We conducted the ambient noise tomography to image the shallow crustal structure of southern Tibet. The2D maps of phase velocity anomalies at the periods of10–16 s show that the low velocities are mainly confined alo...We conducted the ambient noise tomography to image the shallow crustal structure of southern Tibet. The2D maps of phase velocity anomalies at the periods of10–16 s show that the low velocities are mainly confined along or near some of the rift zones. While the maps at the periods of 18–25 s show that the coherent patterns that the low velocities expand outside of the rift zones. It means that the low velocities are prevailing in the middle crust of southern Tibet. According to the previous study of surface wave tomography with teleseismic data,we find that the low velocities from the lower crust to the lithospheric mantle are also restricted to the same rift zones. Thus,the integrated knowledge of the distribution of the low velocities in southern Tibet provides some new insight on the formation of the north–south trending rift zones. Compiling the multidiscipline evidences,we conclude that the rifting was an integrated process of the entire lithosphere in the early stage（＊26–10 Ma）,but mainly occurred within the upper crust due to the weakening a decoupling in the low velocity middle crust in the late stage（later than ＊8 Ma）.展开更多
Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proo...Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proof on 28 September 2025 without any questions.However,on 13 November 2025,the Editorial Office of Medical Data Mining noticed an inconsistency between the data presented in the main text and Figure 1.Specifically,erroneous Figure 1 states“a total of 56,691 literatures were obtained through database search”,while the main text in the Search results section states“According to the search term,a total of 59,220 publications were retrieved from the database.”The authors acknowledge that the original version of Figure 1 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.展开更多
AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 ...AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countries/regions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation.展开更多
Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical ca...Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.展开更多
Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the gl...Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the global burden of esophageal,gastric,and liver cancers in 2022 and analyzes the trends of age-standardized incidence and mortality rate(ASRs)in China from 2000 to 2018,thereby providing evidence for the formulation of cancer control strategies.Methods The global burden of esophageal,gastric and liver cancers including the estimated number of cases and deaths and the ASRs for incidence and mortality were from GLOBALCAN 2022 dataset.Data from 22 cancer registries in China were employed for the trend analysis of the ASRs for incidence and mortality of these three cancers.The Joinpoint model was used to compute the average annual percentage change(AAPC)of the incidence and mortality of the three cancers from 2000 to 2018.Results Globally,esophageal,gastric and liver cancers accounted for 11.8%of incident cancer cases and 19.1%of cancer deaths.China bore a disproportionately high burden,representing 43.8%,37.0%,and 42.4%of global esophageal,gastric,and liver cancer cases respectively,and 42.1%,39.4%,and 41.7%of corresponding deaths.However,the ASRs for incidence and mortality for all three cancers declined significantly in China(2000–2018),with absolute case numbers decreasing for gastric and esophageal cancers during 2010–2022.Age-specific analysis revealed most pronounced declines in incidence and mortality in populations under 40 years old,with AAPCs of less than–6.0%for esophageal cancer,around–4.0%for gastric cancer,and approximately–2.0%for liver cancer.Conclusions China has achieved remarkable progress in controlling esophageal,gastric and liver cancers,yet these malignancies remain major public health challenges.Future efforts should intensify existing prevention measures while expanding screening programs,particularly for aging populations.These findings offer valuable insights for regions undergoing similar epidemiological transitions.展开更多
Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examine...Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examined.In this study,we apply two widely-used objective methods,the self-organizing map(SOM)and K-means clustering analysis,to derive ozone-favorable SWPs at four Chinese megacities in 2015-2022.We find that the two algorithms are largely consistent in recognizing dominant ozone-favorable SWPs for four Chinese megacities.In the case of classifying six SWPs,the derived circulation fields are highly similar with a spatial correlation of 0.99 between the two methods,and the difference in themean frequency of each SWP is less than 7%.The six dominant ozone-favorable SWPs in Guangzhou are all characterized by anomaly higher radiation and temperature,lower cloud cover,relative humidity,and wind speed,and stronger subsidence compared to climatology mean.We find that during 2015-2022,the occurrence of ozone-favorable SWPs days increases significantly at a rate of 3.2 days/year,faster than the increases in the ozone exceedance days(3.0 days/year).The interannual variability between the occurrence of ozone-favorable SWPs and ozone exceedance days are generally consistent with a temporal correlation coefficient of 0.6.In particular,the significant increase in ozone-favorable SWPs in 2022,especially the Subtropical High type which typically occurs in September,is consistent with a long-lasting ozone pollution episode in Guangzhou during September 2022.Our results thus reveal that enhanced frequency of ozone-favorable SWPs plays an important role in the observed 2015-2022 ozone increase in Guangzhou.展开更多
Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 count...Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 countries and territories from 1990 to 2019 and predicted future incidence trends through 2034.Methods COPD data by age and sex from the GBD 2019 database were analyzed for incidence,prevalence,mortality,and disability-adjusted life years(DALY)rates from 1990 to 2019.Joinpoint regression identified significant annual trends,and age-standardized incidence rates were predicted through 2034 using age-period-cohort models.Results The incidence,prevalence,mortality,and disease burden of COPD have been decreasing,and the incidence rates will continue to decrease or remain stable until 2034 in most selected countries and territories,except for a few Southeastern Asian countries.The Lao People’s Democratic Republic and Vietnam are projected to experience an increase in COPD incidence from 165.3 per 100,000 in 2019 to 177 per 100,000 in 2034 and from 179.9 per 100,000 in 2019 to 192.5 per 100,000 in 2034,respectively.Older males had a higher incidence than any other sex or age group.The sex gap in incidence rates continues to widen,though it is smaller and less significant in the younger age group than in those in the older one.Conclusion COPD rates are expected to decline until 2034 but remain a health risk,especially in countries with rising rates.Urgent action on tobacco control,air pollution,and public education is needed.展开更多
Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based ...Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based on the GLOBOCAN 2022,the age-standardized incidence rate(ASIR)and mortality rate(ASMR)were compared and linked to the Human Development Index(HDI)across different populations.The temporal trends in ASIR/ASMR were characterized as estimated annual percentage change(EAPC),and demographic projections were performed up to 2050.Results Globally,an estimated 2,480,675 cases and 1,817,469 deaths from lung cancer occurred in 2022.Both ASIR and ASMR of lung cancer varied widely by world region,with ASIR ranging from 2.06 to 39.38 per 100,000 and ASMR from 1.95 to 31.70 per 100,000.China alone accounted for>40%of cases and deaths worldwide.Both ASIR and ARMR of lung cancer increased with HDI(R2:0.54 and 0.47,all P values<0.001),regardless of gender.Based on available data,both ASIR during 2001–2010 and ASMR during 2001–2015 showed decreasing trends in males(EAPC:1.50%and−2.22%)but increasing trends in females(EAPC:1.08%and 0.07%).Similar trends in ASIR and ASMR were observed among the elder population(≥50 years);however,downward trends were observed in the younger population(<50 years).Alongside the aging and growth of the population,estimated cases and deaths from overall lung cancer would increase by 86.2%and 95.2%up to 2050 as compared with estimates in 2022,respectively.Notably,increased early-onset lung cancer was only observed in transitioning countries,while decreased early-onset lung cancer was observed in transitioned countries.Conclusion Lung cancer maintained as the leading cancer burden worldwide.Unless timely preventive interventions in tobacco mitigation,early screening,and precise treatment,the global lung cancer burden is expected to increase in the future,especially for transitioning countries.展开更多
Objective This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.Methods This study utilized Global Burden of Disease(GBD)1990-2050 prediction data to analyze...Objective This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.Methods This study utilized Global Burden of Disease(GBD)1990-2050 prediction data to analyze changes in mortality rates and disability-adjusted life year(DALY)rates for lower respiratory infections in the elderly population(aged 70 and above)in China from 1990 to 2050.It also discusses future trends in the burden of lower respiratory infections(LRI)in China under different scenarios.Results According to GBD predictions,the burden of lower respiratory infections in the elderly aged 70 years and above in China is lower than the global average.The burden has been decreasing from 1990 to 2020,but is projected to increase from 2020 to 2050.Scenario-based predictions suggest that,under scenarios involving improvements in nutrition and vaccination,the burden of lower respiratory infections in the elderly in China is expected to be the lowest in 2050.Conclusion This study indicates that the burden of lower respiratory infections in elderly people aged 70 years and above in China remains a significant public health issue and may worsen.The government should consider strengthening the preventive measures and management strategies for respiratory infections in the elderly population.展开更多
Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pest...Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pests and their natural enemies is required to minimize the pest population and yield losses.In the current study,analysis of the seasonal population trend of pests and natural enemies and their relative occurrence on cultivars of three cotton species in Central India has been carried out.Results A higher number and diversity of sucking pests were observed during the vegetative cotton growth stage(60 days after sowing),declining as the crop matured.With the exception of cotton jassid(Amrasca biguttula biguttula Ishida),which caused significant crop damage mainly from August to September;populations of other sucking insects seldom reached economic threshold levels(ETL)throughout the studied period.The bollworm complex populations were minimal,except for the pink bollworm(Pectinophora gossypiella Saunders),which re-emerged as a menace to cotton crops during the cotton cropping season 2017–2018 due to resistance development against Bt-cotton.A reasonably good number of predatory arthropods,including coccinellids,lacewings,and spiders,were found actively preying on the arthropod pest complex of the cotton crop during the early vegetative growth stage.Linear regression indicates a significant relationship between green boll infestations and pink bollworm moths in pheromone traps.Multiple linear regression analyse showed mean weekly weather at one-or two-week lag periods had a significant impact on sucking pest population(cotton aphid,cotton jassid,cotton whitefly,and onion thrips)fluctuation.Gossypium hirsutum cultivars RCH 2 and DCH 32,and G.barbadense cultivar Suvin were found susceptible to cotton jassid and onion thrips.Phule Dhanvantary,an G.arboreum cotton cultivar,demonstrated the highest tolerance among all evaluated cultivars against all sucking pests.Conclusion These findings have important implications for pest management in cotton crops.Susceptible cultivars warrant more attention for plant protection measures,making them more input-intensive.The choice of appropriate cultivars can help minimize input costs,thereby increasing net returns for cotton farmers.展开更多
Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition wi...Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition with Random Forest algorithm to investigate ozone dynamics and formation regimes in a coastal area of China.During the period of 2017–2022,significant inter-annual fluctuations emerged,with peaks in mid-2017 attributed to volatile organic compounds(VOCs),and in late-2019 influenced by air temperature.Multifaceted periodicities(daily,weekly,holiday,and yearly)in ozone were revealed,elucidating substantial influences of daily and yearly components on ozone periodicity.A VOC-sensitive ozone formation regime was identified,characterized by lower VOCs/NO_(x) ratios(average=0.88)and significant positive correlations between ozone and VOCs.This interplay manifested in elevated ozone duringweekends,holidays,and pandemic lockdowns.Key variables influencing ozone across diverse timescaleswere uncovered,with solar radiation and temperature driving daily and yearly ozone variations,respectively.Precursor substances,particularly VOCs,significantly shaped weekly/holiday patterns and long-term trends of ozone.Specifically,acetone,ethane,hexanal,and toluene had a notable impact on the multi-year ozone trend,emphasizing the urgency of VOC regulation.Furthermore,our observations indicated that NO_(x) primarily drived the stochastic variations in ozone,a distinguishing characteristic of regions with heavy traffic.This research provides novel insights into ozone dynamics in coastal urban areas and highlights the importance of integrating statistical and machinelearning methods in atmospheric pollution studies,with implications for targeted mitigation strategies beyond this specific region and pollutant.展开更多
Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyro...Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyroidism.This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them.To the best of our knowledge,this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United States.In this 21-year analysis of mortality data,we found a constant increase in mortality rates due to AF/AFL in older adults.From 1999 to 2020,the overall mortality in older adults aged 65 and above,regardless of sex and race,is found to be almost doubled i.e.about a 50.2%increase in the number of deaths due to AF/AFL.Furthermore,other confounding risk factors such has obesity,prior myocardial infarction,inflammation,hypertension,birth weight,diabetes mellitus,hyperthyroidism,hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.展开更多
Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were ...Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were sourced from GLOBOCAN 2022,including estimated new cases and deaths from BC across 21 United Nation(UN)regions and 185 countries,the age-standardized incidence rate(ASIR)and mortality rate(ASMR),the estimated annual percentage changes(EAPC),and demographic projections through 2050.The region-specific and country-specific BC burden for women of all ages and for young women(<40 years old)was reorganized and re-plotted to highlight subgroup differences.Linear regression was used to explore the link between ASIR/ASMR and the human development index(HDI).Transitioning countries referred to those with low or medium HDI,while transitioned countries were those with high or very high HDI.Results In 2022,an estimated 2.3 million new BC cases and 666,000 BC-related deaths occurred globally,accounting for 23.8%and 15.4%of all cancer cases and deaths in women,respectively.Regionally,Eastern Asia reported the highest number of cases(480,019,ASIR:37.54/100,000),while South-Central Asia had the highest number of deaths(135,348,ASMR:13.41/100,000).At the country level,China had the highest number of cases due to its large population,whereas India reported the highest number of deaths.ASIR for both overall and early-onset BC increased with HDI,while ASMR for early-onset BC decreased with HDI(P<0.05).Overall BC showed an increasing trend in ASIR during 2003–2015(EAPC:0.92%)and a decreasing trend in ASMR during 2006–2016(EAPC:-1.06%).Early-onset BC showed a more significant rise in ASIR(EAPCs:1.4%)and a slight increase in ASMR(EAPCs:0.16%).If national rates remain stable,BC cases and deaths will increase by 54.7%and 70.9%,respectively,by 2050.Notably,increased early-onset BC cases are only observed in transitioning countries,while decreased cases are seen in transitioned countries.Conclusions Breast cancer remains the leading cancer burden in women,particularly in transitioning countries.Addressing this growing burden requires urgent integration of primary prevention,early detection and high-quality treatment through multi-sectoral collaboration.展开更多
Mesoscale eddies play a central role in the poleward oceanic heat flux in the Southern Ocean.Previous studies have documented changes in the location of temperature fronts in the Southern Ocean,but little attention ha...Mesoscale eddies play a central role in the poleward oceanic heat flux in the Southern Ocean.Previous studies have documented changes in the location of temperature fronts in the Southern Ocean,but little attention has been paid to changes in the genesis locations of mesoscale eddies.Here,we provide evidence from three decades of satellite altimetry observations for the heterogeneity of the poleward shift of mesoscale activities,with the largest trend of~0.23°±0.05°(10 yr)^(-1) over the Atlantic sector and a moderate trend of~0.1°±0.03°(10 yr)^(-1) over the Indian sector,but no significant trend in the Pacific sector.The poleward shift of mesoscale eddies is associated with a southward shift of the local westerly winds while being constrained by the major topographies.As the poleward shift of westerly winds is projected to persist,the poleward oceanic heat flux from mesoscale eddies may influence future ice melt.展开更多
BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel treatments.Ubiquitination,an intracellular protein modification process,is emerging as a promising strategy for regulating ...BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel treatments.Ubiquitination,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological mechanisms.We hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic approaches.AIM To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric analysis.METHODS Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core Collection.Visual mapping analysis was conducted using the CiteSpace software.RESULTS We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated complications.These articles originated from 54 countries and 386 institutions,with China as the leading contributor.Shanghai Jiao Tong University has the highest number of publications in this field.The most prominent authors contributing to this research area include Wei-Hua Zhang,with Zhang Y being the most frequently cited author.Additionally,The Journal of Biological Chemistry is noted as the most cited in this field.The predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin resistance.CONCLUSION The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research focus.However,these areas require further investigations.展开更多
