Based on the constructivism, using the College English（new edition） CD-ROMs for classroom teaching as main media, this paper explores the feasibility of the classroom teaching mode of appropriate combination of trad...Based on the constructivism, using the College English（new edition） CD-ROMs for classroom teaching as main media, this paper explores the feasibility of the classroom teaching mode of appropriate combination of traditional methods with the multimedia overhead projector. The new teaching mode proves to be successful in that it has greatly improved the students＇ ability to use English in an all-round way and has obvious advantages over the only traditional method.展开更多
RNAs have important biological functions and the functions of RNAs are generally coupled to their structures, especiallytheir secondary structures. In this work, we have made a comprehensive evaluation of the performa...RNAs have important biological functions and the functions of RNAs are generally coupled to their structures, especiallytheir secondary structures. In this work, we have made a comprehensive evaluation of the performances of existingtop RNA secondary structure prediction methods, including five deep-learning (DL) based methods and five minimum freeenergy (MFE) based methods. First, we made a brief overview of these RNA secondary structure prediction methods.Afterwards, we built two rigorous test datasets consisting of RNAs with non-redundant sequences and comprehensivelyexamined the performances of the RNA secondary structure prediction methods through classifying the RNAs into differentlength ranges and different types. Our examination shows that the DL-based methods generally perform better thanthe MFE-based methods for RNAs with long lengths and complex structures, while the MFE-based methods can achievegood performance for small RNAs and some specialized MFE-based methods can achieve good prediction accuracy forpseudoknots. Finally, we provided some insights and perspectives in modeling RNA secondary structures.展开更多
A study on the evaluation of the effectiveness of three traditional methods of protecting guinea fowl from mortality was carried out at CRA-SS （Centre de Recherche Agronomique de la Savane S6che） in northem Togo. Gu...A study on the evaluation of the effectiveness of three traditional methods of protecting guinea fowl from mortality was carried out at CRA-SS （Centre de Recherche Agronomique de la Savane S6che） in northem Togo. Guinea fowl were divided into 5 batches, of which 3 batches received prophylactic medical treatment including plant decoctions, the 4th batch was followed by a medical prophylaxis program as a control group and the 5th batch considered as a negative control, has not received any prophylactic treatment. The results showed that a mortality rate of 25% for the reference lot and two other batches which received plant decoctions （Euphorbia poissonii or Khaya senegalensis） were recorded against a rate of 87.5% in the batch of guinea fowl which received the decoction of Pteleopsis suberosa. Meanwhile, regardless of weight growth, daily average gain （GMQ） or food consumption, no significant difference was observed （p 〉 0.05） between the guinea fowl that received a baseline health monitoring and those having taken the decoction orE. poissonii. On the other hand, the values recorded in these two batches of guinea fowl differed statistically from those in the guinea fowl that received the decoction of K. senegalensis. Although the decoction of K. senegalensis has a protective effect in guinea fowl, the growth of guinea fowl has been slowed down. On the basis of these results, it appears that two endogenous practices tested （K. senegalensis or E. poissonii） have positive effects. However, it would be desirable to carry out a toxicity test in order to determine the recommended doses.展开更多
Environmental DNA(eDNA)has been used as an important tool for fish diversity analysis,which can greatly solve the problems in traditional survey methodology.However,little work has been done on the actual monitoring a...Environmental DNA(eDNA)has been used as an important tool for fish diversity analysis,which can greatly solve the problems in traditional survey methodology.However,little work has been done on the actual monitoring accuracy of eDNA.In this study,we analyzed the current status of fish resources in Erhai Lake in Yunnan,SW China,by dividing the lake into three sectors according to habitat differences,and compared the results of eDNA and traditional capture methods to investigate the shortcomings of the current analysis of eDNA results.A total of 27 fish species were detected by eDNA and traditional capture methods,including 20 and 19 fish species,respectively,and additional differences in fish composition between the two methods.The alpha diversity showed higher fish abundance and lower fish diversity by eDNA method compared to the traditional capture method,demonstrating that eDNA was not superior for use in fish diversity analysis.Fish community similarity analysis showed that community differences were generally significant for eDNA(P<0.05).RDA analysis indicated that environmental factors did not significantly affect fish communities monitored by the eDNA method.However,water temperature,aquatic plants,and water depth had significant(P<0.05)effects on fish communities in the traditional capture method,suggesting that eDNA results are insensitive to the effects of environmental factors.Our results illustrate the effectiveness of eDNA in fish identification and the issues in quantification compared to traditional capture methods.Therefore,combining eDNA with traditional methods is a more effective method for analyzing eDNA metabarcoding,following which the protocols of both quantitative methods can be designed to explore the regularity of eDNA quantification.展开更多
