AIM:To compare intraocular pressure(IOP)measured via the trans palpebral IOP(tp IOP)method using a Diaton or with a Goldman applanation tonometer(GAT)and study the determinants of IOP difference in eyes undergoing tra...AIM:To compare intraocular pressure(IOP)measured via the trans palpebral IOP(tp IOP)method using a Diaton or with a Goldman applanation tonometer(GAT)and study the determinants of IOP difference in eyes undergoing transepithelial photorefractive keratectomy(TPRK)for myopia.METHODS:This cross-sectional validation study was held in 2020 in an eye hospital in Saudi Arabia.IOP was measured by Diaton and GAT before treatment,after one week,and one month of TPRK.It is considered if IOP difference by Diaton and GAT was less than±2 mm Hg acceptable.The IOP difference was tested if correlated to spherical equivalent(SE),central corneal thickness(CCT),age,gender,or tp IOP.RESULTS:Totolly 200 myopic eyes of 100 patients were included in the study.The mean difference of IOP measured by two methods before TPRK,1wk,and 1mo after TPRK were 0.790,-0.790,and-0.920 mm Hg,respectively(P<0.001).Diaton could measure IOP effectively 89.5%eyes before TPRK and 82%and 84%at 1wk and 1mo after TPTK,respectively.At week 1,IOP differences were significantly correlated to baseline CCT(P=0.02)and tp IOP at week 1(P<0.001).One month after TPRK,only tp IOP was significantly correlated to the difference in IOP(P<0.001).CONCLUSION:Diaton is a good screening tool for IOP before TPRK.It helps in monitoring IOP after surgery.Although more practical,it is less efficient than GAT.In eyes with high myopia and low tp IOP before surgery,IOP post-TPRK by Diaton and GAT could differ.展开更多
The authors report a case of Large Anterior mediastinal mass in which Transoesophageal Echocardiography (TEE) revealed a large mass that was compressing the right atrium, SVC, henceforth, TEE helped in guid</span&g...The authors report a case of Large Anterior mediastinal mass in which Transoesophageal Echocardiography (TEE) revealed a large mass that was compressing the right atrium, SVC, henceforth, TEE helped in guid</span><span style="font-size:10.0pt;font-family:"">ing</span><span style="font-size:10.0pt;font-family:""> aspiration and surgical resection of the cystic mass. Therefore, through this case report, <span>authors emphasize the importance of performing intraoperative real-time</span> TEE in the mediastinal mass. This imaging technique helps in visualizing the external compression of cardio-vascular structure and aid in their management, obviating the possibility of large vascular structures from being injured by the surgeon during intraoperative manipulation.展开更多
The rapid melting of Arctic sea ice poses significant risks to the safety of shipping routes.Accurate remote sensing data on sea ice concentration(SIC)is crucial for effective route planning of ships and ensuring navi...The rapid melting of Arctic sea ice poses significant risks to the safety of shipping routes.Accurate remote sensing data on sea ice concentration(SIC)is crucial for effective route planning of ships and ensuring navigational safety.Despite the availability of numerous SIC products in China,these datasets still lag behind mainstream international products in terms of data accuracy,spatiotemporal resolution,and time span.To enhance the accuracy of China's domestic SIC remote sensing data,this study used the SIC data derived from the passive microwave remote sensing dataset provided by the University of Bremen(BRM-SIC)as a reference to conduct a comprehensive evaluation and analysis of two additional SIC datasets:the dataset derived from the microwave radiation imager(MWRI)aboard the FY-3D satellite,provided by the National Satellite Meteorological Center(FY-SIC),and the dataset obtained through the DT-ASI algorithm from the microwave imager of the FY-3D satellite,provided by Ocean University of China(OUC-SIC).Based on the evaluation results,a TransUnet fusion correction model was developed.The performance of this model was then compared against Ordinary Least Squares(OLS),Random Forest(RF),and UNet correction models,through spatial and temporal analyses.Results indicate that,compared