Economic development,food security,and ecological preservation are important issues encountered by karst re-gions.Faced with complex natural and social dynamics,we attempted to explore how interdependence within socio...Economic development,food security,and ecological preservation are important issues encountered by karst re-gions.Faced with complex natural and social dynamics,we attempted to explore how interdependence within socio-ecological system(SES)shaped sustainability in this region.A SES framework was constructed and three scenarios were predesigned:economic priority scenario,food security scenario,and ecological protection sce-nario.The System Dynamics model was used to simulate and forecast the evolution across various scenarios within the SES from 2005 to 2035.Through the Production-Possibility Frontiers in combined scenarios,trade-offpotential was identified and quantified.The results showed that the decoupling between social and ecological subsystems can be weaken in economic priority scenario,while coupling between them can be strengthen in food security scenario and ecological protection scenario.Within the SES,combined scenario analyses further suggest that the rocky desertification rate and the urban-rural income ratio exhibit the least trade-offpotential and inten-sity in combined economic priority scenario and ecological protection scenario,and the Soil Conservation and Food Supply demonstrate the least trade-offpotential and intensity in combined economic priority scenario and food security scenario.We can conclude the ecological engineering plays a significant role in alleviating trade-offs within the SES,but the effectiveness is limited.In light of intertwined socio-ecological challenges,combining ecological engineering with adaptive adjustments is a crucial strategy to enhance SES resilience and promote sustainable development in the South China Karst.展开更多
The Wuding River Basin,situated in the Loess Plateau of northern China,is an ecologically fragile region facing severe soil erosion and imbalanced ecosystem service(ES)functions.However,the mechanisms driving the spat...The Wuding River Basin,situated in the Loess Plateau of northern China,is an ecologically fragile region facing severe soil erosion and imbalanced ecosystem service(ES)functions.However,the mechanisms driving the spatiotemporal evolution of ES functions,as well as the trade-offs and synergies among these functions,remain poorly understood,constraining effective watershed-scale management.To address this challenge,this study quantified four ES functions,i.e.,water yield(WY),carbon storage(CS),habitat quality(HQ),and soil conservation(SC)in the Wuding River Basin from 1990 to 2020 using the Integrated Valuation of Ecosystem Services and Tradeoff(InVEST)model,and proposed an innovative integration of InVEST with a Bayesian Belief Network(BBN)to nonlinearly identify trade-off and synergy relationships among ES functions through probabilistic inference.A trade-off and synergy index(TSI)was developed to assess the spatial interaction intensity among ES functions,while sensitivity and scenario analyses were employed to determine key driving factors,followed by spatial optimization to delineate functional zones.Results revealed distinct spatiotemporal variations:WY increased from 98.69 to 120.52 mm;SC rose to an average of 3.05×10^(4) t/hm^(2);CS remained relatively stable(about 15.50 t/km^(2));and HQ averaged 0.51 with localized declines.The BBN achieved a high accuracy of 81.9%and effectively identified strong synergies between WY and SC,as well as between CS and HQ,while clear trade-offs were observed between WY and SC versus CS and HQ.Sensitivity analysis indicated precipitation(variance reduction of 9.4%),land use(9.8%),and vegetation cover(9.1%)as key driving factors.Spatial optimization further showed that core supply and ecological regulation zones are concentrated in the central-southern and southeastern basin,while ecological strengthening and optimization core zones dominate the central-northern and southeastern margins,highlighting strong spatial heterogeneity.Overall,this study advances ES research by combining process-based quantification with probabilistic modeling,offering a robust framework for studying nonlinear interactions,driving mechanisms,and optimization strategies,and providing a transferable paradigm for watershed-scale ES management and ecological planning in arid and semi-arid areas.展开更多
Accurately revealing the spatial heterogeneity in the trade-offs and synergies of land use functions(LUFs)and their driving factors is imperative for advancing sustainable land utilization and optimizing land use plan...Accurately revealing the spatial heterogeneity in the trade-offs and synergies of land use functions(LUFs)and their driving factors is imperative for advancing sustainable land utilization and optimizing land use planning.This is especially critical for ecologically vulnerable inland river basins in arid regions.However,existing methods struggle to effectively capture complex nonlinear interactions among environmental factors and their multifaceted relationships with trade-offs and synergies of LUFs,especially for the inland river basins in arid regions.Consequently,this study focused on the middle reaches of the Heihe River Basin(MHRB),an arid inland river basin in northwestern China.Using land use,socioeconomic,meteorological,and hydrological data from 2000 to 2020,we analyzed the spatiotemporal patterns of LUFs and their trade-off and synergy relationships from the perspective of production,living,ecological functions.Additionally,we employed an integrated Extreme Gradient Boosting(XGBoost)-SHapley Additive exPlanations(SHAP)framework to investigate the environmental factors influencing the spatial heterogeneity in the trade-offs and synergies of LUFs.Our findings reveal that from 2000 to 2020,the production,living,and ecological functions of land use within the MHRB exhibited an increasing trend,demonstrating a distinct spatial pattern of''high in the southwest and low in the northeast''.Significant spatial heterogeneity defined the trade-off and synergistic relationships,with trade-offs dominating human activity-intensive oasis areas,while synergies prevailed in other areas.During the study period,synergistic relationships between production and living functions and between production and ecological functions were relatively robust,whereas synergies in living-ecological functions remained weaker.Natural factors(digital elevation model(DEM),annual mean temperature,Normalized Difference Vegetation Index(NDVI),and annual precipitation)emerged as the primary factors driving the trade-offs and synergies of LUFs,followed by socioeconomic factors(population density,Gross Domestic Product(GDP),and land use intensity),while distance factors(distance to water bodies,distance to residential areas,and distance to roads)exerted minimal influence.Notably,the interactions among NDVI,annual mean temperature,DEM,and land use intensity exerted the most substantial impacts on the relationships among LUFs.This study provides novel perspectives and methodologies for unraveling the mechanisms underlying the spatial heterogeneity in the trade-offs and synergies of LUFs,offering scientific insights to inform regional land use planning and sustainable natural resource management in inland river basins in arid regions.展开更多
Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsist...Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsistent.It remains unclear whether these associations are causal.Methods We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia.Mendelian randomization(MR)analysis based on summary genome-wide association studies(GWASs)was performed.Genetic correlation and Bayesian colocalization analyses were used to provide robust genetic evidence.Results Ten observational studies involving 80,565,688 participants were included in this metaanalysis.IBD was significantly associated with dementia(risk ratio[RR]=1.36,95%CI=1.04-1.78;I2=84.8%)and VD(RR=2.60,95%CI=1.18-5.70;only one study),but not with AD(RR=2.00,95%CI=0.96-4.13;I^(2)=99.8%).MR analyses did not supported significant causal associations of IBD with dementia(dementia:odds ratio[OR]=1.01,95%CI=0.98-1.03;AD:OR=0.98,95%CI=0.95-1.01;VD:OR=1.02,95%CI=0.97-1.07).In addition,genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia.Conclusion Our study did not provide genetic evidence for a causal association between IBD and dementia risk.The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.展开更多
This paper proposes an interdisciplinary talent training model that combines foreign language education with area studies.The model aims to cultivate international ocean affairs professionals with cross-cultural commu...This paper proposes an interdisciplinary talent training model that combines foreign language education with area studies.The model aims to cultivate international ocean affairs professionals with cross-cultural communication skills,in-depth regional and country knowledge,and practical expertise in ocean affairs.Additionally,the paper presents specific training pathways and policy recommendations for implementing this model.展开更多
In modern society,the globalization of literary works is evident,with exceptional literary pieces from various countries spreading worldwide.Among these,children’s literature,due to the specificity of its target audi...In modern society,the globalization of literary works is evident,with exceptional literary pieces from various countries spreading worldwide.Among these,children’s literature,due to the specificity of its target audience,imposes distinct requirements on children’s books,compelling translators to approach the text from a child’s perspective.“The Little Prince”has renowned both within and outside of China,and a careful reading of this work can provide us with much inspiration.To this end,the present study adopts the perspective of Gideon Toury’s Descriptive Translation Studies to conduct an in-depth analysis of the different English and Chinese translations in conjunction with the original French novel.This approach aims to better guide literary research and explores translation methods for children’s literature through the analysis of translation norms and rules.展开更多
BACKGROUND Gastrointestinal endoscopy technology has significantly improved the diagnostic accuracy and the successful treatment of gastrointestinal diseases.However,a series of ethical issues have emerged,such as exp...BACKGROUND Gastrointestinal endoscopy technology has significantly improved the diagnostic accuracy and the successful treatment of gastrointestinal diseases.However,a series of ethical issues have emerged,such as expanding treatment indications,which affect the fair distribution of medical resources.There is limited research on ethical issues in the field of digestive endoscopy.AIM To investigate the level of ethical awareness among gastrointestinal endoscopy practitioners and analyze the ethical issues involved in gastrointestinal endoscopy technology.METHODS A questionnaire survey was performed to collect relevant data(gender,age,degree of education,professional title,personnel category,the level of understanding medical ethical principles,ethics training and its learning pathways)from gastrointestinal endoscopy practitioners at the Second Hospital of Dalian Medical University and Dalian Friendship Hospital,including licensed physicians and nurses(including trainees and graduate students).RESULTS The majority of gastrointestinal endoscopy practitioners have received training on ethics,but there is still considerable room for improvement in their ethical awareness.Different learning pathways may affect the mastery of ethical principles, and understanding of ethical principles is more easily achieved through hospital ethics institutions.CONCLUSIONTo address the ethical issues in gastrointestinal endoscopy technology, it is necessary to enhance the humanisticeducation of gastrointestinal endoscopy practitioners, incorporate ethical standards into the technology assessmentprocess, and establish a patient-centered diagnostic and treatment model to improve the ethical awareness of practitionersand achieve a balance between technology and ethics.展开更多
Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenn...Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenness with AMD,modification and mediation effect of air pollution,we conducted this prospective study.We con-structed weighted quantile sum(WQS)index as co-exposure to nitrogen oxides(NO_(x)),particulate matter<2.5μm(PM_(2.5)),particulate matter<10μm(PM10).Stratified Cox regression models were applied to test the effect of exposure.Effect modification of air pollution was assessed.Stratified Cox models through the indirect method and Aalen additive risk models were used in mediation analysis.Over median follow-up of 11.67 years,4596 AMD events were ascertained.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)of incident AMD for pollution per interquartile range(IQR)increment were 1.10(1.04–1.16)for nitrogen dioxide(NO_(2)),1.09(1.03–1.15)for NO_(x),1.14(1.05–1.24)for PM_(2.5),1.13(1.05–1.21)for PM10.The HR(95%CI)of AMD associated with greenness 1000 m buffer per IQR increment was 0.91(0.86–0.97),300 m buffer was 0.94(0.89–0.99).The as-sociation between greenness 1000 m and AMD was 28.59%,44.77%,35.59%,32.31%and 27.08%mediated by the decreased WQS index,NO_(2),NO_(x),PM_(2.5) and PM10,respectively.Increased greenness was associated with lower AMD incidence,and air pollution partly mediate it,which implies that interventions aimed at improving air quality and increasing greenness could have a dual benefit in mitigating AMD risk.展开更多
Background:Despite highly effective vaccines against SARS-CoV-2,COVID-19 vaccine hesitancy persisted in some populations in England during the pandemic,with rates and motivations for hesitancy varying by demographic g...Background:Despite highly effective vaccines against SARS-CoV-2,COVID-19 vaccine hesitancy persisted in some populations in England during the pandemic,with rates and motivations for hesitancy varying by demographic group.Addressing the drivers of vaccine hesitancy through targeted interventions in hesitant groups is a public health priority for better and more rapid control of disease spread.We aimed to characterise the determinants and subtypes of vaccine hesitancy and identify more persistent forms of hesitancy via analysis of vaccine uptake in a large cross-sectional cohort with linked National Health Service(NHS)data.展开更多
