Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical ca...Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.展开更多
Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 count...Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 countries and territories from 1990 to 2019 and predicted future incidence trends through 2034.Methods COPD data by age and sex from the GBD 2019 database were analyzed for incidence,prevalence,mortality,and disability-adjusted life years(DALY)rates from 1990 to 2019.Joinpoint regression identified significant annual trends,and age-standardized incidence rates were predicted through 2034 using age-period-cohort models.Results The incidence,prevalence,mortality,and disease burden of COPD have been decreasing,and the incidence rates will continue to decrease or remain stable until 2034 in most selected countries and territories,except for a few Southeastern Asian countries.The Lao People’s Democratic Republic and Vietnam are projected to experience an increase in COPD incidence from 165.3 per 100,000 in 2019 to 177 per 100,000 in 2034 and from 179.9 per 100,000 in 2019 to 192.5 per 100,000 in 2034,respectively.Older males had a higher incidence than any other sex or age group.The sex gap in incidence rates continues to widen,though it is smaller and less significant in the younger age group than in those in the older one.Conclusion COPD rates are expected to decline until 2034 but remain a health risk,especially in countries with rising rates.Urgent action on tobacco control,air pollution,and public education is needed.展开更多
Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pest...Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pests and their natural enemies is required to minimize the pest population and yield losses.In the current study,analysis of the seasonal population trend of pests and natural enemies and their relative occurrence on cultivars of three cotton species in Central India has been carried out.Results A higher number and diversity of sucking pests were observed during the vegetative cotton growth stage(60 days after sowing),declining as the crop matured.With the exception of cotton jassid(Amrasca biguttula biguttula Ishida),which caused significant crop damage mainly from August to September;populations of other sucking insects seldom reached economic threshold levels(ETL)throughout the studied period.The bollworm complex populations were minimal,except for the pink bollworm(Pectinophora gossypiella Saunders),which re-emerged as a menace to cotton crops during the cotton cropping season 2017–2018 due to resistance development against Bt-cotton.A reasonably good number of predatory arthropods,including coccinellids,lacewings,and spiders,were found actively preying on the arthropod pest complex of the cotton crop during the early vegetative growth stage.Linear regression indicates a significant relationship between green boll infestations and pink bollworm moths in pheromone traps.Multiple linear regression analyse showed mean weekly weather at one-or two-week lag periods had a significant impact on sucking pest population(cotton aphid,cotton jassid,cotton whitefly,and onion thrips)fluctuation.Gossypium hirsutum cultivars RCH 2 and DCH 32,and G.barbadense cultivar Suvin were found susceptible to cotton jassid and onion thrips.Phule Dhanvantary,an G.arboreum cotton cultivar,demonstrated the highest tolerance among all evaluated cultivars against all sucking pests.Conclusion These findings have important implications for pest management in cotton crops.Susceptible cultivars warrant more attention for plant protection measures,making them more input-intensive.The choice of appropriate cultivars can help minimize input costs,thereby increasing net returns for cotton farmers.展开更多
Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition wi...Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition with Random Forest algorithm to investigate ozone dynamics and formation regimes in a coastal area of China.During the period of 2017–2022,significant inter-annual fluctuations emerged,with peaks in mid-2017 attributed to volatile organic compounds(VOCs),and in late-2019 influenced by air temperature.Multifaceted periodicities(daily,weekly,holiday,and yearly)in ozone were revealed,elucidating substantial influences of daily and yearly components on ozone periodicity.A VOC-sensitive ozone formation regime was identified,characterized by lower VOCs/NO_(x) ratios(average=0.88)and significant positive correlations between ozone and VOCs.This interplay manifested in elevated ozone duringweekends,holidays,and pandemic lockdowns.Key variables influencing ozone across diverse timescaleswere uncovered,with solar radiation and temperature driving daily and yearly ozone variations,respectively.Precursor substances,particularly VOCs,significantly shaped weekly/holiday patterns and long-term trends of ozone.Specifically,acetone,ethane,hexanal,and toluene had a notable impact on the multi-year ozone trend,emphasizing the urgency of VOC regulation.Furthermore,our observations indicated that NO_(x) primarily drived the stochastic variations in ozone,a distinguishing characteristic of regions with heavy traffic.This research provides novel insights into ozone dynamics in coastal urban areas and highlights the importance of integrating statistical and machinelearning methods in atmospheric pollution studies,with implications for targeted mitigation strategies beyond this specific region and pollutant.展开更多
Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyro...Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyroidism.This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them.To the best of our knowledge,this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United States.In this 21-year analysis of mortality data,we found a constant increase in mortality rates due to AF/AFL in older adults.From 1999 to 2020,the overall mortality in older adults aged 65 and above,regardless of sex and race,is found to be almost doubled i.e.about a 50.2%increase in the number of deaths due to AF/AFL.Furthermore,other confounding risk factors such has obesity,prior myocardial infarction,inflammation,hypertension,birth weight,diabetes mellitus,hyperthyroidism,hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.展开更多
Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were ...Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were sourced from GLOBOCAN 2022,including estimated new cases and deaths from BC across 21 United Nation(UN)regions and 185 countries,the age-standardized incidence rate(ASIR)and mortality rate(ASMR),the estimated annual percentage changes(EAPC),and demographic projections through 2050.The region-specific and country-specific BC burden for women of all ages and for young women(<40 years old)was reorganized and re-plotted to highlight subgroup differences.Linear regression was used to explore the link between ASIR/ASMR and the human development index(HDI).Transitioning countries referred to those with low or medium HDI,while transitioned countries were those with high or very high HDI.Results In 2022,an estimated 2.3 million new BC cases and 666,000 BC-related deaths occurred globally,accounting for 23.8%and 15.4%of all cancer cases and deaths in women,respectively.Regionally,Eastern Asia reported the highest number of cases(480,019,ASIR:37.54/100,000),while South-Central Asia had the highest number of deaths(135,348,ASMR:13.41/100,000).At the country level,China had the highest number of cases due to its large population,whereas India reported the highest number of deaths.ASIR for both overall and early-onset BC increased with HDI,while ASMR for early-onset BC decreased with HDI(P<0.05).Overall BC showed an increasing trend in ASIR during 2003–2015(EAPC:0.92%)and a decreasing trend in ASMR during 2006–2016(EAPC:-1.06%).Early-onset BC showed a more significant rise in ASIR(EAPCs:1.4%)and a slight increase in ASMR(EAPCs:0.16%).If national rates remain stable,BC cases and deaths will increase by 54.7%and 70.9%,respectively,by 2050.Notably,increased early-onset BC cases are only observed in transitioning countries,while decreased cases are seen in transitioned countries.Conclusions Breast cancer remains the leading cancer burden in women,particularly in transitioning countries.Addressing this growing burden requires urgent integration of primary prevention,early detection and high-quality treatment through multi-sectoral collaboration.展开更多
Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the gl...Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the global burden of esophageal,gastric,and liver cancers in 2022 and analyzes the trends of age-standardized incidence and mortality rate(ASRs)in China from 2000 to 2018,thereby providing evidence for the formulation of cancer control strategies.Methods The global burden of esophageal,gastric and liver cancers including the estimated number of cases and deaths and the ASRs for incidence and mortality were from GLOBALCAN 2022 dataset.Data from 22 cancer registries in China were employed for the trend analysis of the ASRs for incidence and mortality of these three cancers.The Joinpoint model was used to compute the average annual percentage change(AAPC)of the incidence and mortality of the three cancers from 2000 to 2018.Results Globally,esophageal,gastric and liver cancers accounted for 11.8%of incident cancer cases and 19.1%of cancer deaths.China bore a disproportionately high burden,representing 43.8%,37.0%,and 42.4%of global esophageal,gastric,and liver cancer cases respectively,and 42.1%,39.4%,and 41.7%of corresponding deaths.However,the ASRs for incidence and mortality for all three cancers declined significantly in China(2000–2018),with absolute case numbers decreasing for gastric and esophageal cancers during 2010–2022.Age-specific analysis revealed most pronounced declines in incidence and mortality in populations under 40 years old,with AAPCs of less than–6.0%for esophageal cancer,around–4.0%for gastric cancer,and approximately–2.0%for liver cancer.Conclusions China has achieved remarkable progress in controlling esophageal,gastric and liver cancers,yet these malignancies remain major public health challenges.Future efforts should intensify existing prevention measures while expanding screening programs,particularly for aging populations.These findings offer valuable insights for regions undergoing similar epidemiological transitions.展开更多
Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-l...Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-long(2015–2022)surface ozone observation data,we attempted to reveal the variation ofmultiple timescale components using the Kolmogorov–Zurbenko filter,and the effects of meteorology and emissions were quantitatively isolated using multiple linear regression with meteorological variables.The results showed that the short-term,seasonal,and long-term components accounted for daily maximum 8-hr average O_(3)(O_(3–8)hr)concentration,46.4%,45.9%,and 1.0%,respectively.The meteorological impacts account for an average of 71.8%of O_(3–8)hr,and the YRD’s eastern and northern sections aremeteorology-sensitive areas.Based on statistical analysis technology with empirical orthogonal function,the contribution of meteorology,local emission,and transport in the long-term component of O_(3–8)hr were 0.21%,0.12%,and 0.6%,respectively.The spatiotemporal analysis indicated that a distinct decreasing spatial pattern could be observed from coastal cities towards the northwest,influenced by the monsoon and synoptic conditions.The central urban agglomeration north and south of the YRD was particularly susceptible to local pollution.Among the cities studied,Shanghai,Anqing,and Xuancheng,located at similar latitudes,were significantly impacted by atmospheric transmission—the contribution of Shanghai,the maximum accounting for 3.6%.展开更多
BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not scr...BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not screened.Current practice guidelines include male gender as a predisposing factor for BE and EAC.The population-based clinical evidence regarding female gender remains limited.AIM To study comparative trends of gender disparities in patients with BE in the United States.METHODS A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)database.Patients with a primary or secondary diagnosis code of BE were identified.The major outcome of interest was determining the gender disparities in patients with BE.Trend analysis for respective outcomes for females was also reported to ascertain any time-based shifts.RESULTS We identified 1204190 patients with BE for the study period.Among the included patients,717439(59.6%)were men and 486751(40.4%)were women.The mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,P<0.001).The rate of BE per 100000 total NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(P<0.001).The rate for females increased from 96.8 in 2009 to 148.7 in 2019(P<0.001).There was a higher frequency of obesity among women compared to men(17.4%vs 12.6%,P<0.001).Obesity prevalence among females increased from 12.3%in 2009 to 21.9%in 2019(P<0.001).A lower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,P<0.001).However,trend analysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(P<0.001).Additionally,there was a lower prevalence of alcohol abuse,Helicobacter pylori(H.pylori),and diabetes mellitus among females than males(P<0.001).Trend analysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of H.pylori and diabetes mellitus among women(P<0.001).CONCLUSION The prevalence of BE among women has steadily increased from 2009 to 2019.The existing knowledge concerning BE development has historically focused on men,but our findings show that the risk in women is not insignificant.展开更多
Rail corrugation, as a prevalent type of rail damage in heavy railways, induces diseases in the track structure. In order to ensure the safe operation of trains, an improved whale optimization algorithm is proposed to...Rail corrugation, as a prevalent type of rail damage in heavy railways, induces diseases in the track structure. In order to ensure the safe operation of trains, an improved whale optimization algorithm is proposed to optimize the rail corrugation evolution trend prediction model of the least squares support vector machine (IPCA-ELWOA-LSSVM). The elite reverse learning combined with the Lévy flight strategy is introduced to improve the whale optimization algorithm. The improved WOA (ELWOA) algorithm is used to continuously optimize the kernel parameter σ and the normalization parameter γ in the LSSVM model. Finally, the improved prediction model is validated using data from a domestic heavy-duty railway experimental line database and compared with the prediction model before optimization and the other commonly used models. The experimental results show that the ELWOA-LSSVM prediction model has the highest accuracy, which proves that the proposed method has high accuracy in predicting the rail corrugation evolution trend.展开更多
Radiation detectors, such as survey meters, are essential for ensuring radiation safety in various sectors, including healthcare, industrial processing, emergency response, etc. However, regular calibration and proper...Radiation detectors, such as survey meters, are essential for ensuring radiation safety in various sectors, including healthcare, industrial processing, emergency response, etc. However, regular calibration and proper maintenance of survey meters are important in order to ascertain their accuracy and reliability. This study provides a comprehensive retrospective assessment of the calibration behaviour, durability, and fault trends of 160 survey meters, spanning ten different models. They were calibrated at the Secondary Standard Dosimetry Laboratory (SSDL) in Nigeria over a decade (2012-2023) using an X-Ray Beam Irradiator Model X80-225K and Cs-137 irradiator (OB6) with a PTW reference spherical chamber traceable to the IAEA SSDL in Seibersdorf, Austria. The calibration stability of each model was evaluated, revealing that models like Instrument A and Instrument B demonstrated high reliability with calibration factors close to the ideal value of 1, while models like Instrument C exhibited higher variability, suggesting less consistent performance for dose rate monitoring. Fault analysis showed that the most common issues were related to the battery compartment, indicating a need for improved handling practices. Correlation analysis reveals no statistically significant correlation between calibration factor and age of survey meter across the analysed models. The study concludes that regular calibration, proper handling, and user training are crucial for maintaining the accuracy and longevity of radiation detectors.展开更多
