In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical applications.The sizes,surface charges or morphologies of transformable NPs would affect their be...In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical applications.The sizes,surface charges or morphologies of transformable NPs would affect their behavior in physiological/pathological conditions including circulation,penetration,accumulation and retention etc.The other way round,the NPs could be precisely modulated in the specific physiological/pathological condition for precision theranostics of diseases.Herein,we summarized recent advances of transformable NPs for disease diagnostics and therapy.In this review,the transformation of NPs was divided into three groups including changes in size,surface charge and morphology,which was induced by internal stimuli,such as p H,enzyme,receptor or external stimuli,such as light,temperature etc.Moreover,we focused on the characterization of structural transformation in vivo,as well as the transformation-induced biological effects for theranostics of disease.展开更多
The inevitable release of engineered silver nanoparticles（Ag NPs） into aquatic environments has drawn great concerns about its environmental toxicity and safety. Although aggregation and transformation play crucial ...The inevitable release of engineered silver nanoparticles（Ag NPs） into aquatic environments has drawn great concerns about its environmental toxicity and safety. Although aggregation and transformation play crucial roles in the transport and toxicity of Ag NPs, how the water chemistry of environmental waters influences the aggregation and transformation of engineered Ag NPs is still not well understood. In this study, the aggregation of polyvinylpyrrolidone（PVP） coated Ag NPs was investigated in eight typical environmental water samples（with different ionic strengths, hardness, and dissolved organic matter（DOM） concentrations） by using UV–visible spectroscopy and dynamic light scattering. Raman spectroscopy was applied to probe the interaction of DOM with the surface of Ag NPs. Further, the photo-transformation and morphology changes of Ag NPs in environmental waters were studied by UV–visible spectroscopy, inductively coupled plasma mass spectrometry, and transmission electron microscopy. The results suggested that both electrolytes（especially Ca2＋and Mg2＋） and DOM in the surface waters are key parameters for Ag NP aggregation, and sunlight could accelerate the morphology change, aggregation, and further sedimentation of Ag NPs. This water chemistry controlled aggregation and photo-transformation should have significant environmental impacts on the transport and toxicity of Ag NPs in the aquatic environments.展开更多
The nanotechnology industry advances rapidly,and at the vanguard are the promising silver nanoparticles（Ag NPs）,which have diverse applications.These nanometer-sized particles have been shown to inhibit the ability ...The nanotechnology industry advances rapidly,and at the vanguard are the promising silver nanoparticles（Ag NPs）,which have diverse applications.These nanometer-sized particles have been shown to inhibit the ability of bacteria to produce adenosine triphosphate（ATP）,a molecule necessary for chemical energy transport in cells.The antimicrobial properties of Ag NPs（and Ag＋）make them valued antibacterial展开更多
In this article, the Capuli （Prunus serotina Ehrh. var. Capuli） cherry extract was used for the synthesis of silver nanoparticles （AgNPs） in the presence of white/visible solar and blue light-emitting diode （LED...In this article, the Capuli （Prunus serotina Ehrh. var. Capuli） cherry extract was used for the synthesis of silver nanoparticles （AgNPs） in the presence of white/visible solar and blue light-emitting diode （LED） light. For the characterization of the extract and the AgNPs, Fourier transform infrared spectroscopy and ultraviolet-visible spectroscopy were employed, along with hydrodynamic particle size analysis, trans- mission electron microscopy and X-ray diffraction. The Ag nanospheres obtained using white light were 40-100 nm in diameter and exhibited an absorption peak at λmax= 445 nm, whereas those obtained using blue LED light were 20-80 nm in diameter with an absorption peak at λmax= 425 nm. Thermal analysis revealed that the content of biomolecules surrounding the AgNPs was about 55-65%, and it was also found that blue LED light AgNPs （56.28%, 0.05 mM） had a higher antioxidant efficacy than the white solar light AgNPs （33.42%, 0.05 mM） against l,l-diphenyl-2-picrylhydrazyl. The results indicate that obtaining AgNPs using a blue LED light may prove to be a simple, cost-effective and easily reproducible method for creating future nanopharmaceuticals.展开更多
Photothermal therapy is emerging as a very promising way for minimally invasive cancer treatment.To enhance thermal energy deposition of laser in target malignant tissues,liquid metal nanoparticles(LMNPs)have been rec...Photothermal therapy is emerging as a very promising way for minimally invasive cancer treatment.To enhance thermal energy deposition of laser in target malignant tissues,liquid metal nanoparticles(LMNPs)have been recently identified as completely unprecedented photothermal sensitizers due to their unique physicochemical properties and superior photothermal conversion rate under near-infrared(NIR)laser irradiation.However,there is currently a strong lack of understanding of the laser energy distribution and the transient temperature field within the biological tissues,which would seriously hinder the development of LMNPs assisted photothermal therapy.Therefore,this paper focused on the distinctive photothermal effect of LMNPs embedded in biological tissues under NIR laser irradiation.The mathematical model coupling the Monte-Carlo photon transport model with Penne's bioheat transfer model has been established.Simulation studies have shown that LMNPs play an important role in enhancing the absorption of NIR laser,which contributes to local temperature rise and improves the temperature distribution.Comparing with the control case without LMNPs,the maximum temperature increases by nearly 1.0 time,the local temperature rise reaches 30℃ in 1.0 second.When the diameter and concentration of LMNPs are 40 nm and 1012/mm3,the resulting temperature variation and distribution is best for the effective killing of tumors without damaging normal tissues.In addition,the simulation results are meaningful for guiding the selection of laser irradiation time in conjunction with the cooling time,ensuring the controllable accuracy of treatment.To the best of our knowledge,the present study is one of the first attempts to quantify the influence of transformable LMNPs on the temperature distributions inside the biological tissues,showing important academic significance for guiding LMNPs assisted photothermal treatment.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51573031,21373726,21303723,21603028 and 21573036)Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.11621505)+1 种基金CAS Key Research Program for Frontier Sciences(No.QYZDJ-SSW-SLH022)Key Project of Chinese Academy of Sciences in Cooperation with Foreign Enterprises(No.GJHZ1541)
