Energy saving and emission reduction for railway systems should not only be studied from a technical perspective but should also be focused on management and economics. On the basis of relevant trainscheduling models ...Energy saving and emission reduction for railway systems should not only be studied from a technical perspective but should also be focused on management and economics. On the basis of relevant trainscheduling models for train operation management, in this paper we introduce an extended multi-objective trainscheduling optimization model considering locomotive assignment and segment emission constraints for energy saving. The objective of setting up this model is to reduce the energy and emission cost as well as total passenger- time. The decision variables include continuous variables such as train arrival and departure time, and binary vari- ables such as locomotive assignment and segment occu- pancy. The constraints are concerned with train movement, trip time, headway, and segment emission, etc. To obtain a non-dominated satisfactory solution on these objectives, a fuzzy multi-objective optimization algorithm is employed to solve the model. Finally, a numerical example is performed and used to compare the proposed model with the existing model. The results show that the proposed model can reduce the energy consumption, meet exhausts emission demands effectively by optimal locomotive assignment, and its solution methodology is effective.展开更多
AIM: To observe the localization of TRAIL/TRAIR (DR4, DR5,DcR1, DcR2) in the fetal pancreas.METHODS: Fetal pancreas of 32 weeks of pregnancy wereobtained from induced abortions, embedded in paraffin, and4-μm sections...AIM: To observe the localization of TRAIL/TRAIR (DR4, DR5,DcR1, DcR2) in the fetal pancreas.METHODS: Fetal pancreas of 32 weeks of pregnancy wereobtained from induced abortions, embedded in paraffin, and4-μm sections were prepared. The localization of TRAIL/TRAILR in fetal pancreas was investigated by fluorescenceimmunohistochemical method combined with laser scanningconfocal microscopy.RESULTS: TRAIL immunoreactive cells were mainly locatedon the periphery of the pancreas islets. There were a fewDcR1 and DcR2 positive cells whereas there were noimmunoreactive cells of DR4 and DR5 in the pancreas islets.In the acini and the ducts of the exocrine pancreas therewere no TRAIL/TRAILR immunoreactive cells.CONCLUSION: This study not only describes thedistribution of TRAIL/TRAILR in the fetal pancreas, but alsoprovides a morphological basis for deducing the functionof TRAIL/TRAILR in pancreas, suggesting that in normalpancreatic islets, the pancreatic cells are resistant towardsapoptosis too.展开更多
基金supported by the National Natural Science Foundation of China (No. 71101007)the National High Technology Research and Development Program of China (No. 2011AA110502)State Key Laboratory of Rail Traffic Control and Safety of Beijing Jiaotong University Program (RCS2010ZZ001)
文摘Energy saving and emission reduction for railway systems should not only be studied from a technical perspective but should also be focused on management and economics. On the basis of relevant trainscheduling models for train operation management, in this paper we introduce an extended multi-objective trainscheduling optimization model considering locomotive assignment and segment emission constraints for energy saving. The objective of setting up this model is to reduce the energy and emission cost as well as total passenger- time. The decision variables include continuous variables such as train arrival and departure time, and binary vari- ables such as locomotive assignment and segment occu- pancy. The constraints are concerned with train movement, trip time, headway, and segment emission, etc. To obtain a non-dominated satisfactory solution on these objectives, a fuzzy multi-objective optimization algorithm is employed to solve the model. Finally, a numerical example is performed and used to compare the proposed model with the existing model. The results show that the proposed model can reduce the energy consumption, meet exhausts emission demands effectively by optimal locomotive assignment, and its solution methodology is effective.
基金the grants of the National Key Basic Research Program of China,No.2001CB510004
文摘AIM: To observe the localization of TRAIL/TRAIR (DR4, DR5,DcR1, DcR2) in the fetal pancreas.METHODS: Fetal pancreas of 32 weeks of pregnancy wereobtained from induced abortions, embedded in paraffin, and4-μm sections were prepared. The localization of TRAIL/TRAILR in fetal pancreas was investigated by fluorescenceimmunohistochemical method combined with laser scanningconfocal microscopy.RESULTS: TRAIL immunoreactive cells were mainly locatedon the periphery of the pancreas islets. There were a fewDcR1 and DcR2 positive cells whereas there were noimmunoreactive cells of DR4 and DR5 in the pancreas islets.In the acini and the ducts of the exocrine pancreas therewere no TRAIL/TRAILR immunoreactive cells.CONCLUSION: This study not only describes thedistribution of TRAIL/TRAILR in the fetal pancreas, but alsoprovides a morphological basis for deducing the functionof TRAIL/TRAILR in pancreas, suggesting that in normalpancreatic islets, the pancreatic cells are resistant towardsapoptosis too.
