Economic efficiency of a multi-station transfer line （TL） is evaluated directly by the quantity of parts produced; therefore, each single manufactured part counts. The contribution presents an approach which applies...Economic efficiency of a multi-station transfer line （TL） is evaluated directly by the quantity of parts produced; therefore, each single manufactured part counts. The contribution presents an approach which applies a reliability-adaptive operating strategy in combination with tool derating. It is the objective to hold the system harmonisation of tool changes as maintenance actions. The significant effectiveness of the approach is demonstrated by different configurations and contexts. The output-time function of a TL without reliability-adaptive control is compared with functions of a system with reliability-adaptive control.展开更多
Predicting the best shutdown time of a steam ethylene cracking furnace in industrial practice remains a challenge due to the complex coking process. As well known, the shutdown time of a furnace is mainly determined b...Predicting the best shutdown time of a steam ethylene cracking furnace in industrial practice remains a challenge due to the complex coking process. As well known, the shutdown time of a furnace is mainly determined by coking condition of the transfer line exchangers （TLE） when naphtha or other heavy hydrocarbon feedstocks are cracked. In practice, it is difficult to measure the coke thickness in TLE through experimental method in the complex industrial situation. However, the outlet temperature of TLE （TLEOT） can indirectly characterize the coking situation in TLE since the coke accumulation in TLE has great influence on TLEOT. Thus, the TLEOT could be a critical factor in deciding when to shut down the furnace to decoke. To predict the TLEOT, a paramewic model was proposed in this work, based on theoretical analysis, mathematic reduction, and parameters estimation. The feasibility of the proposed model was further checked through industrial data and good agreements between model prediction and industrial data with maximum deviation 2% were observed.展开更多
Flexible transfer line(FTL)is now widely used in ma ny manufacturing domains to realize efficiently,high quantity and economic prod uction.These manufacturing domains include automobile,tractor,internal-combu stion en...Flexible transfer line(FTL)is now widely used in ma ny manufacturing domains to realize efficiently,high quantity and economic prod uction.These manufacturing domains include automobile,tractor,internal-combu stion engine,and so on.In today’s competitive business environment,it is vit ally important for machine tool manufacturers to design flexible transfer line m ore effectively and efficiently according to a wider variety of customer demand s.This paper proposes an approach to a bidding-based flexible transfer line sc hematic design system.By analyzing manual FTL design process,the architecture o f flexible transfer line schematic design system(FTLSDS)is established.The syst em consists:of four processes:part feature modeling,process planning,FTL fac i lity layout and FTL evaluation. For FTL schematic design.a five-level proces s planning strategy named hierarchical process planning method is proposed.This method includes selection of manufacturing feature machining operation;part se t-up planning,feature sequencing,operation sequencing and process plan genera ting.The major decision relies on setup planning.According to the proceeding o f the hierarchical process planning,the structure of reasoning is proposed base d on blackboard.Under this paradigm,a cooperative effort between a hybrid coll ection of knowledge sources is possible.Total reasoning task can be divided int o some subtasks,and recursive-reasoning system is formed.It is convenient for process planning with step-by-step solution.Meanwhile,the blackboard is use d as the global data exchange area during all reasoning process.By using modula r technology,special purpose machine tools can be designed more efficiently and rapidly.The framework of machine modular design system to support machine requ irement design for FTL is established.By synthesizing the FTL evaluation criter ia.five evaluation criteria of flexible transfer 1ine schematic design are take n into account.An exampie is supplied to demonstrate and verify the validity an d feasibility of flexible transfer line schematic design approach.展开更多
The line formation process in stellar magnetized atmospheres is studied by observing the wavelength- dependence of Stokes contribution functions. The influence of magnetic field on the escape line photon distribution...The line formation process in stellar magnetized atmospheres is studied by observing the wavelength- dependence of Stokes contribution functions. The influence of magnetic field on the escape line photon distribution and line absorption is obtained by comparing with the null magnetic field case. Two models airs adopted. One assumes limited distributions of both the line absorption and magnetic field where a hypothetical magneto-sensitive line is formed. The other is a model atmosphere of sunspot umbra in which MgI 5172.7 forms. It is found that the magnetic field influences the formation region of Stokes I at wavelengths sufficient close to the Zeeman splitting points ±△ H. The formation regions at wavelengths far away from the Zeeman