Background: Antimicrobial Resistance (AMR) has been recognized as a global public health problem of utmost importance that needs to be tackled. Low-income countries such as Uganda have the greatest burden of severe an...Background: Antimicrobial Resistance (AMR) has been recognized as a global public health problem of utmost importance that needs to be tackled. Low-income countries such as Uganda have the greatest burden of severe and life-threatening infections and are most likely to suffer more from the spread of untreatable resistant bacteria. Despite the generally increasing trends in AMR, there is hardly any documented data on AMR in orthopedic care. Methods: We analyzed data from the pathogenic isolates from pus and tissue from the laboratory from 2019 to 2023. We calculated the proportions of isolates resistant to commonly used antimicrobial classes. We used the chi-square test for trends to evaluate changes in AMR across the study period. Results: Out of the 286 isolates, 104 (43.5%) were from pus, 112 (46.9%) were from tissue samples and the remaining 9.6% were from different fluid aspirates like synovial fluid. Most of the isolates were from males (64.2%) and aged between 19 and 45 years (46.2%). The distribution of whether the bacteria were gram-positive or negative was relatively equal with 114 (45.2%) being gram-negative and 120 (47.6%) gram-positive. Generally, there was increased AMR across all antibiotics from 2019 to 2021 e.g. for Imipinem, it went from 0% in 2019 to 70.8% in 2021 and for Amoxyclav, it went from 10% in 2019 to 93.2% in 2021. There was a general decline in AMR noted from 2021 to 2023. However, currently, the highest resistance is noted in ceftriaxone (80.0%) and the lowest in Imipinem (11.76%). Conclusion: There is a general decreasing trend in AMR, most probably due to increasing policies governing the use of antibiotics. However, there is still high resistance to commonly used and affordable antibiotics. Continuous monitoring of AMR is still recommended to reduce the AMR problem in Uganda at large through public health policy and planning.展开更多
Objective:This study aims to analyze research trends,co-authorship networks,and hotspots over the past decade regarding research on exercise therapy at home for stroke patients.Methods:Articles on exercise therapy at ...Objective:This study aims to analyze research trends,co-authorship networks,and hotspots over the past decade regarding research on exercise therapy at home for stroke patients.Methods:Articles on exercise therapy at home for stroke patients were routinely searched for in the SCOPUS database from 2013 to 2023.To evaluate and predict the most popular topics and trends in this field,the data collected from the reports are processed using the VOSviewer program.Results:The final analysis covered 1943 articles.The number of publications has steadily increased over the past decade.The United States has made the most significant contributions in this field.The University of Toronto(Canada)and Cramer,S.C.were the most productive institutions and researchers.The journal Disability and Rehabilitation has the highest number of publications(Citescore 4.4;SJR 0.76).The research area in this field is predominantly dominated by medicine.The frequently occurring keywords include“stroke,”“rehabilitation,”and“telerehabilitation.”Innovations,such as telerehabilitation and virtual reality(VR),are emerging as key trends,enhancing patient engagement and accessibility in home-based therapy.Conclusions:Using bibliometric analysis and network visualization,this study summarizes the latest research on home-based exercise therapy for stroke patients,highlighting the impact of innovative technologies,such as telerehabilitation and VR.This analysis identifies research gaps,trends,and popular subjects,providing a comprehensive framework for future studies on key topics,collaborative initiatives,and developmental patterns.展开更多
Objective:This study aimed to analyze the temporal trends in cancer mortality in China from 2013-2021 and project the future trends through 2030.Methods:This study was based on the China Causes of Death Surveillance D...Objective:This study aimed to analyze the temporal trends in cancer mortality in China from 2013-2021 and project the future trends through 2030.Methods:This study was based on the China Causes of Death Surveillance Dataset,which covers 2.37 billion person-years.Age-standardized mortality rates(ASMRs)were calculated using Segi’s world standard population and the trends were evaluated via Joinpoint regression.Bayesian age-period-cohort models were used for mortality projections.Contributions of demographic changes(population size and age structure)and risk factors to the mortality burden were quantified using the decomposition analysis.Results:The combined ASMRs for all cancers decreased annually by 2.3%,driven by significant declines in esophageal(4.8%),stomach(4.5%),and liver cancers(2.7%).In contrast,the pancreatic and prostate cancer ASMRs increased by 2.0% and 3.4% annually,respectively.Urban areas demonstrated a more rapid decline in the combined ASMRs for all cancers[average annual percent change(AAPC)=-3.0% in urban areas vs.-2.0% in rural areas],highlighting persistent disparities.Population aging contributed 20%-50% to death increases between 2013 and 2021.The combined ASMRs for all cancers,like the findings of temporal trend analyses,will continue to decrease and the regional(urban and rural)difference is projected to simulate that of the temporal trend through 2030.In fact,cancer deaths are projected to reach 2.4 million by 2030.Conclusions:The cancer burden in China is facing the dual challenges of population aging and urban-rural disparities.It is necessary to prioritize rural screening,control risk factors,such as smoking and diet,and integrate more efficacious cancer prevention and control programmes into the policy to reduce mortality in the future.展开更多
Objective:This paper conducts a bibliometric analysis of the literature on neck pain research from 2000 to 2025,aiming to comprehensively and systematically understand the research landscape,hotspots,and frontier tren...Objective:This paper conducts a bibliometric analysis of the literature on neck pain research from 2000 to 2025,aiming to comprehensively and systematically understand the research landscape,hotspots,and frontier trends in this field,providing a reference for future research directions.Methods:Data were sourced from the Web of Science Core Collection,with the search term TI=“neck pain,”covering the time span from 2000 to 2025,resulting in 2746 articles.Software such as CiteSpace V6.3.R1 and VOSviewer 1.6.20 was used to analyze publication volume,countries,authors,institutions,keywords,and co-citation networks.Results:The number of publications in neck pain research has been increasing year by year,indicating a rising level of research activity.Authors like Falla,D,Jull,G,and institutions such as Univ Queensland and Univ Toronto have significant influence in this field.Co-occurrence analysis of keywords shows that“neck pain,”“low back pain,”and“disability index”are high-frequency keywords,reflecting research hotspots such as the characteristics and treatment of neck pain and its interrelation with pain in other regions.Timeline analysis and keyword emergence analysis reveal the frontiers and development trends in this field,such as the growing attention on emerging therapeutic methods like“exercise therapy”and“dry needling,”while keywords like“intensity,”“individuals,”and“quality”indicate an increasing emphasis on personalization,precision,and quality control in the treatment process.Conclusion:The field of neck pain research is continuously expanding and deepening.Future research should further investigate the pathogenesis of neck pain,its associations with other conditions,the refinement of assessment methods,and the development of innovative rehabilitation strategies.Emphasis should also be placed on interdisciplinary collaboration to provide more robust theoretical foundations and practical guidance for the clinical treatment and rehabilitation management of neck pain.展开更多
Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based ...Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based on the GLOBOCAN 2022,the age-standardized incidence rate(ASIR)and mortality rate(ASMR)were compared and linked to the Human Development Index(HDI)across different populations.The temporal trends in ASIR/ASMR were characterized as estimated annual percentage change(EAPC),and demographic projections were performed up to 2050.Results Globally,an estimated 2,480,675 cases and 1,817,469 deaths from lung cancer occurred in 2022.Both ASIR and ASMR of lung cancer varied widely by world region,with ASIR ranging from 2.06 to 39.38 per 100,000 and ASMR from 1.95 to 31.70 per 100,000.China alone accounted for>40%of cases and deaths worldwide.Both ASIR and ARMR of lung cancer increased with HDI(R2:0.54 and 0.47,all P values<0.001),regardless of gender.Based on available data,both ASIR during 2001–2010 and ASMR during 2001–2015 showed decreasing trends in males(EAPC:1.50%and−2.22%)but increasing trends in females(EAPC:1.08%and 0.07%).Similar trends in ASIR and ASMR were observed among the elder population(≥50 years);however,downward trends were observed in the younger population(<50 years).Alongside the aging and growth of the population,estimated cases and deaths from overall lung cancer would increase by 86.2%and 95.2%up to 2050 as compared with estimates in 2022,respectively.Notably,increased early-onset lung cancer was only observed in transitioning countries,while decreased early-onset lung cancer was observed in transitioned countries.Conclusion Lung cancer maintained as the leading cancer burden worldwide.Unless timely preventive interventions in tobacco mitigation,early screening,and precise treatment,the global lung cancer burden is expected to increase in the future,especially for transitioning countries.展开更多
From February 7 to 10,Creativeworld yet again served as the most important international stage for the latest trends in hobby,arts and crafts.Above all,the Trends 2025 area in Hall 1.2—once more curated by Stilbü...From February 7 to 10,Creativeworld yet again served as the most important international stage for the latest trends in hobby,arts and crafts.Above all,the Trends 2025 area in Hall 1.2—once more curated by Stilbüro Bora.Herke.Palmisano—offered an overview of the most important developments and invited visitors to take a playful stroll through the city,the garden,and the forest.展开更多
Discourse markers(DMs)in many languages have been investigated from various theoretical perspectives and within diverse methodological paradigms for decades.Studies within the field of DMs are accelerating rapidly;how...Discourse markers(DMs)in many languages have been investigated from various theoretical perspectives and within diverse methodological paradigms for decades.Studies within the field of DMs are accelerating rapidly;however,few state-of-the-art reviews have been conducted to systematically inform scholars of the current landscape of DM research.This investigation conducted a comprehensive review of 2,183 studies from 2009 to 2022,leveraging CiteSpace for bibliometric analysis.The study aims to illuminate emerging trends and focal areas within DM research and lay the groundwork for further interdisciplinary exploration and collaboration in this area.The analysis reveals a growing interest in DM studies,identifies leading contributors,including countries,universities,and scholars,highlights the most cited journals and references shaping the field,and delineates prevalent research themes and topics,as well as methodological approaches employed.These findings indicate that DM research has evolved from a linguistic inquiry into an interdisciplinary domain employing varied methodologies such as qualitative and/or quantitative,experimental,and synchronic and/or diachronic.This study can provide important implications for future research in terms of the pragmatic turn,interdisciplinary nature,expansion of data from English to various other languages,and diversified methodologies.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer-related mortality worldwide,and the research landscape has rapidly evolved over the past two decades.Despite significant progress,an in-depth analysis...BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer-related mortality worldwide,and the research landscape has rapidly evolved over the past two decades.Despite significant progress,an in-depth analysis of global research trends,collaborative networks,and emerging themes in HCC remains limited.This study aimed to fill this gap by conducting a bibliometric analysis to map the research output,identify key contributors,and highlight future directions in HCC research.We hypothesized that the analysis would reveal a growing focus on molecular mechanisms and immunotherapy,with increasing contributions from specific countries and institutions.AIM To investigate global research trends,collaborative networks,and emerging themes in HCC from 2004 to 2023.METHODS A bibliometric analysis was performed using 93987 publications from the Science Citation Index Expanded Database of the Web of Science Core Collection.Data were analyzed using the VOSviewer software to identify publication trends,leading contributors,and research themes.Key metrics included annual publication output,country and institutional contributions,journal impact,and thematic clusters.Statistical analysis was carried out to quantify trends and collaborations.RESULTS The number of annual publications increased from 2341 in 2004 to 8756 in 2023,with 65583 papers(69.78%)published between 2014 and 2023.China,the United States,and Japan were the top contributors,constituting 58.3%of total publications.PLOS One published the most studies(n=2145),while Gastroenterology had the highest average number of citations(78.4 citations per paper).Fudan University was the most prolific institution(n=1872).Thematic analysis identified five main clusters,namely molecular mechanisms,therapeutic strategies,prognosis and immunology,risk factors,and diagnostic approaches.CONCLUSION This study highlights the growing focus on HCC research,particularly in immunotherapy and molecular mechanisms,underscoring the significance of international collaboration to advance diagnosis and treatment strategies.展开更多
By using the Chinese stock market data from 2018 to 2024,the weak association between structural trends stocks and market index under investors’preference effect in trading cause the market is lack of liquidity and m...By using the Chinese stock market data from 2018 to 2024,the weak association between structural trends stocks and market index under investors’preference effect in trading cause the market is lack of liquidity and more likely to be dominated by structural trends,as in this market,the willingness to engage in passive trading exceeds that for active trading and investors’preference easy to reverse toward market volatility.The lack of incremental capital in the market often leads to sector-specific rallies rather than broad-based increases,which is one of the key reasons why the Chinese stock market has struggled to achieve overall growth over the long-term period.展开更多
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)National Natural Science Foundation of China(grant numbers:82172894,82073028,82204121)China Postdoctoral Science Foundation(grant number:2023M742617).
