Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold...Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold great promise as miniature detectives capable of detecting mi RNAs within cells.However,current nanoprobes face a challenge in achieving the required precision for accurate miRNA detection,particularly within the intricate confines of the cellular microenvironment,due to interference with biological autofluorescence,off-target effects,and a lack of spatiotemporal control.Here,we have designed a dual-stimuli responsive DNA tracker,synergistically utilizing specific intracellular cues and external triggers,which enables spatiotemporal-controlled and precise detection and imaging of miRNAs"on demand".The tracker,which combines zeolitic imidazolate framework-67(ZIF-67)and unique hairpin DNA structures,effectively anchored onto the ZIF-67 through electrostatic interactions,remains in a dormant state until activated by abundant cellular ATP,resulting in the release of the hairpin structures that include a PC linker incorporated into the loop region.Subsequent irradiation triggers specific recognition of the target miRNA.The newly developed HP-PC-BT@ZIF-67 tracker demonstrates precise spatiotemporal mi RNA detection and exhibits excellent biocompatibility,enabling specific mi RNA recognition"on demand"within cancer cells.This research presents a reliable mi RNA imaging platform in the intricate cellular environment,opening up the possibilities for precise biomedical analysis and disease diagnosis.展开更多
Purpose:Wearable devices are commonly used to measure physical activity.However,it remains unclear the effect of wearing these devices on health awareness.Our aim was to provide evidence related to wearing physical ac...Purpose:Wearable devices are commonly used to measure physical activity.However,it remains unclear the effect of wearing these devices on health awareness.Our aim was to provide evidence related to wearing physical activity trackers and health awareness.Methods:A quantitative comparison study design was used comparing participants who wore physical activity tracking devices(n=108)and those who did not(n=112).A paper-based Physical Health Knowledge survey designed for the purpose of this research was used for data collection in 2018.Results:A difference between participants who wore physical activity tracking devices and those that did not was identified in relation to activity levels and physical health awareness.Wearable devices are suggested as an opportunity for nurses to engage people in physical activity with the potential to improve their health awareness.Conclusions:Nurses are well placed in the healthcare landscape to work with patients who own an activity tracker device concerning increasing activity self-monitoring.This information the patient has from the device can also form the basis of health discussions between nurses and the people in their care.展开更多
This paper presents a study aimed at evaluating and comparing the performance of six different tracking systems for photovoltaic (PV) with diesel-battery hybrid system in arid climate of Kingdom of Saudi Arabia (KSA)....This paper presents a study aimed at evaluating and comparing the performance of six different tracking systems for photovoltaic (PV) with diesel-battery hybrid system in arid climate of Kingdom of Saudi Arabia (KSA). The study considered various technical and economic factors including system net present cost (NPC), levelized cost of energy (LCOE), and PV power generation using energy analysis and microgrid design software “HOMER”. It also presents an overview of the current electricity production and demand in the Kingdom. The weather data used in this study have been collected from the new solar atlas launched by King Abdullah City for Atomic and Renewable Energy (KACARE). The selected solar resource monitoring station for this study is located near to Riyadh city and has an annual average daily total irradiation of 6300 W/m2/day. The study shows that, for stand-alone PV system in the vicinity of Riyadh city, tracking system is economically better than fixed angle system. Among the considered tracking systems, VCA system is the most preferable as it has low NPC and LCOE values with a high return on investment (ROI) as well as low carbon dioxide (CO2) emissions due to a high renewable energy penetration.展开更多