Forest ecosystems play key roles in mitigating human-induced climate change through enhanced carbon uptake;however,frequently occurring climate extremes and human activities have considerably threatened the stability ...Forest ecosystems play key roles in mitigating human-induced climate change through enhanced carbon uptake;however,frequently occurring climate extremes and human activities have considerably threatened the stability of forests.At the same time,detailed accounts of disturbances and forest responses are not yet well quantified in Asia.This study employed the Breaks For Additive Seasonal and Trend method-an abrupt-change detection method-to analyze the Enhanced Vegetation Index time series in East Asia,South Asia,and Southeast Asia.This approach allowed us to detect forest disturbance and quantify the resilience after disturbance.Results showed that 20%of forests experienced disturbance with an increasing trend from 2000 to 2022,and Southeast Asian countries were more severely affected by disturbances.Specifically,95%of forests had robust resilience and could recover from disturbance within a few decades.The resilience of forests suffering from greater magnitude of disturbance tended to be stronger than forests with lower disturbance magnitude.In summary,this study investigated the resilience of forests across the low and middle latitudes of Asia over the past two decades.The authors found that most forests exhibited good resilience after disturbance and about two-thirds had recovered to a better state in 2022.The findings of this study underscore the complex relationship between disturbance and resilience,contributing to comprehension of forest resilience through satellite remote sensing.展开更多
BACKGROUND Diabetic foot ulcers(DFUs)are a significant contributor to disability and mortality in diabetic patients.Macrophage polarization and functional regulation are promising areas of research and show therapeuti...BACKGROUND Diabetic foot ulcers(DFUs)are a significant contributor to disability and mortality in diabetic patients.Macrophage polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU healing.However,the complex mechanism,the difficulty in clinical translation,and the large heterogeneity present significant challenges.Hence,this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU healing.AIM To examine the relevant literature on macrophage polarization in DFU healing.METHODS A bibliometric analysis was conducted using the Web of Science database.Relevant literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software(VOSviewer and CiteSpace)and bibliometric online platforms.The obtained literature was then subjected to visualization and analysis of different countries/regions,institutions,journals,authors,and keywords to reveal the research’s major trends and focus.RESULTS The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023,especially in the latter period.Chinese researchers were the most prolific in this field,with 217 publications,while American researchers had been engaged in this field for a longer period.Qian Tan of Nanjing Drum Tower Hospital and Qian Ding of Nanjing University were the first to publish in this field.Shanghai Jiao Tong University was the institution with the most publications(27).The keywords“bone marrow”,“adjustment,replacement,response,tissue repair”,and“activation,repair,differentiation”appeared more frequently.The study of macrophage polarization in DFU healing focused on the regulatory mechanism,gene expression,and other aspects.CONCLUSION This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polarization in DFU healing from 2013 to 2023 in the Web of Science Core Collection database.The key hotspots in this field mainly include the regulation of macrophage activation,gene expression,wound tissue repair,and new wound materials.This study provides references for future research directions.展开更多
The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue a...The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-II photodiagnosis and phototherapy research over the past decade,bibliometric analy⁃sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-II-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur⁃rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re⁃search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-II imaging clini⁃cal trials.This study delineates the NIR-II research trajectory,highlighting China's leadership,intensifying glob⁃al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-II probe devel⁃opment for NIR-II imaging and clinical translation of photodynamic/immunotherapy combinational platforms.展开更多
基金funded by the National Natural Science Foundation of China (Grant No.: 41274002 and 41125015)
文摘We conducted the ambient noise tomography to image the shallow crustal structure of southern Tibet. The2D maps of phase velocity anomalies at the periods of10–16 s show that the low velocities are mainly confined along or near some of the rift zones. While the maps at the periods of 18–25 s show that the coherent patterns that the low velocities expand outside of the rift zones. It means that the low velocities are prevailing in the middle crust of southern Tibet. According to the previous study of surface wave tomography with teleseismic data,we find that the low velocities from the lower crust to the lithospheric mantle are also restricted to the same rift zones. Thus,the integrated knowledge of the distribution of the low velocities in southern Tibet provides some new insight on the formation of the north–south trending rift zones. Compiling the multidiscipline evidences,we conclude that the rifting was an integrated process of the entire lithosphere in the early stage（＊26–10 Ma）,but mainly occurred within the upper crust due to the weakening a decoupling in the low velocity middle crust in the late stage（later than ＊8 Ma）.