文摘Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.
基金supported by a major project of the Zhejiang Natural Science Foundation(LD21G030001).
文摘Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 countries and territories from 1990 to 2019 and predicted future incidence trends through 2034.Methods COPD data by age and sex from the GBD 2019 database were analyzed for incidence,prevalence,mortality,and disability-adjusted life years(DALY)rates from 1990 to 2019.Joinpoint regression identified significant annual trends,and age-standardized incidence rates were predicted through 2034 using age-period-cohort models.Results The incidence,prevalence,mortality,and disease burden of COPD have been decreasing,and the incidence rates will continue to decrease or remain stable until 2034 in most selected countries and territories,except for a few Southeastern Asian countries.The Lao People’s Democratic Republic and Vietnam are projected to experience an increase in COPD incidence from 165.3 per 100,000 in 2019 to 177 per 100,000 in 2034 and from 179.9 per 100,000 in 2019 to 192.5 per 100,000 in 2034,respectively.Older males had a higher incidence than any other sex or age group.The sex gap in incidence rates continues to widen,though it is smaller and less significant in the younger age group than in those in the older one.Conclusion COPD rates are expected to decline until 2034 but remain a health risk,especially in countries with rising rates.Urgent action on tobacco control,air pollution,and public education is needed.
基金Funding support for the Crop Pest Surveillance and Advisory Project(CROPSAP)。
文摘Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pests and their natural enemies is required to minimize the pest population and yield losses.In the current study,analysis of the seasonal population trend of pests and natural enemies and their relative occurrence on cultivars of three cotton species in Central India has been carried out.Results A higher number and diversity of sucking pests were observed during the vegetative cotton growth stage(60 days after sowing),declining as the crop matured.With the exception of cotton jassid(Amrasca biguttula biguttula Ishida),which caused significant crop damage mainly from August to September;populations of other sucking insects seldom reached economic threshold levels(ETL)throughout the studied period.The bollworm complex populations were minimal,except for the pink bollworm(Pectinophora gossypiella Saunders),which re-emerged as a menace to cotton crops during the cotton cropping season 2017–2018 due to resistance development against Bt-cotton.A reasonably good number of predatory arthropods,including coccinellids,lacewings,and spiders,were found actively preying on the arthropod pest complex of the cotton crop during the early vegetative growth stage.Linear regression indicates a significant relationship between green boll infestations and pink bollworm moths in pheromone traps.Multiple linear regression analyse showed mean weekly weather at one-or two-week lag periods had a significant impact on sucking pest population(cotton aphid,cotton jassid,cotton whitefly,and onion thrips)fluctuation.Gossypium hirsutum cultivars RCH 2 and DCH 32,and G.barbadense cultivar Suvin were found susceptible to cotton jassid and onion thrips.Phule Dhanvantary,an G.arboreum cotton cultivar,demonstrated the highest tolerance among all evaluated cultivars against all sucking pests.Conclusion These findings have important implications for pest management in cotton crops.Susceptible cultivars warrant more attention for plant protection measures,making them more input-intensive.The choice of appropriate cultivars can help minimize input costs,thereby increasing net returns for cotton farmers.
基金supported by Ningbo Natural Science Foundation(No.2023J059)Ningbo Commonweal Programme Key Project(No.2023S038)Guangxi Key Research and Development Programme(No.GuikeAB21220063).
文摘Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition with Random Forest algorithm to investigate ozone dynamics and formation regimes in a coastal area of China.During the period of 2017–2022,significant inter-annual fluctuations emerged,with peaks in mid-2017 attributed to volatile organic compounds(VOCs),and in late-2019 influenced by air temperature.Multifaceted periodicities(daily,weekly,holiday,and yearly)in ozone were revealed,elucidating substantial influences of daily and yearly components on ozone periodicity.A VOC-sensitive ozone formation regime was identified,characterized by lower VOCs/NO_(x) ratios(average=0.88)and significant positive correlations between ozone and VOCs.This interplay manifested in elevated ozone duringweekends,holidays,and pandemic lockdowns.Key variables influencing ozone across diverse timescaleswere uncovered,with solar radiation and temperature driving daily and yearly ozone variations,respectively.Precursor substances,particularly VOCs,significantly shaped weekly/holiday patterns and long-term trends of ozone.Specifically,acetone,ethane,hexanal,and toluene had a notable impact on the multi-year ozone trend,emphasizing the urgency of VOC regulation.Furthermore,our observations indicated that NO_(x) primarily drived the stochastic variations in ozone,a distinguishing characteristic of regions with heavy traffic.This research provides novel insights into ozone dynamics in coastal urban areas and highlights the importance of integrating statistical and machinelearning methods in atmospheric pollution studies,with implications for targeted mitigation strategies beyond this specific region and pollutant.
文摘Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyroidism.This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them.To the best of our knowledge,this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United States.In this 21-year analysis of mortality data,we found a constant increase in mortality rates due to AF/AFL in older adults.From 1999 to 2020,the overall mortality in older adults aged 65 and above,regardless of sex and race,is found to be almost doubled i.e.about a 50.2%increase in the number of deaths due to AF/AFL.Furthermore,other confounding risk factors such has obesity,prior myocardial infarction,inflammation,hypertension,birth weight,diabetes mellitus,hyperthyroidism,hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)Tianjin Health Committee Foundation(grant number:TJWJ2021MS008).
文摘Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were sourced from GLOBOCAN 2022,including estimated new cases and deaths from BC across 21 United Nation(UN)regions and 185 countries,the age-standardized incidence rate(ASIR)and mortality rate(ASMR),the estimated annual percentage changes(EAPC),and demographic projections through 2050.The region-specific and country-specific BC burden for women of all ages and for young women(<40 years old)was reorganized and re-plotted to highlight subgroup differences.Linear regression was used to explore the link between ASIR/ASMR and the human development index(HDI).Transitioning countries referred to those with low or medium HDI,while transitioned countries were those with high or very high HDI.Results In 2022,an estimated 2.3 million new BC cases and 666,000 BC-related deaths occurred globally,accounting for 23.8%and 15.4%of all cancer cases and deaths in women,respectively.Regionally,Eastern Asia reported the highest number of cases(480,019,ASIR:37.54/100,000),while South-Central Asia had the highest number of deaths(135,348,ASMR:13.41/100,000).At the country level,China had the highest number of cases due to its large population,whereas India reported the highest number of deaths.ASIR for both overall and early-onset BC increased with HDI,while ASMR for early-onset BC decreased with HDI(P<0.05).Overall BC showed an increasing trend in ASIR during 2003–2015(EAPC:0.92%)and a decreasing trend in ASMR during 2006–2016(EAPC:-1.06%).Early-onset BC showed a more significant rise in ASIR(EAPCs:1.4%)and a slight increase in ASMR(EAPCs:0.16%).If national rates remain stable,BC cases and deaths will increase by 54.7%and 70.9%,respectively,by 2050.Notably,increased early-onset BC cases are only observed in transitioning countries,while decreased cases are seen in transitioned countries.Conclusions Breast cancer remains the leading cancer burden in women,particularly in transitioning countries.Addressing this growing burden requires urgent integration of primary prevention,early detection and high-quality treatment through multi-sectoral collaboration.