splitting points generally show a non-magnetic behaviour. Further, if the line core is split by the Zeeman effect, the line formation core introduced in the previous paper disappears. On the other hand, Stokes Q, U, V at each wavelength within the line form in the same layers where both the line absorption and magnetic field are present in the models accepted for the lines used. When the line absorption and magnetic field ubiquitously exist, the formation regions of the T peaks or valleys of Stokes Q, U and those of σ of Stokes V generally cover the widest depth range. It is pointed out that such a study is instructive in the explanation of solar polarized filtergrams. It can tell us at each observation point where the received line photons of wavelengths within the bandpass come from and where their polarization states are formed or give us the distributions of these photons as well as their polarization intensities. Thus a three-dimensional image can be constructed for a morphologic study of the observed area from serial filtergrams.展开更多
The distribution or wavelength-dependence of the formation regions of frequently used solar lines, Hα, Hβ, CaIIH and Car18542, in quiet Sun, faint and bright flares is explored in the unpolarized case. We stress fou...The distribution or wavelength-dependence of the formation regions of frequently used solar lines, Hα, Hβ, CaIIH and Car18542, in quiet Sun, faint and bright flares is explored in the unpolarized case. We stress four aspects characterising the property of line formation process: 1) width of line formation core; 2) line formation region; 3) influence of the temperature minimum region; and 4) wavelength ranges within which one can obtain pure chromospheric and photospheric filtergrams. It is shown that the above four aspects depend strongly on the atmospheric physical condition and the lines used. The formation regions of all the wavelength points within a line may be continuously distributed over one depth domain or discretely distributed because of no contribution coming from the temperature minimum region, an important domain in the solar atmosphere that determines the distribution pattern of escape photons. Cm the other hand, the formation region of one wavelength point may cover only one heigh t range or spread over two domains which are separated again by the temperature minimum region. Different lines may form in different regions in the quiet Sun. However, these line formation regions become closer in solar flaring regions. Finally, though the stratification of line-of-sight velocity can alter the position of the line formation core within the line band and result in the asymmetry of the line formation core about the shifted line center, it can only lead to negligible changes in the line formation region or the line formation core width. All these results can be instructive to solar filtering observations.展开更多
To meet the market requirements for Flexible Transf er Line (FTL), which consists of modular NC machining tools of high quality and co st saving, the methodologies and technologies of client-oriented FTL rapid resp on...To meet the market requirements for Flexible Transf er Line (FTL), which consists of modular NC machining tools of high quality and co st saving, the methodologies and technologies of client-oriented FTL rapid resp onse schematic design CAPP-based, one of the key techniques, are presented in t his paper. In order to achieve this purpose, an integrated system for integrated design of CAD/CAPP/FTL with box-type parts is realized. In this paper, firstly the theory of the conceptual design of FTL based on CAPP is established and the software architecture is developed. The global-domain pr oduct model is put forward to meet with data representation. After the manufactu ring feature is analyzed and decomposed for machining operations, the feature-b ased part unified data model object-oriented is built. Secondly the knowledge- based CAPP system data model is established. The process planning unit model is formed by work element (WE), which is tool-cell based function abstraction meth od, and has unified layers with respect to designing and manufacturing. With WEs through dynamic response and simultaneous structure in process planning, the pr inciple solution for CAPP function system can be implemented. Lastly the mapping from process domain to module design domain is built. The unidirectional select ion process based on fuzzy matching technology is easily dealt with computer. Th e algorithm of decision with fuzzy synthetic evaluation method and technology is applied to estimate the feasibility of the results in local working procedure o f modular NC machine tools and make decision of designs in overall FTL, which co nsists of many different factors. The example shows that the rapid response desi gn in bidding-based FTL scheme design is realized.展开更多
