Neurodegenerative diseases(NDs)have become a significant threat to an aging human society.Numerous studies have been conducted in the past decades to clarify their pathologic mechanisms and search for reliable biomark...Neurodegenerative diseases(NDs)have become a significant threat to an aging human society.Numerous studies have been conducted in the past decades to clarify their pathologic mechanisms and search for reliable biomarkers.Magnetic resonance imaging(MRI)is a powerful tool for investigating structural and functional brain alterations in NDs.With the advantages of being non-invasive and non-radioactive,it has been frequently used in both animal research and large-scale clinical investigations.MRI may serve as a bridge connecting micro-and macro-level analysis and promoting bench-to-bed translational research.Nevertheless,due to the abundance and complexity of MRI techniques,exploiting their potential is not always straightforward.This review aims to briefly introduce research progress in clinical imaging studies and discuss possible strategies for applying MRI in translational ND research.展开更多
Rarely,scientific developments centered around the patient as a whole arepublished.Our multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspect...Rarely,scientific developments centered around the patient as a whole arepublished.Our multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspects of thediseases“colon-and rectal cancer”in the long-term developments.Good expertcooperation/knowledge at the Comprehensive Cancer Center Ulm(CCCU)wereapplied in several phase III trials for multimodal treatments of primary tumors(MMT)and metastatic diseases(involving nearly 2000 patients and 64 centers),fortreatment individualization of MMT and of metastatic disease,for psychooncology/quality of life involving the patients’wishes,and for disease prevention.Most of the targets initially were heavily rejected/discussed in thescientific communities,but now have become standards in treatments andnational guidelines or are topics in modern translational research protocolsinvolving molecular biology for e.g.,“patient centered individualized treatment”.In this context we also describe the paths we had to tread in order to realize ournew goals,which at the end were highly beneficial for the patients from manypoints of view.This description is also important for students and youngresearchers who,with an actual view on our recent developments,might want toknow how medical progress was achieved.展开更多
The 8th National Gastric Cancer Academic Conference, organized by Gastric Cancer Association of Chinese Anti- cancer Association and co-hosted by Beijing Cancer Hospital, Chinese Journal of Cancer Research （CJCR）, T...The 8th National Gastric Cancer Academic Conference, organized by Gastric Cancer Association of Chinese Anti- cancer Association and co-hosted by Beijing Cancer Hospital, Chinese Journal of Cancer Research （CJCR）, Translational Gastrointestinal Cancer （TGC）, Chinese Journal of Gastrointestinal Surgery, and Chinese Journal of Practical Surgery, was held at Beijing International Convention Center from June 15 to 16, 2013. Prof. Dr. Jiafu Ji, MD, FACS, the president of Gastric Cancer Committee, Chinese Anti-Cancer Association （CACA） and Editor-in-Chief of TGC, was the chairman of the conference （Figure 1）. Prof. Dr. Yan Sun, MD, academician of Chinese Academy of Engineering （CAE）, was the honorary chairman of the展开更多
THURSDAY,March 18 Pre-Conference Workshops"lntroduction to current issues in acupunclure research""ConsideratiOns for developing COllaboration research between AOM COlleges and conventionaI medicalinsti...THURSDAY,March 18 Pre-Conference Workshops"lntroduction to current issues in acupunclure research""ConsideratiOns for developing COllaboration research between AOM COlleges and conventionaI medicalinstitutions"展开更多
Essentially, the knowledge of science alone offers little utility. With-out the ability to investigate, apply and communicate, science serves no purpose. That is not to undermine the importance of scientific knowledge...Essentially, the knowledge of science alone offers little utility. With-out the ability to investigate, apply and communicate, science serves no purpose. That is not to undermine the importance of scientific knowledge, but there currently exists a major flaw in our high school educational system that inhibits meaningful learning experiences for most students. Application of science in local high schools is largely directed at improving performance on multiple-choice exams. Standardized tests taken by high school students are slowly progressing,展开更多