Objective: in view of the influence of different processing methods of traditional Chinese medicine on the actual curative effect of traditional Chinese medicine decoction pieces, a comprehensive and in-depth analysis...Objective: in view of the influence of different processing methods of traditional Chinese medicine on the actual curative effect of traditional Chinese medicine decoction pieces, a comprehensive and in-depth analysis and research are carried out. Methods: one hundred and twenty patients from 2016 to 2017 were selected from our hospital as the research object. All patients were divided into three groups by the way of random average grouping, that is, Group A, Group B and Group C. For all the patients in Group A, the TCM water treatment pre-grading method was used, all patients in Group B were treated with traditional Chinese medicine before processing, and all patients in Group C were treated with traditional Chinese medicine before water treatment and before processing. After a period of treatment, the clinical treatment conditions of patients in three groups were compared comprehensively. Results: the comprehensive efficiency of clinical treatment of patients in Group C exceeded 90%, which was significantly higher than the treatment effect of Group A and B. Conclusion: the processing method of traditional Chinese medicine plays an important role in improving the clinical treatment effect of traditional Chinese medicine decoction pieces. Therefore, in the teaching of traditional Chinese medicine processing, students should be actively taught relevant knowledge before water treatment and before processing, so as to promote students' in-depth understanding and mastery of the processing method of traditional Chinese medicine decoction pieces.展开更多
Irritable bowel syndrome(IBS-D)with diarrhea is a common gastrointestinal functional disease in clinical practice,which seriously affects the quality of life of patients.Cur‐rently,Western medicine has poor therapeut...Irritable bowel syndrome(IBS-D)with diarrhea is a common gastrointestinal functional disease in clinical practice,which seriously affects the quality of life of patients.Cur‐rently,Western medicine has poor therapeutic effects,while traditional Chinese medi‐cine has unique advantages in relieving IBS-D symptoms and preventing recurrence.In recent years,especially with external treatment of traditional Chinese medicine,it has become a new treatment direction in clinical practice and has achieved good therapeutic effects.This article will provide a review of recent research on the treatment of IBS-D using traditional Chinese medicine external treatment methods.展开更多
Accurate project progress measurement is critical for effective project management. Besides guarantying smooth work progress, it affords project managers the chance to identify early warning signs for peremptory remed...Accurate project progress measurement is critical for effective project management. Besides guarantying smooth work progress, it affords project managers the chance to identify early warning signs for peremptory remedial actions to keep the project on schedule and to budget. However, pertinent barriers can suppress the realization of the benefits of an accurate assessment of construction progress. This study aims to identify, examine and prioritize the critical barriers militating against accurate project progress measurement in the Ghanaian construction industry. Sixteen barriers identified from the literature were administered in a questionnaire survey to professionals with tier one construction firms and consultants. Sixty experienced construction professionals practising with tier-one construction firms and consultancy services took part in the survey. The relative importance index technique was used to rank the factors and correlation in responses of the two parties tested by the Mann-Whitney <em>U</em> statistics. The most critical barriers perceived by the professionals were 1) Reliance on Supervisor’s Judgement, 2) Generic and Non-Systematic Approach, 3) Variable Quality of Data and 4) Intricate Measurement Reports. Other highly ranked barriers include 5) Lack of Timely Information, 6) Laborious Data Gathering and 7) Quality Integration Constraint. The findings underpin the need to minimize dependence on subjective opinions and mere experiences of supervisors for assessment of project progress in this age of information technology. Incorporation of a level of automation into traditional progress methods will not only reduce human errors introduced into manually collected data but facilitate visualization of progress reports. Contiguous to a clear specification of the method of progress measurement in the contract document, a system that conveniently integrates cost, time and scope of work into progress measurement must be pursued. Addressing these identified critical barriers will consolidate current construction progress management practices.展开更多
OBJECTIVE To evaluate the safety and effectiveness of robot-assisted percutaneous coronary intervention(R-PCI)compared to traditional manual percutaneous coronary intervention(M-PCI).METHODS This prospective,multicent...OBJECTIVE To evaluate the safety and effectiveness of robot-assisted percutaneous coronary intervention(R-PCI)compared to traditional manual percutaneous coronary intervention(M-PCI).METHODS This prospective,multicenter,randomized controlled,non-inferior clinical trial enrolled patients with coronary heart disease who met the inclusion criteria and had indications for elective percutaneous coronary intervention.Participants were randomly assigned to either the R-PCI group or the M-PCI group.Primary endpoints were clinical and technical success rates.Clinical success was defined as visually estimated residual post-percutaneous coronary intervention stenosis<30% with no 30-day major adverse cardiac events.Technical success in the R-PCI group was defined as successful completion of percutaneous coronary intervention using the ETcath200 robot-assisted system,without conversion to M-PCI in the event of a guidewire or balloon/stent catheter that was unable to cross the vessel or was poorly supported by the catheter.Secondary endpoints included total procedure time,percutaneous coronary intervention procedure time,fluoroscopy time,contrast volume,operator radiation exposure,air kerma,and dose-area product.RESULTS The trial enrolled 152 patients(R-PCI:73 patients,M-PCI:79 patients).Lesions were predominantly B2/C type(73.6%).Both groups achieved 100% clinical success rate.No major adverse cardiac events occurred during the 30-day follow-up.The R-PCI group had a technical success rate of 100%.The R-PCI group had longer total procedure and fluoroscopy times,but lower operator radiation exposure.The percutaneous coronary intervention procedure time,contrast volume,air kerma,and dose-area product were similar between the two groups.CONCLUSIONS For certain complex lesions,performing percutaneous coronary intervention using the ETcath200 robot-assisted system is safe and effective and does not result in conversion to M-PCI.展开更多