Background:To determine whether initiating a glucagon-like peptide-1 receptor agonist(GLP-1 RA)within 3 months of type 2 diabetes(T2DM)diagnosis alters the subsequent risk of overall and site-specific cancer and wheth...Background:To determine whether initiating a glucagon-like peptide-1 receptor agonist(GLP-1 RA)within 3 months of type 2 diabetes(T2DM)diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index(BMI).Methods:This retrospective cohort study used electronic health records from the TriNetX U.S.research network.Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis.Following 1:1 propensity score matching,both the GLP-1 RA user and non-user groups included 183,264 patients.The study outcome was defined as a diagnosis of malignant neoplasms.Hazard ratios(HRs)for overall and site-specific cancer risk were estimated using Cox proportional hazards models.Kaplan–Meier analysis and stratified analysis by BMI were performed.Results:Early GLP-1 RA use demonstrated a modest but significant association with reduced overall cancer risk(HR 0.93;95%CI:0.90–0.96).Reduced risks were noted for cancers of the digestive(HR 0.81),respiratory(HR 0.66),and female genital(HR 0.87)systems.In stratified analysis,benefits were more pronounced in patients with BMI≥30,particularly for pancreatic and colorectal cancers.Conclusion:Early initiation of GLP-1 receptor agonists in patients with diagnosed T2DM was associated with a modest reduction in overall cancer risk,particularly among individuals with obesity.These findings highlight the dual metabolic and oncologic value of prompt GLP-1 RA therapy.展开更多
Through the questionnaire survey and comparative studies on tourist satisfaction of tourism services among three world heritage sites,i.e.Huangshan Mountain,Lushan Mountain and Wuyi Mountain,this study pointed out the...Through the questionnaire survey and comparative studies on tourist satisfaction of tourism services among three world heritage sites,i.e.Huangshan Mountain,Lushan Mountain and Wuyi Mountain,this study pointed out the problems in tourism services of three scenic areas and then put forward relevant countermeasures for the management of scenic areas.展开更多
Mountain ecosystems play an essential role in supporting regional sustainable development and improving local ecological environments. However, economic development in mountainous areas has long been lagging, and mult...Mountain ecosystems play an essential role in supporting regional sustainable development and improving local ecological environments. However, economic development in mountainous areas has long been lagging, and multiple conflicts related to resource assurance, ecological protection, and economic development have emerged. An accurate grasp of the current status and evolutionary trends of mountain ecosystems is essential to enhance the overall benefits of ecosystem services and maintain regional ecological security. Based on the In VEST(Integrated Valuation of Ecosystem Services and Trade-offs) model, this study analyzed the spatiotemporal evolution patterns and the trade-offs and synergies among ecosystem services(ES) in the Dabie Mountains Area(DMA) of eastern China. The Markov-PLUS(Patch-generating Land Use Simulation) model was used to conduct a multi-scenario simulation of the area's future development. Water yield(WY) and soil conservation(SC) had overall increasing trends during 2000-2020, carbon storage(CS)decreased overall but slowed with time, and habitat quality(HQ) increased and then decreased. The ecological protection scenario is the best scenario for improving ES in the DMA by 2030;compared to 2020, the total WY would decrease by 3.77 × 10^(8) m^(3), SC would increase by 0.65 × 10^(6) t, CS would increase by 1.33 × 10^(6) t, and HQ would increase by 0.06%. The comprehensive development scenario is the second-most effective scenario for ecological improvement, while the natural development scenario did not have a significant effect. However, as the comprehensive development scenario considers both environmental protection and economic development, which are both vital for the sustainable development of the mountainous areas, this scenario is considered the most suitable path for future development. There are trade-offs between WY, CS, and HQ, while there are synergies between SC, CS, and HQ. Spatially, the DMA's central core district is the main strong synergistic area, the marginal zone is the weak synergistic area, and trade-offs are mainly distributed in the transition zone.展开更多
Functional zoning is an important mechanism for achieving national park planning and management objective.Better functional zoning is of great significance to the protection of ecosystem legitimacy and integrity,the a...Functional zoning is an important mechanism for achieving national park planning and management objective.Better functional zoning is of great significance to the protection of ecosystem legitimacy and integrity,the appropriate utilization of resources,community integration,and feasible management.In the present study,the proposed Qinghai Lake National Park is the research object.Based on the critical goal of ecological protection,the importance of ecosystem service functions and the ecological sensitivities were evaluated.The results showed that the ecosystem service functions and the ecological sensitivity of the whole region are high.Among them,lake,river and wetland as the most strictly protected ecosystems account for the highest proportion.Then this study divided the proposed Qinghai Lake National Park into five functional areas through grid calculations,spatial analysis and multifactor trade-off.The results indicated that the goal of functional zoning for national park is to maximize the overall utility of park protection value and its comprehensive functions based on its spatial units with different functions,management and control requirements.The zoning scheme addresses the lack of sustainable development in Qinghai Lake National Park due to ecological environmental changes and single-resource zoning with resource protection as the primary goal.This study can serve as a reference for spatial functional zoning methods of national land parks,nature reserves and other natural protected areas.展开更多