Purpose:This systematic review and meta-analysis aimed to evaluate the effect of wearable devices for improving physical activity and healthrelated outcomes in cancer survivors.Methods:CINAHL,Cochrane,Ebscohost,MEDLIN...Purpose:This systematic review and meta-analysis aimed to evaluate the effect of wearable devices for improving physical activity and healthrelated outcomes in cancer survivors.Methods:CINAHL,Cochrane,Ebscohost,MEDLINE,Pubmed,ProQuest Health and Medical Complete,ProQuest Nursing and Allied Health Source,ScienceDirect,and SPORTDiscus databases were searched for randomized controlled trials published before September 1,2020,that evaluated interventions involving wearable devices in cancer survivors.Standardized mean differences(SMDs)were calculated to assess effects on physical activity and health-related outcomes.Subgroup analyses were conducted to assess whether the effects differed by interventions and cancer characteristics.Risk of bias was assessed using the Cochrane risk of bias tool.Results:Thirty-five trials were included(breast cancer,n=15,43%).Intervention durations ranged between 4 weeks and 1 year.Most trials(n=25,71%)involved pedometer-based physical activity interventions.Seven(20%)involved Fitbit-based interventions,and 3(9%)involved other wearable physical activity trackers(e.g.,Polar,Garmin).Compared to usual care,wearable devices had moderate-to-large effects(SMD range 0.54-0.87,p<0.001)on moderate-intensity physical activity,moderate-to-vigorous-intensity physical activity,total physical activity,and daily steps.Compared to usual care,those in the intervention had higher quality of life,aerobic fitness,physical function,and reduced fatigue(SMD range=0.18-0.66,all p<0.05).Conclusion:Wearable physical activity trackers and pedometers are effective tools that increase physical activity and improve health-related outcomes in individuals with cancer.Identifying how these devices can be implemented for longer-term use with other intervention components remains an area for future research.展开更多
In the 21th century, one of the biggest problems that the world faces is energy provision. Today, the way that most countries use for energy production is not clean and continuous. The most obvious proof for that is t...In the 21th century, one of the biggest problems that the world faces is energy provision. Today, the way that most countries use for energy production is not clean and continuous. The most obvious proof for that is the change in the climate. The amount of CO2 （carbon dioxide） that is caused by fossil fuel burning increases day by day and this situation creates the greenhouse effect and change in the climate. The sun is one of the best solutions to this problem. It is not only clean and continuous, but also available anywhere, anytime. However, the efficiency of a photovoltaic system is directly related to the amount of solar energy acquired by the system which means that, it is necessary to follow the sun to have a high efficient system. There are two types of trackers that follow the sun and there are several ways to build them. In this paper, solar tracker designs are examined and a new dual axis solar tracker design is given.展开更多
Following over 20 years of research,a direct measurement of the QGP temperature has been achieved at Relativistic Heavy-Ion Collider(RHIC),free from the blue-shift effect and contamination from strong interactions.Thi...Following over 20 years of research,a direct measurement of the QGP temperature has been achieved at Relativistic Heavy-Ion Collider(RHIC),free from the blue-shift effect and contamination from strong interactions.This viewpoint discusses a recent measurement of the QGP temperature at different stages at the Solenoidal Tracker at RHIC(STAR),which used e^(+)e^(-)pairs as penetrating probes.展开更多
In order to solve the problem that the star point positioning accuracy of the star sensor in near space is decreased due to atmospheric background stray light and rapid maneuvering of platform, this paper proposes a s...In order to solve the problem that the star point positioning accuracy of the star sensor in near space is decreased due to atmospheric background stray light and rapid maneuvering of platform, this paper proposes a star point positioning algorithm based on the capsule network whose input and output are both vectors. First, a PCTL (Probability-Coordinate Transformation Layer) is designed to represent the mapping relationship between the probability output of the capsule network and the star point sub-pixel coordinates. Then, Coordconv Layer is introduced to implement explicit encoding of space information and the probability is used as the centroid weight to achieve the conversion between probability and star point sub-pixel coordinates, which improves the network’s ability to perceive star point positions. Finally, based on the dynamic imaging principle of star sensors and the characteristics of near-space environment, a star map dataset for algorithm training and testing is constructed. The simulation results show that the proposed algorithm reduces the MAE (Mean Absolute Error) and RMSE (Root Mean Square Error) of the star point positioning by 36.1% and 41.7% respectively compared with the traditional algorithm. The research results can provide important theory and technical support for the scheme design, index demonstration, test and evaluation of large dynamic star sensors in near space.展开更多