Amplification effects of soil site response can significantly impact ground motions, and must be considered in the seismic fortification of buildings/structures to prevent or mitigate this potential seismic hazard. Ut...Amplification effects of soil site response can significantly impact ground motions, and must be considered in the seismic fortification of buildings/structures to prevent or mitigate this potential seismic hazard. Utilizing acceleration time histories from the main shock of the Wenchuan earthquake recorded at four stations （i.e., one on bedrock and three on soil） in the Qionghai Basin, the site responses from three soil sites are studied by using the traditional spectral ratio method. The bedrock site is selected as a reference site. This study found that peak ground accelerations （PGAs） on the soil sites are much larger than on bedrock, with EW, NS and UD components of 3.96-6.58, 6.27-10.98, and 3.17-6.66 times those of the bedrock site, respectively. The amplification effects of the soil sites on ground motions in the frequency range of 0.1 Hz to 10 Hz are significant, depending on the thickness of the soil layer and the frequency content of the site. A significant amplification occurs with high frequency components of ground motion at shallow soil sites, and low and high frequency components of ground motion at intermediate soil sites.展开更多
Model organisms are the important part of modem life sciences. Arabidopsis thaliana, Oryza sativa, and other model plants have been widely applied in the field of plant science and agronomy, while the international st...Model organisms are the important part of modem life sciences. Arabidopsis thaliana, Oryza sativa, and other model plants have been widely applied in the field of plant science and agronomy, while the international studies on traditional medicine lack the model organisms. Salvia miltiorrhiza, a perennial herb, is one Of the most commonly used medicines.展开更多
OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with i...OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with insomnia were randomly assigned to a placebo group, a low-dose (10 mL/day), or a high-dose (20 mL/day) mistura group. Efficacy was assessed by using the sleep dysfunction rating scale (SDRS) and Clinical Global Impression-Improvement (CGI-I) scores. Safety and tolerability assessments included emergent adverse events, laboratory tests, and electrocardiograms. RESULTS: Total SDRS scores decreased in all three groups, and there were significant differences between the placebo group and the lowand high-dose mistura groups (P=0.000). CGI-I ratings in the lowand high-dose mistura groups were sig-nificantly better than that of the placebo group (P= 0.000). Incidences of rebound insomnia were similar in all three groups (placebo group: 6.94% , low-dose mistura group: 12.99% , and high-dose mistura group: 10.96% ; P=0.475). The efficacy of Huadananshen mistura in the lowor high-dose group was significantly better than that of the placebo group (P=0.000), but with no significant difference found between the lowand high-dose mistura groups (P=0.887). The rates of adverse events were similar in the three groups (placebo 2.44% , low-dose mistura 0%, and high-dose mistura 5%; P=0.088). CONCLUSION: Huadananshen mistura is an effective and generally well-tolerated hypnotic medicine for the treatment of Chinese patients with insomnia.展开更多
Objective:To explore the application advantages of problem-based learning(PBL)teaching method in clinical emergency teaching.Methods:Two classes of students in the five-year clinical medicine major of our university w...Objective:To explore the application advantages of problem-based learning(PBL)teaching method in clinical emergency teaching.Methods:Two classes of students in the five-year clinical medicine major of our university were selected as the research subjects and divided into two groups according to different teaching methods.Among them,50 students who received the traditional teaching method constituted the control group,while 52 students who received the PBL teaching method constituted the observation group.After one semester,an exam was conducted to assess their theoretical knowledge and first-aid practical skills,and evaluate their clinical thinking skills.At the same time,a teaching satisfaction questionnaire was distributed to evaluate the teaching satisfaction.Results:The results of the t-test showed that the observation group was significantly higher than the control group in terms of theoretical assessment,first aid practical assessment,and clinical thinking skills,and the differences were statistically significant(P<0.05).The results of theχ2 test showed that the difference in teaching satisfaction between the observation group and the control group was statistically significant(P<0.05),and the teaching satisfaction in the observation group was significantly higher than the control group.Conclusion:Compared with traditional teaching methods,applying PBL teaching method in clinical emergency teaching can achieve more significant teaching effects.Students’mastery of theoretical knowledge,first aid practical skills,and clinical thinking skills can be effectively strengthened,and it is conducive to improving teaching satisfaction.展开更多
