The authors regret that words were typed incorrectly in the Graphical Abstract,Fig.1 and Fig.2.In the original review article,the Graphical Abstract describes the exposure pathways as inhalation,ingestion,and dermal c...The authors regret that words were typed incorrectly in the Graphical Abstract,Fig.1 and Fig.2.In the original review article,the Graphical Abstract describes the exposure pathways as inhalation,ingestion,and dermal contact,but“Ingestion”was incorrectly typed as“Ingeation”.展开更多
Increasing rate of consumption of the common African catfish, Clarias gariepinus, a popular delicacy in Delta State, Nigeria has raised worries about the safety of health of consumers in the face of perceived rising i...Increasing rate of consumption of the common African catfish, Clarias gariepinus, a popular delicacy in Delta State, Nigeria has raised worries about the safety of health of consumers in the face of perceived rising input of recalcitrant pollutants such as the heavy metals in aquatic habitats. This research investigated the presence and levels of Zn in muscle and brain tissues of C. gariepinus sourced from selected markets in Delta State. Replicate adult fish samples were obtained from seven market locations in Oleh, Asaba, Ekpan, Ogwashi-Ukwu, Okere, Abraka and Ughelli towns, labeled and taken to the laboratory in iced coolers. The presence and levels of the heavy metal were determined spectrophotometrically. Concentrations ranged from 0.015 - 0.19 (0.09 ± 0.02) mg/kg d.w. in muscle and 0.035 - 0.36 (0.16 ± 0.03) mg/kg d.w. in brain tissues, even as accumulation levels differed significantly (t = 0.005) between the tissues at p < 0.05. There was also significant locational heterogeneity in accumulations of the metal [F<sub>(100.97)</sub> > F<sub>crit(4.02)</sub>] at the 95% confidence limit;with least accumulation of 0.03 (±0.01) mg/kg d.w. recorded in fish samples obtained from Ughelli and maximum accumulation of 0.28 (±0.07) mg/kg d.w. recorded in those obtained from Oleh locations. However, levels were below the Food and Agricultural Organization and World Health Organization acceptable limits for Zn in edible fish. Results revealed that lipophilic brain tissues accumulated more heavy metal than muscle tissues. Since accumulation levels were low, they do not currently constitute public health risks to consumers in Delta State.展开更多
Alcohol consumption alters gut microflora and damages intestinal tight junction barriers,which may affect arsenic(As)oral bioavailability.In this study,mice were exposed to arsenate in the diet(6μg/g)over a 3-week pe...Alcohol consumption alters gut microflora and damages intestinal tight junction barriers,which may affect arsenic(As)oral bioavailability.In this study,mice were exposed to arsenate in the diet(6μg/g)over a 3-week period and gavaged daily with Chinese liquor(0.05 or 0.10 mL per mouse per day).Following ingestion,78.0%and 72.9%of the total As intake was absorbed and excreted via urine when co-exposed with liquor at daily doses of 0.05 or 0.10 mL,significantly greater than when As was supplied alone(44.7%).Alcohol co-exposure significantly altered gut microbiota but did not significantly alter As biotransformation in the intestinal tract or tissue.Significantly lower relative mRNA expression was observed for genes encoding for tight junctions in the ileum of liquor co-exposed mice,contributing to greater As bioavailability attributable to enhanced As absorption via the intestinal paracellular pathway.However,As concentration in the liver,kidney,and intestinal tissue of liquortreated mice was decreased by 24.4%-42.6%,27.5%-38.1%,and 28.1%-48.9%compared to control mice.This was likely due to greater renal glomerular filtration rate induced by alcohol,as suggested by significantly lower expression of genes encoding for renal tight junctions.In addition,in mice gavaged daily with 0.05 mL liquor,the serum antidiuretic hormone level was significantly lower than control mice(2.83±0.59 vs.5.40±1.10 pg/mL),suggesting the diuretic function of alcohol consumption,which may facilitate As elimination via urine.These results highlight that alcohol consumption has a significant impact on the bioavailability and accumulation of As.展开更多
Fibrosis is a pathological process characterized by chronic inflammation and excessive ECM deposition,leading to tissue scarring and organ dysfunction.(1)Fibrotic tissue accumulation results from persistent injuries t...Fibrosis is a pathological process characterized by chronic inflammation and excessive ECM deposition,leading to tissue scarring and organ dysfunction.(1)Fibrotic tissue accumulation results from persistent injuries triggered by factors such as epigenetic alterations,infections,hypertension,myocardial infarction,autoimmune inflammation,and metabolic disorders.(2.3)Although fibrosis shares similarities with normal wound healing,dysregulated or repeated tissue repair can result in rreversible scarring,ultimately leading to organ failure.(4)The inflammatory response and the activation of myofibroblasts-fibroblasts that secrete collagen and express α-SMA are essential for stimulating the repair response and triggering fibrosis in many organs.Normal tissue repair can become an irreversible fibrotic response if the tissue damage is extensive,repetitive,or if the wound-healing process becomes dysregulated,(5)This irreversible fibrotic response leads to several adverse outcomes,including irreversible scarring,disruption of tissue architecture,organ dysfunction,and ultimately,organ failure and death.(6)Chronic liver diseases,kidney disorders,interstitial lung disease,and heart failure are representative examples.(7.8)The incidence of pulmonary fibrosis has risen globally,particularly following the COVID-19 pandemic.展开更多
文摘The authors regret that words were typed incorrectly in the Graphical Abstract,Fig.1 and Fig.2.In the original review article,the Graphical Abstract describes the exposure pathways as inhalation,ingestion,and dermal contact,but“Ingestion”was incorrectly typed as“Ingeation”.
