Objective: With the increasing volume of trauma surgery, postoperative infections have garnered significant attention, as they not only affect patient outcomes but also raise healthcare costs and the risk of bacterial...Objective: With the increasing volume of trauma surgery, postoperative infections have garnered significant attention, as they not only affect patient outcomes but also raise healthcare costs and the risk of bacterial resistance. This study aims to analyze the microbial spectrum and antibiotic sensitivity of patients with postoperative infections in trauma surgery, providing a basis for clinical treatment and optimizing antibiotic usage strategies in this context. Methods: A retrospective analysis was conducted on patients with traumatic infections who were hospitalized in the departments of spine surgery, upper limb surgery, and lower limb surgery from January 2022 to December 2024. Bacterial culture-positive specimens were analyzed for bacterial species and antibiotic sensitivity. Results: A total of 804 traumatic infection specimens were submitted for testing, including 538 male patients (ages 2 - 95 years) and 266 female patients (ages 4 - 94 years). Among these, 267 cases showed positive culture results, with 172 males (ages 2 - 93 years) and 95 females (ages 4 - 94 years). A total of 153 strains of Gram-negative (G−) bacteria and 114 strains of Gram-positive (G+) bacteria were identified. Among G− bacteria, Escherichia coli was the most frequently isolated (40 strains), followed by Pseudomonas aeruginosa (28 strains) and Enterobacter cloacae (28 strains). Among G+ bacteria, Staphylococcus aureus was the most prevalent (75 strains), followed by Enterococcus faecalis (15 strains) and Streptococcus pyogenes (8 strains). Antibiotic sensitivity testing revealed that the resistance rate of Staphylococcus aureus to penicillin was as high as 93.33%, while the resistance rate of Escherichia coli to trimethoprim-sulfamethoxazole was 57.5%. Conclusion: The main pathogens responsible for postoperative infections in traumatology are Escherichia coli and Staphylococcus aureus, with significant antibiotic resistance. In clinical treatment, antibiotics should be selected rationally based on bacterial spectrum and resistance patterns to improve treatment efficacy.展开更多
Purpose： To compare the effects and side-effects of fondaparinux sodium and low molecular weight heparin in patients with hypercoagulability accompanied with traumatic infection. Methods： Thirty-six patients with po...Purpose： To compare the effects and side-effects of fondaparinux sodium and low molecular weight heparin in patients with hypercoagulability accompanied with traumatic infection. Methods： Thirty-six patients with post-traumatic infections in our hospital intensive care center were diagnosed with hypercoagulability from February 2012 to February 2013. These patients were randomly divided into 2 groups. In group F （18 patients）, the patients were treated with fondaparinux sodium, 2.5 rag, 1/d for 11 d. In group L （18 patients）, the patients were treated with low molecular weight heparin, 4100 U, 1/12 h for 11 d. The incidence of deep vein thrombosis, bleeding events and multiple organ dysfunction syndrome （MODS） and mortality of two groups after anticoagulation therapy were analyzed. Fibrinogen, D-dimer level and activity of antithrombin Ⅲ were measured by the coagulation analyzer. Results： The incidence of deep vein thrombosis, MODS incidence and mortality were not significantly different between the two groups. The rate of bleeding evens in group F was lower than group L （p 〈 0.05）. Antithrombin Ⅲ got an upward trend after anticoagulant therapy, in which it was higher in group F than in group L on the 5th d and llth d （p 〈 0.05）. Fibrinogen levels were gradually increased, and there was no significant difference between two groups （p 〉 0.05）. D-dimer was significantly decreased after anticoagulant therapy for 5 d （p 〈 0.01 ）, and there were significant differences between two groups on the 5th d and 7th d （p 〈 0.05）. It showed no significant difference on the llth d （p 〉 0.05）. Conclusion： Fondaparinux sodium and low molecular weight heparin can effectively improve coagulopathy in patients with traumatic infection. Compared with low molecular weight heparin, fondaparinux sodium may reduce the risk of bleeding events in patients with hypercoagulability accompanied by traumatic infection.展开更多
Objective: to explore the clinical application of closed negative pressure drainage in the treatment of orthopaedic trauma infection. Methods: from January 2020 to October 2020, 90 patients with orthopedic trauma in o...Objective: to explore the clinical application of closed negative pressure drainage in the treatment of orthopaedic trauma infection. Methods: from January 2020 to October 2020, 90 patients with orthopedic trauma in our hospital were divided into experimental group and control group according to computer randomization method. The differences of treatment effects between the two patient groups were compared. Results: the wound healing time and hospital stay in the experimental group were significantly better than those in the control group. The treatment rate and total effective rate of the experimental group were significantly better than those of the control group. The difference was statistically significant (P < 0.05). Conclusion: to sum up, the effect of negative pressure drainage and closed drainage in the treatment of orthopedic trauma infection is clear. It can effectively help to improve the symptoms of patients, promote the recovery and healing of local wounds, improve the treatment effect in clinical diagnosis and treatment, and better protect the health and quality of daily life of patients. It is worth popularizing in clinical practice.展开更多
Objective： To discuss the characteristics and risk factors for intracranial infection post traumatic brain injury to prevent and better the clinical care. Methods： Retrospective study of 520 patients with traumatic ...Objective： To discuss the characteristics and risk factors for intracranial infection post traumatic brain injury to prevent and better the clinical care. Methods： Retrospective study of 520 patients with traumatic brain injury were included, 308 male and 212 female. The risky factors of intracranial infection were identified. Results： Thirty two cases （6.54%, 321520） of intracranial infection were diagnosed, lntracranial infection most likely happened 4-10 days after injury. Cerebrospinal fluid leakage, drainage, multiple craniotomies were significant related to intracranial infection. Logistic regression predicted cerebrospinal fluid leakage and drainage as independent factors. Conclusion： Intracranial infection is a serious complication after traumatic brain injury, Patients with drainage or cerebrospinal fluid leakage are more risky for intracranial infection, Aggressive precaution should be taken to better outcome.展开更多