to FY-SIC data,the RMSE of the OUC-SIC data and the standard data is reduced by24.245%,while the R is increased by 12.516%.Overall,the accuracy of OUC-SIC data is superior to that of FY-SIC data.During the research period(2020–2022),the standard deviation(SD)and coefficient of variation(CV)of OUC-SIC were 3.877%and 10.582%,respectively,while those for FY-SIC were 7.836%and 7.982%,respectively.In the study area,compared with OUC-SIC data,FYSIC data exhibited a larger standard deviation of deviation and a smaller coefficient of variation of deviation across most sea areas.These results indicate that the OUC-SIC data exhibit better temporal and spatial stability,whereas the FY-SIC data show stronger relative dimensionless stability.Among the four correction models,all showed improvements over the original,unfused corrected data.The fusion corrections using the OLS,RF,UNet,and TransUnet models reduced RMSE by 5.563%,14.601%,42.927%,and48.316%,respectively.Correspondingly,R increased by 0.463%,1.176%,3.951%,and 4.342%,respectively.Among these models,TransUnet performed the best,effectively integrating the advantages of FY-SIC and OUC-SIC data and notably improving the overall accuracy and spatiotemporal stability of SIC data.展开更多
Influenza viruses are a major cause of respiratory illness,with significant public health impact due to their ability to cause pandemics.This dialogue brought together experts including Professors George Fu Gao,Stephe...Influenza viruses are a major cause of respiratory illness,with significant public health impact due to their ability to cause pandemics.This dialogue brought together experts including Professors George Fu Gao,Stephen Cusack,Mark von Itzstein,Ervin Fodor,Jonathan Grimes,Aartjan J.W.te Velthuis,and Tao Deng to decode the pressing scientific challenges and future directions in influenza research.They discussed how structural studies of the influenza polymerase have advanced our understanding of viral RNA transcription and replication.These insights are crucial for developing new antiviral drugs,with a particular focus on targeting the polymerase and its interactions with host factors like acidic nuclear phosphoprotein 32(ANP32).The dialogue also highlighted the potential of artificial intelligence(AI)to assist in designing small-molecule drugs,offering new strategies for combating influenza.Future research will continue to unravel the complexities of the polymerase’s role in replication,aiming to translate these findings into effective therapies and resilient public health strategies.展开更多
Dear Editor,Ciliary body masses are diagnostically challenging due to their hidden location,diverse pathologies,and limited examination methods[1].We report a case of a ciliary body inflammatory mass treated with tran...Dear Editor,Ciliary body masses are diagnostically challenging due to their hidden location,diverse pathologies,and limited examination methods[1].We report a case of a ciliary body inflammatory mass treated with trans-scleral excision and antiinflammatory therapy,preserving functional vision.展开更多
现有相关工程与技术多关注建筑构件几何信息的映射,构件语义信息挖掘侧重于工程项目需要的单一信息,导致BIM(Building Information Modeling)数据在语义交互和智能分析中的潜力未被充分挖掘。该文提出一种基于知识图谱的BIM建筑构件语...现有相关工程与技术多关注建筑构件几何信息的映射,构件语义信息挖掘侧重于工程项目需要的单一信息,导致BIM(Building Information Modeling)数据在语义交互和智能分析中的潜力未被充分挖掘。该文提出一种基于知识图谱的BIM建筑构件语义信息提取方法,首先通过设计语义映射规则将IFC(Industry Foundation Classes)模型的实体、属性、物理信息转化为知识图谱,形成可用于语义分析的结构化语义网络,然后采用TransE嵌入模型对构建的BIM知识图谱进行嵌入学习,通过向量化表示增强信息提取能力。以某三层综合建筑楼为研究对象,提取并构建了包含996个BIM语义节点和2173条关系的知识图谱,进一步采用TransE模型进行语义信息嵌入,对提取结果进行验证。实验结果表明:知识图谱能有效提取BIM建筑构件语义信息,选取最优参数后进行TransE模型嵌入学习,实体语义成功率为97.27%,该方法能够精准捕捉建筑构件各类语义信息的关键内容,减少信息遗漏和提取错误,为BIM模型信息分析和决策提供了新思路。展开更多
