Let p be a prime. For any finite p-group G, the deep transfers T H,G ' : H / H ' → G ' / G " from the maximal subgroups H of index (G:H) = p in G to the derived subgroup G ' are introduced as an ...Let p be a prime. For any finite p-group G, the deep transfers T H,G ' : H / H ' → G ' / G " from the maximal subgroups H of index (G:H) = p in G to the derived subgroup G ' are introduced as an innovative tool for identifying G uniquely by means of the family of kernels ùd(G) =(ker(T H,G ')) (G: H) = p. For all finite 3-groups G of coclass cc(G) = 1, the family ùd(G) is determined explicitly. The results are applied to the Galois groups G =Gal(F3 (∞)/ F) of the Hilbert 3-class towers of all real quadratic fields F = Q(√d) with fundamental discriminants d > 1, 3-class group Cl3(F) □ C3 × C3, and total 3-principalization in each of their four unramified cyclic cubic extensions E/F. A systematic statistical evaluation is given for the complete range 1 d 7, and a few exceptional cases are pointed out for 1 d 8.展开更多
Let F be a number field and p be a prime. In the successive approximation theorem, we prove that, for each integer n ≥ 1, finitely many candidates for the Galois group of the nth stage of the p-class tower over F are...Let F be a number field and p be a prime. In the successive approximation theorem, we prove that, for each integer n ≥ 1, finitely many candidates for the Galois group of the nth stage of the p-class tower over F are determined by abelian type invariants of p-class groups C1pE of unramified extensions E/F with degree [E : F] = pn-1. Illustrated by the most extensive numerical results available currently, the transfer kernels (TE, F) of the p-class extensions TE, F : C1pF → C1pE from F to unramified cyclic degree-p extensions E/F are shown to be capable of narrowing down the number of contestants significantly. By determining the isomorphism type of the maximal subgroups S G of all 3-groups G with coclass cc(G) = 1, and establishing a general theorem on the connection between the p-class towers of a number field F and of an unramified abelian p-extension E/F, we are able to provide a theoretical proof of the realization of certain 3-groups S with maximal class by 3-tower groups of dihedral fields E with degree 6, which could not be realized up to now.展开更多
This study investigated the impacts of random negative training datasets(NTDs)on the uncertainty of machine learning models for geologic hazard susceptibility assessment of the Loess Plateau,northern Shaanxi Province,...This study investigated the impacts of random negative training datasets(NTDs)on the uncertainty of machine learning models for geologic hazard susceptibility assessment of the Loess Plateau,northern Shaanxi Province,China.Based on randomly generated 40 NTDs,the study developed models for the geologic hazard susceptibility assessment using the random forest algorithm and evaluated their performances using the area under the receiver operating characteristic curve(AUC).Specifically,the means and standard deviations of the AUC values from all models were then utilized to assess the overall spatial correlation between the conditioning factors and the susceptibility assessment,as well as the uncertainty introduced by the NTDs.A risk and return methodology was thus employed to quantify and mitigate the uncertainty,with log odds ratios used to characterize the susceptibility assessment levels.The risk and return values were calculated based on the standard deviations and means of the log odds ratios of various locations.After the mean log odds ratios were converted into probability values,the final susceptibility map was plotted,which accounts for the uncertainty induced by random NTDs.The results indicate that the AUC values of the models ranged from 0.810 to 0.963,with an average of 0.852 and a standard deviation of 0.035,indicating encouraging prediction effects and certain uncertainty.The risk and return analysis reveals that low-risk and high-return areas suggest lower standard deviations and higher means across multiple model-derived assessments.Overall,this study introduces a new framework for quantifying the uncertainty of multiple training and evaluation models,aimed at improving their robustness and reliability.Additionally,by identifying low-risk and high-return areas,resource allocation for geologic hazard prevention and control can be optimized,thus ensuring that limited resources are directed toward the most effective prevention and control measures.展开更多
BACKGROUND This case report presents an innovative approach to managing a complex class II division 1 malocclusion with ectopic maxillary canines using a modified twin block(TB)appliance.The modification facilitated s...BACKGROUND This case report presents an innovative approach to managing a complex class II division 1 malocclusion with ectopic maxillary canines using a modified twin block(TB)appliance.The modification facilitated simultaneous skeletal correction and canine eruption,reducing treatment time and improving patient satisfaction.CASE SUMMARY A 14-year-old male presented with concerns about a retruded chin and spacing between teeth.Clinical and radiographic evaluation revealed a class II division 1 malocclusion on a moderate class II skeletal base,with palatally impacted maxillary canines.Treatment involved a modified Clark TB appliance designed with hooks to allow active traction of the canines,followed by comprehensive fixed orthodontics.Over 18 months,the patient achieved improved occlusion,corrected overjet and overbite,successful eruption of the impacted canines,and enhanced facial aesthetics.The final results showed significant dental and skeletal improvement without requiring surgical intervention.CONCLUSION A modified TB appliance can effectively manage class II malocclusion with impacted canines in growing patients.The modified approach combining functional mandibular advancement and active canine traction represents a lessdocumented clinical adaptation,offering a valuable,efficient alternative to traditional two-phase interventions.展开更多
