首次报道了中国兰科新记录属三角兰属(Trias),并对该属及该属新种疣花三角兰(T.verrucosa Z.J.Liu,L.J.Chen et S.P.Lei)进行了描述与讨论。三角兰属含19种,分布于自印度的阿萨姆经缅甸向东南扩展至印度尼西亚与澳大利亚,向西南延伸至...首次报道了中国兰科新记录属三角兰属(Trias),并对该属及该属新种疣花三角兰(T.verrucosa Z.J.Liu,L.J.Chen et S.P.Lei)进行了描述与讨论。三角兰属含19种,分布于自印度的阿萨姆经缅甸向东南扩展至印度尼西亚与澳大利亚,向西南延伸至印度德干高原。它在云南西部的发现进一步表明了该地区与热带亚洲在植物地理学上的亲密关系。新种生于林下较阴蔽的石上,对其物候学与开花生物学特征的观察,发现该物种有大量世代重叠的克隆分株,未见结实的植株,克隆繁殖的发生与分株是否开花无关。花期自4月初至5月初,花在植株或花序上的开放毫无规律,而且单花的花期较短,仅有4～5d,未发现有结实的花。交配系统检测,人工自花传粉和异花传粉的花未见有结实。由于该植物的花期常处于雨季来临之前,此时干燥,风力大,低温和弱光的生态条件对于植物的开花、传粉、结实显然是不利的。缩短开花时间和不结实可避免植株的能量在不利环境的无效消耗,将有限的能量用于其较为有效的无性繁殖,增加了在不可预测环境中繁衍的机会,以保障繁殖的成功。它的P/O(花粉/胚珠)值为187.4±22.4,显然是与它的花粉粘合成坚硬块状可在传粉中的高效利用有关,表明该物种仍然保留有性繁殖的特性。该种植物所采取强化无性繁殖,弱化有性繁殖生殖策略是对该地区较为恶劣生态条件的适应,可能正是由于这个原因,疣花三角兰能够在远离其同属近亲的地方生存下来。展开更多
The epiphytic plants belong to a group that harmlessly grows on other plants by utilizing the nutrition from the host plants with their unique adaptation features along with symbiotic associations with fungi or bacter...The epiphytic plants belong to a group that harmlessly grows on other plants by utilizing the nutrition from the host plants with their unique adaptation features along with symbiotic associations with fungi or bacteria.The various biological activities exhibited by the mycoendophytes inhabiting medicinally-important epiphytic orchids serve as the primary source of novel drug leads,industrially-essential enzymes,and plant growth-promoting metabolites.In the present study,a total of 956 culturable mycoendophytes out of 1600 segments belonging to 17 genera were isolated from different tissue parts of Trias stocksii and Dendrobium herbaceum.The Xylariaceae taxa were the predominant mycoendophytes present in both plants,followed by Pestalotiopsis sp.,Colletotrichum sp.,and Fusarium sp.An estimation of the Shannon-Wiener and Simpson diversity indices showed that the bulbs of T.stocksii have the highest species diversity index and the stems of D.herbaceum the lowest.The highest species richness was observed in the leaves of T.stocksii and the lowest in the leaves of D.herbaceum.Overall,T.stocksii harbored more mycoendophytes along with the highest diversity indices compared to D.herbaceum.The antimicrobial evaluation revealed that Xylaria sp.has a higher potential of producing anti-infectives and opens a new arena for industrial exploration.展开更多
Background Recombinant human GH(rhGH)was first approved to treat children with growth hormone deficiency(GHD)by Food and Drug Administration(FDA)in the United States in 1985.The indications subsequently expanded to gr...Background Recombinant human GH(rhGH)was first approved to treat children with growth hormone deficiency(GHD)by Food and Drug Administration(FDA)in the United States in 1985.The indications subsequently expanded to growth failure secondary to chronic renal failure,Turner syndrome,Prader‒Willi syndrome,small for gestational age(SGA)without catch-up growth,idiopathic short stature(ISS),SHOX deficiency,Noonan syndrome and so on[1].The efficacy and the safety of rhGH have been proven in randomized controlled trials(RCTs),which are considered the highest level of evidences in clinical practice.However,due to the strict criteria and short observational time,RCTs could not fully reflect the reality of rhGH,especially in terms of safety[2].展开更多