For some time,ELT in China has been undergoing a heated discussion as to the best way ofteaching.Some think that the communicative approaches is inappropriate while others think that the tra-ditional Chinese methods a...For some time,ELT in China has been undergoing a heated discussion as to the best way ofteaching.Some think that the communicative approaches is inappropriate while others think that the tra-ditional Chinese methods are too old-fashioned.From various points of view,this paper argues that boththe communicative approach and the traditional Chinese methods can co-exist and influence each other inthe present Chinese teaching context.展开更多
To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods. The patients of acute bronchitis were randomly divided into 2 groups. In the observati...To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods. The patients of acute bronchitis were randomly divided into 2 groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results： The total effective rate of the observation group was 97.2% while that of the control group was 82,8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group （P 〈 0.01） and on the fifth and seventh days, the comparison showed no significant difference （P〉0.05）. Conclusion： The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.展开更多
This study explores the learning effect of comprehension teaching method on basketball cognition, skills, affection and performance of secondary vocational students. The experiment was designed to carry out 18 weeks o...This study explores the learning effect of comprehension teaching method on basketball cognition, skills, affection and performance of secondary vocational students. The experiment was designed to carry out 18 weeks of basketball teaching in the way of comprehension teaching method, and the basketball cognition test, skill test, PE affection scale and competition performance evaluation (GPAI) were pretested and posttested, and the dependent sample T test was used for statistical analysis. Through this study, it is concluded that the comprehending teaching method can promote the learning effect of basketball for secondary vocational students and provide a new teaching method.展开更多
Objective: to explore the influence of unprotected perineal delivery in delivery room nursing. Methods: the selection time was from January 2020 to January 2021, and the subjects were parturients who delivered natural...Objective: to explore the influence of unprotected perineal delivery in delivery room nursing. Methods: the selection time was from January 2020 to January 2021, and the subjects were parturients who delivered naturally through vagina. The above 100 parturients were divided into control group and experimental group by drawing lots, with 50 cases in each group. The control group was given the traditional delivery method, and the experimental group was given the unprotected perineal delivery method. The degree of perineal laceration, the time of the second stage of labor, the total amount of bleeding and the quality of life three months after delivery were compared between the two groups. Results: the degree of perineal laceration in the experimental group was lower than that in the control group (P < 0.05), and the data comparison was statistically significant. The duration of the second stage of labor and the amount of blood loss in the experimental group were less than those in the control group (P < 0.05), and the difference was statistically significant. 3months after delivery, two kinds of postpartum quality of life were investigated. The score of the experimental group was higher than that of the control group (P < 0.05), and the data difference is of comparative significance. Conclusion: unprotected perineal delivery method has less perineal damage to pregnant women, and is helpful to improve the quality of life of pregnant women after delivery. It is worthy of popularization and application.展开更多
Predicting free energy changes(DDG)is essential for enhancing our understanding of protein evolution and plays a pivotal role in protein engineering and pharmaceutical development.While traditional methods offer valua...Predicting free energy changes(DDG)is essential for enhancing our understanding of protein evolution and plays a pivotal role in protein engineering and pharmaceutical development.While traditional methods offer valuable insights,they are often constrained by computational speed and reliance on biased training datasets.These constraints become particularly evident when aiming for accurate DDG predictions across a diverse array of protein sequences.Herein,we introduce Pythia,a self-supervised graph neural network specifically designed for zero-shot DDG predictions.Our comparative benchmarks demonstrate that Pythia outperforms other self-supervised pretraining models and force field-based approaches while also exhibiting competitive performance with fully supervised models.Notably,Pythia shows strong correlations and achieves a remarkable increase in computational speed of up to 105-fold.We further validated Pythia’s performance in predicting the thermostabilizing mutations of limonene epoxide hydrolase,leading to higher experimental success rates.This exceptional efficiency has enabled us to explore 26 million high-quality protein structures,marking a significant advancement in our ability to navigate the protein sequence space and enhance our understanding of the relationships between protein genotype and phenotype.In addition,we established a web server at https://pythia.wulab.xyz to allow users to easily perform such predictions.展开更多
文摘Based on the constructivism, using the College English（new edition） CD-ROMs for classroom teaching as main media, this paper explores the feasibility of the classroom teaching mode of appropriate combination of traditional methods with the multimedia overhead projector. The new teaching mode proves to be successful in that it has greatly improved the students＇ ability to use English in an all-round way and has obvious advantages over the only traditional method.