Objective:To explore the application effect of group cooperative learning combined with flipped classroom in standardized training of emergency surgery resident physicians.Methods:95 resident physicians undergoing eme...Objective:To explore the application effect of group cooperative learning combined with flipped classroom in standardized training of emergency surgery resident physicians.Methods:95 resident physicians undergoing emergency surgery standardized training in our hospital were randomly divided into an experimental group(46,group cooperative learning+flipped classroom)and a control group(49,traditional teaching).The training period was 2 months.Results:The graduation assessment scores of the experimental group were higher than those of the control group(P<0.05).The improvement in critical thinking ability and self-learning ability was better than that of the control group(P<0.05).The response rate of“yes”to all items of course teaching satisfaction was significantly higher than that of the control group(P<0.05).The satisfaction scores for training teachers were higher than those of the control group(P<0.05).Conclusion:The teaching model of group cooperative learning combined with flipped classroom,through reconstructing the learning process and activating interactive participation,can significantly improve the clinical operation and theoretical foundation of emergency surgery standardized training students.It also cultivates core professional qualities such as critical thinking,self-learning,and team collaboration,providing a feasible paradigm for integrated medical education in this discipline.展开更多
RehabilNation training is believed to be beneficial to patients with stroke, but its molecular mechanism is still unclear. Rat models of cerebral ischemic stroke were established by middle cerebral artery occlusion/re...RehabilNation training is believed to be beneficial to patients with stroke, but its molecular mechanism is still unclear. Rat models of cerebral ischemic stroke were established by middle cerebral artery occlusion/reperfusion, and then received treadmill training of different intens让ies, twice a day for 30 minutes for 1 week. Low-intensity training was conducted at 5 m/min, with a 10-minute running, 10-minute rest, and 10-minute running cycle. In the moderate-intensity training, the intensity gradually increased from 5 m/min to 10 m/min in 5 minutes, with the same rest cycle as above. In high-intensity training, the intensity gradually increased from 5 m/min to 25 m/min in 5 minutes, with the same rest cycle as above. The Bederson scale was used to evaluate the improvement of motor function. Infarct volume was detected using 2,3,5-triphenyltetrazolium chloride staining. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining was applied to detect the apoptosis of nerve cells in brain tissue. Western blot assay was employed to analyze the activation of cyclic adenosine monophosphate (cAMP)/protein kinase A and Akt/glycogen synthase kinase-3卩 signaling pathways in rat brain tissue. All training intensities reduced the neurological deficit score, infarct volume, and apoptosis in nerve cells in brain tissue of stroke rats. Training intensities activated the cAMP/protein kinase A and Akt/glycogen synthase kinase-3 beta signaling pathways. This activation was more obvious with higher training intensities. These changes were reversed by intracerebroventricular injection of protein kinase A inhibitor Rp-cAMP. Our findings indicate that the neuroprotective effect of rehabilitation training is achieved via activation of the cAMP/ protein kinase A and Akt/glycogen synthase kinase-3 beta signaling pathways. This study was approved by the Ethics Committee of Animal Experimentation in Shanghai No. 8 Peoples Hospital, China.展开更多
[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold...[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold-dampness obstruction syndrome.[Methods]A total of 162 KOA patients admitted to Huadong Hospital Affiliated to Fudan University from January 2021 to May 2023 were enrolled and randomly divided into an electroacupuncture group and a control group,with 81 patients in each group.The control group received routine rehabilitation training,while the electroacupuncture group received electroacupuncture treatment in addition to the same rehabilitation training,both for 4 weeks.The efficacy,syndrome scores,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),Lysholm Knee Score(LKS),3D gait parameters,and levels of inflammatory markers were compared between the two groups.[Results]Following treatment,the total effective rate in the electroacupuncture group was 92.59%,which was significantly higher than 77.78%observed in the control group(P<0.05).Additionally,the electroacupuncture group exhibited lower TCM syndrome scores(P<0.05),reduced WOMAC scores,and elevated LKS scores compared to the control group(P<0.05).Gait parameters,including step frequency,step speed,stride length,initial ground contact flexion angle,maximum swing phase extension angle,and support phase extension angle,were all higher in the electroacupuncture group.Additionally,the sagittal plane maximum abduction moment was lower in the electroacupuncture group.Inflammatory markers showed that interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were lower in the electroacupuncture group,while transforming growth factor-β1(TGF-β1)was higher(P<0.05).[Conclusions]Electroacupuncture combined with rehabilitation training effectively enhances clinical efficacy,alleviates symptoms,improves knee joint mobility and walking ability,enhances knee function scores,and reduces inflammatory levels,contributing to the rapid recovery of knee joints in KOA patients.展开更多
AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active adolescents.METHODS:This is a pragmatic randomised controlled intervention.The study was carried o...AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active adolescents.METHODS:This is a pragmatic randomised controlled intervention.The study was carried out in a Hong Kong Government secondary school.Thirty-eight lean and active boys and girls were randomised to either the resistance training group or the control group.Students in the resistance training group received in-school 10-wk supervised resistance training twice per week,with each session lasting 70 min.Main outcome measures taken before and after training included brachial endothelial dependent flow-mediated dilation,body composition,fasting serum lipids,fasting glucose and insulin,high sensitive C-reactive protein,24-h ambulatory blood pressure and aerobic fitness.RESULTS:The only training related change was in endothelial dependent flow-mediated dilation which increased from 8.5%to 9.8%.A main effect of time and an interaction(P<0.005) indicated that this improvement was a result of the 10-wk resistance training.Main effects for time(P<0.05) in a number of anthropometric,metabolic and vascular variables were noted;however,there were no significant interactions indicating the change was more likely an outcome of normal growth and development as opposed to a training effect.CONCLUSION:Ten weeks of resistance training in school appears to have some vascular benefit in active,lean children.展开更多
The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can serio...The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore,early orthodontic treatment for Class Ⅲ malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class Ⅲ malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class Ⅲ malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class Ⅲ malocclusion through early orthodontic treatment.展开更多