Aim： To compare the use of the suprapubic puncture method versus the transurethral method in pressure-flow studies in patients with benign prostatic hyperplasia. Methods： Twenty-three men with benign prostatic hyper...Aim： To compare the use of the suprapubic puncture method versus the transurethral method in pressure-flow studies in patients with benign prostatic hyperplasia. Methods： Twenty-three men with benign prostatic hyperplasia underwent both suprapubic and transurethral pressure-flow studies during a single session. Standard pressure-flow variables were recorded in all patients with both methods, enabling calculation of obstruction using commonly used grading systems, such as the urethral resistance algorithm, the Abrams-Griffith （AG） number and the Schaefer linear nomogram. Results： There were statistically significant differences between the methods in the mean values of maximum flow rate （P 〈 0.05）, detrusor pressure at the maximum flow （P 〈 0.01）, urethral resistance algorithm （P 〈 0.01）, AG number （P 〈 0.01） and maximum cystic capacity （P 〈 0.01）. Of the men in the study, 10 （43.5%） remained in the same Schaefer class with both methods and 18 （78.3%） in the same AG number area. Using the transurethral method, 12 （52.2%） men increased their Schaefer class by one and 1 （4.3%） by two. There were also differences between the suprapubic and transurethral methods using the AG number： 4 （17.4%） men moved from a classification of equivocal to obstructed and 1 （4.3%） from unobstructed to equivocal. Conclusion： The differences between the techniques for measuring intravesical pressure alter the grading of obstruction determined by several of the commonly used classifications. An 8 F transurethral catheter significantly increases the likelihood of a diagnosis of bladder outlet obstruction when compared with the suprapubic method.展开更多
BACKGROUND Previous systematic reviews have consistently reported that coffee consumption has a preventive effect on the occurrence of type 2 diabetes mellitus(T2DM).However,further evaluations between coffee consumpt...BACKGROUND Previous systematic reviews have consistently reported that coffee consumption has a preventive effect on the occurrence of type 2 diabetes mellitus(T2DM).However,further evaluations between coffee consumption and the risk of T2DM in Asian populations are needed.AIM To conduct a meta-epidemiological study on systematic reviews evaluating the association between coffee consumption and the risk of T2DM in Asian people.METHODS The selection criterion was defined as a population-based prospective cohort study evaluating the association between coffee consumption and the risk of T2DM in Asian populations,reporting the adjusted relative risk(RR)and its 95%confidence interval(CI)for potential confounders.A fixed-effect model metaanalysis was applied to calculate the summary RR and its 95%CI in less than 50%of the I2 value indicating the level of heterogeneity.A two-stage fixed-effects doseresponse meta-analysis(DRMA)was performed to calculate the risk per unit dose(a cup per day).RESULTS A total of seven studies were selected in this meta-epidemiological study.The risk of T2DM in Asian populations was significantly reduced in the highest to the lowest dose group(summary RR=0.73,95%CI:0.66-0.82;I2 value=0.0%).The DRMA showed that drinking one cup of coffee per day reduced the risk of T2DM in Asian populations by 8%(RR=0.92,95%CI:0.90-0.95).CONCLUSION These findings support the conclusion that coffee consumption has a protective effect on the occurrence of T2DM in Asian men and women.展开更多
Of Studies is an important one in The Essays of Francis Bacon, of which words are concise and refining, reasoning is profound and logic. Wang Zuoliang's translated version is so efficient and smooth with classical...Of Studies is an important one in The Essays of Francis Bacon, of which words are concise and refining, reasoning is profound and logic. Wang Zuoliang's translated version is so efficient and smooth with classical Chinese style that it perfectly reveals the original text, turning out to be the best version among all the translation of Of Studies. This thesis compares Of Studies and Wang Zuoliang's translated version to analyze their linguistic feature in terms of diction, sentence and figures of speech.展开更多
Randomized controlled trials(RCTs) are the gold standard in terms of study design, however, in the surgical setting conducting RCTs can often be unethical or logistically impossible. Case-control studies should become...Randomized controlled trials(RCTs) are the gold standard in terms of study design, however, in the surgical setting conducting RCTs can often be unethical or logistically impossible. Case-control studies should become the major study design used in surgical research when RCTs are unable to be conducted and definitely replacing case series which offer little insight into surgical outcomes and disease processes.展开更多
Using comparative molecular field analysis approach, the interaction of 17 tetrahydroprotdederines to D1 reccptor and15 ones to D2 reccptor have ben studied by 3D-QsAR. respectively. The results indicated that the int...Using comparative molecular field analysis approach, the interaction of 17 tetrahydroprotdederines to D1 reccptor and15 ones to D2 reccptor have ben studied by 3D-QsAR. respectively. The results indicated that the interactions of THPBs withdopamine receplors were primarily clectrostatic interactions. with more positive charge in lignnd and more negative in receptor.展开更多
Some geological studies were performed in the Rafflesia Trail, near Kampung Jedip, in Lojing Highlands, Kelantan. This area is famous for its Rafflesia and has become one of the tourism attractions in Kelantan. Howeve...Some geological studies were performed in the Rafflesia Trail, near Kampung Jedip, in Lojing Highlands, Kelantan. This area is famous for its Rafflesia and has become one of the tourism attractions in Kelantan. However, the recent development of agricultural activities has significant effects on the area. The objective of these studies is to give substantial geological information including geomorphology, lithology, structural features, geohazard potentials, and water quality analysis in the study area. Desk study was conducted by reviewing some literatures related to the topic and the study area. Field work was organized during a scientific expedition in January 2014, to collect data, samples, and photographs. Geomorphologically, the study area is a mountainous area which mostly consists of mountain ridges and mountain valleys. Some fluvial features occur in the study area, such as waterfalls, cascades, rapids, runs, pools, potholes, lateral bars, and point bars. This area is composed of granitic rocks, mostly granite porphyry, and covered by superficial deposits of Quaternary age. The geological structure that is commonly found in the study area is joints, where they divide the rock body into large, roughly angular blocks, which is called as brecciation. The potential geohazard in the study area is landslides, where some of them are composed of soil only and others are mixtures of rock and soil. The water quality analysis has managed to identify that the stream water in this area generally has the quality of Class III (according to INWQS for Malaysia). These studies recommend that this area should be supported as a sustainable tourism site in Lojing Highlands.展开更多
基金supported by the National Key Research and Develop-ment Program of China(Grant No.2022YFF1300701)the Sichuan Science and Technology Program(Grant No.2022JDJQ0015).