The continuous clinical and technological advances,together with the social,health and economic challenges that the global population faces,have created an environment where the evolution of the field of transplantati...The continuous clinical and technological advances,together with the social,health and economic challenges that the global population faces,have created an environment where the evolution of the field of transplantation is essentially necessary.The goal of this special issue is to provide a picture of the current status of transplantation in Greece as well as in many other countries in Europe and around the world.Authors from Greece and several other countries provide us with valuable insight into their respective areas of transplant expertise,with a main focus on the field of translational research and innovation.The papers that are part of this Special Issue“Translational Research and Innovation and the current status of Transplantation in Greece”have presented innovative and meaningful approaches in modern transplant research and practice.They provide us with a clear overview of the current landscape in transplantation,including liver transplantation in the context of a major pandemic,the evolution of living donor kidney transplantation or the evolution of the effect of hepatitis C virus infection in transplantation,while at the same time explore more recent challenges,such as the issue of frailty in the transplant candidate and the changes brought by newer treatments,such as immunotherapy,in transplant oncology.Additionally,they offer us a glimpse of the effect that technological innovations,such as virtual reality,can have on transplantation,both in terms of clinical and educational aspects.Just as critical is the fact that this Special Issue emphasizes the multidisciplinary,collaborative efforts currently taking place that link transplant research and innovation with other cutting-edge disciplines such as bioengineering,advanced information technology and artificial intelligence.In this Special Issue,in addition to the clinical and research evolution of the field of transplantation,we are witnessing the importance of interdisciplinary collaboration in medicine.展开更多
The 3D cancer models fill the discovery gap of 2D cancer models and play an important role in cancer research.In addition to cancer cells,a range of other factors include the stroma,density and composition of extracel...The 3D cancer models fill the discovery gap of 2D cancer models and play an important role in cancer research.In addition to cancer cells,a range of other factors include the stroma,density and composition of extracellular matrix,cancer-associated immune cells(e.g.,cancer-associated fibroblasts cancer cell-stroma interactions and subsequent interactions,and a number of other factors(e.g.,tumor vasculature and tumor-like microenvironment in vivo)has been widely ignored in the 2D concept of culture.Despite this knowledge,the continued use of monolayer cell culture methods has led to the failure of a series of clinical trials.This review discusses the immense importance of tumor microenvironment(TME)recapitulation in cancer research,prioritizing the individual roles of TME elements in cancer histopathology.The TME provided by the 3D model fulfills the requirements of in vivo spatiotemporal arrangement,components,and is helpful in analyzing various different aspects of drug sensitivity in preclinical and clinical trials,some of which are discussed here.Furthermore,it discusses models for the co-assembly of different TME elements in vitro and focuses on their synergistic function and responsiveness as tumors.Furthermore,this review broadly describes of a handful of recently developed 3D models whose main focus is limited to drug development and their screening and/or the impact of this approach in preclinical and translational research.展开更多
Translational research has become a globally recognized model of medical research. Chinese government and doctors have begun to discuss the plan for its development. But most articles are focusing on the advantages ra...Translational research has become a globally recognized model of medical research. Chinese government and doctors have begun to discuss the plan for its development. But most articles are focusing on the advantages rather than its pros and cons. In this essay, the authors discuss the disadvantages of translational research, its effects on clinical work and medical education, highlighting some potential problems and risks in theory and practice on case basis. Some important research management requirements are summarized in this essay to help bring the therapy from the research laboratory to the patient＇s bedside.展开更多
Welcome to the journal of Burns & Trauma launched in 2013 and published by the prestigious Wolters Kluwer Health. We are grateful to promote a cultural challenge toward a new horizon in the field of translational ...Welcome to the journal of Burns & Trauma launched in 2013 and published by the prestigious Wolters Kluwer Health. We are grateful to promote a cultural challenge toward a new horizon in the field of translational research (TR). We enjoy to work together with the common objective to perform continuous medical education programs, exploring the methods in research, designing study, and to improve multidisciplinary and multiprofessional collaboration in the basic sciences and in the clinical trials. Defined narrowly, epistemology is the study of knowledge and justified belief. Epistemology is concerned with the following questions: What are the necessary and sufficient conditions of knowledge? What are its sources? What is its structure and what are its limits? More broadly, epistemology is about issues having to do with the creation and dissemination of knowledge in particular areas of inquiry as defined and revisiting at the beginning of the last decades. Translational medicine (TM) should meet the demands to maintain or expanding the biomedical workforce