Soft independent modeling of class analogy (SIMCA) was successful in classifying a large library of 758 commercially available, non-blended samples of acetate, cotton, polyester, rayon, silk and wool 89% - 98% of the ...Soft independent modeling of class analogy (SIMCA) was successful in classifying a large library of 758 commercially available, non-blended samples of acetate, cotton, polyester, rayon, silk and wool 89% - 98% of the time at the 95% confidence level (p = 0.05 significance level). In the present study, cotton and silk had a 62% and 24% chance, respectively, of being classified with their own group and also with rayon. SIMCA correctly identified a counterfeit “silk” sample as polyester. When coupled with diffuse NIR reflectance spectroscopy and a large sample library, SIMCA shows considerable promise as a quick, non-destructive, multivariate method for fiber identification. A major advantage is simplicity. No sample pretreatment of any kind was required, and no adjust-ments were made for fiber origin, manufacturing process residues, topical finishes, weave pattern, or dye content. Increasing the sample library should make the models more robust and improve identification rates over those reported in this paper.展开更多
Background Schizophrenia is characterised by pervasive cognitive deficits that significantly impair daily functioning and quality of life.Pharmacological treatments have limited efficacy in addressing these deficits,h...Background Schizophrenia is characterised by pervasive cognitive deficits that significantly impair daily functioning and quality of life.Pharmacological treatments have limited efficacy in addressing these deficits,highlighting the need for adjunctive interventions like computerised cognitive training(CCT).Aims This study aimed to evaluate the effects of a 30-session CCT programme on mental well-being and cognitive performance in individuals with schizophrenia.Additionally,it assessed the usability and acceptability of CCT in this population.Methods A double-blind,randomised clinical trial was conducted with 54 participants assigned to intervention and control groups.Cognitive and mental health outcomes were assessed using validated tools such as the Depression Anxiety Stress Scale 21,the Warwick-Edinburgh Mental Wellbeing Scale and the Cambridge Neuropsychological Test Automated Battery.Usability was measured with the System Usability Scale(SUS).Assessments were conducted at baseline,post-intervention and 3 months post-follow-up.Results The CCT intervention significantly improved mental well-being,reduced stress and enhanced working memory(paired associate learning,spatial working memory and spatial span)compared with controls.However,no significant effects were observed for anxiety,depression or executive function.Usability scores were high(SUS=83.51),and compliance rates were strong(92.7%),indicating favourable participant engagement.Conclusion CCT demonstrated potential as an adjunctive treatment for schizophrenia,with significant improvements in targeted cognitive and mental health domains.The high usability and compliance rates support its feasibility for broader implementation.Further research is needed to optimise protocols and explore long-term benefits.CCT offers a promising approach to addressing mental health and cognitive challenges in schizophrenia,particularly for stress and working memory.Its usability and acceptability suggest it could be seamlessly integrated into clinical practice.展开更多
Aerobic capacity, which is expressed as peak oxygen consumption (VO2peak), is well-known to be an independent predictor of all-cause mortality and cardiovascular prognosis. This is true even for people with various co...Aerobic capacity, which is expressed as peak oxygen consumption (VO2peak), is well-known to be an independent predictor of all-cause mortality and cardiovascular prognosis. This is true even for people with various coronary risk factors and cardiovascular diseases. Although exercise training is the best method to improve VO2peak, the guidelines of most academic societies recommend 150 or 75 min of moderate- or vigorous- intensity physical activities, respectively, every week to gain health benefits. For general health and primary and secondary cardiovascular prevention, high-intensity interval training (HIIT) has been recognized as an efficient exercise protocol with short exercise sessions. Given the availability of the numerous HIIT protocols, which can be classified into aerobic HIIT and anaerobic HIIT [usually called sprint interval training (SIT)], professionals in health-related fields, including primary physicians and cardiologists, may find it confusing when trying to select an appropriate protocol for their patients. This review describes the classifications of aerobic HIIT and SIT, and their differences in terms of effects, target subjects, adaptability, working mechanisms, and safety. Understanding the HIIT protocols and adopting the correct type for each subject would lead to better improvements in VO2peak with higher adherence and less risk.展开更多
The lethal brain tumor “Glioblastoma” has the propensity to grow over time. To improve patient outcomes, it is essential to classify GBM accurately and promptly in order to provide a focused and individualized treat...The lethal brain tumor “Glioblastoma” has the propensity to grow over time. To improve patient outcomes, it is essential to classify GBM accurately and promptly in order to provide a focused and individualized treatment plan. Despite this, deep learning methods, particularly Convolutional Neural Networks (CNNs), have demonstrated a high level of accuracy in a myriad of medical image analysis applications as a result of recent technical breakthroughs. The overall aim of the research is to investigate how CNNs can be used to classify GBMs using data from medical imaging, to improve prognosis precision and effectiveness. This research study will demonstrate a suggested methodology that makes use of the CNN architecture and is trained using a database of MRI pictures with this tumor. The constructed model will be assessed based on its overall performance. Extensive experiments and comparisons with conventional machine learning techniques and existing classification methods will also be made. It will be crucial to emphasize the possibility of early and accurate prediction in a clinical workflow because it can have a big impact on treatment planning and patient outcomes. The paramount objective is to not only address the classification challenge but also to outline a clear pathway towards enhancing prognosis precision and treatment effectiveness.展开更多