文摘Economic development,food security,and ecological preservation are important issues encountered by karst re-gions.Faced with complex natural and social dynamics,we attempted to explore how interdependence within socio-ecological system(SES)shaped sustainability in this region.A SES framework was constructed and three scenarios were predesigned:economic priority scenario,food security scenario,and ecological protection sce-nario.The System Dynamics model was used to simulate and forecast the evolution across various scenarios within the SES from 2005 to 2035.Through the Production-Possibility Frontiers in combined scenarios,trade-offpotential was identified and quantified.The results showed that the decoupling between social and ecological subsystems can be weaken in economic priority scenario,while coupling between them can be strengthen in food security scenario and ecological protection scenario.Within the SES,combined scenario analyses further suggest that the rocky desertification rate and the urban-rural income ratio exhibit the least trade-offpotential and inten-sity in combined economic priority scenario and ecological protection scenario,and the Soil Conservation and Food Supply demonstrate the least trade-offpotential and intensity in combined economic priority scenario and food security scenario.We can conclude the ecological engineering plays a significant role in alleviating trade-offs within the SES,but the effectiveness is limited.In light of intertwined socio-ecological challenges,combining ecological engineering with adaptive adjustments is a crucial strategy to enhance SES resilience and promote sustainable development in the South China Karst.
基金supported by the Science and Technology Project of Shaanxi Province Water Conservancy,China(2025slkj-10)the Natural Science Basic Research Program of Shaanxi Province,China(S2025-JC-QN-2416).
文摘The Wuding River Basin,situated in the Loess Plateau of northern China,is an ecologically fragile region facing severe soil erosion and imbalanced ecosystem service(ES)functions.However,the mechanisms driving the spatiotemporal evolution of ES functions,as well as the trade-offs and synergies among these functions,remain poorly understood,constraining effective watershed-scale management.To address this challenge,this study quantified four ES functions,i.e.,water yield(WY),carbon storage(CS),habitat quality(HQ),and soil conservation(SC)in the Wuding River Basin from 1990 to 2020 using the Integrated Valuation of Ecosystem Services and Tradeoff(InVEST)model,and proposed an innovative integration of InVEST with a Bayesian Belief Network(BBN)to nonlinearly identify trade-off and synergy relationships among ES functions through probabilistic inference.A trade-off and synergy index(TSI)was developed to assess the spatial interaction intensity among ES functions,while sensitivity and scenario analyses were employed to determine key driving factors,followed by spatial optimization to delineate functional zones.Results revealed distinct spatiotemporal variations:WY increased from 98.69 to 120.52 mm;SC rose to an average of 3.05×10^(4) t/hm^(2);CS remained relatively stable(about 15.50 t/km^(2));and HQ averaged 0.51 with localized declines.The BBN achieved a high accuracy of 81.9%and effectively identified strong synergies between WY and SC,as well as between CS and HQ,while clear trade-offs were observed between WY and SC versus CS and HQ.Sensitivity analysis indicated precipitation(variance reduction of 9.4%),land use(9.8%),and vegetation cover(9.1%)as key driving factors.Spatial optimization further showed that core supply and ecological regulation zones are concentrated in the central-southern and southeastern basin,while ecological strengthening and optimization core zones dominate the central-northern and southeastern margins,highlighting strong spatial heterogeneity.Overall,this study advances ES research by combining process-based quantification with probabilistic modeling,offering a robust framework for studying nonlinear interactions,driving mechanisms,and optimization strategies,and providing a transferable paradigm for watershed-scale ES management and ecological planning in arid and semi-arid areas.
基金funded by the University Teachers Innovation Fund Project of Gansu Province(2025A-001)the Northwest Normal University Young Teachers'Scientific Research Ability Improvement Plan(NWNULKQN2024-20).
