Background and Objective:TriNetX is a global,federated,health research network that has become increasingly utilized in academic medicine.In the last 2 years,the field of ophthalmology has seen an uptick in the number...Background and Objective:TriNetX is a global,federated,health research network that has become increasingly utilized in academic medicine.In the last 2 years,the field of ophthalmology has seen an uptick in the number of publications of TriNetX analyses.The objective of this review is to summarize the process of conducting a TriNetX study,the trends in TriNetX use,and the utility of TriNetX in ophthalmology research.Additionally,the strengths and limitations of TriNetX use in ophthalmology research will be discussed.Methods:A PubMed and Scopus literature search was performed using the search terms:“TriNetX”and“Ophthalmology”or“Eye”.Included articles were English language only from the years 1994 to June 1,2024.The twenty-one included articles were analyzed for trends in study design,strengths,and weaknesses.Additionally,a mock study was performed to describe the process of completing a TriNetX study.Key Content and Findings:The literature search revealed a marked increase in TriNetX publications in ophthalmology journals in the years 2023 to 2024.Using a methodology similar to the studies identified in the literature search,a mock investigation of the relationship between cataract removal and hip fracture was detailed from start to finish,providing a framework for the use of TriNetX in ophthalmology research.The mock study provided results consistent with previously reported findings.Lastly,a thorough review of the strengths and limitations of TriNetX identified major considerations in study design,coding,data availability,propensity score matching,bias,and analytical challenges that researchers must be aware of when conducting research with TriNetX.However,many of the discussed limitations can be circumvented with careful and informed use of the platform.Conclusions:TriNetX is a powerful research tool that offers volumetric advantages and time efficiency,making it an attractive option for conducting observational studies.Despite its strengths,caution must be exercised when designing studies to ensure their validity and quality.With careful informed use,TriNetX is a valuable resource in ophthalmology research.展开更多
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient popula...BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient population.However,these conditions seem to have disparate rates and outcomes between different ethnic populations.The combination of MASLD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma(HCC),and Hispanic patients experience the greatest burden,particularly those in South Texas.AIM To compare outcomes between Hispanic and non-Hispanic patients in the United States,while further focusing on the Hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic consideration.METHODS This cohort analysis was conducted with data obtained from TriNetX,LLC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations worldwide.Two cohort networks were used:University of Texas Medical Branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast Texas.RESULTS This study findings revealed Hispanics/Latinos have a statistically significant higher occurrence of HCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/Latino groups.Allcause mortality in Hispanics/Latinos was lower within the United States group and not statistically elevated in the UTMB cohort.CONCLUSION This would appear to support that Hispanic patients in Southeast Texas are not uniquely affected compared to the national Hispanic population.展开更多
文摘Background and Objective:TriNetX is a global,federated,health research network that has become increasingly utilized in academic medicine.In the last 2 years,the field of ophthalmology has seen an uptick in the number of publications of TriNetX analyses.The objective of this review is to summarize the process of conducting a TriNetX study,the trends in TriNetX use,and the utility of TriNetX in ophthalmology research.Additionally,the strengths and limitations of TriNetX use in ophthalmology research will be discussed.Methods:A PubMed and Scopus literature search was performed using the search terms:“TriNetX”and“Ophthalmology”or“Eye”.Included articles were English language only from the years 1994 to June 1,2024.The twenty-one included articles were analyzed for trends in study design,strengths,and weaknesses.Additionally,a mock study was performed to describe the process of completing a TriNetX study.Key Content and Findings:The literature search revealed a marked increase in TriNetX publications in ophthalmology journals in the years 2023 to 2024.Using a methodology similar to the studies identified in the literature search,a mock investigation of the relationship between cataract removal and hip fracture was detailed from start to finish,providing a framework for the use of TriNetX in ophthalmology research.The mock study provided results consistent with previously reported findings.Lastly,a thorough review of the strengths and limitations of TriNetX identified major considerations in study design,coding,data availability,propensity score matching,bias,and analytical challenges that researchers must be aware of when conducting research with TriNetX.However,many of the discussed limitations can be circumvented with careful and informed use of the platform.Conclusions:TriNetX is a powerful research tool that offers volumetric advantages and time efficiency,making it an attractive option for conducting observational studies.Despite its strengths,caution must be exercised when designing studies to ensure their validity and quality.With careful informed use,TriNetX is a valuable resource in ophthalmology research.
基金Supported by Institute for Translational Sciences at the University of Texas Medical Branch,supported in part by a Clinical and Translational Science Award from the National Center for Advancing Translational Sciences at the National Institutes of Health,UL1TR001439Moody Endowment Grant,2014-07.
文摘BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient population.However,these conditions seem to have disparate rates and outcomes between different ethnic populations.The combination of MASLD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma(HCC),and Hispanic patients experience the greatest burden,particularly those in South Texas.AIM To compare outcomes between Hispanic and non-Hispanic patients in the United States,while further focusing on the Hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic consideration.METHODS This cohort analysis was conducted with data obtained from TriNetX,LLC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations worldwide.Two cohort networks were used:University of Texas Medical Branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast Texas.RESULTS This study findings revealed Hispanics/Latinos have a statistically significant higher occurrence of HCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/Latino groups.Allcause mortality in Hispanics/Latinos was lower within the United States group and not statistically elevated in the UTMB cohort.CONCLUSION This would appear to support that Hispanic patients in Southeast Texas are not uniquely affected compared to the national Hispanic population.