How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classif...How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classification due to the powerful feature representation ability and better performance. However,the training and testing of CNN mainly rely on single machine.Single machine has its natural limitation and bottleneck in processing RSIs due to limited hardware resources and huge time consuming. Besides, overfitting is a challenge for the CNN model due to the unbalance between RSIs data and the model structure.When a model is complex or the training data is relatively small,overfitting occurs and leads to a poor predictive performance. To address these problems, a distributed CNN architecture for RSIs target classification is proposed, which dramatically increases the training speed of CNN and system scalability. It improves the storage ability and processing efficiency of RSIs. Furthermore,Bayesian regularization approach is utilized in order to initialize the weights of the CNN extractor, which increases the robustness and flexibility of the CNN model. It helps prevent the overfitting and avoid the local optima caused by limited RSI training images or the inappropriate CNN structure. In addition, considering the efficiency of the Na¨?ve Bayes classifier, a distributed Na¨?ve Bayes classifier is designed to reduce the training cost. Compared with other algorithms, the proposed system and method perform the best and increase the recognition accuracy. The results show that the distributed system framework and the proposed algorithms are suitable for RSIs target classification tasks.展开更多
In this paper,the class of starlike functions of complex order γ(γ∈ℂ−{0})is extended from the case on unit disk U=(z∈C:|z|<1)to the case on the unit ball B in a complex Banach space or the unit polydisk U^(n) i...In this paper,the class of starlike functions of complex order γ(γ∈ℂ−{0})is extended from the case on unit disk U=(z∈C:|z|<1)to the case on the unit ball B in a complex Banach space or the unit polydisk U^(n) in C^(n).Let g be a convex function in U. We mainly establish the sharp bounds of all terms of homogeneous polynomial expansions for a subclass of g-parametric starlike mappings of complex order γ on B (resp.U^(n))when the mappings f are k-fold symmetric, k ∈ N. Our results partly solve the Bieberbach conjecture in several complex variables and generalize some prior works.展开更多
On April 19th,"the Youth Table Tennis Programme—Photo Exhibition of Zhou Enlai and the Bandung Conference&China-ASEAN(Indonesia)Youth Table Tennis Training Camp"opened in Jakarta,Indonesia.The event was...On April 19th,"the Youth Table Tennis Programme—Photo Exhibition of Zhou Enlai and the Bandung Conference&China-ASEAN(Indonesia)Youth Table Tennis Training Camp"opened in Jakarta,Indonesia.The event was guided by the Chinese Embassy in Indonesia and co-organised by the ASEAN-China Centre(ACC),the Memorial to Zhou Enlai and Deng Yingchao,the China Friendship Foundation for Peace and Development,the Beijing One Heart Sphere Charity Foundation,and the Enlai Foundation.展开更多
The first in vivo measurements of serial sarcomere number in human muscles before and after eccentric strength training have just been published and the results will interest anyone involved with sport or health:Train...The first in vivo measurements of serial sarcomere number in human muscles before and after eccentric strength training have just been published and the results will interest anyone involved with sport or health:Training the hamstrings 3 times per week for 9 weeks with the Nordic hamstring exercise was found to increase the number of sarcomeres in series in the biceps femoris long head(BFlh)by≥25%.1 In this commentary,we highlight an additional,paradoxical finding,which was not discussed by the authors;namely that the substantial serial sarcomere addition must have been accompanied by a subtraction of sarcomeres in parallel to match the relatively small increase in muscle volume after training.展开更多
Background Evidence on the effects of different exercise interventions on cognitive function is insufficient.Aims To evaluate the feasibility and effects of remotely supervised aerobic exercise(AE)and resistance exerc...Background Evidence on the effects of different exercise interventions on cognitive function is insufficient.Aims To evaluate the feasibility and effects of remotely supervised aerobic exercise(AE)and resistance exercise(RE)interventions in older adults with mild cognitive impairment(MCI).Methods This study is a 6-month pilot three-arm randomised controlled trial.Eligible participants(n=108)were recruited and randomised to the AE group,RE group or control(CON)group with a 1:1:1 ratio.Interventions were delivered at home with remote supervision.We evaluated participants’global cognition,memory,executive function,attention,physical activity levels,physical performance and muscle strength of limbs at baseline,3 months(T1)and 6 months(T2)after randomisation.A linear mixed-effects model was adopted for data analyses after controlling for covariates.Tukey’s method was used for adjusting for multiple comparisons.Sensitivity analyses were performed after excluding individuals with low compliance rates.Results 15(13.89%)participants dropped out.The median compliance rates in the AE group and RE group were 67.31%and 93.27%,respectively.After adjusting for covariates,the scores of the Alzheimer’s Disease Assessment Scale-Cognitive subscale in the AE group decreased by 2.04(95%confidence interval(CI)−3.41 to−0.67,t=−2.94,p=0.004)and 1.53(95%CI−2.88 to−0.17,t=−2.22,p=0.028)points more than those in the CON group at T1 and T2,respectively.The effects of AE were still significant at T1(estimate=−1.70,95%CI−3.20 to−0.21,t=−2.69,p=0.021),but lost statistical significance at T2 after adjusting for multiple comparisons.As for executive function,the Stroop time interference in the RE group decreased by 11.76 s(95%CI−21.62 to−1.90,t=−2.81,p=0.015)more than that in the AE group at T2 after Tukey’s adjustment.No other significant effects on cognitive functions were found.Conclusions Both remotely supervised AE and RE programmes are feasible in older adults with MCI.AE has positive effects on global cognition,and RE improves executive function.展开更多
文摘Let p be a prime. For any finite p-group G, the deep transfers T H,G ' : H / H ' → G ' / G " from the maximal subgroups H of index (G:H) = p in G to the derived subgroup G ' are introduced as an innovative tool for identifying G uniquely by means of the family of kernels ùd(G) =(ker(T H,G ')) (G: H) = p. For all finite 3-groups G of coclass cc(G) = 1, the family ùd(G) is determined explicitly. The results are applied to the Galois groups G =Gal(F3 (∞)/ F) of the Hilbert 3-class towers of all real quadratic fields F = Q(√d) with fundamental discriminants d > 1, 3-class group Cl3(F) □ C3 × C3, and total 3-principalization in each of their four unramified cyclic cubic extensions E/F. A systematic statistical evaluation is given for the complete range 1 d 7, and a few exceptional cases are pointed out for 1 d 8.