基金supported by the National Natural Science Foundation of China(grant numbers:82273721,82304220)Cooperation Fund of CHCAMS and SZCH(grant number:CFA202201003).
文摘Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the global burden of esophageal,gastric,and liver cancers in 2022 and analyzes the trends of age-standardized incidence and mortality rate(ASRs)in China from 2000 to 2018,thereby providing evidence for the formulation of cancer control strategies.Methods The global burden of esophageal,gastric and liver cancers including the estimated number of cases and deaths and the ASRs for incidence and mortality were from GLOBALCAN 2022 dataset.Data from 22 cancer registries in China were employed for the trend analysis of the ASRs for incidence and mortality of these three cancers.The Joinpoint model was used to compute the average annual percentage change(AAPC)of the incidence and mortality of the three cancers from 2000 to 2018.Results Globally,esophageal,gastric and liver cancers accounted for 11.8%of incident cancer cases and 19.1%of cancer deaths.China bore a disproportionately high burden,representing 43.8%,37.0%,and 42.4%of global esophageal,gastric,and liver cancer cases respectively,and 42.1%,39.4%,and 41.7%of corresponding deaths.However,the ASRs for incidence and mortality for all three cancers declined significantly in China(2000–2018),with absolute case numbers decreasing for gastric and esophageal cancers during 2010–2022.Age-specific analysis revealed most pronounced declines in incidence and mortality in populations under 40 years old,with AAPCs of less than–6.0%for esophageal cancer,around–4.0%for gastric cancer,and approximately–2.0%for liver cancer.Conclusions China has achieved remarkable progress in controlling esophageal,gastric and liver cancers,yet these malignancies remain major public health challenges.Future efforts should intensify existing prevention measures while expanding screening programs,particularly for aging populations.These findings offer valuable insights for regions undergoing similar epidemiological transitions.
基金supported by the National Natural Science Foundation of China(No.42075177)the National Key Research and Development Program of China(No.2017YFC0210003).
文摘Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-long(2015–2022)surface ozone observation data,we attempted to reveal the variation ofmultiple timescale components using the Kolmogorov–Zurbenko filter,and the effects of meteorology and emissions were quantitatively isolated using multiple linear regression with meteorological variables.The results showed that the short-term,seasonal,and long-term components accounted for daily maximum 8-hr average O_(3)(O_(3–8)hr)concentration,46.4%,45.9%,and 1.0%,respectively.The meteorological impacts account for an average of 71.8%of O_(3–8)hr,and the YRD’s eastern and northern sections aremeteorology-sensitive areas.Based on statistical analysis technology with empirical orthogonal function,the contribution of meteorology,local emission,and transport in the long-term component of O_(3–8)hr were 0.21%,0.12%,and 0.6%,respectively.The spatiotemporal analysis indicated that a distinct decreasing spatial pattern could be observed from coastal cities towards the northwest,influenced by the monsoon and synoptic conditions.The central urban agglomeration north and south of the YRD was particularly susceptible to local pollution.Among the cities studied,Shanghai,Anqing,and Xuancheng,located at similar latitudes,were significantly impacted by atmospheric transmission—the contribution of Shanghai,the maximum accounting for 3.6%.
文摘BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not screened.Current practice guidelines include male gender as a predisposing factor for BE and EAC.The population-based clinical evidence regarding female gender remains limited.AIM To study comparative trends of gender disparities in patients with BE in the United States.METHODS A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)database.Patients with a primary or secondary diagnosis code of BE were identified.The major outcome of interest was determining the gender disparities in patients with BE.Trend analysis for respective outcomes for females was also reported to ascertain any time-based shifts.RESULTS We identified 1204190 patients with BE for the study period.Among the included patients,717439(59.6%)were men and 486751(40.4%)were women.The mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,P<0.001).The rate of BE per 100000 total NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(P<0.001).The rate for females increased from 96.8 in 2009 to 148.7 in 2019(P<0.001).There was a higher frequency of obesity among women compared to men(17.4%vs 12.6%,P<0.001).Obesity prevalence among females increased from 12.3%in 2009 to 21.9%in 2019(P<0.001).A lower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,P<0.001).However,trend analysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(P<0.001).Additionally,there was a lower prevalence of alcohol abuse,Helicobacter pylori(H.pylori),and diabetes mellitus among females than males(P<0.001).Trend analysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of H.pylori and diabetes mellitus among women(P<0.001).CONCLUSION The prevalence of BE among women has steadily increased from 2009 to 2019.The existing knowledge concerning BE development has historically focused on men,but our findings show that the risk in women is not insignificant.
文摘Rail corrugation, as a prevalent type of rail damage in heavy railways, induces diseases in the track structure. In order to ensure the safe operation of trains, an improved whale optimization algorithm is proposed to optimize the rail corrugation evolution trend prediction model of the least squares support vector machine (IPCA-ELWOA-LSSVM). The elite reverse learning combined with the Lévy flight strategy is introduced to improve the whale optimization algorithm. The improved WOA (ELWOA) algorithm is used to continuously optimize the kernel parameter σ and the normalization parameter γ in the LSSVM model. Finally, the improved prediction model is validated using data from a domestic heavy-duty railway experimental line database and compared with the prediction model before optimization and the other commonly used models. The experimental results show that the ELWOA-LSSVM prediction model has the highest accuracy, which proves that the proposed method has high accuracy in predicting the rail corrugation evolution trend.