and education programs that attract and retain young people in the translational and biomedical sciences. With this present contributes, we invite the members of the editorial board of Burns & Trauma to encourage submitting, in a special section, their personal experience about the philosophy of "Translation research." If this has a chance, welcome to the researchers, clinicians, and the allied people for their decisive contributions to strengthen the importance of a common way about the principles and methods of basic and clinical research. TR and TM represent a dynamic entity making a link, a sort of bridge, "from bench to bedside", or from laboratory experiments through clinical trials to point-of-care patient applications. Epistemological pluralism is a critical point for conducting innovative, collaborative research which can lead to more successful integrated and successfully study, particularly important in the field of burns and trauma.展开更多
Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and ther...Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed.展开更多
Although first-generation drug-eluting stents(DES)have markedly reduced restenosis,complications of late and very late in-stent thrombosis have emerged as prime limitations to this technology.The development of new DE...Although first-generation drug-eluting stents(DES)have markedly reduced restenosis,complications of late and very late in-stent thrombosis have emerged as prime limitations to this technology.The development of new DES is a key process to prevent these complications.Translational research plays a very important role in experiments which determine the safety and efficacy of DES before human clinical trials.The present review focuses on translational research of novel DES,including drug discovery,creation of preclinical research models,planning and conducting of first-in-man studies,and developing next-generation DES systems.展开更多
Over the past two decades, improved diagnosis, pharmaceutical therapies, and interventional strategies have impressively improved the armamentarium of modern cardiologists in the fight against the most incident and le...Over the past two decades, improved diagnosis, pharmaceutical therapies, and interventional strategies have impressively improved the armamentarium of modern cardiologists in the fight against the most incident and lethal diseases： heart failure, ischemic heart disease, and arrhythmia. The innovations in the field have mostly been enabled by inventions based on hypothesis-driven approaches. The invention and development of key cardiac biomarkers, such as natriuretic peptides and cardiac-specific troponins, may serve as examples.展开更多
In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabdi...In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish, have been established and used widely for many decades. The controllability of environmental conditions, the high reproducibility, the ease of scale and the comparability of results, as well as the ability to use different standards for ethical protocols, all make an animal model the ideal tool for carrying out studies on human diseases and the development of novel pharmaceuticals and new therapies （Xue et al., 2014）. An ideal animal model should reflect the complete spectra of a specific human disease, with similar features on the following key issues： （1） genetic basis; （2） anatomy and physiology; （3） pathological response（s） and underlying mechanism（s）; （4） phenotypic endpoints as clinical studies; （5） responsiveness to known drugs with clinical efficacy; and （6） prediction of clinical efficacy （McGonigle and Ruggeri, 2014）.展开更多
Somatic stem cells （SSCs）, being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are i...Somatic stem cells （SSCs）, being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells （CSCs） which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated （1）.展开更多
Cardiovascular complications remain a leading cause of morbidity and mortality in liver transplantation(LT),exposing the limitations of current risk assessment strategies.YKL-40,a glycoprotein involved in inflammation...Cardiovascular complications remain a leading cause of morbidity and mortality in liver transplantation(LT),exposing the limitations of current risk assessment strategies.YKL-40,a glycoprotein involved in inflammation,endothelial dysfunction,and fibrotic remodeling,has emerged as a biomarker associated with adverse cardiovascular outcomes and liver disease severity.Its inclusion in structured cardiovascular assessment frameworks may improve transplantspecific risk scores and support earlier identification of high-risk LT recipients.Mechanistically,YKL-40 contributes to vascular injury and myocardial dysfunction via nuclear factor-κB and STAT3 signaling,and is under investigation as a biomarker in preclinical studies aimed at cardiovascular risk modulation in LT.Integration of YKL-40 into predictive models,particularly those supported by artificial intelligence,may enhance individualized perioperative decision-making.This editorial outlines translational directions for integrating YKL-40 into cardiovascular risk models and therapeutic research,supporting its clinical adoption in precision-guided LT care.展开更多