文摘Accurately revealing the spatial heterogeneity in the trade-offs and synergies of land use functions(LUFs)and their driving factors is imperative for advancing sustainable land utilization and optimizing land use planning.This is especially critical for ecologically vulnerable inland river basins in arid regions.However,existing methods struggle to effectively capture complex nonlinear interactions among environmental factors and their multifaceted relationships with trade-offs and synergies of LUFs,especially for the inland river basins in arid regions.Consequently,this study focused on the middle reaches of the Heihe River Basin(MHRB),an arid inland river basin in northwestern China.Using land use,socioeconomic,meteorological,and hydrological data from 2000 to 2020,we analyzed the spatiotemporal patterns of LUFs and their trade-off and synergy relationships from the perspective of production,living,ecological functions.Additionally,we employed an integrated Extreme Gradient Boosting(XGBoost)-SHapley Additive exPlanations(SHAP)framework to investigate the environmental factors influencing the spatial heterogeneity in the trade-offs and synergies of LUFs.Our findings reveal that from 2000 to 2020,the production,living,and ecological functions of land use within the MHRB exhibited an increasing trend,demonstrating a distinct spatial pattern of''high in the southwest and low in the northeast''.Significant spatial heterogeneity defined the trade-off and synergistic relationships,with trade-offs dominating human activity-intensive oasis areas,while synergies prevailed in other areas.During the study period,synergistic relationships between production and living functions and between production and ecological functions were relatively robust,whereas synergies in living-ecological functions remained weaker.Natural factors(digital elevation model(DEM),annual mean temperature,Normalized Difference Vegetation Index(NDVI),and annual precipitation)emerged as the primary factors driving the trade-offs and synergies of LUFs,followed by socioeconomic factors(population density,Gross Domestic Product(GDP),and land use intensity),while distance factors(distance to water bodies,distance to residential areas,and distance to roads)exerted minimal influence.Notably,the interactions among NDVI,annual mean temperature,DEM,and land use intensity exerted the most substantial impacts on the relationships among LUFs.This study provides novel perspectives and methodologies for unraveling the mechanisms underlying the spatial heterogeneity in the trade-offs and synergies of LUFs,offering scientific insights to inform regional land use planning and sustainable natural resource management in inland river basins in arid regions.
基金supported by the China Postdoctoral Science Foundation(Grant No.2021M703366)Shenzhen Science and Technology Program(Grant No.KQTD20190929172835662).
文摘Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsistent.It remains unclear whether these associations are causal.Methods We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia.Mendelian randomization(MR)analysis based on summary genome-wide association studies(GWASs)was performed.Genetic correlation and Bayesian colocalization analyses were used to provide robust genetic evidence.Results Ten observational studies involving 80,565,688 participants were included in this metaanalysis.IBD was significantly associated with dementia(risk ratio[RR]=1.36,95%CI=1.04-1.78;I2=84.8%)and VD(RR=2.60,95%CI=1.18-5.70;only one study),but not with AD(RR=2.00,95%CI=0.96-4.13;I^(2)=99.8%).MR analyses did not supported significant causal associations of IBD with dementia(dementia:odds ratio[OR]=1.01,95%CI=0.98-1.03;AD:OR=0.98,95%CI=0.95-1.01;VD:OR=1.02,95%CI=0.97-1.07).In addition,genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia.Conclusion Our study did not provide genetic evidence for a causal association between IBD and dementia risk.The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.
基金supported by“Dalian Maritime University Teaching Reform Research Fund 2022 Annual Project”(Fund No.XJG2022-96).
文摘This paper proposes an interdisciplinary talent training model that combines foreign language education with area studies.The model aims to cultivate international ocean affairs professionals with cross-cultural communication skills,in-depth regional and country knowledge,and practical expertise in ocean affairs.Additionally,the paper presents specific training pathways and policy recommendations for implementing this model.
文摘In modern society,the globalization of literary works is evident,with exceptional literary pieces from various countries spreading worldwide.Among these,children’s literature,due to the specificity of its target audience,imposes distinct requirements on children’s books,compelling translators to approach the text from a child’s perspective.“The Little Prince”has renowned both within and outside of China,and a careful reading of this work can provide us with much inspiration.To this end,the present study adopts the perspective of Gideon Toury’s Descriptive Translation Studies to conduct an in-depth analysis of the different English and Chinese translations in conjunction with the original French novel.This approach aims to better guide literary research and explores translation methods for children’s literature through the analysis of translation norms and rules.
文摘BACKGROUND Gastrointestinal endoscopy technology has significantly improved the diagnostic accuracy and the successful treatment of gastrointestinal diseases.However,a series of ethical issues have emerged,such as expanding treatment indications,which affect the fair distribution of medical resources.There is limited research on ethical issues in the field of digestive endoscopy.AIM To investigate the level of ethical awareness among gastrointestinal endoscopy practitioners and analyze the ethical issues involved in gastrointestinal endoscopy technology.METHODS A questionnaire survey was performed to collect relevant data(gender,age,degree of education,professional title,personnel category,the level of understanding medical ethical principles,ethics training and its learning pathways)from gastrointestinal endoscopy practitioners at the Second Hospital of Dalian Medical University and Dalian Friendship Hospital,including licensed physicians and nurses(including trainees and graduate students).RESULTS The majority of gastrointestinal endoscopy practitioners have received training on ethics,but there is still considerable room for improvement in their ethical awareness.Different learning pathways may affect the mastery of ethical principles, and understanding of ethical principles is more easily achieved through hospital ethics institutions.CONCLUSIONTo address the ethical issues in gastrointestinal endoscopy technology, it is necessary to enhance the humanisticeducation of gastrointestinal endoscopy practitioners, incorporate ethical standards into the technology assessmentprocess, and establish a patient-centered diagnostic and treatment model to improve the ethical awareness of practitionersand achieve a balance between technology and ethics.