A technique for obtaining a three-dimensional distribution of received photons in Hα flares in the solar atmosphere is presented. It is well known that during flares hydrogen atoms in the chromosphere and photosphere...A technique for obtaining a three-dimensional distribution of received photons in Hα flares in the solar atmosphere is presented. It is well known that during flares hydrogen atoms in the chromosphere and photosphere are excited （even ionized） by the downward heating of non-thermal particles and then emit Hα photons. We trace back these Hα photons to their original layers by use of the contribution function in the theory of spectral line formation, and so acquire their three-dimensional （3D） distribution. This technique is applied to the two-ribbon flare of 2002 January 20. The atmospheric models are obtained by fitting the ＂quasi-profiles＂ with the help of the generally used model atmospheres. Since the variety of the 3D images reflects the response of the atmospheric layers to the impact of energy transport, an analysis of the development of the flare is given through a comparison of the 3D images with the 2D temperature distribution.展开更多
A real-time workbench able to reproduce the same behavior as an indoor network is in order. Such a tool will help researchers and industrials extend the smart grid technology indoors and have a better acknowledgment o...A real-time workbench able to reproduce the same behavior as an indoor network is in order. Such a tool will help researchers and industrials extend the smart grid technology indoors and have a better acknowledgment of Smart Grid systems interoperability. In order to develop such a tool many approaches should be studied to choose the most suitable one by comparing the models and the technologies. The considered hardware are the embedded systems and the selected approach is the statistical one. It appears that the FlR filter is the most pertinent approach.展开更多
Objective To investigate whether TNF-α gene-modified Tca8113 cells (Tca8113/TNF-α) canbe used as vaccine for oral squamous cell carcinoma. Methods TNF-α gene was transduced into Tca8113 cellsin vitro with retrovira...Objective To investigate whether TNF-α gene-modified Tca8113 cells (Tca8113/TNF-α) canbe used as vaccine for oral squamous cell carcinoma. Methods TNF-α gene was transduced into Tca8113 cellsin vitro with retroviral vector carring genes for both TNF-α and NeoR. After that, presence and expression of exoge-nous gene in the transgenic cells, expression of HLA antigen on the cells, expression of TNF-α and survival rate ofthe cells after irradiation and cryopreservation, and mutagenic activity of the cells were analyzed by PCR technique,EL1SA technique, FACS technique, 60Co irradiation inactivation test, cryopreservation test, and Ames test, respec-tively. Results The presence of both TNF-a and NeoR gene and expression of TNF-α gene were demonstrated intransgenic cells. The levels of the HLA-A, B, C, DR expressed by Tca8113/TNF-α were higher than by the parentalcells. Tca8113/TNF-α continued to secrete TNF-α for 14 d, there was a secretion peak time from d4 to d6;and, allthe cells died by dl4 after irradiation. The Level of TNF-α secreted by Tca8113/TNF-α cryopreserved for 48 h wasno different from that cryopreserved for 1 week after irradiation, the level of TNF-α secreted by the cryopreservedcells was just a little lower than that secreted by the noncryopreserved cells. Both DNA and supernatant of the cellshave no mutagenic activity. Conclusion TNF-α gene can be transduced into Tca8113 cells with retroviral vec-tor, and the cells can express TNF-α. Expression of HLA 1,11 antigens on Tca8113 cells can be increased by TNF-αgene transduction. Irradiation is a reliable inactivation method, and cryopreservation is a feasible conservationmethod for Tca8113/TNF-α. Ames test result indicate that Tca8113/TNF-α has no mutagenic activity.展开更多
This paper presents an efficient method of equivalient workstations for modeling and analysis of multistage transfer lines with unreliable machines and finites buffers. The deterministic processing times for discrete ...This paper presents an efficient method of equivalient workstations for modeling and analysis of multistage transfer lines with unreliable machines and finites buffers. The deterministic processing times for discrete parts and random failuse and repair times for machines are assumed. These buffers lead to blockage and starvation in operation due to limited storage capacities and make the problem of modelling and analysis very difficult to treat because they have large state spaces and cannot be decomposed exactly. A single buffer between two reliable workstations is analysed first. Then an equivalent workstation without starvation and blockage is constructed. Thereafter connecting all the equivalent workstations in series we get the equivalent transfer line. A set of preformance measures such as the production rates, efficiencies and average inventory levels are derived in explicit analytical expressions. Finally two numerical examples are given for comparing these calculated results with those of S. B. Gershwin (1987) and C. R. Glasseye & Y. Hong (1993) and illustrating the application of the method in engineering design directly.展开更多
The effect of the annealing time and annealing temperature on Ni/Ge/Au electrode contacts deposited on the n-type InP contact layer has been studied using a circular transmission line model. The minimum specific conta...The effect of the annealing time and annealing temperature on Ni/Ge/Au electrode contacts deposited on the n-type InP contact layer has been studied using a circular transmission line model. The minimum specific contact resistance of 3.210 7 cm2was achieved on the low-doped n-type InP contact layer with a 40 s anneal at 425 ℃. In order to improve the ohmic contact and reduce the difficulty in the fabrication of the high doped InP epi-layer, the doping concentration in the InP contact layer was chosen to be 51018cm 3in the fabrication of transferred electronic devices. Excellent differential negative resistance properties were obtained by an electron beam evaporating the Ni/Ge/Au/Ge/Ni/Au composite electrode on an InP epi-layer with a 60 s anneal at 380 ℃.展开更多