基金supported by grants from the National Science Foundation of China(Grant Nos.12375038 and 12075171 to ZJT,and 12205223 to YLT).
文摘RNAs have important biological functions and the functions of RNAs are generally coupled to their structures, especiallytheir secondary structures. In this work, we have made a comprehensive evaluation of the performances of existingtop RNA secondary structure prediction methods, including five deep-learning (DL) based methods and five minimum freeenergy (MFE) based methods. First, we made a brief overview of these RNA secondary structure prediction methods.Afterwards, we built two rigorous test datasets consisting of RNAs with non-redundant sequences and comprehensivelyexamined the performances of the RNA secondary structure prediction methods through classifying the RNAs into differentlength ranges and different types. Our examination shows that the DL-based methods generally perform better thanthe MFE-based methods for RNAs with long lengths and complex structures, while the MFE-based methods can achievegood performance for small RNAs and some specialized MFE-based methods can achieve good prediction accuracy forpseudoknots. Finally, we provided some insights and perspectives in modeling RNA secondary structures.
文摘A study on the evaluation of the effectiveness of three traditional methods of protecting guinea fowl from mortality was carried out at CRA-SS （Centre de Recherche Agronomique de la Savane S6che） in northem Togo. Guinea fowl were divided into 5 batches, of which 3 batches received prophylactic medical treatment including plant decoctions, the 4th batch was followed by a medical prophylaxis program as a control group and the 5th batch considered as a negative control, has not received any prophylactic treatment. The results showed that a mortality rate of 25% for the reference lot and two other batches which received plant decoctions （Euphorbia poissonii or Khaya senegalensis） were recorded against a rate of 87.5% in the batch of guinea fowl which received the decoction of Pteleopsis suberosa. Meanwhile, regardless of weight growth, daily average gain （GMQ） or food consumption, no significant difference was observed （p 〉 0.05） between the guinea fowl that received a baseline health monitoring and those having taken the decoction orE. poissonii. On the other hand, the values recorded in these two batches of guinea fowl differed statistically from those in the guinea fowl that received the decoction of K. senegalensis. Although the decoction of K. senegalensis has a protective effect in guinea fowl, the growth of guinea fowl has been slowed down. On the basis of these results, it appears that two endogenous practices tested （K. senegalensis or E. poissonii） have positive effects. However, it would be desirable to carry out a toxicity test in order to determine the recommended doses.
基金Supported by the Project of Basic Investigation on Ecological Environment Quality of Erhai Lake(No.TPDL-2021-C 265)the Ecological Effects,Population Regulation and Management Strategies of Invasion of Japanese Smelt(Hypomesus nipponensis)in Erhai Lake funded by the government of Dali City,Yunnan Province,China(No.[2018]447)。
文摘Environmental DNA(eDNA)has been used as an important tool for fish diversity analysis,which can greatly solve the problems in traditional survey methodology.However,little work has been done on the actual monitoring accuracy of eDNA.In this study,we analyzed the current status of fish resources in Erhai Lake in Yunnan,SW China,by dividing the lake into three sectors according to habitat differences,and compared the results of eDNA and traditional capture methods to investigate the shortcomings of the current analysis of eDNA results.A total of 27 fish species were detected by eDNA and traditional capture methods,including 20 and 19 fish species,respectively,and additional differences in fish composition between the two methods.The alpha diversity showed higher fish abundance and lower fish diversity by eDNA method compared to the traditional capture method,demonstrating that eDNA was not superior for use in fish diversity analysis.Fish community similarity analysis showed that community differences were generally significant for eDNA(P<0.05).RDA analysis indicated that environmental factors did not significantly affect fish communities monitored by the eDNA method.However,water temperature,aquatic plants,and water depth had significant(P<0.05)effects on fish communities in the traditional capture method,suggesting that eDNA results are insensitive to the effects of environmental factors.Our results illustrate the effectiveness of eDNA in fish identification and the issues in quantification compared to traditional capture methods.Therefore,combining eDNA with traditional methods is a more effective method for analyzing eDNA metabarcoding,following which the protocols of both quantitative methods can be designed to explore the regularity of eDNA quantification.