文摘Let F be a number field and p be a prime. In the successive approximation theorem, we prove that, for each integer n ≥ 1, finitely many candidates for the Galois group of the nth stage of the p-class tower over F are determined by abelian type invariants of p-class groups C1pE of unramified extensions E/F with degree [E : F] = pn-1. Illustrated by the most extensive numerical results available currently, the transfer kernels (TE, F) of the p-class extensions TE, F : C1pF → C1pE from F to unramified cyclic degree-p extensions E/F are shown to be capable of narrowing down the number of contestants significantly. By determining the isomorphism type of the maximal subgroups S G of all 3-groups G with coclass cc(G) = 1, and establishing a general theorem on the connection between the p-class towers of a number field F and of an unramified abelian p-extension E/F, we are able to provide a theoretical proof of the realization of certain 3-groups S with maximal class by 3-tower groups of dihedral fields E with degree 6, which could not be realized up to now.
基金supported by a project entitled Loess Plateau Region-Watershed-Slope Geological Hazard Multi-Scale Collaborative Intelligent Early Warning System of the National Key R&D Program of China(2022YFC3003404)a project of the Shaanxi Youth Science and Technology Star(2021KJXX-87)public welfare geological survey projects of Shaanxi Institute of Geologic Survey(20180301,201918,202103,and 202413).
文摘This study investigated the impacts of random negative training datasets(NTDs)on the uncertainty of machine learning models for geologic hazard susceptibility assessment of the Loess Plateau,northern Shaanxi Province,China.Based on randomly generated 40 NTDs,the study developed models for the geologic hazard susceptibility assessment using the random forest algorithm and evaluated their performances using the area under the receiver operating characteristic curve(AUC).Specifically,the means and standard deviations of the AUC values from all models were then utilized to assess the overall spatial correlation between the conditioning factors and the susceptibility assessment,as well as the uncertainty introduced by the NTDs.A risk and return methodology was thus employed to quantify and mitigate the uncertainty,with log odds ratios used to characterize the susceptibility assessment levels.The risk and return values were calculated based on the standard deviations and means of the log odds ratios of various locations.After the mean log odds ratios were converted into probability values,the final susceptibility map was plotted,which accounts for the uncertainty induced by random NTDs.The results indicate that the AUC values of the models ranged from 0.810 to 0.963,with an average of 0.852 and a standard deviation of 0.035,indicating encouraging prediction effects and certain uncertainty.The risk and return analysis reveals that low-risk and high-return areas suggest lower standard deviations and higher means across multiple model-derived assessments.Overall,this study introduces a new framework for quantifying the uncertainty of multiple training and evaluation models,aimed at improving their robustness and reliability.Additionally,by identifying low-risk and high-return areas,resource allocation for geologic hazard prevention and control can be optimized,thus ensuring that limited resources are directed toward the most effective prevention and control measures.
文摘BACKGROUND This case report presents an innovative approach to managing a complex class II division 1 malocclusion with ectopic maxillary canines using a modified twin block(TB)appliance.The modification facilitated simultaneous skeletal correction and canine eruption,reducing treatment time and improving patient satisfaction.CASE SUMMARY A 14-year-old male presented with concerns about a retruded chin and spacing between teeth.Clinical and radiographic evaluation revealed a class II division 1 malocclusion on a moderate class II skeletal base,with palatally impacted maxillary canines.Treatment involved a modified Clark TB appliance designed with hooks to allow active traction of the canines,followed by comprehensive fixed orthodontics.Over 18 months,the patient achieved improved occlusion,corrected overjet and overbite,successful eruption of the impacted canines,and enhanced facial aesthetics.The final results showed significant dental and skeletal improvement without requiring surgical intervention.CONCLUSION A modified TB appliance can effectively manage class II malocclusion with impacted canines in growing patients.The modified approach combining functional mandibular advancement and active canine traction represents a lessdocumented clinical adaptation,offering a valuable,efficient alternative to traditional two-phase interventions.
