In this study, seven alkaloids were detected in Wu-tou decoction using ultra performance liquid chromatography coupled with tandem mass spectrometry （UPLC-MSn）. The aim of this study was to investigate the effect of...In this study, seven alkaloids were detected in Wu-tou decoction using ultra performance liquid chromatography coupled with tandem mass spectrometry （UPLC-MSn）. The aim of this study was to investigate the effect of Fritillariae Cirrhosae Bulbus, Fritillariae Thunbergii Bulbus, Pinelliae Rhizoma in different ratios with Wu-tou decoction （2：1, 1：1, 1：2） by measuring the therapeutic effects in Wu-tou decoction of main seven alkaloids including benzoylaconitine （BA）, benzoylmesaconitine （BM）, benzoylhypaconitine （BH）, hypaconitine （HA）, fuziline （FU）, niaolin （NE） and deoxyaconitine （DA）. The permeability of aconitum alkaloids extract through a Caco-2 cell monolayer was analyzed in the absence and presence of Fritillariae Cirrhosae Bulbus, Fritillariae Thunbergii Bulbus, and Pinelliae Rhizoma, respectively. The results showed that Pinelliae Rhizoma could reduce the absorption of the alkaloids and increase the excretion of the alkaloids, which would attenuate the therapeutic effects of Wu-tou decoction. Therefore, Pinelliae Rhizoma is an incompatible herb of Wu-tou decoction because of the inhibition of the absorption of alkaloids in the intestine. And that Fritillariae Cirrhosae Bulbus and Fritillariae rhunbergii Bulbus showed the effects to improve the permeability of the alkaloids in Wu-tou decoction. These effects of these two herbs were similar, but the former was stronger than the latter, which most likely is due to the fact that the compositions of these two traditional Chinese medicines are similar. The in vitro data suggests that the compounds such as fritillary presented in alkaloids in the formula maybe improve the therapeutic function caused by the increased bioavailability of alkaloids in intestine.展开更多
Large-scale electric vehicle charging has a significant impact on power grid load, disorderly charging will increase power grid peak load. This article proposes an orderly charging mechanism based on TOU price. To bui...Large-scale electric vehicle charging has a significant impact on power grid load, disorderly charging will increase power grid peak load. This article proposes an orderly charging mechanism based on TOU price. To build an orderly charging model by researching TOU price and user price reaction model. This article research the impact of electric vehicle charging on grid load by orderly charging model. With this model the grid’s peak and valley characteristics, the utilization of charging equipment, the economics of grid operation can all be improved.展开更多
This research paper delves into the intricate role of music as a symbolic form in Pascal Quignard’s novel Tous les matins du monde,exploring its capacity to convey profound human emotions and experiences.Set against ...This research paper delves into the intricate role of music as a symbolic form in Pascal Quignard’s novel Tous les matins du monde,exploring its capacity to convey profound human emotions and experiences.Set against the backdrop of 17th-century France,the narrative follows the lives of Monsieur de Sainte Colombe and Marin Marais,renowned viola da gamba players,to contemplate the essence of music and its representation of human sentiment.The paper examines the semiotic nature of music,its relationship with memory and emotion,and the philosophical inquiry into music’s intrinsic value as an art form.It also discusses the novel’s adaptation into a film and its impact on the revival of Baroque music.Furthermore,the paper draws parallels between the myth of Orpheus and the characters’personal journeys,highlighting the transformative power of music and its ability to transcend reality.The analysis is grounded in the works of various scholars,including Ferdinand de Saussure,Suzanne Langer,and Charles Sanders Peirce,to provide a comprehensive understanding of music’s symbolic essence in Quignard’s literary creation.展开更多
目的观察不同穴位针刺治疗无先兆偏头痛的临床疗效及对患者血清降钙素基因相关肽(calcitonin gene-related peptide,CGRP)和5-羟色胺(5-hydroxytrptamine,5-HT)水平的影响。方法将60例无先兆偏头痛患者随机分为观察组和对照组,每组30例...目的观察不同穴位针刺治疗无先兆偏头痛的临床疗效及对患者血清降钙素基因相关肽(calcitonin gene-related peptide,CGRP)和5-羟色胺(5-hydroxytrptamine,5-HT)水平的影响。方法将60例无先兆偏头痛患者随机分为观察组和对照组,每组30例。对照组采用常规针刺治疗,观察组采用“头七针”针刺治疗。观察两组治疗前后和随访时视觉模拟量表(visual analog scale,VAS)评分、头痛症状评分及偏头痛-特异生活质量问卷(migraine-specific quality of life,MSQOL)评分的变化,观察两组治疗前后血清CGRP和5-HT水平,并比较两组临床疗效和不良反应发生情况。结果两组治疗后和随访时VAS评分低于治疗前(P<0.05);对照组随访时VAS评分低于治疗后(P<0.05);观察组治疗后和随访时VAS评分低于对照组(P<0.05)。两组治疗后和随访时头痛症状评分低于治疗前(P<0.05);观察组治疗后和随访时头痛症状评分低于对照组(P<0.05)。对照组随访时MSQOL评分高于治疗前(P<0.05);观察组治疗后和随访时MSQOL评分高于治疗前,随访时高于治疗后,差异有统计学意义(P<0.05);观察组治疗后和随访时MSQOL评分高于对照组(P<0.05)。治疗后,两组血清CGRP水平较治疗前降低(P<0.05),血清5-HT水平较治疗前升高(P<0.05),且观察组上述指标均优于对照组(P<0.05)。观察组治疗后总有效率为86.7%,高于对照组的63.3%(P<0.05)。观察组随访时总有效率为83.3%,高于对照组的53.3%(P<0.05)。两组均未发生不良反应。结论“头七针”针刺与常规针刺治疗无先兆偏头痛均有效。“头七针”针刺在缓解疼痛、提高生活质量方面优于常规针刺,可能与调节血清CGRP和5-HT水平有关。展开更多