文摘Objective: in view of the influence of different processing methods of traditional Chinese medicine on the actual curative effect of traditional Chinese medicine decoction pieces, a comprehensive and in-depth analysis and research are carried out. Methods: one hundred and twenty patients from 2016 to 2017 were selected from our hospital as the research object. All patients were divided into three groups by the way of random average grouping, that is, Group A, Group B and Group C. For all the patients in Group A, the TCM water treatment pre-grading method was used, all patients in Group B were treated with traditional Chinese medicine before processing, and all patients in Group C were treated with traditional Chinese medicine before water treatment and before processing. After a period of treatment, the clinical treatment conditions of patients in three groups were compared comprehensively. Results: the comprehensive efficiency of clinical treatment of patients in Group C exceeded 90%, which was significantly higher than the treatment effect of Group A and B. Conclusion: the processing method of traditional Chinese medicine plays an important role in improving the clinical treatment effect of traditional Chinese medicine decoction pieces. Therefore, in the teaching of traditional Chinese medicine processing, students should be actively taught relevant knowledge before water treatment and before processing, so as to promote students' in-depth understanding and mastery of the processing method of traditional Chinese medicine decoction pieces.
文摘Irritable bowel syndrome(IBS-D)with diarrhea is a common gastrointestinal functional disease in clinical practice,which seriously affects the quality of life of patients.Cur‐rently,Western medicine has poor therapeutic effects,while traditional Chinese medi‐cine has unique advantages in relieving IBS-D symptoms and preventing recurrence.In recent years,especially with external treatment of traditional Chinese medicine,it has become a new treatment direction in clinical practice and has achieved good therapeutic effects.This article will provide a review of recent research on the treatment of IBS-D using traditional Chinese medicine external treatment methods.
文摘Accurate project progress measurement is critical for effective project management. Besides guarantying smooth work progress, it affords project managers the chance to identify early warning signs for peremptory remedial actions to keep the project on schedule and to budget. However, pertinent barriers can suppress the realization of the benefits of an accurate assessment of construction progress. This study aims to identify, examine and prioritize the critical barriers militating against accurate project progress measurement in the Ghanaian construction industry. Sixteen barriers identified from the literature were administered in a questionnaire survey to professionals with tier one construction firms and consultants. Sixty experienced construction professionals practising with tier-one construction firms and consultancy services took part in the survey. The relative importance index technique was used to rank the factors and correlation in responses of the two parties tested by the Mann-Whitney <em>U</em> statistics. The most critical barriers perceived by the professionals were 1) Reliance on Supervisor’s Judgement, 2) Generic and Non-Systematic Approach, 3) Variable Quality of Data and 4) Intricate Measurement Reports. Other highly ranked barriers include 5) Lack of Timely Information, 6) Laborious Data Gathering and 7) Quality Integration Constraint. The findings underpin the need to minimize dependence on subjective opinions and mere experiences of supervisors for assessment of project progress in this age of information technology. Incorporation of a level of automation into traditional progress methods will not only reduce human errors introduced into manually collected data but facilitate visualization of progress reports. Contiguous to a clear specification of the method of progress measurement in the contract document, a system that conveniently integrates cost, time and scope of work into progress measurement must be pursued. Addressing these identified critical barriers will consolidate current construction progress management practices.
基金supported by the National Key Research and Development Program of China(No.2022YFC3602500)Beijing High-level Public Health Technical Talents Construction Project(Discipline Leader-03-24)Beijing Hospitals Authority’s Ascent Plan(DFL20240601).