In this paper, we consider a transfer line with two unreliable machines and a single storage buffer, in which the second machine’s processing time and repair time have general distributions, and a piece processed by ...In this paper, we consider a transfer line with two unreliable machines and a single storage buffer, in which the second machine’s processing time and repair time have general distributions, and a piece processed by machine i will be reprocessed with probability q i (i=1, 2) because of uncompletely or not very well processed just before. At first, the exactly results of the reprocessed rate, the output rate and the blocked probability of machine 1, the reprocessed rate and the starved probability of machine 2, and the production rate of the system, are obtained when the first machine is reliable. And then, some approximating results of above indices are given when two machines are both unreliable.展开更多
Purpose The high energy photon source(HEPS),a 6-GeV synchrotron radiation facility with ultralow emittance,is under construction in China.Three transfer lines are designed for HEPS.One low-energy transfer line is used...Purpose The high energy photon source(HEPS),a 6-GeV synchrotron radiation facility with ultralow emittance,is under construction in China.Three transfer lines are designed for HEPS.One low-energy transfer line is used to deliver the 500 MeV beam provided by the linac to the booster.Two high-energy transfer lines are used to connect the booster and the storage ring to realize beam accumulation in the booster at 6 GeV.Method The design of the transfer lines is closely related to the layout and optics design of the storage ring,booster and linac.Based on the physics design of the storage ring,booster and linac,the design of the transfer lines has been adjusted.Results and conclusion In this paper,the considerations and design of the latest lattice of transfer lines are described.The design satisfies the requirements of the high efficiency transmission and injection.展开更多
In this paper we propose a COncurrent Production Engineering System （COPES） for the flexible transfer line （FTL） layout design in a restricted area. COPES first determines the buffer size in front of the bay of ea...In this paper we propose a COncurrent Production Engineering System （COPES） for the flexible transfer line （FTL） layout design in a restricted area. COPES first determines the buffer size in front of the bay of each machine tool in the FTL and then initializes a computer aided design （CAD） system to draw the FTL in a restricted area. We develop a set of modules systems which have been integrated into a single framework, in accordance with the practice of concurrent engineering. Concurrent engineering involves the cooperation of these activities. It＇s expected that the developed COPES can improve the cooperation between production engineers＇ and the plant designer. This can be done by enabling the production engineers＇ to make better decision regarding FTL buffer size.展开更多
文摘Economic efficiency of a multi-station transfer line （TL） is evaluated directly by the quantity of parts produced; therefore, each single manufactured part counts. The contribution presents an approach which applies a reliability-adaptive operating strategy in combination with tool derating. It is the objective to hold the system harmonisation of tool changes as maintenance actions. The significant effectiveness of the approach is demonstrated by different configurations and contexts. The output-time function of a TL without reliability-adaptive control is compared with functions of a system with reliability-adaptive control.
基金Supported by the Major State Basic Research Development Program of China (2012CB720500)the National Natural Science Foundation of China (U1162202, 21276078)+2 种基金the National Science Fund for Outstanding Young Scholars (61222303)the Shanghai Key Technologies R&D Program (12dz1125100)the Shanghai Leading Academic Discipline Project (B504)
文摘Predicting the best shutdown time of a steam ethylene cracking furnace in industrial practice remains a challenge due to the complex coking process. As well known, the shutdown time of a furnace is mainly determined by coking condition of the transfer line exchangers （TLE） when naphtha or other heavy hydrocarbon feedstocks are cracked. In practice, it is difficult to measure the coke thickness in TLE through experimental method in the complex industrial situation. However, the outlet temperature of TLE （TLEOT） can indirectly characterize the coking situation in TLE since the coke accumulation in TLE has great influence on TLEOT. Thus, the TLEOT could be a critical factor in deciding when to shut down the furnace to decoke. To predict the TLEOT, a paramewic model was proposed in this work, based on theoretical analysis, mathematic reduction, and parameters estimation. The feasibility of the proposed model was further checked through industrial data and good agreements between model prediction and industrial data with maximum deviation 2% were observed.