Flaxseed oil,a key source of plant-based ω-3α-linolenic acid,is susceptible to oxidation and hazardous substance formation during refining and storage.This study evaluated the effects of refining stages(crude,degumm...Flaxseed oil,a key source of plant-based ω-3α-linolenic acid,is susceptible to oxidation and hazardous substance formation during refining and storage.This study evaluated the effects of refining stages(crude,degumming,complete refining)on aldehydes,trans fatty acids,and oxidative stability in flaxseed oil.The results indicate that heat-pressed oil has dark color with high a*and b*values,but exhibits the relatively highest oxidative stability during the oxidation process.However,compared to cold-pressing,heat-pressing promotes the generation of three additional aldehydes,butenal,nonanal,and trans,trans-2,4-decadienal.Degumming optimizes the color of crude oil while maintaining α-linolenic acid.In contrast,complete refining(degumming,deacidification,bleaching,and deodorization)caused the loss of substantial carotenoids and polyphenols,and α-linolenic acid decreased by 3.48%–4.47%,as well as a large amount of production of trans fatty acids.In addition,complete refining not only leads to the formation of newborn acrolein and trans-2-nominal but also results in a significant increase in most aldehydes concentration.This study provides a reference for the processing of flaxseed oil when considering the formation of hazardous substances induced by the oxidation and isomerization of polyunsaturated fatty acids.展开更多
BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment...BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment efficacy and increasing morbidity.AIM To investigate the risk factors associated with post-operative infection in HCC patients undergoing D-TACE,and to provide evidence for clinical prevention and targeted intervention strategies.METHODS Clinical data of 77 primary HCC patients who underwent D-TACE in our hospital from January 2022 to December 2023 were retrospectively analyzed.Patient demographics,laboratory test results,tumor characteristics,and surgery-related parameters were collected.Univariate and multivariate logistic regression analyses were performed to identify risk factors for post-operative infection.RESULTS Post-operative infection occurred in 20 cases(25.97%)among the 77 patients.Univariate analysis showed that age≥65 years,Child-Pugh grade B,tumor diameter≥5 cm,operation time≥120 minutes,preoperative albumin<35 g/L,and comorbid diabetes were significantly associated with post-operative infection(P<0.05).Multivariate logistic regression analysis identified Child-Pugh grade B(OR=2.851,95%CI:1.426-5.698),operation time≥120 minutes(OR=2.367,95%CI:1.238-4.523),and preoperative albumin<35 g/L(OR=2.156,95%CI:1.147-4.052)as independent risk factors for post-operative infection.CONCLUSION Liver function status,operation time,and preoperative albumin level are significant factors affecting post-operative infection in HCC patients undergoing D-TACE.For high-risk patients,enhanced perioperative management,appropriate timing of surgery,and active improvement of nutritional status should be implemented to reduce the risk of post-operative infection.展开更多
文摘AIM:To compare intraocular pressure(IOP)measured via the trans palpebral IOP(tp IOP)method using a Diaton or with a Goldman applanation tonometer(GAT)and study the determinants of IOP difference in eyes undergoing transepithelial photorefractive keratectomy(TPRK)for myopia.METHODS:This cross-sectional validation study was held in 2020 in an eye hospital in Saudi Arabia.IOP was measured by Diaton and GAT before treatment,after one week,and one month of TPRK.It is considered if IOP difference by Diaton and GAT was less than±2 mm Hg acceptable.The IOP difference was tested if correlated to spherical equivalent(SE),central corneal thickness(CCT),age,gender,or tp IOP.RESULTS:Totolly 200 myopic eyes of 100 patients were included in the study.The mean difference of IOP measured by two methods before TPRK,1wk,and 1mo after TPRK were 0.790,-0.790,and-0.920 mm Hg,respectively(P<0.001).Diaton could measure IOP effectively 89.5%eyes before TPRK and 82%and 84%at 1wk and 1mo after TPTK,respectively.At week 1,IOP differences were significantly correlated to baseline CCT(P=0.02)and tp IOP at week 1(P<0.001).One month after TPRK,only tp IOP was significantly correlated to the difference in IOP(P<0.001).CONCLUSION:Diaton is a good screening tool for IOP before TPRK.It helps in monitoring IOP after surgery.Although more practical,it is less efficient than GAT.In eyes with high myopia and low tp IOP before surgery,IOP post-TPRK by Diaton and GAT could differ.
