, to yield three blue AIEgens of 3,4-BtPE-PI, 4,4- BtPE-PI and 4,4-BtPE-PPI. Nondoped electroluminescence devices are fabricated by using these three AIEgens as the emitting material layer, the best performance of 3.8 cd/A as the maximum current efficiency achieved at the commission internationale de l＇Eclairage coordinates of （0.17, 0.18）.展开更多
基金the National Natural Science Foundation of China(NSFC,No.20902016)
文摘Novel trimers of triphenylethylene-coumarin hybrid containing two amino side chains （5a-d and 6a-d） were designed and synthesized by the condensation of 1,3,5-benzenetricarboxylic acid with the varied amino monomeric hybrids catalyzed by HATU and DIPEA at room temperature. The extended trimeric compound 6a （R = piperidinyl） exhibited significant anti-proliferative activity against three cancer cells at IC5o of near 10 μmol/L. UV-vis, fluorescence （lifetime） and thermal denaturation exhibited that 6a had significant interaction with Ct-DNA by the intercalative mode of binding. The order of their anti- proliferative activities was 6（a, d） 〉 5（a, d） and （5-6）a 〉 （5-6）d, respectively, in accordance with that of their DNA binding properties, which suggested that the prolonged linker （six carbons） and piperidinyl ~roun on the side chains are beneficial to DNA binding and the anti-tumor activity.
基金supported by the National Natural Science Foundation of China (21325416 and 51573140)the National Basic Research Program of China (2013CB834701)
文摘The new approaches to construct deep blue aggregation-induced emission （ALE） materials have been explored, which control the conjugation by two different strategies, to make a great step for the commercialization of organic light-emitting diodes. In order to shorten the intramolecular conjugation length, triphenylethylene （tPE） was utilized to construct blue AIEgens as peripheral groups, instead of tetraphenylethylene （TPE）, the famous AIE star molecule, to yield three blue AIEgens of 3,4-BtPE-PI, 4,4- BtPE-PI and 4,4-BtPE-PPI. Nondoped electroluminescence devices are fabricated by using these three AIEgens as the emitting material layer, the best performance of 3.8 cd/A as the maximum current efficiency achieved at the commission internationale de l＇Eclairage coordinates of （0.17, 0.18）.