This paper addresses the challenges of insufficient navigation accuracy,low path-planning efficiency,and poor environmental adaptability faced by deep space rovers in complex extraterrestrial environments(e.g.,the Moo...This paper addresses the challenges of insufficient navigation accuracy,low path-planning efficiency,and poor environmental adaptability faced by deep space rovers in complex extraterrestrial environments(e.g.,the Moon and Mars).A novel autonomous navigation scheme is proposed that integrates laser Doppler velocimetry(LDV)with star trackers(ST)and inertial navigation system(INS).The scheme suppresses slip errors from wheel odometry through non-contact,high-precision laser speed measurement(accuracy better than 0.1%).By deeply fusing multi-source data via a Kalman filter algorithm,high-precision positioning is realized under extreme extraterrestrial conditions such as weak illumination and dust coverage.This solution features high accuracy,non-contact measurement,and anti-interference capabilities,significantly improving the navigation accuracy and autonomy of deep space rovers in complex environments.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21904095,22004089)Peiyang Talents Project of Tianjin University+1 种基金Young Thousand Talented ProgramProgram of Tianjin Science and Technology Major Project and Engineering(No.19ZXYXSY00090)。
文摘Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold great promise as miniature detectives capable of detecting mi RNAs within cells.However,current nanoprobes face a challenge in achieving the required precision for accurate miRNA detection,particularly within the intricate confines of the cellular microenvironment,due to interference with biological autofluorescence,off-target effects,and a lack of spatiotemporal control.Here,we have designed a dual-stimuli responsive DNA tracker,synergistically utilizing specific intracellular cues and external triggers,which enables spatiotemporal-controlled and precise detection and imaging of miRNAs"on demand".The tracker,which combines zeolitic imidazolate framework-67(ZIF-67)and unique hairpin DNA structures,effectively anchored onto the ZIF-67 through electrostatic interactions,remains in a dormant state until activated by abundant cellular ATP,resulting in the release of the hairpin structures that include a PC linker incorporated into the loop region.Subsequent irradiation triggers specific recognition of the target miRNA.The newly developed HP-PC-BT@ZIF-67 tracker demonstrates precise spatiotemporal mi RNA detection and exhibits excellent biocompatibility,enabling specific mi RNA recognition"on demand"within cancer cells.This research presents a reliable mi RNA imaging platform in the intricate cellular environment,opening up the possibilities for precise biomedical analysis and disease diagnosis.
文摘Purpose:Wearable devices are commonly used to measure physical activity.However,it remains unclear the effect of wearing these devices on health awareness.Our aim was to provide evidence related to wearing physical activity trackers and health awareness.Methods:A quantitative comparison study design was used comparing participants who wore physical activity tracking devices(n=108)and those who did not(n=112).A paper-based Physical Health Knowledge survey designed for the purpose of this research was used for data collection in 2018.Results:A difference between participants who wore physical activity tracking devices and those that did not was identified in relation to activity levels and physical health awareness.Wearable devices are suggested as an opportunity for nurses to engage people in physical activity with the potential to improve their health awareness.Conclusions:Nurses are well placed in the healthcare landscape to work with patients who own an activity tracker device concerning increasing activity self-monitoring.This information the patient has from the device can also form the basis of health discussions between nurses and the people in their care.
文摘This paper presents a study aimed at evaluating and comparing the performance of six different tracking systems for photovoltaic (PV) with diesel-battery hybrid system in arid climate of Kingdom of Saudi Arabia (KSA). The study considered various technical and economic factors including system net present cost (NPC), levelized cost of energy (LCOE), and PV power generation using energy analysis and microgrid design software “HOMER”. It also presents an overview of the current electricity production and demand in the Kingdom. The weather data used in this study have been collected from the new solar atlas launched by King Abdullah City for Atomic and Renewable Energy (KACARE). The selected solar resource monitoring station for this study is located near to Riyadh city and has an annual average daily total irradiation of 6300 W/m2/day. The study shows that, for stand-alone PV system in the vicinity of Riyadh city, tracking system is economically better than fixed angle system. Among the considered tracking systems, VCA system is the most preferable as it has low NPC and LCOE values with a high return on investment (ROI) as well as low carbon dioxide (CO2) emissions due to a high renewable energy penetration.
