BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and p...BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.展开更多
Transcranial electrical stimulation(tES)is a non-invasive nerve stimulation technique that modulates changes in neural activities in cerebral cortex through a weak current of specific intensity(and frequency).It has b...Transcranial electrical stimulation(tES)is a non-invasive nerve stimulation technique that modulates changes in neural activities in cerebral cortex through a weak current of specific intensity(and frequency).It has become a valuable tool for the study of human behavior and cognitive neurophysiological processes.As a brain stimulation technology with broad development prospects,it is not mature enough in the field of human auditory research.However,the research on tES has obtained preliminary results in regulating motor ability.This article mainly introduces the effects of tES and auditory steady state response on auditory,and the applications of tES in auditory diseases.By summarizing and discussing tES during auditory processing as comprehensively as possible,the potential application value of tES in the treatment of auditory diseases could be illustrated.展开更多
The transcranial electrical stimulation(tES)has the potential to modulate the brain cognitive function.However,the dynamic mechanisms underlying this modulation remain incompletely understood.Based on a whole-brain ne...The transcranial electrical stimulation(tES)has the potential to modulate the brain cognitive function.However,the dynamic mechanisms underlying this modulation remain incompletely understood.Based on a whole-brain network dynamic model,this study investigates the regulatory mechanisms of tES on brain integration levels and its restorative effects under conditions of structural lesion.The results demonstrate that in normal networks,both the integration level and synchronization level exhibit an inverted U-shaped relationship with the global coupling strengthγ,peaking in the central region of the parameter space.Under unilateral or bilateral tES,the integration level shows a bidirectional regulatory effect related to the stimulation intensity.The moderate stimulation enhances the integration peak while maintaining the inverted U-shaped curve,whereas excessive stimulation leads to a decline in integration.In structural lesion models,both focal node lesions and diffuse connection losses lead to a reduction in the integration level,with more severe connection losses resulting in more significant decline in integration.Further research reveals that the impact of node lesions on integration is modulated by the inhibitory gainβ,and the appropriate adjustment toβcan mitigate the functional decline caused by lesions.At specific stimulation intensities,tES can partially restore the integration capacity of the lesion network.However,the restorative effect is simultaneously dependent on bothβandγ.This study suggests that tES may influence multi-scale information integration by modulating nodal excitability and network dynamic stability.The relevant findings provide a theoretical basis for parameter optimization and target selection in individualized neuromodulation strategies for diseases such as stroke and traumatic brain injury.展开更多
Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects ...Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects of tTIS on the superior colliculus(SC),a region involved in eye movement control,in mice.Computational modeling revealed that tTIS delivers more focused stimulation to the SC than traditional transcranial alternating current stimulation.In vivo experiments,including Ca^(2+)signal recordings and eye movement tracking,showed that tTIS effectively modulates SC neural activity and induces eye movements.A significant correlation was found between stimulation frequency and saccade frequency,suggesting direct tTIS-induced modulation of SC activity.These results demonstrate the precision of tTIS in targeting deep brain regions and regulating eye movements,highlighting its potential for neuroscientific research and therapeutic applications.展开更多
The visual system remains highly malleable even after its maturity or impairment.Our visual function can be enhanced through many ways,such as transcranial electrical stimulation(tES)and visual perceptual learning(VPL...The visual system remains highly malleable even after its maturity or impairment.Our visual function can be enhanced through many ways,such as transcranial electrical stimulation(tES)and visual perceptual learning(VPL).TES can change visual function rapidly,but its modulation effect is short-lived and unstable.By contrast,VPL can lead to a substantial and long-lasting improvement in visual function,but extensive training is typically required.Theoretically,visual function could be further improved in a shorter time frame by combining tES and VPL than by solely using tES or VPL.Vision enhancement by combining these two methods concurrently is both theoretically and practically significant.In this review,we firstly introduced the basic concept and possible mechanisms of VPL and tES;then we reviewed the current research progress of visual enhancement using the combination of two methods in both general and clinical population;finally,we discussed the limitations and future directions in this field.Our review provides a guide for future research and application of vision enhancement and restoration by combining VPL and tES.展开更多