Objective This systematic review assessed trial-based economic evaluations to provide empirical evidence on the cost-effectiveness of non-drug interventions(NDIs)that are currently recommended within the Royal Austral...Objective This systematic review assessed trial-based economic evaluations to provide empirical evidence on the cost-effectiveness of non-drug interventions(NDIs)that are currently recommended within the Royal Australian College of General Practitioners Handbook of Non-Drug Interventions(HANDI).Methods Medline,CINAHL and PsycINFO along with clinical trial registries(clinicaltrials.gov and WHO International Clinical Trials Registry Platform)were searched from inception to 1 July 2025.Randomised controlled trials(RCTs)that reported cost effectiveness for a prescribed non-drug intervention(NDI)from HANDI were included in the study.The primary outcome was the incremental cost-utility ratio(ICUR)derived from cost-utility analyses(CUAs).Results A total of 11187 citations were identified,from which 156 RCTs were included.These RCTs enrolled a total of 66926 participants(median=214,IQR 139–342),with a median follow-up duration of 12 months(IQR 6–12 months).Over half of the CUA NDIs were for mental health conditions(n=81;54.0%),one-third were for were for musculoskeletal conditions(n=44;29.3%),while only 16.0%(n=24)were for those with cardiovascular/metabolic conditions.Out of the 150 NDIs that reported CUAs,40%were deemed to be in the south-east(SE)quadrant(cheaper and more effective)and 49.3%fell in the north-east(NE)quadrant(more costly but more effective),with 70%considered cost effective against a￡25000/quality-adjusted life-year(QALY)willingness to pay threshold.The overall median ICUR was￡2400/QALY(IQR−18986 to 20027).Conclusions Most of the HANDI NDIs that were included within this systematic review are cost-effective compared with a variety of alternatives including usual care or waiting list controls.HANDI NDIs warrant use as a first line of treatment when clinically appropriate.展开更多
20072040 Zhu Xuebo(College of Earth Sciences,Chengdu University of Technology,Chengdu 610059,China);Liu Dengzhong Paleocommunity Analysis of the Late Devonian--Early Permian in the Huanglong Area,Sichuan Province,Chin...20072040 Zhu Xuebo(College of Earth Sciences,Chengdu University of Technology,Chengdu 610059,China);Liu Dengzhong Paleocommunity Analysis of the Late Devonian--Early Permian in the Huanglong Area,Sichuan Province,China(Journal of Chengdu University of展开更多
20061426 Bai Yunshan (Yichang Institute ofGeology and Mineral Resources, Yichang,Hubei 443003); Li Li Characteristics andTectonic Setting of Eerlongba FormationVolcanic Rocks in Geladandong Area of Cen-tral Qiangtang ...20061426 Bai Yunshan (Yichang Institute ofGeology and Mineral Resources, Yichang,Hubei 443003); Li Li Characteristics andTectonic Setting of Eerlongba FormationVolcanic Rocks in Geladandong Area of Cen-tral Qiangtang (Acta Geoscientica Sinica,ISSN1006-3021, CN44-1398/P, 26(2),2005, p.113-120, 6 illus., 5 tables, 11refs.)volcanic rocks,展开更多
20131708 Cai Xiyao(Research Institute of Exploration&Production,SINOPEC,Beijing100083,China);Jin Xianmei The Stratigraphic Classification and Correlation of Jurassic in Caohu Depression,Tarim Basin(Xinjiang Geolog...20131708 Cai Xiyao(Research Institute of Exploration&Production,SINOPEC,Beijing100083,China);Jin Xianmei The Stratigraphic Classification and Correlation of Jurassic in Caohu Depression,Tarim Basin(Xinjiang Geology,ISSN1000-8845,CN65-1092/P,30(3),2012,p.287-291,2illus.,1table,10refs.)展开更多
文摘首次报道了中国兰科新记录属三角兰属(Trias),并对该属及该属新种疣花三角兰(T.verrucosa Z.J.Liu,L.J.Chen et S.P.Lei)进行了描述与讨论。三角兰属含19种,分布于自印度的阿萨姆经缅甸向东南扩展至印度尼西亚与澳大利亚,向西南延伸至印度德干高原。它在云南西部的发现进一步表明了该地区与热带亚洲在植物地理学上的亲密关系。新种生于林下较阴蔽的石上,对其物候学与开花生物学特征的观察,发现该物种有大量世代重叠的克隆分株,未见结实的植株,克隆繁殖的发生与分株是否开花无关。花期自4月初至5月初,花在植株或花序上的开放毫无规律,而且单花的花期较短,仅有4～5d,未发现有结实的花。交配系统检测,人工自花传粉和异花传粉的花未见有结实。由于该植物的花期常处于雨季来临之前,此时干燥,风力大,低温和弱光的生态条件对于植物的开花、传粉、结实显然是不利的。缩短开花时间和不结实可避免植株的能量在不利环境的无效消耗,将有限的能量用于其较为有效的无性繁殖,增加了在不可预测环境中繁衍的机会,以保障繁殖的成功。它的P/O(花粉/胚珠)值为187.4±22.4,显然是与它的花粉粘合成坚硬块状可在传粉中的高效利用有关,表明该物种仍然保留有性繁殖的特性。该种植物所采取强化无性繁殖,弱化有性繁殖生殖策略是对该地区较为恶劣生态条件的适应,可能正是由于这个原因,疣花三角兰能够在远离其同属近亲的地方生存下来。
基金supported by the ICMR-SRF grants(Indian Council for Medical Research,OMI-Fellowship/23/2018-ECD-I)for this study.