文摘Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proof on 28 September 2025 without any questions.However,on 13 November 2025,the Editorial Office of Medical Data Mining noticed an inconsistency between the data presented in the main text and Figure 1.Specifically,erroneous Figure 1 states“a total of 56,691 literatures were obtained through database search”,while the main text in the Search results section states“According to the search term,a total of 59,220 publications were retrieved from the database.”The authors acknowledge that the original version of Figure 1 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.
基金Supported by National Natural Science Foundation of China(No.82020108006,No.81730025).
文摘AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countries/regions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation.
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)National Natural Science Foundation of China(grant numbers:82172894,82073028,82204121)China Postdoctoral Science Foundation(grant number:2023M742617).
文摘Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.
基金supported by the National Natural Science Foundation of China(grant numbers:82273721,82304220)Cooperation Fund of CHCAMS and SZCH(grant number:CFA202201003).
文摘Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the global burden of esophageal,gastric,and liver cancers in 2022 and analyzes the trends of age-standardized incidence and mortality rate(ASRs)in China from 2000 to 2018,thereby providing evidence for the formulation of cancer control strategies.Methods The global burden of esophageal,gastric and liver cancers including the estimated number of cases and deaths and the ASRs for incidence and mortality were from GLOBALCAN 2022 dataset.Data from 22 cancer registries in China were employed for the trend analysis of the ASRs for incidence and mortality of these three cancers.The Joinpoint model was used to compute the average annual percentage change(AAPC)of the incidence and mortality of the three cancers from 2000 to 2018.Results Globally,esophageal,gastric and liver cancers accounted for 11.8%of incident cancer cases and 19.1%of cancer deaths.China bore a disproportionately high burden,representing 43.8%,37.0%,and 42.4%of global esophageal,gastric,and liver cancer cases respectively,and 42.1%,39.4%,and 41.7%of corresponding deaths.However,the ASRs for incidence and mortality for all three cancers declined significantly in China(2000–2018),with absolute case numbers decreasing for gastric and esophageal cancers during 2010–2022.Age-specific analysis revealed most pronounced declines in incidence and mortality in populations under 40 years old,with AAPCs of less than–6.0%for esophageal cancer,around–4.0%for gastric cancer,and approximately–2.0%for liver cancer.Conclusions China has achieved remarkable progress in controlling esophageal,gastric and liver cancers,yet these malignancies remain major public health challenges.Future efforts should intensify existing prevention measures while expanding screening programs,particularly for aging populations.These findings offer valuable insights for regions undergoing similar epidemiological transitions.
基金supported by the Guangdong Basic and Applied Basic Research project (No.2020B0301030004)the Key-Area Research and Development Program of Guangdong Province (No.2020B1111360003)+1 种基金the National Natural Science Foundation of China (No.42105103)the Guangdong Basic and Applied Basic Research Foundation (No.2022A1515011554).
文摘Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examined.In this study,we apply two widely-used objective methods,the self-organizing map(SOM)and K-means clustering analysis,to derive ozone-favorable SWPs at four Chinese megacities in 2015-2022.We find that the two algorithms are largely consistent in recognizing dominant ozone-favorable SWPs for four Chinese megacities.In the case of classifying six SWPs,the derived circulation fields are highly similar with a spatial correlation of 0.99 between the two methods,and the difference in themean frequency of each SWP is less than 7%.The six dominant ozone-favorable SWPs in Guangzhou are all characterized by anomaly higher radiation and temperature,lower cloud cover,relative humidity,and wind speed,and stronger subsidence compared to climatology mean.We find that during 2015-2022,the occurrence of ozone-favorable SWPs days increases significantly at a rate of 3.2 days/year,faster than the increases in the ozone exceedance days(3.0 days/year).The interannual variability between the occurrence of ozone-favorable SWPs and ozone exceedance days are generally consistent with a temporal correlation coefficient of 0.6.In particular,the significant increase in ozone-favorable SWPs in 2022,especially the Subtropical High type which typically occurs in September,is consistent with a long-lasting ozone pollution episode in Guangzhou during September 2022.Our results thus reveal that enhanced frequency of ozone-favorable SWPs plays an important role in the observed 2015-2022 ozone increase in Guangzhou.
基金supported by a major project of the Zhejiang Natural Science Foundation(LD21G030001).
文摘Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 countries and territories from 1990 to 2019 and predicted future incidence trends through 2034.Methods COPD data by age and sex from the GBD 2019 database were analyzed for incidence,prevalence,mortality,and disability-adjusted life years(DALY)rates from 1990 to 2019.Joinpoint regression identified significant annual trends,and age-standardized incidence rates were predicted through 2034 using age-period-cohort models.Results The incidence,prevalence,mortality,and disease burden of COPD have been decreasing,and the incidence rates will continue to decrease or remain stable until 2034 in most selected countries and territories,except for a few Southeastern Asian countries.The Lao People’s Democratic Republic and Vietnam are projected to experience an increase in COPD incidence from 165.3 per 100,000 in 2019 to 177 per 100,000 in 2034 and from 179.9 per 100,000 in 2019 to 192.5 per 100,000 in 2034,respectively.Older males had a higher incidence than any other sex or age group.The sex gap in incidence rates continues to widen,though it is smaller and less significant in the younger age group than in those in the older one.Conclusion COPD rates are expected to decline until 2034 but remain a health risk,especially in countries with rising rates.Urgent action on tobacco control,air pollution,and public education is needed.