Journal of Translational Neuroscience(JTN),is a quarterly,peer reviewed electronic journal taking the CD for medium.Aims and Scope JTN covers research findings in all subfields of neuroscience as well as in the fields...Journal of Translational Neuroscience(JTN),is a quarterly,peer reviewed electronic journal taking the CD for medium.Aims and Scope JTN covers research findings in all subfields of neuroscience as well as in the fields of neurology,neurosurgery and psychiatry.It provides a closer interaction between basic and clinical neuroscientists to expand understanding of brain structure,function and disease,and translate this knowledge into clinical applications and novel therapies of nervous system disorders.展开更多
This review focuses on rat models for studying the short-term and long-term effects of mild and severe hypoglycemia.We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experi...This review focuses on rat models for studying the short-term and long-term effects of mild and severe hypoglycemia.We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experimental models.This study aims to investigate the therapeutic potential of phytotherapeutic agents and their efficacy in mitigating the adverse effects of hypoglycemia.Insights from our planned research will be beneficial in improving quality of life for individuals at risk of episodes of low blood sugar.Optimizing hypoglycemic rat models for research requires selecting a suitable experimental model that will be susceptible to hypoglycemia induction,effective monitoring of blood glucose levels,and maintaining a high survival rate throughout the required experimental duration.展开更多
Peripheral nerve injuries remain a challenging problem in need of better treatment strategies.Despite best efforts at surgical reconstruction and postoperative rehabilitation,patients are often left with persistent,de...Peripheral nerve injuries remain a challenging problem in need of better treatment strategies.Despite best efforts at surgical reconstruction and postoperative rehabilitation,patients are often left with persistent,debilitating motor and sensory deficits.There are currently no therapeutic strategies proven to enhance the regenerative process in humans.A clinical need exists for the development of technologies to promote nerve regeneration and improve functional outcomes.Recent advances in the fields of tissue engineering and nanotechnology have enabled biomaterial scaffolds to modulate the host response to tissue repair through tailored mechanical,chemical,and conductive cues.New bioengineered approaches have enabled targeted,sustained delivery of protein therapeutics with the capacity to unlock the clinical potential of a myriad of neurotrophic growth factors that have demonstrated promise in enhancing regenerative outcomes.As such,further exploration of combinatory strategies leveraging these technological advances may offer a pathway towards clinically translatable solutions to advance the care of patients with peripheral nerve injuries.This review first presents the various emerging bioengineering strategies that can be applied for the management of nerve gap injuries.We cover the rationale and limitations for their use as an alternative to autografts,focusing on the approaches to increase the number of regenerating axons crossing the repair site,and facilitating their growth towards the distal stump.We also discuss the emerging growth factor-based therapeutic strategies designed to improve functional outcomes in a multimodal fashion,by accelerating axonal growth,improving the distal regenerative environment,and preventing end-organs atrophy.展开更多
From the perspective of literary stylistics,this paper explores the discourse styles and Chinese translation characteristics of Robert Burns’farewell poems.Burns’farewell poems mostly appear in three types:love poem...From the perspective of literary stylistics,this paper explores the discourse styles and Chinese translation characteristics of Robert Burns’farewell poems.Burns’farewell poems mostly appear in three types:love poems,patriotic poems and animal poems,corresponding to the explicit,implicit and personified discourse styles.In the love farewell poems,the explicit ones express emotions directly by using words such as“farewell”;the implicit ones express emotions indirectly through the female perspective and the repetition of phrases.In the patriotic farewell poems,“farewell”and its phrases are used to express patriotism and the sentiment of separation.In the animal farewell poems,personification is used to endow animals with human nature,and images are used to imply death.When translating,the translator skillfully uses auxiliary words and adopts multiple translations for one word in dealing with explicit discourse;flexibly handles person and repeated phrases in implicit discourse;and conducts part-of-speech conversion and reproduces the rhythm in personified discourse.This study aims to explore how to understand the source text equivalently and express the ideas and styles of the source text appropriately,so as to achieve the standards of accuracy and vividness.展开更多
基金supported by the National Natural Science Foundation of China(81971577 and 81771820)the Natural Science Foundation of Zhejiang Province(LSZ19H180001)the 13th Five-year Plan for National Key Research and Development Program of China(2016YFC1306600).