文摘Purpose:This systematic review and meta-analysis aimed to evaluate the effect of wearable devices for improving physical activity and healthrelated outcomes in cancer survivors.Methods:CINAHL,Cochrane,Ebscohost,MEDLINE,Pubmed,ProQuest Health and Medical Complete,ProQuest Nursing and Allied Health Source,ScienceDirect,and SPORTDiscus databases were searched for randomized controlled trials published before September 1,2020,that evaluated interventions involving wearable devices in cancer survivors.Standardized mean differences(SMDs)were calculated to assess effects on physical activity and health-related outcomes.Subgroup analyses were conducted to assess whether the effects differed by interventions and cancer characteristics.Risk of bias was assessed using the Cochrane risk of bias tool.Results:Thirty-five trials were included(breast cancer,n=15,43%).Intervention durations ranged between 4 weeks and 1 year.Most trials(n=25,71%)involved pedometer-based physical activity interventions.Seven(20%)involved Fitbit-based interventions,and 3(9%)involved other wearable physical activity trackers(e.g.,Polar,Garmin).Compared to usual care,wearable devices had moderate-to-large effects(SMD range 0.54-0.87,p<0.001)on moderate-intensity physical activity,moderate-to-vigorous-intensity physical activity,total physical activity,and daily steps.Compared to usual care,those in the intervention had higher quality of life,aerobic fitness,physical function,and reduced fatigue(SMD range=0.18-0.66,all p<0.05).Conclusion:Wearable physical activity trackers and pedometers are effective tools that increase physical activity and improve health-related outcomes in individuals with cancer.Identifying how these devices can be implemented for longer-term use with other intervention components remains an area for future research.
文摘In the 21th century, one of the biggest problems that the world faces is energy provision. Today, the way that most countries use for energy production is not clean and continuous. The most obvious proof for that is the change in the climate. The amount of CO2 （carbon dioxide） that is caused by fossil fuel burning increases day by day and this situation creates the greenhouse effect and change in the climate. The sun is one of the best solutions to this problem. It is not only clean and continuous, but also available anywhere, anytime. However, the efficiency of a photovoltaic system is directly related to the amount of solar energy acquired by the system which means that, it is necessary to follow the sun to have a high efficient system. There are two types of trackers that follow the sun and there are several ways to build them. In this paper, solar tracker designs are examined and a new dual axis solar tracker design is given.
文摘Following over 20 years of research,a direct measurement of the QGP temperature has been achieved at Relativistic Heavy-Ion Collider(RHIC),free from the blue-shift effect and contamination from strong interactions.This viewpoint discusses a recent measurement of the QGP temperature at different stages at the Solenoidal Tracker at RHIC(STAR),which used e^(+)e^(-)pairs as penetrating probes.
文摘In order to solve the problem that the star point positioning accuracy of the star sensor in near space is decreased due to atmospheric background stray light and rapid maneuvering of platform, this paper proposes a star point positioning algorithm based on the capsule network whose input and output are both vectors. First, a PCTL (Probability-Coordinate Transformation Layer) is designed to represent the mapping relationship between the probability output of the capsule network and the star point sub-pixel coordinates. Then, Coordconv Layer is introduced to implement explicit encoding of space information and the probability is used as the centroid weight to achieve the conversion between probability and star point sub-pixel coordinates, which improves the network’s ability to perceive star point positions. Finally, based on the dynamic imaging principle of star sensors and the characteristics of near-space environment, a star map dataset for algorithm training and testing is constructed. The simulation results show that the proposed algorithm reduces the MAE (Mean Absolute Error) and RMSE (Root Mean Square Error) of the star point positioning by 36.1% and 41.7% respectively compared with the traditional algorithm. The research results can provide important theory and technical support for the scheme design, index demonstration, test and evaluation of large dynamic star sensors in near space.
文摘This paper addresses the challenges of insufficient navigation accuracy,low path-planning efficiency,and poor environmental adaptability faced by deep space rovers in complex extraterrestrial environments(e.g.,the Moon and Mars).A novel autonomous navigation scheme is proposed that integrates laser Doppler velocimetry(LDV)with star trackers(ST)and inertial navigation system(INS).The scheme suppresses slip errors from wheel odometry through non-contact,high-precision laser speed measurement(accuracy better than 0.1%).By deeply fusing multi-source data via a Kalman filter algorithm,high-precision positioning is realized under extreme extraterrestrial conditions such as weak illumination and dust coverage.This solution features high accuracy,non-contact measurement,and anti-interference capabilities,significantly improving the navigation accuracy and autonomy of deep space rovers in complex environments.