基金supported by the National Key Research and Development Program of China(grant number:2021YFC2500400)Tianjin Health Committee Foundation(grant number:TJWJ2021MS008)+2 种基金Tianjin Key Medical Discipline(Specialty)Construction Project(grant number:TYXZDXK-009A)Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences(grant number:2023GLLH0132)Scientific Research Fund for the Demonstration Project of Public Hospital Reform and Quality Development(Gastrointestinal Tumour)that is approved by Peking University Cancer Hospital(Inner Mongolia Campus)(grant number:2023SGGZ068)。
文摘Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based on the GLOBOCAN 2022,the age-standardized incidence rate(ASIR)and mortality rate(ASMR)were compared and linked to the Human Development Index(HDI)across different populations.The temporal trends in ASIR/ASMR were characterized as estimated annual percentage change(EAPC),and demographic projections were performed up to 2050.Results Globally,an estimated 2,480,675 cases and 1,817,469 deaths from lung cancer occurred in 2022.Both ASIR and ASMR of lung cancer varied widely by world region,with ASIR ranging from 2.06 to 39.38 per 100,000 and ASMR from 1.95 to 31.70 per 100,000.China alone accounted for>40%of cases and deaths worldwide.Both ASIR and ARMR of lung cancer increased with HDI(R2:0.54 and 0.47,all P values<0.001),regardless of gender.Based on available data,both ASIR during 2001–2010 and ASMR during 2001–2015 showed decreasing trends in males(EAPC:1.50%and−2.22%)but increasing trends in females(EAPC:1.08%and 0.07%).Similar trends in ASIR and ASMR were observed among the elder population(≥50 years);however,downward trends were observed in the younger population(<50 years).Alongside the aging and growth of the population,estimated cases and deaths from overall lung cancer would increase by 86.2%and 95.2%up to 2050 as compared with estimates in 2022,respectively.Notably,increased early-onset lung cancer was only observed in transitioning countries,while decreased early-onset lung cancer was observed in transitioned countries.Conclusion Lung cancer maintained as the leading cancer burden worldwide.Unless timely preventive interventions in tobacco mitigation,early screening,and precise treatment,the global lung cancer burden is expected to increase in the future,especially for transitioning countries.
基金supported by the National High Level Hospital Clinical Research Funding(No.BJ-2023-066).
文摘Objective This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.Methods This study utilized Global Burden of Disease(GBD)1990-2050 prediction data to analyze changes in mortality rates and disability-adjusted life year(DALY)rates for lower respiratory infections in the elderly population(aged 70 and above)in China from 1990 to 2050.It also discusses future trends in the burden of lower respiratory infections(LRI)in China under different scenarios.Results According to GBD predictions,the burden of lower respiratory infections in the elderly aged 70 years and above in China is lower than the global average.The burden has been decreasing from 1990 to 2020,but is projected to increase from 2020 to 2050.Scenario-based predictions suggest that,under scenarios involving improvements in nutrition and vaccination,the burden of lower respiratory infections in the elderly in China is expected to be the lowest in 2050.Conclusion This study indicates that the burden of lower respiratory infections in elderly people aged 70 years and above in China remains a significant public health issue and may worsen.The government should consider strengthening the preventive measures and management strategies for respiratory infections in the elderly population.
基金Funding support for the Crop Pest Surveillance and Advisory Project(CROPSAP)。
文摘Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pests and their natural enemies is required to minimize the pest population and yield losses.In the current study,analysis of the seasonal population trend of pests and natural enemies and their relative occurrence on cultivars of three cotton species in Central India has been carried out.Results A higher number and diversity of sucking pests were observed during the vegetative cotton growth stage(60 days after sowing),declining as the crop matured.With the exception of cotton jassid(Amrasca biguttula biguttula Ishida),which caused significant crop damage mainly from August to September;populations of other sucking insects seldom reached economic threshold levels(ETL)throughout the studied period.The bollworm complex populations were minimal,except for the pink bollworm(Pectinophora gossypiella Saunders),which re-emerged as a menace to cotton crops during the cotton cropping season 2017–2018 due to resistance development against Bt-cotton.A reasonably good number of predatory arthropods,including coccinellids,lacewings,and spiders,were found actively preying on the arthropod pest complex of the cotton crop during the early vegetative growth stage.Linear regression indicates a significant relationship between green boll infestations and pink bollworm moths in pheromone traps.Multiple linear regression analyse showed mean weekly weather at one-or two-week lag periods had a significant impact on sucking pest population(cotton aphid,cotton jassid,cotton whitefly,and onion thrips)fluctuation.Gossypium hirsutum cultivars RCH 2 and DCH 32,and G.barbadense cultivar Suvin were found susceptible to cotton jassid and onion thrips.Phule Dhanvantary,an G.arboreum cotton cultivar,demonstrated the highest tolerance among all evaluated cultivars against all sucking pests.Conclusion These findings have important implications for pest management in cotton crops.Susceptible cultivars warrant more attention for plant protection measures,making them more input-intensive.The choice of appropriate cultivars can help minimize input costs,thereby increasing net returns for cotton farmers.