文摘Neurodegenerative diseases(NDs)have become a significant threat to an aging human society.Numerous studies have been conducted in the past decades to clarify their pathologic mechanisms and search for reliable biomarkers.Magnetic resonance imaging(MRI)is a powerful tool for investigating structural and functional brain alterations in NDs.With the advantages of being non-invasive and non-radioactive,it has been frequently used in both animal research and large-scale clinical investigations.MRI may serve as a bridge connecting micro-and macro-level analysis and promoting bench-to-bed translational research.Nevertheless,due to the abundance and complexity of MRI techniques,exploiting their potential is not always straightforward.This review aims to briefly introduce research progress in clinical imaging studies and discuss possible strategies for applying MRI in translational ND research.
文摘Rarely,scientific developments centered around the patient as a whole arepublished.Our multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspects of thediseases“colon-and rectal cancer”in the long-term developments.Good expertcooperation/knowledge at the Comprehensive Cancer Center Ulm(CCCU)wereapplied in several phase III trials for multimodal treatments of primary tumors(MMT)and metastatic diseases(involving nearly 2000 patients and 64 centers),fortreatment individualization of MMT and of metastatic disease,for psychooncology/quality of life involving the patients’wishes,and for disease prevention.Most of the targets initially were heavily rejected/discussed in thescientific communities,but now have become standards in treatments andnational guidelines or are topics in modern translational research protocolsinvolving molecular biology for e.g.,“patient centered individualized treatment”.In this context we also describe the paths we had to tread in order to realize ournew goals,which at the end were highly beneficial for the patients from manypoints of view.This description is also important for students and youngresearchers who,with an actual view on our recent developments,might want toknow how medical progress was achieved.
文摘The 8th National Gastric Cancer Academic Conference, organized by Gastric Cancer Association of Chinese Anti- cancer Association and co-hosted by Beijing Cancer Hospital, Chinese Journal of Cancer Research （CJCR）, Translational Gastrointestinal Cancer （TGC）, Chinese Journal of Gastrointestinal Surgery, and Chinese Journal of Practical Surgery, was held at Beijing International Convention Center from June 15 to 16, 2013. Prof. Dr. Jiafu Ji, MD, FACS, the president of Gastric Cancer Committee, Chinese Anti-Cancer Association （CACA） and Editor-in-Chief of TGC, was the chairman of the conference （Figure 1）. Prof. Dr. Yan Sun, MD, academician of Chinese Academy of Engineering （CAE）, was the honorary chairman of the
文摘THURSDAY,March 18 Pre-Conference Workshops"lntroduction to current issues in acupunclure research""ConsideratiOns for developing COllaboration research between AOM COlleges and conventionaI medicalinstitutions"
文摘Essentially, the knowledge of science alone offers little utility. With-out the ability to investigate, apply and communicate, science serves no purpose. That is not to undermine the importance of scientific knowledge, but there currently exists a major flaw in our high school educational system that inhibits meaningful learning experiences for most students. Application of science in local high schools is largely directed at improving performance on multiple-choice exams. Standardized tests taken by high school students are slowly progressing,