基金Key Research and Development Program of Shaanxi Province,“Exploring the Changes and Mechanisms of Cerebral Microcirculation in Patients with Cerebral Small Vessel Disease and Mild Cognitive Impairment Based on OCTA Assessment”(Project No.:2023-YBSF-569)Shaanxi Provincial People’s Hospital Science and Technology Development Incubation Fund,“Early Identification of Cognitive Impairment in Cerebral Small Vessel Disease Based on Eye Tracking Technology”(Project No.:2023YJY-72)Key Research and Development Program of Shaanxi Province,“Study on the Correlation between Deep Medullary Veins and Cognitive Dysfunction in Cerebral Small Vessel Disease”(Project No.:2023-YBSF-033)。
文摘Objective:To explore the application effect of group cooperative learning combined with flipped classroom in standardized training of emergency surgery resident physicians.Methods:95 resident physicians undergoing emergency surgery standardized training in our hospital were randomly divided into an experimental group(46,group cooperative learning+flipped classroom)and a control group(49,traditional teaching).The training period was 2 months.Results:The graduation assessment scores of the experimental group were higher than those of the control group(P<0.05).The improvement in critical thinking ability and self-learning ability was better than that of the control group(P<0.05).The response rate of“yes”to all items of course teaching satisfaction was significantly higher than that of the control group(P<0.05).The satisfaction scores for training teachers were higher than those of the control group(P<0.05).Conclusion:The teaching model of group cooperative learning combined with flipped classroom,through reconstructing the learning process and activating interactive participation,can significantly improve the clinical operation and theoretical foundation of emergency surgery standardized training students.It also cultivates core professional qualities such as critical thinking,self-learning,and team collaboration,providing a feasible paradigm for integrated medical education in this discipline.
基金supported by Clinical Study on Treatment of Cerebral Small Blood Vessel Disease by Integrated Traditional Chinese and Western Medicine,No.ZHYY-ZXYJHZX-201625
文摘RehabilNation training is believed to be beneficial to patients with stroke, but its molecular mechanism is still unclear. Rat models of cerebral ischemic stroke were established by middle cerebral artery occlusion/reperfusion, and then received treadmill training of different intens让ies, twice a day for 30 minutes for 1 week. Low-intensity training was conducted at 5 m/min, with a 10-minute running, 10-minute rest, and 10-minute running cycle. In the moderate-intensity training, the intensity gradually increased from 5 m/min to 10 m/min in 5 minutes, with the same rest cycle as above. In high-intensity training, the intensity gradually increased from 5 m/min to 25 m/min in 5 minutes, with the same rest cycle as above. The Bederson scale was used to evaluate the improvement of motor function. Infarct volume was detected using 2,3,5-triphenyltetrazolium chloride staining. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining was applied to detect the apoptosis of nerve cells in brain tissue. Western blot assay was employed to analyze the activation of cyclic adenosine monophosphate (cAMP)/protein kinase A and Akt/glycogen synthase kinase-3卩 signaling pathways in rat brain tissue. All training intensities reduced the neurological deficit score, infarct volume, and apoptosis in nerve cells in brain tissue of stroke rats. Training intensities activated the cAMP/protein kinase A and Akt/glycogen synthase kinase-3 beta signaling pathways. This activation was more obvious with higher training intensities. These changes were reversed by intracerebroventricular injection of protein kinase A inhibitor Rp-cAMP. Our findings indicate that the neuroprotective effect of rehabilitation training is achieved via activation of the cAMP/ protein kinase A and Akt/glycogen synthase kinase-3 beta signaling pathways. This study was approved by the Ethics Committee of Animal Experimentation in Shanghai No. 8 Peoples Hospital, China.
基金Supported by General Program of the National Natural Science Foundation of China(81973883)Three-Year Action Plan Project for Enhancing Clinical Skills and Clinical Innovation Capabilities of Municipal Hospitals(SHDC2020CR1010A).
文摘[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold-dampness obstruction syndrome.[Methods]A total of 162 KOA patients admitted to Huadong Hospital Affiliated to Fudan University from January 2021 to May 2023 were enrolled and randomly divided into an electroacupuncture group and a control group,with 81 patients in each group.The control group received routine rehabilitation training,while the electroacupuncture group received electroacupuncture treatment in addition to the same rehabilitation training,both for 4 weeks.The efficacy,syndrome scores,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),Lysholm Knee Score(LKS),3D gait parameters,and levels of inflammatory markers were compared between the two groups.[Results]Following treatment,the total effective rate in the electroacupuncture group was 92.59%,which was significantly higher than 77.78%observed in the control group(P<0.05).Additionally,the electroacupuncture group exhibited lower TCM syndrome scores(P<0.05),reduced WOMAC scores,and elevated LKS scores compared to the control group(P<0.05).Gait parameters,including step frequency,step speed,stride length,initial ground contact flexion angle,maximum swing phase extension angle,and support phase extension angle,were all higher in the electroacupuncture group.Additionally,the sagittal plane maximum abduction moment was lower in the electroacupuncture group.Inflammatory markers showed that interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were lower in the electroacupuncture group,while transforming growth factor-β1(TGF-β1)was higher(P<0.05).[Conclusions]Electroacupuncture combined with rehabilitation training effectively enhances clinical efficacy,alleviates symptoms,improves knee joint mobility and walking ability,enhances knee function scores,and reduces inflammatory levels,contributing to the rapid recovery of knee joints in KOA patients.