文摘OBJECTIVE To evaluate the safety and effectiveness of robot-assisted percutaneous coronary intervention(R-PCI)compared to traditional manual percutaneous coronary intervention(M-PCI).METHODS This prospective,multicenter,randomized controlled,non-inferior clinical trial enrolled patients with coronary heart disease who met the inclusion criteria and had indications for elective percutaneous coronary intervention.Participants were randomly assigned to either the R-PCI group or the M-PCI group.Primary endpoints were clinical and technical success rates.Clinical success was defined as visually estimated residual post-percutaneous coronary intervention stenosis<30% with no 30-day major adverse cardiac events.Technical success in the R-PCI group was defined as successful completion of percutaneous coronary intervention using the ETcath200 robot-assisted system,without conversion to M-PCI in the event of a guidewire or balloon/stent catheter that was unable to cross the vessel or was poorly supported by the catheter.Secondary endpoints included total procedure time,percutaneous coronary intervention procedure time,fluoroscopy time,contrast volume,operator radiation exposure,air kerma,and dose-area product.RESULTS The trial enrolled 152 patients(R-PCI:73 patients,M-PCI:79 patients).Lesions were predominantly B2/C type(73.6%).Both groups achieved 100% clinical success rate.No major adverse cardiac events occurred during the 30-day follow-up.The R-PCI group had a technical success rate of 100%.The R-PCI group had longer total procedure and fluoroscopy times,but lower operator radiation exposure.The percutaneous coronary intervention procedure time,contrast volume,air kerma,and dose-area product were similar between the two groups.CONCLUSIONS For certain complex lesions,performing percutaneous coronary intervention using the ETcath200 robot-assisted system is safe and effective and does not result in conversion to M-PCI.
基金International Science & Technology Cooperation Program of China under Grant No. 2011DFA71100National Natural Science Foundation of China under Grant No.50878199National Basic Research Program of China under Grant No. 2007CB714201
文摘Amplification effects of soil site response can significantly impact ground motions, and must be considered in the seismic fortification of buildings/structures to prevent or mitigate this potential seismic hazard. Utilizing acceleration time histories from the main shock of the Wenchuan earthquake recorded at four stations （i.e., one on bedrock and three on soil） in the Qionghai Basin, the site responses from three soil sites are studied by using the traditional spectral ratio method. The bedrock site is selected as a reference site. This study found that peak ground accelerations （PGAs） on the soil sites are much larger than on bedrock, with EW, NS and UD components of 3.96-6.58, 6.27-10.98, and 3.17-6.66 times those of the bedrock site, respectively. The amplification effects of the soil sites on ground motions in the frequency range of 0.1 Hz to 10 Hz are significant, depending on the thickness of the soil layer and the frequency content of the site. A significant amplification occurs with high frequency components of ground motion at shallow soil sites, and low and high frequency components of ground motion at intermediate soil sites.
文摘Model organisms are the important part of modem life sciences. Arabidopsis thaliana, Oryza sativa, and other model plants have been widely applied in the field of plant science and agronomy, while the international studies on traditional medicine lack the model organisms. Salvia miltiorrhiza, a perennial herb, is one Of the most commonly used medicines.
基金Supported by the Grants from National Major Project for IND(2012ZX09303-003)Shanghai Health Talent Professional Project(XBR2011049)
文摘OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with insomnia were randomly assigned to a placebo group, a low-dose (10 mL/day), or a high-dose (20 mL/day) mistura group. Efficacy was assessed by using the sleep dysfunction rating scale (SDRS) and Clinical Global Impression-Improvement (CGI-I) scores. Safety and tolerability assessments included emergent adverse events, laboratory tests, and electrocardiograms. RESULTS: Total SDRS scores decreased in all three groups, and there were significant differences between the placebo group and the lowand high-dose mistura groups (P=0.000). CGI-I ratings in the lowand high-dose mistura groups were sig-nificantly better than that of the placebo group (P= 0.000). Incidences of rebound insomnia were similar in all three groups (placebo group: 6.94% , low-dose mistura group: 12.99% , and high-dose mistura group: 10.96% ; P=0.475). The efficacy of Huadananshen mistura in the lowor high-dose group was significantly better than that of the placebo group (P=0.000), but with no significant difference found between the lowand high-dose mistura groups (P=0.887). The rates of adverse events were similar in the three groups (placebo 2.44% , low-dose mistura 0%, and high-dose mistura 5%; P=0.088). CONCLUSION: Huadananshen mistura is an effective and generally well-tolerated hypnotic medicine for the treatment of Chinese patients with insomnia.