文摘The continuous clinical and technological advances,together with the social,health and economic challenges that the global population faces,have created an environment where the evolution of the field of transplantation is essentially necessary.The goal of this special issue is to provide a picture of the current status of transplantation in Greece as well as in many other countries in Europe and around the world.Authors from Greece and several other countries provide us with valuable insight into their respective areas of transplant expertise,with a main focus on the field of translational research and innovation.The papers that are part of this Special Issue“Translational Research and Innovation and the current status of Transplantation in Greece”have presented innovative and meaningful approaches in modern transplant research and practice.They provide us with a clear overview of the current landscape in transplantation,including liver transplantation in the context of a major pandemic,the evolution of living donor kidney transplantation or the evolution of the effect of hepatitis C virus infection in transplantation,while at the same time explore more recent challenges,such as the issue of frailty in the transplant candidate and the changes brought by newer treatments,such as immunotherapy,in transplant oncology.Additionally,they offer us a glimpse of the effect that technological innovations,such as virtual reality,can have on transplantation,both in terms of clinical and educational aspects.Just as critical is the fact that this Special Issue emphasizes the multidisciplinary,collaborative efforts currently taking place that link transplant research and innovation with other cutting-edge disciplines such as bioengineering,advanced information technology and artificial intelligence.In this Special Issue,in addition to the clinical and research evolution of the field of transplantation,we are witnessing the importance of interdisciplinary collaboration in medicine.
基金MHRD,Grant/Award Number:MHRD IMPRINT(4291)SERB,Grant/Award Number:CRG/2020/005069+1 种基金Indian Institute of Technology,Hyderabad,Grant/Award Number:IITH/BME/SOCH3Ministry of Education,Grant/Award Number:MoE-STARS/2023/0640。
文摘The 3D cancer models fill the discovery gap of 2D cancer models and play an important role in cancer research.In addition to cancer cells,a range of other factors include the stroma,density and composition of extracellular matrix,cancer-associated immune cells(e.g.,cancer-associated fibroblasts cancer cell-stroma interactions and subsequent interactions,and a number of other factors(e.g.,tumor vasculature and tumor-like microenvironment in vivo)has been widely ignored in the 2D concept of culture.Despite this knowledge,the continued use of monolayer cell culture methods has led to the failure of a series of clinical trials.This review discusses the immense importance of tumor microenvironment(TME)recapitulation in cancer research,prioritizing the individual roles of TME elements in cancer histopathology.The TME provided by the 3D model fulfills the requirements of in vivo spatiotemporal arrangement,components,and is helpful in analyzing various different aspects of drug sensitivity in preclinical and clinical trials,some of which are discussed here.Furthermore,it discusses models for the co-assembly of different TME elements in vitro and focuses on their synergistic function and responsiveness as tumors.Furthermore,this review broadly describes of a handful of recently developed 3D models whose main focus is limited to drug development and their screening and/or the impact of this approach in preclinical and translational research.
文摘Translational research has become a globally recognized model of medical research. Chinese government and doctors have begun to discuss the plan for its development. But most articles are focusing on the advantages rather than its pros and cons. In this essay, the authors discuss the disadvantages of translational research, its effects on clinical work and medical education, highlighting some potential problems and risks in theory and practice on case basis. Some important research management requirements are summarized in this essay to help bring the therapy from the research laboratory to the patient＇s bedside.