Transcranial electrical stimulation(tES)is a non-invasive technique widely used in modulating brain activity and behavior,but its effects differ across individuals and are influenced by head anatomy.In this study,we i...Transcranial electrical stimulation(tES)is a non-invasive technique widely used in modulating brain activity and behavior,but its effects differ across individuals and are influenced by head anatomy.In this study,we investigated how the electric field(EF)generated by high-definition tES varies across the lifespan among different demographic groups and its relationship with neural responses measured by functional magnetic resonance imaging(fMRI).We employed an MRI-guided finite element method to simulate the EF for the two most common tES montages(i.e.,targeting the dorsolateral prefrontal cortex and motor cortex,respectively)in two large cohorts of white and Asian participants aged 12 to 100 years.We found that the EF intensity decreased with age,particularly in individuals under 25 years of age,and was influenced by gender and ethnicity.We identified skull thickness,scalp thickness,and epidural cerebrospinal fluid thickness,as the primary anatomical factors accounting for the inter-individual EF variability.Using a concurrent tES-fMRI approach,we observed a spatial consistency between the simulated EF and the brain activity changes induced by tES in the target region.Finally,we developed an open-source toolbox incorporating age-stratified head models to facilitate efficient EF calculations.These findings characterize and quantify the individual differences in tES-induced EF,offering a reference for implementing personalized neuromodulation strategies.展开更多
Random noise stimulation technique involves applying any form of energy(for instance,light,mechanical,electrical,sound)with unpredictable intensities through time to the brain or sensory receptors to enhance sensory,m...Random noise stimulation technique involves applying any form of energy(for instance,light,mechanical,electrical,sound)with unpredictable intensities through time to the brain or sensory receptors to enhance sensory,motor,or cognitive functions.Random noise stimulation initially employed mechanical noise in auditory and cutaneous stimuli,but electrical energies applied to the brain or the skin are becoming more frequent,with a series of clinical applications.Indeed,recent evidence shows that transcranial random noise stimulation can increase corticospinal excitability,improve cognitive/motor performance,and produce beneficial aftereffects at the behavioral and psychological levels.Here,we present a narrative review about the potential uses of random noise stimulation to treat neurological disorders,including attention deficit hyperactivity disorder,schizophrenia,amblyopia,myopia,tinnitus,multiple sclerosis,post-stroke,vestibular-postural disorders,and sensitivity loss.Many of the reviewed studies reveal that the optimal way to deliver random noise stimulation-based therapies is with the concomitant use of neurological and neuropsychological assessments to validate the beneficial aftereffects.In addition,we highlight the requirement of more randomized controlled trials and more physiological studies of random noise stimulation to discover another optimal way to perform the random noise stimulation interventions.展开更多
Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson...Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental disorders.Although significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural circuits.Moreove r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly understood.Recently,advancements in neuroimaging have provided insight into neuromodulation techniques.Functional near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic interference.Coupling functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro rehabilitation.We aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer interfaces.Furthermore,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are summarized.In conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system diseases.展开更多
Neuromodulation represents a cutting edge class of both invasive and non-invasive therapeutic methods which alter the activity of neurons.Currently,several different techniques have been developed-or are currently bei...Neuromodulation represents a cutting edge class of both invasive and non-invasive therapeutic methods which alter the activity of neurons.Currently,several different techniques have been developed-or are currently being investigated–to treat a wide variety of neurological and neuropsychiatric disorders.Recently,in vivo and in vitro studies have revealed that neuromodulation can also induce myelination,meaning that it could hold potential as a therapy for various demyelinating diseases including multiple sclerosis and progressive multifocal leukencepalopathy.These findings come on the heels of a paradigm shift in the view of myelin's role within the nervous system from a static structure to an active co-regulator of central nervous system plasticity and participant in neuron-mediated modulation.In the present review,we highlight several of the recent findings regarding the role of neural activity in altering myelination including several soluble and contact-dependent factors that seem to mediate neural activitydependent myelination.We also highlight several considerations for neuromodulatory techniques,including the need for further research into spatiotemporal precision,dosage,and the safety and efficacy of transcranial focused ultrasound stimulation,an emerging neuromodulation technology.As the field of neuromodulation continues to evolve,it could potentially bring forth methods for the treatment of demyelinating diseases,and as such,further investigation into the mechanisms of neuron-dependent myelination as well as neuro-imaging modalities that can monitor myelination activity is warranted.展开更多