文摘Flexible transfer line(FTL)is now widely used in ma ny manufacturing domains to realize efficiently,high quantity and economic prod uction.These manufacturing domains include automobile,tractor,internal-combu stion engine,and so on.In today’s competitive business environment,it is vit ally important for machine tool manufacturers to design flexible transfer line m ore effectively and efficiently according to a wider variety of customer demand s.This paper proposes an approach to a bidding-based flexible transfer line sc hematic design system.By analyzing manual FTL design process,the architecture o f flexible transfer line schematic design system(FTLSDS)is established.The syst em consists:of four processes:part feature modeling,process planning,FTL fac i lity layout and FTL evaluation. For FTL schematic design.a five-level proces s planning strategy named hierarchical process planning method is proposed.This method includes selection of manufacturing feature machining operation;part se t-up planning,feature sequencing,operation sequencing and process plan genera ting.The major decision relies on setup planning.According to the proceeding o f the hierarchical process planning,the structure of reasoning is proposed base d on blackboard.Under this paradigm,a cooperative effort between a hybrid coll ection of knowledge sources is possible.Total reasoning task can be divided int o some subtasks,and recursive-reasoning system is formed.It is convenient for process planning with step-by-step solution.Meanwhile,the blackboard is use d as the global data exchange area during all reasoning process.By using modula r technology,special purpose machine tools can be designed more efficiently and rapidly.The framework of machine modular design system to support machine requ irement design for FTL is established.By synthesizing the FTL evaluation criter ia.five evaluation criteria of flexible transfer 1ine schematic design are take n into account.An exampie is supplied to demonstrate and verify the validity an d feasibility of flexible transfer line schematic design approach.
文摘The line formation process in stellar magnetized atmospheres is studied by observing the wavelength- dependence of Stokes contribution functions. The influence of magnetic field on the escape line photon distribution and line absorption is obtained by comparing with the null magnetic field case. Two models airs adopted. One assumes limited distributions of both the line absorption and magnetic field where a hypothetical magneto-sensitive line is formed. The other is a model atmosphere of sunspot umbra in which MgI 5172.7 forms. It is found that the magnetic field influences the formation region of Stokes I at wavelengths sufficient close to the Zeeman splitting points ±△ H. The formation regions at wavelengths far away from the Zeeman splitting points generally show a non-magnetic behaviour. Further, if the line core is split by the Zeeman effect, the line formation core introduced in the previous paper disappears. On the other hand, Stokes Q, U, V at each wavelength within the line form in the same layers where both the line absorption and magnetic field are present in the models accepted for the lines used. When the line absorption and magnetic field ubiquitously exist, the formation regions of the T peaks or valleys of Stokes Q, U and those of σ of Stokes V generally cover the widest depth range. It is pointed out that such a study is instructive in the explanation of solar polarized filtergrams. It can tell us at each observation point where the received line photons of wavelengths within the bandpass come from and where their polarization states are formed or give us the distributions of these photons as well as their polarization intensities. Thus a three-dimensional image can be constructed for a morphologic study of the observed area from serial filtergrams.
基金Item 199730l6 of National Science Founda-tion of China and National Major Project 973 under the grant G2000078401. The authors
文摘The distribution or wavelength-dependence of the formation regions of frequently used solar lines, Hα, Hβ, CaIIH and Car18542, in quiet Sun, faint and bright flares is explored in the unpolarized case. We stress four aspects characterising the property of line formation process: 1) width of line formation core; 2) line formation region; 3) influence of the temperature minimum region; and 4) wavelength ranges within which one can obtain pure chromospheric and photospheric filtergrams. It is shown that the above four aspects depend strongly on the atmospheric physical condition and the lines used. The formation regions of all the wavelength points within a line may be continuously distributed over one depth domain or discretely distributed because of no contribution coming from the temperature minimum region, an important domain in the solar atmosphere that determines the distribution pattern of escape photons. Cm the other hand, the formation region of one wavelength point may cover only one heigh t range or spread over two domains which are separated again by the temperature minimum region. Different lines may form in different regions in the quiet Sun. However, these line formation regions become closer in solar flaring regions. Finally, though the stratification of line-of-sight velocity can alter the position of the line formation core within the line band and result in the asymmetry of the line formation core about the shifted line center, it can only lead to negligible changes in the line formation region or the line formation core width. All these results can be instructive to solar filtering observations.