文摘Objective:To explore the application advantages of problem-based learning(PBL)teaching method in clinical emergency teaching.Methods:Two classes of students in the five-year clinical medicine major of our university were selected as the research subjects and divided into two groups according to different teaching methods.Among them,50 students who received the traditional teaching method constituted the control group,while 52 students who received the PBL teaching method constituted the observation group.After one semester,an exam was conducted to assess their theoretical knowledge and first-aid practical skills,and evaluate their clinical thinking skills.At the same time,a teaching satisfaction questionnaire was distributed to evaluate the teaching satisfaction.Results:The results of the t-test showed that the observation group was significantly higher than the control group in terms of theoretical assessment,first aid practical assessment,and clinical thinking skills,and the differences were statistically significant(P<0.05).The results of theχ2 test showed that the difference in teaching satisfaction between the observation group and the control group was statistically significant(P<0.05),and the teaching satisfaction in the observation group was significantly higher than the control group.Conclusion:Compared with traditional teaching methods,applying PBL teaching method in clinical emergency teaching can achieve more significant teaching effects.Students’mastery of theoretical knowledge,first aid practical skills,and clinical thinking skills can be effectively strengthened,and it is conducive to improving teaching satisfaction.
文摘For some time,ELT in China has been undergoing a heated discussion as to the best way ofteaching.Some think that the communicative approaches is inappropriate while others think that the tra-ditional Chinese methods are too old-fashioned.From various points of view,this paper argues that boththe communicative approach and the traditional Chinese methods can co-exist and influence each other inthe present Chinese teaching context.
文摘To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods. The patients of acute bronchitis were randomly divided into 2 groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results： The total effective rate of the observation group was 97.2% while that of the control group was 82,8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group （P 〈 0.01） and on the fifth and seventh days, the comparison showed no significant difference （P〉0.05）. Conclusion： The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.
文摘This study explores the learning effect of comprehension teaching method on basketball cognition, skills, affection and performance of secondary vocational students. The experiment was designed to carry out 18 weeks of basketball teaching in the way of comprehension teaching method, and the basketball cognition test, skill test, PE affection scale and competition performance evaluation (GPAI) were pretested and posttested, and the dependent sample T test was used for statistical analysis. Through this study, it is concluded that the comprehending teaching method can promote the learning effect of basketball for secondary vocational students and provide a new teaching method.
文摘Objective: to explore the influence of unprotected perineal delivery in delivery room nursing. Methods: the selection time was from January 2020 to January 2021, and the subjects were parturients who delivered naturally through vagina. The above 100 parturients were divided into control group and experimental group by drawing lots, with 50 cases in each group. The control group was given the traditional delivery method, and the experimental group was given the unprotected perineal delivery method. The degree of perineal laceration, the time of the second stage of labor, the total amount of bleeding and the quality of life three months after delivery were compared between the two groups. Results: the degree of perineal laceration in the experimental group was lower than that in the control group (P < 0.05), and the data comparison was statistically significant. The duration of the second stage of labor and the amount of blood loss in the experimental group were less than those in the control group (P < 0.05), and the difference was statistically significant. 3months after delivery, two kinds of postpartum quality of life were investigated. The score of the experimental group was higher than that of the control group (P < 0.05), and the data difference is of comparative significance. Conclusion: unprotected perineal delivery method has less perineal damage to pregnant women, and is helpful to improve the quality of life of pregnant women after delivery. It is worthy of popularization and application.
基金supported by the National Key R&D Program of China(grant no.2023YFA0916000)the National Natural Science Foundation of China(32225002,32170033,and 32422001)+2 种基金the Key Research Program of Frontier Sciences(ZDBS-LYSM014)the Biological Resources Program(KFJ-BRP-009 and KFJ-BRP-017-58)from the Chinese Academy of Sciences,the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0111)the Youth Innovation Promotion Association CAS(2022086).
文摘Predicting free energy changes(DDG)is essential for enhancing our understanding of protein evolution and plays a pivotal role in protein engineering and pharmaceutical development.While traditional methods offer valuable insights,they are often constrained by computational speed and reliance on biased training datasets.These constraints become particularly evident when aiming for accurate DDG predictions across a diverse array of protein sequences.Herein,we introduce Pythia,a self-supervised graph neural network specifically designed for zero-shot DDG predictions.Our comparative benchmarks demonstrate that Pythia outperforms other self-supervised pretraining models and force field-based approaches while also exhibiting competitive performance with fully supervised models.Notably,Pythia shows strong correlations and achieves a remarkable increase in computational speed of up to 105-fold.We further validated Pythia’s performance in predicting the thermostabilizing mutations of limonene epoxide hydrolase,leading to higher experimental success rates.This exceptional efficiency has enabled us to explore 26 million high-quality protein structures,marking a significant advancement in our ability to navigate the protein sequence space and enhance our understanding of the relationships between protein genotype and phenotype.In addition,we established a web server at https://pythia.wulab.xyz to allow users to easily perform such predictions.
