As to Fortress Besieged,it is the English version translated by Kelly.J.and N.K.Mao of Wei Cheng written by Qian Zhongshu,which includes various and fancy metaphors.To explore and find more proper and effective transl...As to Fortress Besieged,it is the English version translated by Kelly.J.and N.K.Mao of Wei Cheng written by Qian Zhongshu,which includes various and fancy metaphors.To explore and find more proper and effective translation methods of metaphors under foreignization and domestication,~1 this paper combines exemplifications in Fortress Besieged with translationrelated theories,which may help readers comprehend literary works better and promote cross-cultural communication.展开更多
Pediatric oncology has always been a dynamic and everevolving field dedicated to understanding and combating cancers in children and adolescents.While survival rates for many pediatric malignancies have improved signi...Pediatric oncology has always been a dynamic and everevolving field dedicated to understanding and combating cancers in children and adolescents.While survival rates for many pediatric malignancies have improved significantly especially until the late 1990s,[1-3]a closer examination reveals areas where progress has since stagnated,particularly in solid tumors and rare cancers[4,5].We herein explore two critical issues in pediatric oncology:the challenges in translating molecular insights into effective treatments for solid tumors and the urgent need for advancing practice-changing research on rare pediatric malignancies.展开更多
The effective and translational strategy to regenerate knee meniscal fibrocartilage remained challenging.Herein,we first identified vascular smooth muscle cells(VSMCs)transdifferentiated into fibrochondrocytes and par...The effective and translational strategy to regenerate knee meniscal fibrocartilage remained challenging.Herein,we first identified vascular smooth muscle cells(VSMCs)transdifferentiated into fibrochondrocytes and participated in spontaneous meniscal regeneration using smooth muscle cell lineage tracing transgenic mice meniscal defect model.Then,we identified low-intensity pulsed ultrasound(LIPUS)acoustic stimulus enhanced fibrochondrogenic transdifferentiation of VSMCs in vitro and in vivo.Mechanistically,LIPUS stimulus could up-regulate mechanosensitive ion channel Piezo1 expression and then activate the transforming growth factorβ1(TGFβ1)signal,following repression of the Notch signal,consequently enhancing fibrochondrogenic transdifferentiation of VSMCs.Finally,we demonstrated that the regular LIPUS stimulus enhanced anisotropic native-like meniscal fibrocartilage tissue regeneration in a beagle canine subtotal meniscectomy model at 6 months postoperatively.The single-cell RNA sequencing analysis confirmed the role of VSMC fibrochondrogenic transdifferentiation in meniscal regeneration.展开更多
文摘As to Fortress Besieged,it is the English version translated by Kelly.J.and N.K.Mao of Wei Cheng written by Qian Zhongshu,which includes various and fancy metaphors.To explore and find more proper and effective translation methods of metaphors under foreignization and domestication,~1 this paper combines exemplifications in Fortress Besieged with translationrelated theories,which may help readers comprehend literary works better and promote cross-cultural communication.
文摘Pediatric oncology has always been a dynamic and everevolving field dedicated to understanding and combating cancers in children and adolescents.While survival rates for many pediatric malignancies have improved significantly especially until the late 1990s,[1-3]a closer examination reveals areas where progress has since stagnated,particularly in solid tumors and rare cancers[4,5].We herein explore two critical issues in pediatric oncology:the challenges in translating molecular insights into effective treatments for solid tumors and the urgent need for advancing practice-changing research on rare pediatric malignancies.
基金supported by the National Natural Science Foundation of China(no.82172420)China Postdoctoral Science Foundation(2022M710260)Peking University Medicine Sailing Program for Young Scholars’Scientific&Technological Innovation(BMU2023YFJHMX008 and BMU2023YFJHPY023).
文摘The effective and translational strategy to regenerate knee meniscal fibrocartilage remained challenging.Herein,we first identified vascular smooth muscle cells(VSMCs)transdifferentiated into fibrochondrocytes and participated in spontaneous meniscal regeneration using smooth muscle cell lineage tracing transgenic mice meniscal defect model.Then,we identified low-intensity pulsed ultrasound(LIPUS)acoustic stimulus enhanced fibrochondrogenic transdifferentiation of VSMCs in vitro and in vivo.Mechanistically,LIPUS stimulus could up-regulate mechanosensitive ion channel Piezo1 expression and then activate the transforming growth factorβ1(TGFβ1)signal,following repression of the Notch signal,consequently enhancing fibrochondrogenic transdifferentiation of VSMCs.Finally,we demonstrated that the regular LIPUS stimulus enhanced anisotropic native-like meniscal fibrocartilage tissue regeneration in a beagle canine subtotal meniscectomy model at 6 months postoperatively.The single-cell RNA sequencing analysis confirmed the role of VSMC fibrochondrogenic transdifferentiation in meniscal regeneration.