文摘To meet the market requirements for Flexible Transf er Line (FTL), which consists of modular NC machining tools of high quality and co st saving, the methodologies and technologies of client-oriented FTL rapid resp onse schematic design CAPP-based, one of the key techniques, are presented in t his paper. In order to achieve this purpose, an integrated system for integrated design of CAD/CAPP/FTL with box-type parts is realized. In this paper, firstly the theory of the conceptual design of FTL based on CAPP is established and the software architecture is developed. The global-domain pr oduct model is put forward to meet with data representation. After the manufactu ring feature is analyzed and decomposed for machining operations, the feature-b ased part unified data model object-oriented is built. Secondly the knowledge- based CAPP system data model is established. The process planning unit model is formed by work element (WE), which is tool-cell based function abstraction meth od, and has unified layers with respect to designing and manufacturing. With WEs through dynamic response and simultaneous structure in process planning, the pr inciple solution for CAPP function system can be implemented. Lastly the mapping from process domain to module design domain is built. The unidirectional select ion process based on fuzzy matching technology is easily dealt with computer. Th e algorithm of decision with fuzzy synthetic evaluation method and technology is applied to estimate the feasibility of the results in local working procedure o f modular NC machine tools and make decision of designs in overall FTL, which co nsists of many different factors. The example shows that the rapid response desi gn in bidding-based FTL scheme design is realized.
基金Supported by the National Natural Science Foundation of China
文摘A technique for obtaining a three-dimensional distribution of received photons in Hα flares in the solar atmosphere is presented. It is well known that during flares hydrogen atoms in the chromosphere and photosphere are excited （even ionized） by the downward heating of non-thermal particles and then emit Hα photons. We trace back these Hα photons to their original layers by use of the contribution function in the theory of spectral line formation, and so acquire their three-dimensional （3D） distribution. This technique is applied to the two-ribbon flare of 2002 January 20. The atmospheric models are obtained by fitting the ＂quasi-profiles＂ with the help of the generally used model atmospheres. Since the variety of the 3D images reflects the response of the atmospheric layers to the impact of energy transport, an analysis of the development of the flare is given through a comparison of the 3D images with the 2D temperature distribution.
文摘A real-time workbench able to reproduce the same behavior as an indoor network is in order. Such a tool will help researchers and industrials extend the smart grid technology indoors and have a better acknowledgment of Smart Grid systems interoperability. In order to develop such a tool many approaches should be studied to choose the most suitable one by comparing the models and the technologies. The considered hardware are the embedded systems and the selected approach is the statistical one. It appears that the FlR filter is the most pertinent approach.
文摘Objective To investigate whether TNF-α gene-modified Tca8113 cells (Tca8113/TNF-α) canbe used as vaccine for oral squamous cell carcinoma. Methods TNF-α gene was transduced into Tca8113 cellsin vitro with retroviral vector carring genes for both TNF-α and NeoR. After that, presence and expression of exoge-nous gene in the transgenic cells, expression of HLA antigen on the cells, expression of TNF-α and survival rate ofthe cells after irradiation and cryopreservation, and mutagenic activity of the cells were analyzed by PCR technique,EL1SA technique, FACS technique, 60Co irradiation inactivation test, cryopreservation test, and Ames test, respec-tively. Results The presence of both TNF-a and NeoR gene and expression of TNF-α gene were demonstrated intransgenic cells. The levels of the HLA-A, B, C, DR expressed by Tca8113/TNF-α were higher than by the parentalcells. Tca8113/TNF-α continued to secrete TNF-α for 14 d, there was a secretion peak time from d4 to d6;and, allthe cells died by dl4 after irradiation. The Level of TNF-α secreted by Tca8113/TNF-α cryopreserved for 48 h wasno different from that cryopreserved for 1 week after irradiation, the level of TNF-α secreted by the cryopreservedcells was just a little lower than that secreted by the noncryopreserved cells. Both DNA and supernatant of the cellshave no mutagenic activity. Conclusion TNF-α gene can be transduced into Tca8113 cells with retroviral vec-tor, and the cells can express TNF-α. Expression of HLA 1,11 antigens on Tca8113 cells can be increased by TNF-αgene transduction. Irradiation is a reliable inactivation method, and cryopreservation is a feasible conservationmethod for Tca8113/TNF-α. Ames test result indicate that Tca8113/TNF-α has no mutagenic activity.