基金supported by the National Natural Sciences Foundation of China(No.81274046)National Basic Research Program of China("973 Program")(Nos.2011CB505300, 2011CB505305)
文摘In this study, seven alkaloids were detected in Wu-tou decoction using ultra performance liquid chromatography coupled with tandem mass spectrometry （UPLC-MSn）. The aim of this study was to investigate the effect of Fritillariae Cirrhosae Bulbus, Fritillariae Thunbergii Bulbus, Pinelliae Rhizoma in different ratios with Wu-tou decoction （2：1, 1：1, 1：2） by measuring the therapeutic effects in Wu-tou decoction of main seven alkaloids including benzoylaconitine （BA）, benzoylmesaconitine （BM）, benzoylhypaconitine （BH）, hypaconitine （HA）, fuziline （FU）, niaolin （NE） and deoxyaconitine （DA）. The permeability of aconitum alkaloids extract through a Caco-2 cell monolayer was analyzed in the absence and presence of Fritillariae Cirrhosae Bulbus, Fritillariae Thunbergii Bulbus, and Pinelliae Rhizoma, respectively. The results showed that Pinelliae Rhizoma could reduce the absorption of the alkaloids and increase the excretion of the alkaloids, which would attenuate the therapeutic effects of Wu-tou decoction. Therefore, Pinelliae Rhizoma is an incompatible herb of Wu-tou decoction because of the inhibition of the absorption of alkaloids in the intestine. And that Fritillariae Cirrhosae Bulbus and Fritillariae rhunbergii Bulbus showed the effects to improve the permeability of the alkaloids in Wu-tou decoction. These effects of these two herbs were similar, but the former was stronger than the latter, which most likely is due to the fact that the compositions of these two traditional Chinese medicines are similar. The in vitro data suggests that the compounds such as fritillary presented in alkaloids in the formula maybe improve the therapeutic function caused by the increased bioavailability of alkaloids in intestine.
文摘Large-scale electric vehicle charging has a significant impact on power grid load, disorderly charging will increase power grid peak load. This article proposes an orderly charging mechanism based on TOU price. To build an orderly charging model by researching TOU price and user price reaction model. This article research the impact of electric vehicle charging on grid load by orderly charging model. With this model the grid’s peak and valley characteristics, the utilization of charging equipment, the economics of grid operation can all be improved.
文摘This research paper delves into the intricate role of music as a symbolic form in Pascal Quignard’s novel Tous les matins du monde,exploring its capacity to convey profound human emotions and experiences.Set against the backdrop of 17th-century France,the narrative follows the lives of Monsieur de Sainte Colombe and Marin Marais,renowned viola da gamba players,to contemplate the essence of music and its representation of human sentiment.The paper examines the semiotic nature of music,its relationship with memory and emotion,and the philosophical inquiry into music’s intrinsic value as an art form.It also discusses the novel’s adaptation into a film and its impact on the revival of Baroque music.Furthermore,the paper draws parallels between the myth of Orpheus and the characters’personal journeys,highlighting the transformative power of music and its ability to transcend reality.The analysis is grounded in the works of various scholars,including Ferdinand de Saussure,Suzanne Langer,and Charles Sanders Peirce,to provide a comprehensive understanding of music’s symbolic essence in Quignard’s literary creation.
文摘目的观察不同穴位针刺治疗无先兆偏头痛的临床疗效及对患者血清降钙素基因相关肽(calcitonin gene-related peptide,CGRP)和5-羟色胺(5-hydroxytrptamine,5-HT)水平的影响。方法将60例无先兆偏头痛患者随机分为观察组和对照组,每组30例。对照组采用常规针刺治疗,观察组采用“头七针”针刺治疗。观察两组治疗前后和随访时视觉模拟量表(visual analog scale,VAS)评分、头痛症状评分及偏头痛-特异生活质量问卷(migraine-specific quality of life,MSQOL)评分的变化,观察两组治疗前后血清CGRP和5-HT水平,并比较两组临床疗效和不良反应发生情况。结果两组治疗后和随访时VAS评分低于治疗前(P<0.05);对照组随访时VAS评分低于治疗后(P<0.05);观察组治疗后和随访时VAS评分低于对照组(P<0.05)。两组治疗后和随访时头痛症状评分低于治疗前(P<0.05);观察组治疗后和随访时头痛症状评分低于对照组(P<0.05)。对照组随访时MSQOL评分高于治疗前(P<0.05);观察组治疗后和随访时MSQOL评分高于治疗前,随访时高于治疗后,差异有统计学意义(P<0.05);观察组治疗后和随访时MSQOL评分高于对照组(P<0.05)。治疗后,两组血清CGRP水平较治疗前降低(P<0.05),血清5-HT水平较治疗前升高(P<0.05),且观察组上述指标均优于对照组(P<0.05)。观察组治疗后总有效率为86.7%,高于对照组的63.3%(P<0.05)。观察组随访时总有效率为83.3%,高于对照组的53.3%(P<0.05)。两组均未发生不良反应。结论“头七针”针刺与常规针刺治疗无先兆偏头痛均有效。“头七针”针刺在缓解疼痛、提高生活质量方面优于常规针刺,可能与调节血清CGRP和5-HT水平有关。