文摘Welcome to the journal of Burns & Trauma launched in 2013 and published by the prestigious Wolters Kluwer Health. We are grateful to promote a cultural challenge toward a new horizon in the field of translational research (TR). We enjoy to work together with the common objective to perform continuous medical education programs, exploring the methods in research, designing study, and to improve multidisciplinary and multiprofessional collaboration in the basic sciences and in the clinical trials. Defined narrowly, epistemology is the study of knowledge and justified belief. Epistemology is concerned with the following questions: What are the necessary and sufficient conditions of knowledge? What are its sources? What is its structure and what are its limits? More broadly, epistemology is about issues having to do with the creation and dissemination of knowledge in particular areas of inquiry as defined and revisiting at the beginning of the last decades. Translational medicine (TM) should meet the demands to maintain or expanding the biomedical workforce and education programs that attract and retain young people in the translational and biomedical sciences. With this present contributes, we invite the members of the editorial board of Burns & Trauma to encourage submitting, in a special section, their personal experience about the philosophy of "Translation research." If this has a chance, welcome to the researchers, clinicians, and the allied people for their decisive contributions to strengthen the importance of a common way about the principles and methods of basic and clinical research. TR and TM represent a dynamic entity making a link, a sort of bridge, "from bench to bedside", or from laboratory experiments through clinical trials to point-of-care patient applications. Epistemological pluralism is a critical point for conducting innovative, collaborative research which can lead to more successful integrated and successfully study, particularly important in the field of burns and trauma.
文摘Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed.
文摘Although first-generation drug-eluting stents(DES)have markedly reduced restenosis,complications of late and very late in-stent thrombosis have emerged as prime limitations to this technology.The development of new DES is a key process to prevent these complications.Translational research plays a very important role in experiments which determine the safety and efficacy of DES before human clinical trials.The present review focuses on translational research of novel DES,including drug discovery,creation of preclinical research models,planning and conducting of first-in-man studies,and developing next-generation DES systems.
基金supported by grants from the German Ministry of Education and Research (BMBF)Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK, German Centre for Cardiovascular Research), and Siemens Health Care Gmb H (Siemens/University Heidelberg Joint Research Project: Care4DCM) of Germany as well as the European Union (FP7 Best Ageing)supported by grants from Siemens Health Care Gmb H (Siemens/University Heidelberg Joint Research Project: Care4DCM) of Germany and the European Union (FP7 Best Ageing)
文摘Over the past two decades, improved diagnosis, pharmaceutical therapies, and interventional strategies have impressively improved the armamentarium of modern cardiologists in the fight against the most incident and lethal diseases： heart failure, ischemic heart disease, and arrhythmia. The innovations in the field have mostly been enabled by inventions based on hypothesis-driven approaches. The invention and development of key cardiac biomarkers, such as natriuretic peptides and cardiac-specific troponins, may serve as examples.
文摘In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish, have been established and used widely for many decades. The controllability of environmental conditions, the high reproducibility, the ease of scale and the comparability of results, as well as the ability to use different standards for ethical protocols, all make an animal model the ideal tool for carrying out studies on human diseases and the development of novel pharmaceuticals and new therapies （Xue et al., 2014）. An ideal animal model should reflect the complete spectra of a specific human disease, with similar features on the following key issues： （1） genetic basis; （2） anatomy and physiology; （3） pathological response（s） and underlying mechanism（s）; （4） phenotypic endpoints as clinical studies; （5） responsiveness to known drugs with clinical efficacy; and （6） prediction of clinical efficacy （McGonigle and Ruggeri, 2014）.
文摘Somatic stem cells （SSCs）, being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells （CSCs） which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated （1）.
文摘Cardiovascular complications remain a leading cause of morbidity and mortality in liver transplantation(LT),exposing the limitations of current risk assessment strategies.YKL-40,a glycoprotein involved in inflammation,endothelial dysfunction,and fibrotic remodeling,has emerged as a biomarker associated with adverse cardiovascular outcomes and liver disease severity.Its inclusion in structured cardiovascular assessment frameworks may improve transplantspecific risk scores and support earlier identification of high-risk LT recipients.Mechanistically,YKL-40 contributes to vascular injury and myocardial dysfunction via nuclear factor-κB and STAT3 signaling,and is under investigation as a biomarker in preclinical studies aimed at cardiovascular risk modulation in LT.Integration of YKL-40 into predictive models,particularly those supported by artificial intelligence,may enhance individualized perioperative decision-making.This editorial outlines translational directions for integrating YKL-40 into cardiovascular risk models and therapeutic research,supporting its clinical adoption in precision-guided LT care.