文摘The authors report a case of Large Anterior mediastinal mass in which Transoesophageal Echocardiography (TEE) revealed a large mass that was compressing the right atrium, SVC, henceforth, TEE helped in guid</span><span style="font-size:10.0pt;font-family:"">ing</span><span style="font-size:10.0pt;font-family:""> aspiration and surgical resection of the cystic mass. Therefore, through this case report, <span>authors emphasize the importance of performing intraoperative real-time</span> TEE in the mediastinal mass. This imaging technique helps in visualizing the external compression of cardio-vascular structure and aid in their management, obviating the possibility of large vascular structures from being injured by the surgeon during intraoperative manipulation.
基金supported by the National Natural Science Foundation of China(No.41971339)the SDUST Research Fund(No.2019TDJH103)。
文摘The rapid melting of Arctic sea ice poses significant risks to the safety of shipping routes.Accurate remote sensing data on sea ice concentration(SIC)is crucial for effective route planning of ships and ensuring navigational safety.Despite the availability of numerous SIC products in China,these datasets still lag behind mainstream international products in terms of data accuracy,spatiotemporal resolution,and time span.To enhance the accuracy of China's domestic SIC remote sensing data,this study used the SIC data derived from the passive microwave remote sensing dataset provided by the University of Bremen(BRM-SIC)as a reference to conduct a comprehensive evaluation and analysis of two additional SIC datasets:the dataset derived from the microwave radiation imager(MWRI)aboard the FY-3D satellite,provided by the National Satellite Meteorological Center(FY-SIC),and the dataset obtained through the DT-ASI algorithm from the microwave imager of the FY-3D satellite,provided by Ocean University of China(OUC-SIC).Based on the evaluation results,a TransUnet fusion correction model was developed.The performance of this model was then compared against Ordinary Least Squares(OLS),Random Forest(RF),and UNet correction models,through spatial and temporal analyses.Results indicate that,compared to FY-SIC data,the RMSE of the OUC-SIC data and the standard data is reduced by24.245%,while the R is increased by 12.516%.Overall,the accuracy of OUC-SIC data is superior to that of FY-SIC data.During the research period(2020–2022),the standard deviation(SD)and coefficient of variation(CV)of OUC-SIC were 3.877%and 10.582%,respectively,while those for FY-SIC were 7.836%and 7.982%,respectively.In the study area,compared with OUC-SIC data,FYSIC data exhibited a larger standard deviation of deviation and a smaller coefficient of variation of deviation across most sea areas.These results indicate that the OUC-SIC data exhibit better temporal and spatial stability,whereas the FY-SIC data show stronger relative dimensionless stability.Among the four correction models,all showed improvements over the original,unfused corrected data.The fusion corrections using the OLS,RF,UNet,and TransUnet models reduced RMSE by 5.563%,14.601%,42.927%,and48.316%,respectively.Correspondingly,R increased by 0.463%,1.176%,3.951%,and 4.342%,respectively.Among these models,TransUnet performed the best,effectively integrating the advantages of FY-SIC and OUC-SIC data and notably improving the overall accuracy and spatiotemporal stability of SIC data.
文摘Influenza viruses are a major cause of respiratory illness,with significant public health impact due to their ability to cause pandemics.This dialogue brought together experts including Professors George Fu Gao,Stephen Cusack,Mark von Itzstein,Ervin Fodor,Jonathan Grimes,Aartjan J.W.te Velthuis,and Tao Deng to decode the pressing scientific challenges and future directions in influenza research.They discussed how structural studies of the influenza polymerase have advanced our understanding of viral RNA transcription and replication.These insights are crucial for developing new antiviral drugs,with a particular focus on targeting the polymerase and its interactions with host factors like acidic nuclear phosphoprotein 32(ANP32).The dialogue also highlighted the potential of artificial intelligence(AI)to assist in designing small-molecule drugs,offering new strategies for combating influenza.Future research will continue to unravel the complexities of the polymerase’s role in replication,aiming to translate these findings into effective therapies and resilient public health strategies.