基金supported by Ningbo Natural Science Foundation(No.2023J059)Ningbo Commonweal Programme Key Project(No.2023S038)Guangxi Key Research and Development Programme(No.GuikeAB21220063).
文摘Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition with Random Forest algorithm to investigate ozone dynamics and formation regimes in a coastal area of China.During the period of 2017–2022,significant inter-annual fluctuations emerged,with peaks in mid-2017 attributed to volatile organic compounds(VOCs),and in late-2019 influenced by air temperature.Multifaceted periodicities(daily,weekly,holiday,and yearly)in ozone were revealed,elucidating substantial influences of daily and yearly components on ozone periodicity.A VOC-sensitive ozone formation regime was identified,characterized by lower VOCs/NO_(x) ratios(average=0.88)and significant positive correlations between ozone and VOCs.This interplay manifested in elevated ozone duringweekends,holidays,and pandemic lockdowns.Key variables influencing ozone across diverse timescaleswere uncovered,with solar radiation and temperature driving daily and yearly ozone variations,respectively.Precursor substances,particularly VOCs,significantly shaped weekly/holiday patterns and long-term trends of ozone.Specifically,acetone,ethane,hexanal,and toluene had a notable impact on the multi-year ozone trend,emphasizing the urgency of VOC regulation.Furthermore,our observations indicated that NO_(x) primarily drived the stochastic variations in ozone,a distinguishing characteristic of regions with heavy traffic.This research provides novel insights into ozone dynamics in coastal urban areas and highlights the importance of integrating statistical and machinelearning methods in atmospheric pollution studies,with implications for targeted mitigation strategies beyond this specific region and pollutant.
文摘Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyroidism.This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them.To the best of our knowledge,this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United States.In this 21-year analysis of mortality data,we found a constant increase in mortality rates due to AF/AFL in older adults.From 1999 to 2020,the overall mortality in older adults aged 65 and above,regardless of sex and race,is found to be almost doubled i.e.about a 50.2%increase in the number of deaths due to AF/AFL.Furthermore,other confounding risk factors such has obesity,prior myocardial infarction,inflammation,hypertension,birth weight,diabetes mellitus,hyperthyroidism,hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)Tianjin Health Committee Foundation(grant number:TJWJ2021MS008).
文摘Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were sourced from GLOBOCAN 2022,including estimated new cases and deaths from BC across 21 United Nation(UN)regions and 185 countries,the age-standardized incidence rate(ASIR)and mortality rate(ASMR),the estimated annual percentage changes(EAPC),and demographic projections through 2050.The region-specific and country-specific BC burden for women of all ages and for young women(<40 years old)was reorganized and re-plotted to highlight subgroup differences.Linear regression was used to explore the link between ASIR/ASMR and the human development index(HDI).Transitioning countries referred to those with low or medium HDI,while transitioned countries were those with high or very high HDI.Results In 2022,an estimated 2.3 million new BC cases and 666,000 BC-related deaths occurred globally,accounting for 23.8%and 15.4%of all cancer cases and deaths in women,respectively.Regionally,Eastern Asia reported the highest number of cases(480,019,ASIR:37.54/100,000),while South-Central Asia had the highest number of deaths(135,348,ASMR:13.41/100,000).At the country level,China had the highest number of cases due to its large population,whereas India reported the highest number of deaths.ASIR for both overall and early-onset BC increased with HDI,while ASMR for early-onset BC decreased with HDI(P<0.05).Overall BC showed an increasing trend in ASIR during 2003–2015(EAPC:0.92%)and a decreasing trend in ASMR during 2006–2016(EAPC:-1.06%).Early-onset BC showed a more significant rise in ASIR(EAPCs:1.4%)and a slight increase in ASMR(EAPCs:0.16%).If national rates remain stable,BC cases and deaths will increase by 54.7%and 70.9%,respectively,by 2050.Notably,increased early-onset BC cases are only observed in transitioning countries,while decreased cases are seen in transitioned countries.Conclusions Breast cancer remains the leading cancer burden in women,particularly in transitioning countries.Addressing this growing burden requires urgent integration of primary prevention,early detection and high-quality treatment through multi-sectoral collaboration.
基金supported by the National Natural Science Foundation of China(Grant Nos.42230405,42006029)Science and Technology Plan of Liaoning Province(2024JH2/102400061)+1 种基金Dalian Science and Technology Innovation Fund(2024JJ11PT007)Dalian Science and Technology Pro-gram for Innovation Talents of Dalian(2022RJ06).