文摘Journal of Translational Neuroscience(JTN),is a quarterly,peer reviewed electronic journal taking the CD for medium.Aims and Scope JTN covers research findings in all subfields of neuroscience as well as in the fields of neurology,neurosurgery and psychiatry.It provides a closer interaction between basic and clinical neuroscientists to expand understanding of brain structure,function and disease,and translate this knowledge into clinical applications and novel therapies of nervous system disorders.
基金Correspondence:Christina Gertrude Yap,Jeffrey Cheah School of Medicine and Health Sciences,Monash University,Jalan Lagoon Selatan,Bandar Sunway,Subang Jaya 47500,Selangor,Malaysia.Email:christina.yap@monash.edu。
文摘This review focuses on rat models for studying the short-term and long-term effects of mild and severe hypoglycemia.We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experimental models.This study aims to investigate the therapeutic potential of phytotherapeutic agents and their efficacy in mitigating the adverse effects of hypoglycemia.Insights from our planned research will be beneficial in improving quality of life for individuals at risk of episodes of low blood sugar.Optimizing hypoglycemic rat models for research requires selecting a suitable experimental model that will be susceptible to hypoglycemia induction,effective monitoring of blood glucose levels,and maintaining a high survival rate throughout the required experimental duration.
基金supported by The Plastic Surgery Foundation Research Pilot Grant,No.627383(to KAS).
文摘Peripheral nerve injuries remain a challenging problem in need of better treatment strategies.Despite best efforts at surgical reconstruction and postoperative rehabilitation,patients are often left with persistent,debilitating motor and sensory deficits.There are currently no therapeutic strategies proven to enhance the regenerative process in humans.A clinical need exists for the development of technologies to promote nerve regeneration and improve functional outcomes.Recent advances in the fields of tissue engineering and nanotechnology have enabled biomaterial scaffolds to modulate the host response to tissue repair through tailored mechanical,chemical,and conductive cues.New bioengineered approaches have enabled targeted,sustained delivery of protein therapeutics with the capacity to unlock the clinical potential of a myriad of neurotrophic growth factors that have demonstrated promise in enhancing regenerative outcomes.As such,further exploration of combinatory strategies leveraging these technological advances may offer a pathway towards clinically translatable solutions to advance the care of patients with peripheral nerve injuries.This review first presents the various emerging bioengineering strategies that can be applied for the management of nerve gap injuries.We cover the rationale and limitations for their use as an alternative to autografts,focusing on the approaches to increase the number of regenerating axons crossing the repair site,and facilitating their growth towards the distal stump.We also discuss the emerging growth factor-based therapeutic strategies designed to improve functional outcomes in a multimodal fashion,by accelerating axonal growth,improving the distal regenerative environment,and preventing end-organs atrophy.
基金funded by A stage achievement of the 2024 Hebei Provincial Higher Education English Teaching Reform Research and Practice Project(Key Project)entitled“Research and Practice on the Construction of Characteristic Courses for First-Class English Majors in the Context of Normal Universities”(Project No.2024YYJG007).
文摘From the perspective of literary stylistics,this paper explores the discourse styles and Chinese translation characteristics of Robert Burns’farewell poems.Burns’farewell poems mostly appear in three types:love poems,patriotic poems and animal poems,corresponding to the explicit,implicit and personified discourse styles.In the love farewell poems,the explicit ones express emotions directly by using words such as“farewell”;the implicit ones express emotions indirectly through the female perspective and the repetition of phrases.In the patriotic farewell poems,“farewell”and its phrases are used to express patriotism and the sentiment of separation.In the animal farewell poems,personification is used to endow animals with human nature,and images are used to imply death.When translating,the translator skillfully uses auxiliary words and adopts multiple translations for one word in dealing with explicit discourse;flexibly handles person and repeated phrases in implicit discourse;and conducts part-of-speech conversion and reproduces the rhythm in personified discourse.This study aims to explore how to understand the source text equivalently and express the ideas and styles of the source text appropriately,so as to achieve the standards of accuracy and vividness.