文摘In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical applications.The sizes,surface charges or morphologies of transformable NPs would affect their behavior in physiological/pathological conditions including circulation,penetration,accumulation and retention etc.The other way round,the NPs could be precisely modulated in the specific physiological/pathological condition for precision theranostics of diseases.Herein,we summarized recent advances of transformable NPs for disease diagnostics and therapy.In this review,the transformation of NPs was divided into three groups including changes in size,surface charge and morphology,which was induced by internal stimuli,such as p H,enzyme,receptor or external stimuli,such as light,temperature etc.Moreover,we focused on the characterization of structural transformation in vivo,as well as the transformation-induced biological effects for theranostics of disease.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDB14020101)the External Cooperation Program of Chinese Academy of Sciences (No.GJHZ1206)+1 种基金the National Natural Science Foundation of China (No.21337004)the Young Scientists Fund of RCEES (No.RCEES-QN-20130028F)
文摘The inevitable release of engineered silver nanoparticles（Ag NPs） into aquatic environments has drawn great concerns about its environmental toxicity and safety. Although aggregation and transformation play crucial roles in the transport and toxicity of Ag NPs, how the water chemistry of environmental waters influences the aggregation and transformation of engineered Ag NPs is still not well understood. In this study, the aggregation of polyvinylpyrrolidone（PVP） coated Ag NPs was investigated in eight typical environmental water samples（with different ionic strengths, hardness, and dissolved organic matter（DOM） concentrations） by using UV–visible spectroscopy and dynamic light scattering. Raman spectroscopy was applied to probe the interaction of DOM with the surface of Ag NPs. Further, the photo-transformation and morphology changes of Ag NPs in environmental waters were studied by UV–visible spectroscopy, inductively coupled plasma mass spectrometry, and transmission electron microscopy. The results suggested that both electrolytes（especially Ca2＋and Mg2＋） and DOM in the surface waters are key parameters for Ag NP aggregation, and sunlight could accelerate the morphology change, aggregation, and further sedimentation of Ag NPs. This water chemistry controlled aggregation and photo-transformation should have significant environmental impacts on the transport and toxicity of Ag NPs in the aquatic environments.
文摘The nanotechnology industry advances rapidly,and at the vanguard are the promising silver nanoparticles（Ag NPs）,which have diverse applications.These nanometer-sized particles have been shown to inhibit the ability of bacteria to produce adenosine triphosphate（ATP）,a molecule necessary for chemical energy transport in cells.The antimicrobial properties of Ag NPs（and Ag＋）make them valued antibacterial
文摘In this article, the Capuli （Prunus serotina Ehrh. var. Capuli） cherry extract was used for the synthesis of silver nanoparticles （AgNPs） in the presence of white/visible solar and blue light-emitting diode （LED） light. For the characterization of the extract and the AgNPs, Fourier transform infrared spectroscopy and ultraviolet-visible spectroscopy were employed, along with hydrodynamic particle size analysis, trans- mission electron microscopy and X-ray diffraction. The Ag nanospheres obtained using white light were 40-100 nm in diameter and exhibited an absorption peak at λmax= 445 nm, whereas those obtained using blue LED light were 20-80 nm in diameter with an absorption peak at λmax= 425 nm. Thermal analysis revealed that the content of biomolecules surrounding the AgNPs was about 55-65%, and it was also found that blue LED light AgNPs （56.28%, 0.05 mM） had a higher antioxidant efficacy than the white solar light AgNPs （33.42%, 0.05 mM） against l,l-diphenyl-2-picrylhydrazyl. The results indicate that obtaining AgNPs using a blue LED light may prove to be a simple, cost-effective and easily reproducible method for creating future nanopharmaceuticals.
基金the National Key R&D Program of China(No.2018YFC1705106)National Natural Science Foundation of China(No.51890893)。
文摘Photothermal therapy is emerging as a very promising way for minimally invasive cancer treatment.To enhance thermal energy deposition of laser in target malignant tissues,liquid metal nanoparticles(LMNPs)have been recently identified as completely unprecedented photothermal sensitizers due to their unique physicochemical properties and superior photothermal conversion rate under near-infrared(NIR)laser irradiation.However,there is currently a strong lack of understanding of the laser energy distribution and the transient temperature field within the biological tissues,which would seriously hinder the development of LMNPs assisted photothermal therapy.Therefore,this paper focused on the distinctive photothermal effect of LMNPs embedded in biological tissues under NIR laser irradiation.The mathematical model coupling the Monte-Carlo photon transport model with Penne's bioheat transfer model has been established.Simulation studies have shown that LMNPs play an important role in enhancing the absorption of NIR laser,which contributes to local temperature rise and improves the temperature distribution.Comparing with the control case without LMNPs,the maximum temperature increases by nearly 1.0 time,the local temperature rise reaches 30℃ in 1.0 second.When the diameter and concentration of LMNPs are 40 nm and 1012/mm3,the resulting temperature variation and distribution is best for the effective killing of tumors without damaging normal tissues.In addition,the simulation results are meaningful for guiding the selection of laser irradiation time in conjunction with the cooling time,ensuring the controllable accuracy of treatment.To the best of our knowledge,the present study is one of the first attempts to quantify the influence of transformable LMNPs on the temperature distributions inside the biological tissues,showing important academic significance for guiding LMNPs assisted photothermal treatment.