文摘AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active adolescents.METHODS:This is a pragmatic randomised controlled intervention.The study was carried out in a Hong Kong Government secondary school.Thirty-eight lean and active boys and girls were randomised to either the resistance training group or the control group.Students in the resistance training group received in-school 10-wk supervised resistance training twice per week,with each session lasting 70 min.Main outcome measures taken before and after training included brachial endothelial dependent flow-mediated dilation,body composition,fasting serum lipids,fasting glucose and insulin,high sensitive C-reactive protein,24-h ambulatory blood pressure and aerobic fitness.RESULTS:The only training related change was in endothelial dependent flow-mediated dilation which increased from 8.5%to 9.8%.A main effect of time and an interaction(P<0.005) indicated that this improvement was a result of the 10-wk resistance training.Main effects for time(P<0.05) in a number of anthropometric,metabolic and vascular variables were noted;however,there were no significant interactions indicating the change was more likely an outcome of normal growth and development as opposed to a training effect.CONCLUSION:Ten weeks of resistance training in school appears to have some vascular benefit in active,lean children.
文摘The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore,early orthodontic treatment for Class Ⅲ malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class Ⅲ malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class Ⅲ malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class Ⅲ malocclusion through early orthodontic treatment.
文摘Soft independent modeling of class analogy (SIMCA) was successful in classifying a large library of 758 commercially available, non-blended samples of acetate, cotton, polyester, rayon, silk and wool 89% - 98% of the time at the 95% confidence level (p = 0.05 significance level). In the present study, cotton and silk had a 62% and 24% chance, respectively, of being classified with their own group and also with rayon. SIMCA correctly identified a counterfeit “silk” sample as polyester. When coupled with diffuse NIR reflectance spectroscopy and a large sample library, SIMCA shows considerable promise as a quick, non-destructive, multivariate method for fiber identification. A major advantage is simplicity. No sample pretreatment of any kind was required, and no adjust-ments were made for fiber origin, manufacturing process residues, topical finishes, weave pattern, or dye content. Increasing the sample library should make the models more robust and improve identification rates over those reported in this paper.
基金supported by a grant from University of Social Welfare and Rehabilitation Sciences for the research expenses.
文摘Background Schizophrenia is characterised by pervasive cognitive deficits that significantly impair daily functioning and quality of life.Pharmacological treatments have limited efficacy in addressing these deficits,highlighting the need for adjunctive interventions like computerised cognitive training(CCT).Aims This study aimed to evaluate the effects of a 30-session CCT programme on mental well-being and cognitive performance in individuals with schizophrenia.Additionally,it assessed the usability and acceptability of CCT in this population.Methods A double-blind,randomised clinical trial was conducted with 54 participants assigned to intervention and control groups.Cognitive and mental health outcomes were assessed using validated tools such as the Depression Anxiety Stress Scale 21,the Warwick-Edinburgh Mental Wellbeing Scale and the Cambridge Neuropsychological Test Automated Battery.Usability was measured with the System Usability Scale(SUS).Assessments were conducted at baseline,post-intervention and 3 months post-follow-up.Results The CCT intervention significantly improved mental well-being,reduced stress and enhanced working memory(paired associate learning,spatial working memory and spatial span)compared with controls.However,no significant effects were observed for anxiety,depression or executive function.Usability scores were high(SUS=83.51),and compliance rates were strong(92.7%),indicating favourable participant engagement.Conclusion CCT demonstrated potential as an adjunctive treatment for schizophrenia,with significant improvements in targeted cognitive and mental health domains.The high usability and compliance rates support its feasibility for broader implementation.Further research is needed to optimise protocols and explore long-term benefits.CCT offers a promising approach to addressing mental health and cognitive challenges in schizophrenia,particularly for stress and working memory.Its usability and acceptability suggest it could be seamlessly integrated into clinical practice.
文摘Aerobic capacity, which is expressed as peak oxygen consumption (VO2peak), is well-known to be an independent predictor of all-cause mortality and cardiovascular prognosis. This is true even for people with various coronary risk factors and cardiovascular diseases. Although exercise training is the best method to improve VO2peak, the guidelines of most academic societies recommend 150 or 75 min of moderate- or vigorous- intensity physical activities, respectively, every week to gain health benefits. For general health and primary and secondary cardiovascular prevention, high-intensity interval training (HIIT) has been recognized as an efficient exercise protocol with short exercise sessions. Given the availability of the numerous HIIT protocols, which can be classified into aerobic HIIT and anaerobic HIIT [usually called sprint interval training (SIT)], professionals in health-related fields, including primary physicians and cardiologists, may find it confusing when trying to select an appropriate protocol for their patients. This review describes the classifications of aerobic HIIT and SIT, and their differences in terms of effects, target subjects, adaptability, working mechanisms, and safety. Understanding the HIIT protocols and adopting the correct type for each subject would lead to better improvements in VO2peak with higher adherence and less risk.
文摘The lethal brain tumor “Glioblastoma” has the propensity to grow over time. To improve patient outcomes, it is essential to classify GBM accurately and promptly in order to provide a focused and individualized treatment plan. Despite this, deep learning methods, particularly Convolutional Neural Networks (CNNs), have demonstrated a high level of accuracy in a myriad of medical image analysis applications as a result of recent technical breakthroughs. The overall aim of the research is to investigate how CNNs can be used to classify GBMs using data from medical imaging, to improve prognosis precision and effectiveness. This research study will demonstrate a suggested methodology that makes use of the CNN architecture and is trained using a database of MRI pictures with this tumor. The constructed model will be assessed based on its overall performance. Extensive experiments and comparisons with conventional machine learning techniques and existing classification methods will also be made. It will be crucial to emphasize the possibility of early and accurate prediction in a clinical workflow because it can have a big impact on treatment planning and patient outcomes. The paramount objective is to not only address the classification challenge but also to outline a clear pathway towards enhancing prognosis precision and treatment effectiveness.