基金supported by the High-level Talents Introduction Plan from Central South University(No.502045003)the National Natural Science Foundation of China(No.42277438)Hunan Provincial Natural Science Foundation for Distinguished Young Scholars(No.2024JJ2082)to Fang Xiao,and the Postgraduate Independent Exploration and Innovation Project of Central South University,China(Nos.2024ZZTS0557 and 2023ZZTS0993)。
文摘Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenness with AMD,modification and mediation effect of air pollution,we conducted this prospective study.We con-structed weighted quantile sum(WQS)index as co-exposure to nitrogen oxides(NO_(x)),particulate matter<2.5μm(PM_(2.5)),particulate matter<10μm(PM10).Stratified Cox regression models were applied to test the effect of exposure.Effect modification of air pollution was assessed.Stratified Cox models through the indirect method and Aalen additive risk models were used in mediation analysis.Over median follow-up of 11.67 years,4596 AMD events were ascertained.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)of incident AMD for pollution per interquartile range(IQR)increment were 1.10(1.04–1.16)for nitrogen dioxide(NO_(2)),1.09(1.03–1.15)for NO_(x),1.14(1.05–1.24)for PM_(2.5),1.13(1.05–1.21)for PM10.The HR(95%CI)of AMD associated with greenness 1000 m buffer per IQR increment was 0.91(0.86–0.97),300 m buffer was 0.94(0.89–0.99).The as-sociation between greenness 1000 m and AMD was 28.59%,44.77%,35.59%,32.31%and 27.08%mediated by the decreased WQS index,NO_(2),NO_(x),PM_(2.5) and PM10,respectively.Increased greenness was associated with lower AMD incidence,and air pollution partly mediate it,which implies that interventions aimed at improving air quality and increasing greenness could have a dual benefit in mitigating AMD risk.
文摘Background:Despite highly effective vaccines against SARS-CoV-2,COVID-19 vaccine hesitancy persisted in some populations in England during the pandemic,with rates and motivations for hesitancy varying by demographic group.Addressing the drivers of vaccine hesitancy through targeted interventions in hesitant groups is a public health priority for better and more rapid control of disease spread.We aimed to characterise the determinants and subtypes of vaccine hesitancy and identify more persistent forms of hesitancy via analysis of vaccine uptake in a large cross-sectional cohort with linked National Health Service(NHS)data.
基金financial support fromthe Chung Shan Medical University Hospital,Taiwan(CSH-2022-A-009).
文摘Background:To determine whether initiating a glucagon-like peptide-1 receptor agonist(GLP-1 RA)within 3 months of type 2 diabetes(T2DM)diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index(BMI).Methods:This retrospective cohort study used electronic health records from the TriNetX U.S.research network.Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis.Following 1:1 propensity score matching,both the GLP-1 RA user and non-user groups included 183,264 patients.The study outcome was defined as a diagnosis of malignant neoplasms.Hazard ratios(HRs)for overall and site-specific cancer risk were estimated using Cox proportional hazards models.Kaplan–Meier analysis and stratified analysis by BMI were performed.Results:Early GLP-1 RA use demonstrated a modest but significant association with reduced overall cancer risk(HR 0.93;95%CI:0.90–0.96).Reduced risks were noted for cancers of the digestive(HR 0.81),respiratory(HR 0.66),and female genital(HR 0.87)systems.In stratified analysis,benefits were more pronounced in patients with BMI≥30,particularly for pancreatic and colorectal cancers.Conclusion:Early initiation of GLP-1 receptor agonists in patients with diagnosed T2DM was associated with a modest reduction in overall cancer risk,particularly among individuals with obesity.These findings highlight the dual metabolic and oncologic value of prompt GLP-1 RA therapy.
文摘Through the questionnaire survey and comparative studies on tourist satisfaction of tourism services among three world heritage sites,i.e.Huangshan Mountain,Lushan Mountain and Wuyi Mountain,this study pointed out the problems in tourism services of three scenic areas and then put forward relevant countermeasures for the management of scenic areas.
基金Under the auspices of National Natural Science Foundation of China (No. U2102209)。
文摘Mountain ecosystems play an essential role in supporting regional sustainable development and improving local ecological environments. However, economic development in mountainous areas has long been lagging, and multiple conflicts related to resource assurance, ecological protection, and economic development have emerged. An accurate grasp of the current status and evolutionary trends of mountain ecosystems is essential to enhance the overall benefits of ecosystem services and maintain regional ecological security. Based on the In VEST(Integrated Valuation of Ecosystem Services and Trade-offs) model, this study analyzed the spatiotemporal evolution patterns and the trade-offs and synergies among ecosystem services(ES) in the Dabie Mountains Area(DMA) of eastern China. The Markov-PLUS(Patch-generating Land Use Simulation) model was used to conduct a multi-scenario simulation of the area's future development. Water yield(WY) and soil conservation(SC) had overall increasing trends during 2000-2020, carbon storage(CS)decreased overall but slowed with time, and habitat quality(HQ) increased and then decreased. The ecological protection scenario is the best scenario for improving ES in the DMA by 2030;compared to 2020, the total WY would decrease by 3.77 × 10^(8) m^(3), SC would increase by 0.65 × 10^(6) t, CS would increase by 1.33 × 10^(6) t, and HQ would increase by 0.06%. The comprehensive development scenario is the second-most effective scenario for ecological improvement, while the natural development scenario did not have a significant effect. However, as the comprehensive development scenario considers both environmental protection and economic development, which are both vital for the sustainable development of the mountainous areas, this scenario is considered the most suitable path for future development. There are trade-offs between WY, CS, and HQ, while there are synergies between SC, CS, and HQ. Spatially, the DMA's central core district is the main strong synergistic area, the marginal zone is the weak synergistic area, and trade-offs are mainly distributed in the transition zone.
基金National Key Research and Development Program of China(2019YFD1100401)The Young Talent Program of Xi’an Jiaotong University(GG6J007)The Fundamental Research Funds for the Central Universities(2662021JC009)。
文摘Functional zoning is an important mechanism for achieving national park planning and management objective.Better functional zoning is of great significance to the protection of ecosystem legitimacy and integrity,the appropriate utilization of resources,community integration,and feasible management.In the present study,the proposed Qinghai Lake National Park is the research object.Based on the critical goal of ecological protection,the importance of ecosystem service functions and the ecological sensitivities were evaluated.The results showed that the ecosystem service functions and the ecological sensitivity of the whole region are high.Among them,lake,river and wetland as the most strictly protected ecosystems account for the highest proportion.Then this study divided the proposed Qinghai Lake National Park into five functional areas through grid calculations,spatial analysis and multifactor trade-off.The results indicated that the goal of functional zoning for national park is to maximize the overall utility of park protection value and its comprehensive functions based on its spatial units with different functions,management and control requirements.The zoning scheme addresses the lack of sustainable development in Qinghai Lake National Park due to ecological environmental changes and single-resource zoning with resource protection as the primary goal.This study can serve as a reference for spatial functional zoning methods of national land parks,nature reserves and other natural protected areas.