基金Supported by National Natural Science Foundation of China(No.82101113).
文摘Dear Editor,Ciliary body masses are diagnostically challenging due to their hidden location,diverse pathologies,and limited examination methods[1].We report a case of a ciliary body inflammatory mass treated with trans-scleral excision and antiinflammatory therapy,preserving functional vision.
文摘现有相关工程与技术多关注建筑构件几何信息的映射,构件语义信息挖掘侧重于工程项目需要的单一信息,导致BIM(Building Information Modeling)数据在语义交互和智能分析中的潜力未被充分挖掘。该文提出一种基于知识图谱的BIM建筑构件语义信息提取方法,首先通过设计语义映射规则将IFC(Industry Foundation Classes)模型的实体、属性、物理信息转化为知识图谱,形成可用于语义分析的结构化语义网络,然后采用TransE嵌入模型对构建的BIM知识图谱进行嵌入学习,通过向量化表示增强信息提取能力。以某三层综合建筑楼为研究对象,提取并构建了包含996个BIM语义节点和2173条关系的知识图谱,进一步采用TransE模型进行语义信息嵌入,对提取结果进行验证。实验结果表明:知识图谱能有效提取BIM建筑构件语义信息,选取最优参数后进行TransE模型嵌入学习,实体语义成功率为97.27%,该方法能够精准捕捉建筑构件各类语义信息的关键内容,减少信息遗漏和提取错误,为BIM模型信息分析和决策提供了新思路。
文摘Flaxseed oil,a key source of plant-based ω-3α-linolenic acid,is susceptible to oxidation and hazardous substance formation during refining and storage.This study evaluated the effects of refining stages(crude,degumming,complete refining)on aldehydes,trans fatty acids,and oxidative stability in flaxseed oil.The results indicate that heat-pressed oil has dark color with high a*and b*values,but exhibits the relatively highest oxidative stability during the oxidation process.However,compared to cold-pressing,heat-pressing promotes the generation of three additional aldehydes,butenal,nonanal,and trans,trans-2,4-decadienal.Degumming optimizes the color of crude oil while maintaining α-linolenic acid.In contrast,complete refining(degumming,deacidification,bleaching,and deodorization)caused the loss of substantial carotenoids and polyphenols,and α-linolenic acid decreased by 3.48%–4.47%,as well as a large amount of production of trans fatty acids.In addition,complete refining not only leads to the formation of newborn acrolein and trans-2-nominal but also results in a significant increase in most aldehydes concentration.This study provides a reference for the processing of flaxseed oil when considering the formation of hazardous substances induced by the oxidation and isomerization of polyunsaturated fatty acids.
文摘BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment efficacy and increasing morbidity.AIM To investigate the risk factors associated with post-operative infection in HCC patients undergoing D-TACE,and to provide evidence for clinical prevention and targeted intervention strategies.METHODS Clinical data of 77 primary HCC patients who underwent D-TACE in our hospital from January 2022 to December 2023 were retrospectively analyzed.Patient demographics,laboratory test results,tumor characteristics,and surgery-related parameters were collected.Univariate and multivariate logistic regression analyses were performed to identify risk factors for post-operative infection.RESULTS Post-operative infection occurred in 20 cases(25.97%)among the 77 patients.Univariate analysis showed that age≥65 years,Child-Pugh grade B,tumor diameter≥5 cm,operation time≥120 minutes,preoperative albumin<35 g/L,and comorbid diabetes were significantly associated with post-operative infection(P<0.05).Multivariate logistic regression analysis identified Child-Pugh grade B(OR=2.851,95%CI:1.426-5.698),operation time≥120 minutes(OR=2.367,95%CI:1.238-4.523),and preoperative albumin<35 g/L(OR=2.156,95%CI:1.147-4.052)as independent risk factors for post-operative infection.CONCLUSION Liver function status,operation time,and preoperative albumin level are significant factors affecting post-operative infection in HCC patients undergoing D-TACE.For high-risk patients,enhanced perioperative management,appropriate timing of surgery,and active improvement of nutritional status should be implemented to reduce the risk of post-operative infection.
