This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper(TiCu)alloy.In general,most studies on antibacterial implants have used a single p...This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper(TiCu)alloy.In general,most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models.However,dental implant-associated infections are polymicrobial diseases.We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria.The anti-infection ability,biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection,hematology,imageology(micro-CT),microbiology(16S rDNA and metagenome),histology,and Cu ion detections.Compared with Ti implant,TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility.Additionally,the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis.It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle(TCA)cycles,which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens,thereby maintaining the microflora balance between aerobic and anaerobic bacteria.展开更多
由于存在大的温度梯度,激光熔化沉积过程会沿沉积方向形成具有择优取向的粗大柱状晶,导致材料产生显著的各向异性。拟通过在钛合金中添加Cu以实现改变初生β晶粒形态、细化组织并弱化织构的目的。系统研究了不同含量的Cu添加对激光熔化...由于存在大的温度梯度,激光熔化沉积过程会沿沉积方向形成具有择优取向的粗大柱状晶,导致材料产生显著的各向异性。拟通过在钛合金中添加Cu以实现改变初生β晶粒形态、细化组织并弱化织构的目的。系统研究了不同含量的Cu添加对激光熔化沉积TC4钛合金组织及织构的影响,结果表明,Cu元素能够显著细化柱状初生β晶粒,并使晶粒尺寸分布更加均匀,Cu元素添加量为4%(质量分数,下同)时能够实现完全的柱状晶向等轴晶转变,平均晶粒尺寸由未添加时的1490μm降低到385μm。添加Cu试样的晶粒内部仍为网篮组织,主要由α-Ti、β-Ti和少量Ti2Cu相组成,其中Ti2Cu呈短棒状分布在α-Ti板条的边界处,其在组织中的占比随Cu添加量的增大而增加。当添加8%Cu时,α-Ti的平均宽度为0.44μm,与未添加Cu试样的1.18μm相比降低了约63%。Cu添加能够显著降低激光熔化沉积钛合金的织构强度,当添加4%Cu时,α-Ti极图均匀分布倍数(multiples of uniform distribution,MUD)的最大值相比TC4降低了约71%。展开更多
目的:比较铜镍钛弓丝与普通镍钛弓丝在正畸排齐阶段的临床疗效差异。方法:选取72例首次正畸患者为研究对象,按照治疗材料不同将患者分为研究组(铜镍钛弓丝)和对照组(普通镍钛弓丝)。在矫治初期(T0)、3个月(T1)及完成弓丝阶段(T2)分别测...目的:比较铜镍钛弓丝与普通镍钛弓丝在正畸排齐阶段的临床疗效差异。方法:选取72例首次正畸患者为研究对象,按照治疗材料不同将患者分为研究组(铜镍钛弓丝)和对照组(普通镍钛弓丝)。在矫治初期(T0)、3个月(T1)及完成弓丝阶段(T2)分别测量尖牙/磨牙间宽度、上颌Little s不规则指数,记录计划复诊24 h后VAS疼痛评分、治疗周期及复诊次数。结果:研究组与对照组患者治疗周期及牙弓形态指标改善均无统计学差异(P>0.05)。研究组患者初始24 h VAS疼痛评分及复诊次数均低于对照组(P<0.05),但T1、T2期疼痛评分组间差异均无统计学意义(P>0.05)。结论:铜镍钛弓丝在减轻初始疼痛和减少复诊次数方面展现出优势,可作为正畸排齐阶段初始弓丝的选择之一。展开更多
基金supported by the Bureau of International Cooperation,Chinese Academy of Sciences[174321KYSB20180006]National Key Research and Development Program of China[2018YFC1106600,2016YFC1100600]+1 种基金Natural Science Foundation of China[51631009,31870954]Liaoning Revitalization Talents Program[XLYC1807069].
文摘This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper(TiCu)alloy.In general,most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models.However,dental implant-associated infections are polymicrobial diseases.We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria.The anti-infection ability,biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection,hematology,imageology(micro-CT),microbiology(16S rDNA and metagenome),histology,and Cu ion detections.Compared with Ti implant,TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility.Additionally,the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis.It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle(TCA)cycles,which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens,thereby maintaining the microflora balance between aerobic and anaerobic bacteria.
文摘由于存在大的温度梯度,激光熔化沉积过程会沿沉积方向形成具有择优取向的粗大柱状晶,导致材料产生显著的各向异性。拟通过在钛合金中添加Cu以实现改变初生β晶粒形态、细化组织并弱化织构的目的。系统研究了不同含量的Cu添加对激光熔化沉积TC4钛合金组织及织构的影响,结果表明,Cu元素能够显著细化柱状初生β晶粒,并使晶粒尺寸分布更加均匀,Cu元素添加量为4%(质量分数,下同)时能够实现完全的柱状晶向等轴晶转变,平均晶粒尺寸由未添加时的1490μm降低到385μm。添加Cu试样的晶粒内部仍为网篮组织,主要由α-Ti、β-Ti和少量Ti2Cu相组成,其中Ti2Cu呈短棒状分布在α-Ti板条的边界处,其在组织中的占比随Cu添加量的增大而增加。当添加8%Cu时,α-Ti的平均宽度为0.44μm,与未添加Cu试样的1.18μm相比降低了约63%。Cu添加能够显著降低激光熔化沉积钛合金的织构强度,当添加4%Cu时,α-Ti极图均匀分布倍数(multiples of uniform distribution,MUD)的最大值相比TC4降低了约71%。
文摘目的:比较铜镍钛弓丝与普通镍钛弓丝在正畸排齐阶段的临床疗效差异。方法:选取72例首次正畸患者为研究对象,按照治疗材料不同将患者分为研究组(铜镍钛弓丝)和对照组(普通镍钛弓丝)。在矫治初期(T0)、3个月(T1)及完成弓丝阶段(T2)分别测量尖牙/磨牙间宽度、上颌Little s不规则指数,记录计划复诊24 h后VAS疼痛评分、治疗周期及复诊次数。结果:研究组与对照组患者治疗周期及牙弓形态指标改善均无统计学差异(P>0.05)。研究组患者初始24 h VAS疼痛评分及复诊次数均低于对照组(P<0.05),但T1、T2期疼痛评分组间差异均无统计学意义(P>0.05)。结论:铜镍钛弓丝在减轻初始疼痛和减少复诊次数方面展现出优势,可作为正畸排齐阶段初始弓丝的选择之一。