文摘Aim： To compare the use of the suprapubic puncture method versus the transurethral method in pressure-flow studies in patients with benign prostatic hyperplasia. Methods： Twenty-three men with benign prostatic hyperplasia underwent both suprapubic and transurethral pressure-flow studies during a single session. Standard pressure-flow variables were recorded in all patients with both methods, enabling calculation of obstruction using commonly used grading systems, such as the urethral resistance algorithm, the Abrams-Griffith （AG） number and the Schaefer linear nomogram. Results： There were statistically significant differences between the methods in the mean values of maximum flow rate （P 〈 0.05）, detrusor pressure at the maximum flow （P 〈 0.01）, urethral resistance algorithm （P 〈 0.01）, AG number （P 〈 0.01） and maximum cystic capacity （P 〈 0.01）. Of the men in the study, 10 （43.5%） remained in the same Schaefer class with both methods and 18 （78.3%） in the same AG number area. Using the transurethral method, 12 （52.2%） men increased their Schaefer class by one and 1 （4.3%） by two. There were also differences between the suprapubic and transurethral methods using the AG number： 4 （17.4%） men moved from a classification of equivocal to obstructed and 1 （4.3%） from unobstructed to equivocal. Conclusion： The differences between the techniques for measuring intravesical pressure alter the grading of obstruction determined by several of the commonly used classifications. An 8 F transurethral catheter significantly increases the likelihood of a diagnosis of bladder outlet obstruction when compared with the suprapubic method.
文摘BACKGROUND Previous systematic reviews have consistently reported that coffee consumption has a preventive effect on the occurrence of type 2 diabetes mellitus(T2DM).However,further evaluations between coffee consumption and the risk of T2DM in Asian populations are needed.AIM To conduct a meta-epidemiological study on systematic reviews evaluating the association between coffee consumption and the risk of T2DM in Asian people.METHODS The selection criterion was defined as a population-based prospective cohort study evaluating the association between coffee consumption and the risk of T2DM in Asian populations,reporting the adjusted relative risk(RR)and its 95%confidence interval(CI)for potential confounders.A fixed-effect model metaanalysis was applied to calculate the summary RR and its 95%CI in less than 50%of the I2 value indicating the level of heterogeneity.A two-stage fixed-effects doseresponse meta-analysis(DRMA)was performed to calculate the risk per unit dose(a cup per day).RESULTS A total of seven studies were selected in this meta-epidemiological study.The risk of T2DM in Asian populations was significantly reduced in the highest to the lowest dose group(summary RR=0.73,95%CI:0.66-0.82;I2 value=0.0%).The DRMA showed that drinking one cup of coffee per day reduced the risk of T2DM in Asian populations by 8%(RR=0.92,95%CI:0.90-0.95).CONCLUSION These findings support the conclusion that coffee consumption has a protective effect on the occurrence of T2DM in Asian men and women.
文摘Of Studies is an important one in The Essays of Francis Bacon, of which words are concise and refining, reasoning is profound and logic. Wang Zuoliang's translated version is so efficient and smooth with classical Chinese style that it perfectly reveals the original text, turning out to be the best version among all the translation of Of Studies. This thesis compares Of Studies and Wang Zuoliang's translated version to analyze their linguistic feature in terms of diction, sentence and figures of speech.
文摘Randomized controlled trials(RCTs) are the gold standard in terms of study design, however, in the surgical setting conducting RCTs can often be unethical or logistically impossible. Case-control studies should become the major study design used in surgical research when RCTs are unable to be conducted and definitely replacing case series which offer little insight into surgical outcomes and disease processes.
文摘Using comparative molecular field analysis approach, the interaction of 17 tetrahydroprotdederines to D1 reccptor and15 ones to D2 reccptor have ben studied by 3D-QsAR. respectively. The results indicated that the interactions of THPBs withdopamine receplors were primarily clectrostatic interactions. with more positive charge in lignnd and more negative in receptor.
文摘Some geological studies were performed in the Rafflesia Trail, near Kampung Jedip, in Lojing Highlands, Kelantan. This area is famous for its Rafflesia and has become one of the tourism attractions in Kelantan. However, the recent development of agricultural activities has significant effects on the area. The objective of these studies is to give substantial geological information including geomorphology, lithology, structural features, geohazard potentials, and water quality analysis in the study area. Desk study was conducted by reviewing some literatures related to the topic and the study area. Field work was organized during a scientific expedition in January 2014, to collect data, samples, and photographs. Geomorphologically, the study area is a mountainous area which mostly consists of mountain ridges and mountain valleys. Some fluvial features occur in the study area, such as waterfalls, cascades, rapids, runs, pools, potholes, lateral bars, and point bars. This area is composed of granitic rocks, mostly granite porphyry, and covered by superficial deposits of Quaternary age. The geological structure that is commonly found in the study area is joints, where they divide the rock body into large, roughly angular blocks, which is called as brecciation. The potential geohazard in the study area is landslides, where some of them are composed of soil only and others are mixtures of rock and soil. The water quality analysis has managed to identify that the stream water in this area generally has the quality of Class III (according to INWQS for Malaysia). These studies recommend that this area should be supported as a sustainable tourism site in Lojing Highlands.