文摘Radiation detectors, such as survey meters, are essential for ensuring radiation safety in various sectors, including healthcare, industrial processing, emergency response, etc. However, regular calibration and proper maintenance of survey meters are important in order to ascertain their accuracy and reliability. This study provides a comprehensive retrospective assessment of the calibration behaviour, durability, and fault trends of 160 survey meters, spanning ten different models. They were calibrated at the Secondary Standard Dosimetry Laboratory (SSDL) in Nigeria over a decade (2012-2023) using an X-Ray Beam Irradiator Model X80-225K and Cs-137 irradiator (OB6) with a PTW reference spherical chamber traceable to the IAEA SSDL in Seibersdorf, Austria. The calibration stability of each model was evaluated, revealing that models like Instrument A and Instrument B demonstrated high reliability with calibration factors close to the ideal value of 1, while models like Instrument C exhibited higher variability, suggesting less consistent performance for dose rate monitoring. Fault analysis showed that the most common issues were related to the battery compartment, indicating a need for improved handling practices. Correlation analysis reveals no statistically significant correlation between calibration factor and age of survey meter across the analysed models. The study concludes that regular calibration, proper handling, and user training are crucial for maintaining the accuracy and longevity of radiation detectors.
文摘Background: Antimicrobial Resistance (AMR) has been recognized as a global public health problem of utmost importance that needs to be tackled. Low-income countries such as Uganda have the greatest burden of severe and life-threatening infections and are most likely to suffer more from the spread of untreatable resistant bacteria. Despite the generally increasing trends in AMR, there is hardly any documented data on AMR in orthopedic care. Methods: We analyzed data from the pathogenic isolates from pus and tissue from the laboratory from 2019 to 2023. We calculated the proportions of isolates resistant to commonly used antimicrobial classes. We used the chi-square test for trends to evaluate changes in AMR across the study period. Results: Out of the 286 isolates, 104 (43.5%) were from pus, 112 (46.9%) were from tissue samples and the remaining 9.6% were from different fluid aspirates like synovial fluid. Most of the isolates were from males (64.2%) and aged between 19 and 45 years (46.2%). The distribution of whether the bacteria were gram-positive or negative was relatively equal with 114 (45.2%) being gram-negative and 120 (47.6%) gram-positive. Generally, there was increased AMR across all antibiotics from 2019 to 2021 e.g. for Imipinem, it went from 0% in 2019 to 70.8% in 2021 and for Amoxyclav, it went from 10% in 2019 to 93.2% in 2021. There was a general decline in AMR noted from 2021 to 2023. However, currently, the highest resistance is noted in ceftriaxone (80.0%) and the lowest in Imipinem (11.76%). Conclusion: There is a general decreasing trend in AMR, most probably due to increasing policies governing the use of antibiotics. However, there is still high resistance to commonly used and affordable antibiotics. Continuous monitoring of AMR is still recommended to reduce the AMR problem in Uganda at large through public health policy and planning.
文摘Objective:This study aims to analyze research trends,co-authorship networks,and hotspots over the past decade regarding research on exercise therapy at home for stroke patients.Methods:Articles on exercise therapy at home for stroke patients were routinely searched for in the SCOPUS database from 2013 to 2023.To evaluate and predict the most popular topics and trends in this field,the data collected from the reports are processed using the VOSviewer program.Results:The final analysis covered 1943 articles.The number of publications has steadily increased over the past decade.The United States has made the most significant contributions in this field.The University of Toronto(Canada)and Cramer,S.C.were the most productive institutions and researchers.The journal Disability and Rehabilitation has the highest number of publications(Citescore 4.4;SJR 0.76).The research area in this field is predominantly dominated by medicine.The frequently occurring keywords include“stroke,”“rehabilitation,”and“telerehabilitation.”Innovations,such as telerehabilitation and virtual reality(VR),are emerging as key trends,enhancing patient engagement and accessibility in home-based therapy.Conclusions:Using bibliometric analysis and network visualization,this study summarizes the latest research on home-based exercise therapy for stroke patients,highlighting the impact of innovative technologies,such as telerehabilitation and VR.This analysis identifies research gaps,trends,and popular subjects,providing a comprehensive framework for future studies on key topics,collaborative initiatives,and developmental patterns.
基金supported by the CAMS Innovation Fund for Medical Sciences(Grant No.2021-I2M-1-011)the Capital’s Funds for Health Improvement and Research(Grant No.CFH2024-2G-40214).
文摘Objective:This study aimed to analyze the temporal trends in cancer mortality in China from 2013-2021 and project the future trends through 2030.Methods:This study was based on the China Causes of Death Surveillance Dataset,which covers 2.37 billion person-years.Age-standardized mortality rates(ASMRs)were calculated using Segi’s world standard population and the trends were evaluated via Joinpoint regression.Bayesian age-period-cohort models were used for mortality projections.Contributions of demographic changes(population size and age structure)and risk factors to the mortality burden were quantified using the decomposition analysis.Results:The combined ASMRs for all cancers decreased annually by 2.3%,driven by significant declines in esophageal(4.8%),stomach(4.5%),and liver cancers(2.7%).In contrast,the pancreatic and prostate cancer ASMRs increased by 2.0% and 3.4% annually,respectively.Urban areas demonstrated a more rapid decline in the combined ASMRs for all cancers[average annual percent change(AAPC)=-3.0% in urban areas vs.-2.0% in rural areas],highlighting persistent disparities.Population aging contributed 20%-50% to death increases between 2013 and 2021.The combined ASMRs for all cancers,like the findings of temporal trend analyses,will continue to decrease and the regional(urban and rural)difference is projected to simulate that of the temporal trend through 2030.In fact,cancer deaths are projected to reach 2.4 million by 2030.Conclusions:The cancer burden in China is facing the dual challenges of population aging and urban-rural disparities.It is necessary to prioritize rural screening,control risk factors,such as smoking and diet,and integrate more efficacious cancer prevention and control programmes into the policy to reduce mortality in the future.
基金Hubei Provincial Natural Science Foundation Innovation and Development Joint Fund Project(Project No.:2025AFD278)Three Gorges University Scientific Fund Project(Project No.:2022kj008)Three Gorges University Special Scientific Fund Project(Project No.:2023kjzx001)。
文摘Objective:This paper conducts a bibliometric analysis of the literature on neck pain research from 2000 to 2025,aiming to comprehensively and systematically understand the research landscape,hotspots,and frontier trends in this field,providing a reference for future research directions.Methods:Data were sourced from the Web of Science Core Collection,with the search term TI=“neck pain,”covering the time span from 2000 to 2025,resulting in 2746 articles.Software such as CiteSpace V6.3.R1 and VOSviewer 1.6.20 was used to analyze publication volume,countries,authors,institutions,keywords,and co-citation networks.Results:The number of publications in neck pain research has been increasing year by year,indicating a rising level of research activity.Authors like Falla,D,Jull,G,and institutions such as Univ Queensland and Univ Toronto have significant influence in this field.Co-occurrence analysis of keywords shows that“neck pain,”“low back pain,”and“disability index”are high-frequency keywords,reflecting research hotspots such as the characteristics and treatment of neck pain and its interrelation with pain in other regions.Timeline analysis and keyword emergence analysis reveal the frontiers and development trends in this field,such as the growing attention on emerging therapeutic methods like“exercise therapy”and“dry needling,”while keywords like“intensity,”“individuals,”and“quality”indicate an increasing emphasis on personalization,precision,and quality control in the treatment process.Conclusion:The field of neck pain research is continuously expanding and deepening.Future research should further investigate the pathogenesis of neck pain,its associations with other conditions,the refinement of assessment methods,and the development of innovative rehabilitation strategies.Emphasis should also be placed on interdisciplinary collaboration to provide more robust theoretical foundations and practical guidance for the clinical treatment and rehabilitation management of neck pain.