文摘The epiphytic plants belong to a group that harmlessly grows on other plants by utilizing the nutrition from the host plants with their unique adaptation features along with symbiotic associations with fungi or bacteria.The various biological activities exhibited by the mycoendophytes inhabiting medicinally-important epiphytic orchids serve as the primary source of novel drug leads,industrially-essential enzymes,and plant growth-promoting metabolites.In the present study,a total of 956 culturable mycoendophytes out of 1600 segments belonging to 17 genera were isolated from different tissue parts of Trias stocksii and Dendrobium herbaceum.The Xylariaceae taxa were the predominant mycoendophytes present in both plants,followed by Pestalotiopsis sp.,Colletotrichum sp.,and Fusarium sp.An estimation of the Shannon-Wiener and Simpson diversity indices showed that the bulbs of T.stocksii have the highest species diversity index and the stems of D.herbaceum the lowest.The highest species richness was observed in the leaves of T.stocksii and the lowest in the leaves of D.herbaceum.Overall,T.stocksii harbored more mycoendophytes along with the highest diversity indices compared to D.herbaceum.The antimicrobial evaluation revealed that Xylaria sp.has a higher potential of producing anti-infectives and opens a new arena for industrial exploration.
文摘Background Recombinant human GH(rhGH)was first approved to treat children with growth hormone deficiency(GHD)by Food and Drug Administration(FDA)in the United States in 1985.The indications subsequently expanded to growth failure secondary to chronic renal failure,Turner syndrome,Prader‒Willi syndrome,small for gestational age(SGA)without catch-up growth,idiopathic short stature(ISS),SHOX deficiency,Noonan syndrome and so on[1].The efficacy and the safety of rhGH have been proven in randomized controlled trials(RCTs),which are considered the highest level of evidences in clinical practice.However,due to the strict criteria and short observational time,RCTs could not fully reflect the reality of rhGH,especially in terms of safety[2].
基金funded by the Australian National Health and Medical Research Council(NHMRC)Investigator Grant(2008379).
文摘Objective This systematic review assessed trial-based economic evaluations to provide empirical evidence on the cost-effectiveness of non-drug interventions(NDIs)that are currently recommended within the Royal Australian College of General Practitioners Handbook of Non-Drug Interventions(HANDI).Methods Medline,CINAHL and PsycINFO along with clinical trial registries(clinicaltrials.gov and WHO International Clinical Trials Registry Platform)were searched from inception to 1 July 2025.Randomised controlled trials(RCTs)that reported cost effectiveness for a prescribed non-drug intervention(NDI)from HANDI were included in the study.The primary outcome was the incremental cost-utility ratio(ICUR)derived from cost-utility analyses(CUAs).Results A total of 11187 citations were identified,from which 156 RCTs were included.These RCTs enrolled a total of 66926 participants(median=214,IQR 139–342),with a median follow-up duration of 12 months(IQR 6–12 months).Over half of the CUA NDIs were for mental health conditions(n=81;54.0%),one-third were for were for musculoskeletal conditions(n=44;29.3%),while only 16.0%(n=24)were for those with cardiovascular/metabolic conditions.Out of the 150 NDIs that reported CUAs,40%were deemed to be in the south-east(SE)quadrant(cheaper and more effective)and 49.3%fell in the north-east(NE)quadrant(more costly but more effective),with 70%considered cost effective against a￡25000/quality-adjusted life-year(QALY)willingness to pay threshold.The overall median ICUR was￡2400/QALY(IQR−18986 to 20027).Conclusions Most of the HANDI NDIs that were included within this systematic review are cost-effective compared with a variety of alternatives including usual care or waiting list controls.HANDI NDIs warrant use as a first line of treatment when clinically appropriate.
文摘20072040 Zhu Xuebo(College of Earth Sciences,Chengdu University of Technology,Chengdu 610059,China);Liu Dengzhong Paleocommunity Analysis of the Late Devonian--Early Permian in the Huanglong Area,Sichuan Province,China(Journal of Chengdu University of
文摘20061426 Bai Yunshan (Yichang Institute ofGeology and Mineral Resources, Yichang,Hubei 443003); Li Li Characteristics andTectonic Setting of Eerlongba FormationVolcanic Rocks in Geladandong Area of Cen-tral Qiangtang (Acta Geoscientica Sinica,ISSN1006-3021, CN44-1398/P, 26(2),2005, p.113-120, 6 illus., 5 tables, 11refs.)volcanic rocks,
文摘20131708 Cai Xiyao(Research Institute of Exploration&Production,SINOPEC,Beijing100083,China);Jin Xianmei The Stratigraphic Classification and Correlation of Jurassic in Caohu Depression,Tarim Basin(Xinjiang Geology,ISSN1000-8845,CN65-1092/P,30(3),2012,p.287-291,2illus.,1table,10refs.)