文摘Objective: With the increasing volume of trauma surgery, postoperative infections have garnered significant attention, as they not only affect patient outcomes but also raise healthcare costs and the risk of bacterial resistance. This study aims to analyze the microbial spectrum and antibiotic sensitivity of patients with postoperative infections in trauma surgery, providing a basis for clinical treatment and optimizing antibiotic usage strategies in this context. Methods: A retrospective analysis was conducted on patients with traumatic infections who were hospitalized in the departments of spine surgery, upper limb surgery, and lower limb surgery from January 2022 to December 2024. Bacterial culture-positive specimens were analyzed for bacterial species and antibiotic sensitivity. Results: A total of 804 traumatic infection specimens were submitted for testing, including 538 male patients (ages 2 - 95 years) and 266 female patients (ages 4 - 94 years). Among these, 267 cases showed positive culture results, with 172 males (ages 2 - 93 years) and 95 females (ages 4 - 94 years). A total of 153 strains of Gram-negative (G−) bacteria and 114 strains of Gram-positive (G+) bacteria were identified. Among G− bacteria, Escherichia coli was the most frequently isolated (40 strains), followed by Pseudomonas aeruginosa (28 strains) and Enterobacter cloacae (28 strains). Among G+ bacteria, Staphylococcus aureus was the most prevalent (75 strains), followed by Enterococcus faecalis (15 strains) and Streptococcus pyogenes (8 strains). Antibiotic sensitivity testing revealed that the resistance rate of Staphylococcus aureus to penicillin was as high as 93.33%, while the resistance rate of Escherichia coli to trimethoprim-sulfamethoxazole was 57.5%. Conclusion: The main pathogens responsible for postoperative infections in traumatology are Escherichia coli and Staphylococcus aureus, with significant antibiotic resistance. In clinical treatment, antibiotics should be selected rationally based on bacterial spectrum and resistance patterns to improve treatment efficacy.
文摘Purpose： To compare the effects and side-effects of fondaparinux sodium and low molecular weight heparin in patients with hypercoagulability accompanied with traumatic infection. Methods： Thirty-six patients with post-traumatic infections in our hospital intensive care center were diagnosed with hypercoagulability from February 2012 to February 2013. These patients were randomly divided into 2 groups. In group F （18 patients）, the patients were treated with fondaparinux sodium, 2.5 rag, 1/d for 11 d. In group L （18 patients）, the patients were treated with low molecular weight heparin, 4100 U, 1/12 h for 11 d. The incidence of deep vein thrombosis, bleeding events and multiple organ dysfunction syndrome （MODS） and mortality of two groups after anticoagulation therapy were analyzed. Fibrinogen, D-dimer level and activity of antithrombin Ⅲ were measured by the coagulation analyzer. Results： The incidence of deep vein thrombosis, MODS incidence and mortality were not significantly different between the two groups. The rate of bleeding evens in group F was lower than group L （p 〈 0.05）. Antithrombin Ⅲ got an upward trend after anticoagulant therapy, in which it was higher in group F than in group L on the 5th d and llth d （p 〈 0.05）. Fibrinogen levels were gradually increased, and there was no significant difference between two groups （p 〉 0.05）. D-dimer was significantly decreased after anticoagulant therapy for 5 d （p 〈 0.01 ）, and there were significant differences between two groups on the 5th d and 7th d （p 〈 0.05）. It showed no significant difference on the llth d （p 〉 0.05）. Conclusion： Fondaparinux sodium and low molecular weight heparin can effectively improve coagulopathy in patients with traumatic infection. Compared with low molecular weight heparin, fondaparinux sodium may reduce the risk of bleeding events in patients with hypercoagulability accompanied by traumatic infection.
文摘Objective: to explore the clinical application of closed negative pressure drainage in the treatment of orthopaedic trauma infection. Methods: from January 2020 to October 2020, 90 patients with orthopedic trauma in our hospital were divided into experimental group and control group according to computer randomization method. The differences of treatment effects between the two patient groups were compared. Results: the wound healing time and hospital stay in the experimental group were significantly better than those in the control group. The treatment rate and total effective rate of the experimental group were significantly better than those of the control group. The difference was statistically significant (P < 0.05). Conclusion: to sum up, the effect of negative pressure drainage and closed drainage in the treatment of orthopedic trauma infection is clear. It can effectively help to improve the symptoms of patients, promote the recovery and healing of local wounds, improve the treatment effect in clinical diagnosis and treatment, and better protect the health and quality of daily life of patients. It is worth popularizing in clinical practice.
文摘Objective： To discuss the characteristics and risk factors for intracranial infection post traumatic brain injury to prevent and better the clinical care. Methods： Retrospective study of 520 patients with traumatic brain injury were included, 308 male and 212 female. The risky factors of intracranial infection were identified. Results： Thirty two cases （6.54%, 321520） of intracranial infection were diagnosed, lntracranial infection most likely happened 4-10 days after injury. Cerebrospinal fluid leakage, drainage, multiple craniotomies were significant related to intracranial infection. Logistic regression predicted cerebrospinal fluid leakage and drainage as independent factors. Conclusion： Intracranial infection is a serious complication after traumatic brain injury, Patients with drainage or cerebrospinal fluid leakage are more risky for intracranial infection, Aggressive precaution should be taken to better outcome.