基金supported by the National Key Research and Development Program of China(grant number:2021YFC2500400)Tianjin Health Committee Foundation(grant number:TJWJ2021MS008)+2 种基金Tianjin Key Medical Discipline(Specialty)Construction Project(grant number:TYXZDXK-009A)Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences(grant number:2023GLLH0132)Scientific Research Fund for the Demonstration Project of Public Hospital Reform and Quality Development(Gastrointestinal Tumour)that is approved by Peking University Cancer Hospital(Inner Mongolia Campus)(grant number:2023SGGZ068)。
文摘Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based on the GLOBOCAN 2022,the age-standardized incidence rate(ASIR)and mortality rate(ASMR)were compared and linked to the Human Development Index(HDI)across different populations.The temporal trends in ASIR/ASMR were characterized as estimated annual percentage change(EAPC),and demographic projections were performed up to 2050.Results Globally,an estimated 2,480,675 cases and 1,817,469 deaths from lung cancer occurred in 2022.Both ASIR and ASMR of lung cancer varied widely by world region,with ASIR ranging from 2.06 to 39.38 per 100,000 and ASMR from 1.95 to 31.70 per 100,000.China alone accounted for>40%of cases and deaths worldwide.Both ASIR and ARMR of lung cancer increased with HDI(R2:0.54 and 0.47,all P values<0.001),regardless of gender.Based on available data,both ASIR during 2001–2010 and ASMR during 2001–2015 showed decreasing trends in males(EAPC:1.50%and−2.22%)but increasing trends in females(EAPC:1.08%and 0.07%).Similar trends in ASIR and ASMR were observed among the elder population(≥50 years);however,downward trends were observed in the younger population(<50 years).Alongside the aging and growth of the population,estimated cases and deaths from overall lung cancer would increase by 86.2%and 95.2%up to 2050 as compared with estimates in 2022,respectively.Notably,increased early-onset lung cancer was only observed in transitioning countries,while decreased early-onset lung cancer was observed in transitioned countries.Conclusion Lung cancer maintained as the leading cancer burden worldwide.Unless timely preventive interventions in tobacco mitigation,early screening,and precise treatment,the global lung cancer burden is expected to increase in the future,especially for transitioning countries.
文摘From February 7 to 10,Creativeworld yet again served as the most important international stage for the latest trends in hobby,arts and crafts.Above all,the Trends 2025 area in Hall 1.2—once more curated by Stilbüro Bora.Herke.Palmisano—offered an overview of the most important developments and invited visitors to take a playful stroll through the city,the garden,and the forest.
文摘Discourse markers(DMs)in many languages have been investigated from various theoretical perspectives and within diverse methodological paradigms for decades.Studies within the field of DMs are accelerating rapidly;however,few state-of-the-art reviews have been conducted to systematically inform scholars of the current landscape of DM research.This investigation conducted a comprehensive review of 2,183 studies from 2009 to 2022,leveraging CiteSpace for bibliometric analysis.The study aims to illuminate emerging trends and focal areas within DM research and lay the groundwork for further interdisciplinary exploration and collaboration in this area.The analysis reveals a growing interest in DM studies,identifies leading contributors,including countries,universities,and scholars,highlights the most cited journals and references shaping the field,and delineates prevalent research themes and topics,as well as methodological approaches employed.These findings indicate that DM research has evolved from a linguistic inquiry into an interdisciplinary domain employing varied methodologies such as qualitative and/or quantitative,experimental,and synchronic and/or diachronic.This study can provide important implications for future research in terms of the pragmatic turn,interdisciplinary nature,expansion of data from English to various other languages,and diversified methodologies.
基金Supported by National Natural Science Foundation of China,No.82372070 and No.82072037。
文摘BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer-related mortality worldwide,and the research landscape has rapidly evolved over the past two decades.Despite significant progress,an in-depth analysis of global research trends,collaborative networks,and emerging themes in HCC remains limited.This study aimed to fill this gap by conducting a bibliometric analysis to map the research output,identify key contributors,and highlight future directions in HCC research.We hypothesized that the analysis would reveal a growing focus on molecular mechanisms and immunotherapy,with increasing contributions from specific countries and institutions.AIM To investigate global research trends,collaborative networks,and emerging themes in HCC from 2004 to 2023.METHODS A bibliometric analysis was performed using 93987 publications from the Science Citation Index Expanded Database of the Web of Science Core Collection.Data were analyzed using the VOSviewer software to identify publication trends,leading contributors,and research themes.Key metrics included annual publication output,country and institutional contributions,journal impact,and thematic clusters.Statistical analysis was carried out to quantify trends and collaborations.RESULTS The number of annual publications increased from 2341 in 2004 to 8756 in 2023,with 65583 papers(69.78%)published between 2014 and 2023.China,the United States,and Japan were the top contributors,constituting 58.3%of total publications.PLOS One published the most studies(n=2145),while Gastroenterology had the highest average number of citations(78.4 citations per paper).Fudan University was the most prolific institution(n=1872).Thematic analysis identified five main clusters,namely molecular mechanisms,therapeutic strategies,prognosis and immunology,risk factors,and diagnostic approaches.CONCLUSION This study highlights the growing focus on HCC research,particularly in immunotherapy and molecular mechanisms,underscoring the significance of international collaboration to advance diagnosis and treatment strategies.
文摘By using the Chinese stock market data from 2018 to 2024,the weak association between structural trends stocks and market index under investors’preference effect in trading cause the market is lack of liquidity and more likely to be dominated by structural trends,as in this market,the willingness to engage in passive trading exceeds that for active trading and investors’preference easy to reverse toward market volatility.The lack of incremental capital in the market often leads to sector-specific rallies rather than broad-based increases,which is one of the key reasons why the Chinese stock market has struggled to achieve overall growth over the long-term period.