Migraine is a common and recurrent chronic disorder.Migraine is often associated with anxiety,depression and other emotional diseases.With the development of physical rehabilitation techniques,the long-term clinical e...Migraine is a common and recurrent chronic disorder.Migraine is often associated with anxiety,depression and other emotional diseases.With the development of physical rehabilitation techniques,the long-term clinical efficacy of rehabilitation in the treatment of migraine and the prevention of recurrence have been widely accepted.This paper reviews the effectiveness of physical rehabilitation therapy in clinical treatment of migraine in recent years.展开更多
Background Neurophysiologic monitoring during surgery is to prevent permanent neurological injury resulting from surgical manipulation. To improve the accuracy and sensitivity of intraoperative neuromonitoring, combin...Background Neurophysiologic monitoring during surgery is to prevent permanent neurological injury resulting from surgical manipulation. To improve the accuracy and sensitivity of intraoperative neuromonitoring, combined monitoring of transcranial electrical stimulation motor evoked potentials （TES-MEPs）, somatosensory evoked potentials （SSEPs） and brainstem auditory evoked potentials （BAEPs） was attempted in microsurgery for lesions adjacent to the brainstem and intracranial aneurysms. Methods Monitoring of combined TES-MEPs with SSEPs was attempted in 68 consecutive patients with lesions adjacent to the brainstem as well as intracranial aneurysms. Among them, 31 patients （31 operations, 28 of posterior cranial fossa tumors, 3 of posterior circulation aneurysms） were also subjected to monitoring of BAEPs. The correlation of monitoring results and clinical outcome was studied prospectively. Results Combined monitoring of evoked potentials （EPs） was done in 64 （94.1%） of the 68 patients. MEPs monitoring was impossible for 4 patients （5.9%）. No complication was observed during the combined monitoring in all the patients. In 45 （66.2%） of the 68 patients, EPs were stable, and they were neurologically intact. Motor dysfunction was detected by MEPs in 8 patients, SSEPs in 5, and BAEPs in 4, respectively. Conclusions A close relationship exists between postoperative motor function and the results of TES-MEPs monitoring TES-MEPs are superior to SSEPs and BAEPs in detecting motor dysfunction, but combined EPs serve as a safe, effective and invasive method for intraoperative monitoring of the function of the motor nervous system. Monitoring of combined EPs during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms may detect potentially hazardous maneuvers and improve the safety of subsequent procedures.展开更多
文摘BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.
文摘Transcranial electrical stimulation(tES)is a non-invasive nerve stimulation technique that modulates changes in neural activities in cerebral cortex through a weak current of specific intensity(and frequency).It has become a valuable tool for the study of human behavior and cognitive neurophysiological processes.As a brain stimulation technology with broad development prospects,it is not mature enough in the field of human auditory research.However,the research on tES has obtained preliminary results in regulating motor ability.This article mainly introduces the effects of tES and auditory steady state response on auditory,and the applications of tES in auditory diseases.By summarizing and discussing tES during auditory processing as comprehensively as possible,the potential application value of tES in the treatment of auditory diseases could be illustrated.
基金National Natural Science Foundation of China(Nos.12472053,12332004)Beijing Natural Science Foundation(No.1242008)Young Elite Scientists Sponsorship Program by CAST(No.2024-2026QNRC001)。
文摘The transcranial electrical stimulation(tES)has the potential to modulate the brain cognitive function.However,the dynamic mechanisms underlying this modulation remain incompletely understood.Based on a whole-brain network dynamic model,this study investigates the regulatory mechanisms of tES on brain integration levels and its restorative effects under conditions of structural lesion.The results demonstrate that in normal networks,both the integration level and synchronization level exhibit an inverted U-shaped relationship with the global coupling strengthγ,peaking in the central region of the parameter space.Under unilateral or bilateral tES,the integration level shows a bidirectional regulatory effect related to the stimulation intensity.The moderate stimulation enhances the integration peak while maintaining the inverted U-shaped curve,whereas excessive stimulation leads to a decline in integration.In structural lesion models,both focal node lesions and diffuse connection losses lead to a reduction in the integration level,with more severe connection losses resulting in more significant decline in integration.Further research reveals that the impact of node lesions on integration is modulated by the inhibitory gainβ,and the appropriate adjustment toβcan mitigate the functional decline caused by lesions.At specific stimulation intensities,tES can partially restore the integration capacity of the lesion network.However,the restorative effect is simultaneously dependent on bothβandγ.This study suggests that tES may influence multi-scale information integration by modulating nodal excitability and network dynamic stability.The relevant findings provide a theoretical basis for parameter optimization and target selection in individualized neuromodulation strategies for diseases such as stroke and traumatic brain injury.