文摘This paper presents an efficient method of equivalient workstations for modeling and analysis of multistage transfer lines with unreliable machines and finites buffers. The deterministic processing times for discrete parts and random failuse and repair times for machines are assumed. These buffers lead to blockage and starvation in operation due to limited storage capacities and make the problem of modelling and analysis very difficult to treat because they have large state spaces and cannot be decomposed exactly. A single buffer between two reliable workstations is analysed first. Then an equivalent workstation without starvation and blockage is constructed. Thereafter connecting all the equivalent workstations in series we get the equivalent transfer line. A set of preformance measures such as the production rates, efficiencies and average inventory levels are derived in explicit analytical expressions. Finally two numerical examples are given for comparing these calculated results with those of S. B. Gershwin (1987) and C. R. Glasseye & Y. Hong (1993) and illustrating the application of the method in engineering design directly.
基金Project supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(No.YYYJ1123)
文摘The effect of the annealing time and annealing temperature on Ni/Ge/Au electrode contacts deposited on the n-type InP contact layer has been studied using a circular transmission line model. The minimum specific contact resistance of 3.210 7 cm2was achieved on the low-doped n-type InP contact layer with a 40 s anneal at 425 ℃. In order to improve the ohmic contact and reduce the difficulty in the fabrication of the high doped InP epi-layer, the doping concentration in the InP contact layer was chosen to be 51018cm 3in the fabrication of transferred electronic devices. Excellent differential negative resistance properties were obtained by an electron beam evaporating the Ni/Ge/Au/Ge/Ni/Au composite electrode on an InP epi-layer with a 60 s anneal at 380 ℃.
文摘In this paper, we consider a transfer line with two unreliable machines and a single storage buffer, in which the second machine’s processing time and repair time have general distributions, and a piece processed by machine i will be reprocessed with probability q i (i=1, 2) because of uncompletely or not very well processed just before. At first, the exactly results of the reprocessed rate, the output rate and the blocked probability of machine 1, the reprocessed rate and the starved probability of machine 2, and the production rate of the system, are obtained when the first machine is reliable. And then, some approximating results of above indices are given when two machines are both unreliable.
基金supported by high-energy photon source(HEPS),a major national science and technology infrastruc-tureNational Natural Science Foundation of China(No.11805217,11922512)Youth Innovation Promotion Association of Chinese Academy of Sciences(No.Y201904)
文摘Purpose The high energy photon source(HEPS),a 6-GeV synchrotron radiation facility with ultralow emittance,is under construction in China.Three transfer lines are designed for HEPS.One low-energy transfer line is used to deliver the 500 MeV beam provided by the linac to the booster.Two high-energy transfer lines are used to connect the booster and the storage ring to realize beam accumulation in the booster at 6 GeV.Method The design of the transfer lines is closely related to the layout and optics design of the storage ring,booster and linac.Based on the physics design of the storage ring,booster and linac,the design of the transfer lines has been adjusted.Results and conclusion In this paper,the considerations and design of the latest lattice of transfer lines are described.The design satisfies the requirements of the high efficiency transmission and injection.
文摘In this paper we propose a COncurrent Production Engineering System （COPES） for the flexible transfer line （FTL） layout design in a restricted area. COPES first determines the buffer size in front of the bay of each machine tool in the FTL and then initializes a computer aided design （CAD） system to draw the FTL in a restricted area. We develop a set of modules systems which have been integrated into a single framework, in accordance with the practice of concurrent engineering. Concurrent engineering involves the cooperation of these activities. It＇s expected that the developed COPES can improve the cooperation between production engineers＇ and the plant designer. This can be done by enabling the production engineers＇ to make better decision regarding FTL buffer size.