基金supported by the National Natural Science Foundation of China(U1435220)
文摘How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classification due to the powerful feature representation ability and better performance. However,the training and testing of CNN mainly rely on single machine.Single machine has its natural limitation and bottleneck in processing RSIs due to limited hardware resources and huge time consuming. Besides, overfitting is a challenge for the CNN model due to the unbalance between RSIs data and the model structure.When a model is complex or the training data is relatively small,overfitting occurs and leads to a poor predictive performance. To address these problems, a distributed CNN architecture for RSIs target classification is proposed, which dramatically increases the training speed of CNN and system scalability. It improves the storage ability and processing efficiency of RSIs. Furthermore,Bayesian regularization approach is utilized in order to initialize the weights of the CNN extractor, which increases the robustness and flexibility of the CNN model. It helps prevent the overfitting and avoid the local optima caused by limited RSI training images or the inappropriate CNN structure. In addition, considering the efficiency of the Na¨?ve Bayes classifier, a distributed Na¨?ve Bayes classifier is designed to reduce the training cost. Compared with other algorithms, the proposed system and method perform the best and increase the recognition accuracy. The results show that the distributed system framework and the proposed algorithms are suitable for RSIs target classification tasks.
基金supported by the National Natural Science Foundation of China(12061035)the Research Foundation of Jiangxi Science and Technology Normal University of China(2021QNBJRC003)supported by the Graduate Innovation Fund of Jiangxi Science and Technology Normal University(YC2024-X10).
文摘In this paper,the class of starlike functions of complex order γ(γ∈ℂ−{0})is extended from the case on unit disk U=(z∈C:|z|<1)to the case on the unit ball B in a complex Banach space or the unit polydisk U^(n) in C^(n).Let g be a convex function in U. We mainly establish the sharp bounds of all terms of homogeneous polynomial expansions for a subclass of g-parametric starlike mappings of complex order γ on B (resp.U^(n))when the mappings f are k-fold symmetric, k ∈ N. Our results partly solve the Bieberbach conjecture in several complex variables and generalize some prior works.
文摘On April 19th,"the Youth Table Tennis Programme—Photo Exhibition of Zhou Enlai and the Bandung Conference&China-ASEAN(Indonesia)Youth Table Tennis Training Camp"opened in Jakarta,Indonesia.The event was guided by the Chinese Embassy in Indonesia and co-organised by the ASEAN-China Centre(ACC),the Memorial to Zhou Enlai and Deng Yingchao,the China Friendship Foundation for Peace and Development,the Beijing One Heart Sphere Charity Foundation,and the Enlai Foundation.
文摘The first in vivo measurements of serial sarcomere number in human muscles before and after eccentric strength training have just been published and the results will interest anyone involved with sport or health:Training the hamstrings 3 times per week for 9 weeks with the Nordic hamstring exercise was found to increase the number of sarcomeres in series in the biceps femoris long head(BFlh)by≥25%.1 In this commentary,we highlight an additional,paradoxical finding,which was not discussed by the authors;namely that the substantial serial sarcomere addition must have been accompanied by a subtraction of sarcomeres in parallel to match the relatively small increase in muscle volume after training.
基金funded by the National Natural Science Foundation of China(81871854,72374014)the National Key R&D Program of China(2020YFC2008804)+1 种基金the Shanghai Jiao Tong University Young Talent Cultivation Program in Liberal Arts(2024QN041)the Shanghai Jiao Tong University School of Medicine:Nursing Development Program(SJTUHLXK2024).
文摘Background Evidence on the effects of different exercise interventions on cognitive function is insufficient.Aims To evaluate the feasibility and effects of remotely supervised aerobic exercise(AE)and resistance exercise(RE)interventions in older adults with mild cognitive impairment(MCI).Methods This study is a 6-month pilot three-arm randomised controlled trial.Eligible participants(n=108)were recruited and randomised to the AE group,RE group or control(CON)group with a 1:1:1 ratio.Interventions were delivered at home with remote supervision.We evaluated participants’global cognition,memory,executive function,attention,physical activity levels,physical performance and muscle strength of limbs at baseline,3 months(T1)and 6 months(T2)after randomisation.A linear mixed-effects model was adopted for data analyses after controlling for covariates.Tukey’s method was used for adjusting for multiple comparisons.Sensitivity analyses were performed after excluding individuals with low compliance rates.Results 15(13.89%)participants dropped out.The median compliance rates in the AE group and RE group were 67.31%and 93.27%,respectively.After adjusting for covariates,the scores of the Alzheimer’s Disease Assessment Scale-Cognitive subscale in the AE group decreased by 2.04(95%confidence interval(CI)−3.41 to−0.67,t=−2.94,p=0.004)and 1.53(95%CI−2.88 to−0.17,t=−2.22,p=0.028)points more than those in the CON group at T1 and T2,respectively.The effects of AE were still significant at T1(estimate=−1.70,95%CI−3.20 to−0.21,t=−2.69,p=0.021),but lost statistical significance at T2 after adjusting for multiple comparisons.As for executive function,the Stroop time interference in the RE group decreased by 11.76 s(95%CI−21.62 to−1.90,t=−2.81,p=0.015)more than that in the AE group at T2 after Tukey’s adjustment.No other significant effects on cognitive functions were found.Conclusions Both remotely supervised AE and RE programmes are feasible in older adults with MCI.AE has positive effects on global cognition,and RE improves executive function.