基金supported by the National Natural Science Foundation of China(T2394533,32222036,82030038,and 62472206)the National Key Research and Development Program of China(2018YFA0701400)the Shenzhen Science and Technology Innovation Committee(2022410129,KJZD20230923115221044,and KCXFZ20201221173400001).
文摘Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects of tTIS on the superior colliculus(SC),a region involved in eye movement control,in mice.Computational modeling revealed that tTIS delivers more focused stimulation to the SC than traditional transcranial alternating current stimulation.In vivo experiments,including Ca^(2+)signal recordings and eye movement tracking,showed that tTIS effectively modulates SC neural activity and induces eye movements.A significant correlation was found between stimulation frequency and saccade frequency,suggesting direct tTIS-induced modulation of SC activity.These results demonstrate the precision of tTIS in targeting deep brain regions and regulating eye movements,highlighting its potential for neuroscientific research and therapeutic applications.
基金supported by the National Science and Technology Innovation 2030 Major Program(2022ZD0204802)National Natural Science Foundation of China(31930053)Beijing Academy of Artificial Intelligence(BAAI).
文摘The visual system remains highly malleable even after its maturity or impairment.Our visual function can be enhanced through many ways,such as transcranial electrical stimulation(tES)and visual perceptual learning(VPL).TES can change visual function rapidly,but its modulation effect is short-lived and unstable.By contrast,VPL can lead to a substantial and long-lasting improvement in visual function,but extensive training is typically required.Theoretically,visual function could be further improved in a shorter time frame by combining tES and VPL than by solely using tES or VPL.Vision enhancement by combining these two methods concurrently is both theoretically and practically significant.In this review,we firstly introduced the basic concept and possible mechanisms of VPL and tES;then we reviewed the current research progress of visual enhancement using the combination of two methods in both general and clinical population;finally,we discussed the limitations and future directions in this field.Our review provides a guide for future research and application of vision enhancement and restoration by combining VPL and tES.
基金supported by the National Natural Science Foundation of China(32171078 and 32322035)STI2030-Major Projects by the Ministry of Science and Technology of China(2022ZD0206400)+1 种基金Scientific Foundation of the Institute of Psychology,Chinese Academy of Sciences(E0CX52 and E2CX4015)Young Elite Scientist Sponsorship Program by the China Association for Science and Technology(E1KX0210).
文摘Transcranial electrical stimulation(tES)is a non-invasive technique widely used in modulating brain activity and behavior,but its effects differ across individuals and are influenced by head anatomy.In this study,we investigated how the electric field(EF)generated by high-definition tES varies across the lifespan among different demographic groups and its relationship with neural responses measured by functional magnetic resonance imaging(fMRI).We employed an MRI-guided finite element method to simulate the EF for the two most common tES montages(i.e.,targeting the dorsolateral prefrontal cortex and motor cortex,respectively)in two large cohorts of white and Asian participants aged 12 to 100 years.We found that the EF intensity decreased with age,particularly in individuals under 25 years of age,and was influenced by gender and ethnicity.We identified skull thickness,scalp thickness,and epidural cerebrospinal fluid thickness,as the primary anatomical factors accounting for the inter-individual EF variability.Using a concurrent tES-fMRI approach,we observed a spatial consistency between the simulated EF and the brain activity changes induced by tES in the target region.Finally,we developed an open-source toolbox incorporating age-stratified head models to facilitate efficient EF calculations.These findings characterize and quantify the individual differences in tES-induced EF,offering a reference for implementing personalized neuromodulation strategies.
基金supported by Cátedra Marcos Moshinsky (to EM)CONACyT Fronteras de la Ciencia#536 (to EM)+1 种基金VIEP-PIFI-FOMES-PROMEP-BUAP-Puebla (to EM)Comitéde Internacionalización de la Investigación (to EM),México
文摘Random noise stimulation technique involves applying any form of energy(for instance,light,mechanical,electrical,sound)with unpredictable intensities through time to the brain or sensory receptors to enhance sensory,motor,or cognitive functions.Random noise stimulation initially employed mechanical noise in auditory and cutaneous stimuli,but electrical energies applied to the brain or the skin are becoming more frequent,with a series of clinical applications.Indeed,recent evidence shows that transcranial random noise stimulation can increase corticospinal excitability,improve cognitive/motor performance,and produce beneficial aftereffects at the behavioral and psychological levels.Here,we present a narrative review about the potential uses of random noise stimulation to treat neurological disorders,including attention deficit hyperactivity disorder,schizophrenia,amblyopia,myopia,tinnitus,multiple sclerosis,post-stroke,vestibular-postural disorders,and sensitivity loss.Many of the reviewed studies reveal that the optimal way to deliver random noise stimulation-based therapies is with the concomitant use of neurological and neuropsychological assessments to validate the beneficial aftereffects.In addition,we highlight the requirement of more randomized controlled trials and more physiological studies of random noise stimulation to discover another optimal way to perform the random noise stimulation interventions.