文摘Mesoscale eddies play a central role in the poleward oceanic heat flux in the Southern Ocean.Previous studies have documented changes in the location of temperature fronts in the Southern Ocean,but little attention has been paid to changes in the genesis locations of mesoscale eddies.Here,we provide evidence from three decades of satellite altimetry observations for the heterogeneity of the poleward shift of mesoscale activities,with the largest trend of~0.23°±0.05°(10 yr)^(-1) over the Atlantic sector and a moderate trend of~0.1°±0.03°(10 yr)^(-1) over the Indian sector,but no significant trend in the Pacific sector.The poleward shift of mesoscale eddies is associated with a southward shift of the local westerly winds while being constrained by the major topographies.As the poleward shift of westerly winds is projected to persist,the poleward oceanic heat flux from mesoscale eddies may influence future ice melt.
基金Supported by Key Project of Anhui Provincial Education Department,No.2022AH050486and 2021 High-level Talent Introduction Scientific Project of Anhui University of Chinese Medicine,No.2022rczd005.
文摘BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel treatments.Ubiquitination,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological mechanisms.We hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic approaches.AIM To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric analysis.METHODS Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core Collection.Visual mapping analysis was conducted using the CiteSpace software.RESULTS We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated complications.These articles originated from 54 countries and 386 institutions,with China as the leading contributor.Shanghai Jiao Tong University has the highest number of publications in this field.The most prominent authors contributing to this research area include Wei-Hua Zhang,with Zhang Y being the most frequently cited author.Additionally,The Journal of Biological Chemistry is noted as the most cited in this field.The predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin resistance.CONCLUSION The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research focus.However,these areas require further investigations.
基金jointly supported by the National Natural Science Foundation of China [grant number 42265012]the Funding by the Fengyun Application Pioneering Project [grant number FY-APP-ZX-2022.0221]。
文摘Forest ecosystems play key roles in mitigating human-induced climate change through enhanced carbon uptake;however,frequently occurring climate extremes and human activities have considerably threatened the stability of forests.At the same time,detailed accounts of disturbances and forest responses are not yet well quantified in Asia.This study employed the Breaks For Additive Seasonal and Trend method-an abrupt-change detection method-to analyze the Enhanced Vegetation Index time series in East Asia,South Asia,and Southeast Asia.This approach allowed us to detect forest disturbance and quantify the resilience after disturbance.Results showed that 20%of forests experienced disturbance with an increasing trend from 2000 to 2022,and Southeast Asian countries were more severely affected by disturbances.Specifically,95%of forests had robust resilience and could recover from disturbance within a few decades.The resilience of forests suffering from greater magnitude of disturbance tended to be stronger than forests with lower disturbance magnitude.In summary,this study investigated the resilience of forests across the low and middle latitudes of Asia over the past two decades.The authors found that most forests exhibited good resilience after disturbance and about two-thirds had recovered to a better state in 2022.The findings of this study underscore the complex relationship between disturbance and resilience,contributing to comprehension of forest resilience through satellite remote sensing.
基金Supported by the Qilu Medical School Traditional Chinese Medicine Academic School Inheritance Project,No.93 LW[2022]Construction Project of the Inheritance Studio of National Famous Traditional Chinese Medicine Experts,Traditional Chinese Medicine Teaching Letter No.75[2022]Qilu Health and Fitness Talents in 2019,No.3 LWRZ[2020].
文摘BACKGROUND Diabetic foot ulcers(DFUs)are a significant contributor to disability and mortality in diabetic patients.Macrophage polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU healing.However,the complex mechanism,the difficulty in clinical translation,and the large heterogeneity present significant challenges.Hence,this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU healing.AIM To examine the relevant literature on macrophage polarization in DFU healing.METHODS A bibliometric analysis was conducted using the Web of Science database.Relevant literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software(VOSviewer and CiteSpace)and bibliometric online platforms.The obtained literature was then subjected to visualization and analysis of different countries/regions,institutions,journals,authors,and keywords to reveal the research’s major trends and focus.RESULTS The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023,especially in the latter period.Chinese researchers were the most prolific in this field,with 217 publications,while American researchers had been engaged in this field for a longer period.Qian Tan of Nanjing Drum Tower Hospital and Qian Ding of Nanjing University were the first to publish in this field.Shanghai Jiao Tong University was the institution with the most publications(27).The keywords“bone marrow”,“adjustment,replacement,response,tissue repair”,and“activation,repair,differentiation”appeared more frequently.The study of macrophage polarization in DFU healing focused on the regulatory mechanism,gene expression,and other aspects.CONCLUSION This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polarization in DFU healing from 2013 to 2023 in the Web of Science Core Collection database.The key hotspots in this field mainly include the regulation of macrophage activation,gene expression,wound tissue repair,and new wound materials.This study provides references for future research directions.
基金Supported by National Natural Science Foundation of China(81874059 and 82102105)the Natural Science Foundation of Zhejiang Province(LQ22H160017)the China Postdoctoral Science Foundation(2021M702825).
文摘The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-II photodiagnosis and phototherapy research over the past decade,bibliometric analy⁃sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-II-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur⁃rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re⁃search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-II imaging clini⁃cal trials.This study delineates the NIR-II research trajectory,highlighting China's leadership,intensifying glob⁃al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-II probe devel⁃opment for NIR-II imaging and clinical translation of photodynamic/immunotherapy combinational platforms.