文摘Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental disorders.Although significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural circuits.Moreove r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly understood.Recently,advancements in neuroimaging have provided insight into neuromodulation techniques.Functional near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic interference.Coupling functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro rehabilitation.We aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer interfaces.Furthermore,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are summarized.In conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system diseases.
基金the Medical Scientist Training Program(T32GM007250)Predoctoral Training in Molecular Therapeutics Program(T32GM008803)。
文摘Neuromodulation represents a cutting edge class of both invasive and non-invasive therapeutic methods which alter the activity of neurons.Currently,several different techniques have been developed-or are currently being investigated–to treat a wide variety of neurological and neuropsychiatric disorders.Recently,in vivo and in vitro studies have revealed that neuromodulation can also induce myelination,meaning that it could hold potential as a therapy for various demyelinating diseases including multiple sclerosis and progressive multifocal leukencepalopathy.These findings come on the heels of a paradigm shift in the view of myelin's role within the nervous system from a static structure to an active co-regulator of central nervous system plasticity and participant in neuron-mediated modulation.In the present review,we highlight several of the recent findings regarding the role of neural activity in altering myelination including several soluble and contact-dependent factors that seem to mediate neural activitydependent myelination.We also highlight several considerations for neuromodulatory techniques,including the need for further research into spatiotemporal precision,dosage,and the safety and efficacy of transcranial focused ultrasound stimulation,an emerging neuromodulation technology.As the field of neuromodulation continues to evolve,it could potentially bring forth methods for the treatment of demyelinating diseases,and as such,further investigation into the mechanisms of neuron-dependent myelination as well as neuro-imaging modalities that can monitor myelination activity is warranted.
文摘Migraine is a common and recurrent chronic disorder.Migraine is often associated with anxiety,depression and other emotional diseases.With the development of physical rehabilitation techniques,the long-term clinical efficacy of rehabilitation in the treatment of migraine and the prevention of recurrence have been widely accepted.This paper reviews the effectiveness of physical rehabilitation therapy in clinical treatment of migraine in recent years.
文摘Background Neurophysiologic monitoring during surgery is to prevent permanent neurological injury resulting from surgical manipulation. To improve the accuracy and sensitivity of intraoperative neuromonitoring, combined monitoring of transcranial electrical stimulation motor evoked potentials （TES-MEPs）, somatosensory evoked potentials （SSEPs） and brainstem auditory evoked potentials （BAEPs） was attempted in microsurgery for lesions adjacent to the brainstem and intracranial aneurysms. Methods Monitoring of combined TES-MEPs with SSEPs was attempted in 68 consecutive patients with lesions adjacent to the brainstem as well as intracranial aneurysms. Among them, 31 patients （31 operations, 28 of posterior cranial fossa tumors, 3 of posterior circulation aneurysms） were also subjected to monitoring of BAEPs. The correlation of monitoring results and clinical outcome was studied prospectively. Results Combined monitoring of evoked potentials （EPs） was done in 64 （94.1%） of the 68 patients. MEPs monitoring was impossible for 4 patients （5.9%）. No complication was observed during the combined monitoring in all the patients. In 45 （66.2%） of the 68 patients, EPs were stable, and they were neurologically intact. Motor dysfunction was detected by MEPs in 8 patients, SSEPs in 5, and BAEPs in 4, respectively. Conclusions A close relationship exists between postoperative motor function and the results of TES-MEPs monitoring TES-MEPs are superior to SSEPs and BAEPs in detecting motor dysfunction, but combined EPs serve as a safe, effective and invasive method for intraoperative monitoring of the function of the motor nervous system. Monitoring of combined EPs during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms may detect potentially hazardous maneuvers and improve the safety of subsequent procedures.