文摘Increasing rate of consumption of the common African catfish, Clarias gariepinus, a popular delicacy in Delta State, Nigeria has raised worries about the safety of health of consumers in the face of perceived rising input of recalcitrant pollutants such as the heavy metals in aquatic habitats. This research investigated the presence and levels of Zn in muscle and brain tissues of C. gariepinus sourced from selected markets in Delta State. Replicate adult fish samples were obtained from seven market locations in Oleh, Asaba, Ekpan, Ogwashi-Ukwu, Okere, Abraka and Ughelli towns, labeled and taken to the laboratory in iced coolers. The presence and levels of the heavy metal were determined spectrophotometrically. Concentrations ranged from 0.015 - 0.19 (0.09 ± 0.02) mg/kg d.w. in muscle and 0.035 - 0.36 (0.16 ± 0.03) mg/kg d.w. in brain tissues, even as accumulation levels differed significantly (t = 0.005) between the tissues at p < 0.05. There was also significant locational heterogeneity in accumulations of the metal [F<sub>(100.97)</sub> > F<sub>crit(4.02)</sub>] at the 95% confidence limit;with least accumulation of 0.03 (±0.01) mg/kg d.w. recorded in fish samples obtained from Ughelli and maximum accumulation of 0.28 (±0.07) mg/kg d.w. recorded in those obtained from Oleh locations. However, levels were below the Food and Agricultural Organization and World Health Organization acceptable limits for Zn in edible fish. Results revealed that lipophilic brain tissues accumulated more heavy metal than muscle tissues. Since accumulation levels were low, they do not currently constitute public health risks to consumers in Delta State.
基金supported by the National Natural Science Foundation of China(42022058,and 41877356)Jiangsu Agricultural Independent Innovation Program[CX(21)3095].
文摘Alcohol consumption alters gut microflora and damages intestinal tight junction barriers,which may affect arsenic(As)oral bioavailability.In this study,mice were exposed to arsenate in the diet(6μg/g)over a 3-week period and gavaged daily with Chinese liquor(0.05 or 0.10 mL per mouse per day).Following ingestion,78.0%and 72.9%of the total As intake was absorbed and excreted via urine when co-exposed with liquor at daily doses of 0.05 or 0.10 mL,significantly greater than when As was supplied alone(44.7%).Alcohol co-exposure significantly altered gut microbiota but did not significantly alter As biotransformation in the intestinal tract or tissue.Significantly lower relative mRNA expression was observed for genes encoding for tight junctions in the ileum of liquor co-exposed mice,contributing to greater As bioavailability attributable to enhanced As absorption via the intestinal paracellular pathway.However,As concentration in the liver,kidney,and intestinal tissue of liquortreated mice was decreased by 24.4%-42.6%,27.5%-38.1%,and 28.1%-48.9%compared to control mice.This was likely due to greater renal glomerular filtration rate induced by alcohol,as suggested by significantly lower expression of genes encoding for renal tight junctions.In addition,in mice gavaged daily with 0.05 mL liquor,the serum antidiuretic hormone level was significantly lower than control mice(2.83±0.59 vs.5.40±1.10 pg/mL),suggesting the diuretic function of alcohol consumption,which may facilitate As elimination via urine.These results highlight that alcohol consumption has a significant impact on the bioavailability and accumulation of As.
基金Supported by the National Natural Science Foundation of China(No.82004254)。
文摘Fibrosis is a pathological process characterized by chronic inflammation and excessive ECM deposition,leading to tissue scarring and organ dysfunction.(1)Fibrotic tissue accumulation results from persistent injuries triggered by factors such as epigenetic alterations,infections,hypertension,myocardial infarction,autoimmune inflammation,and metabolic disorders.(2.3)Although fibrosis shares similarities with normal wound healing,dysregulated or repeated tissue repair can result in rreversible scarring,ultimately leading to organ failure.(4)The inflammatory response and the activation of myofibroblasts-fibroblasts that secrete collagen and express α-SMA are essential for stimulating the repair response and triggering fibrosis in many organs.Normal tissue repair can become an irreversible fibrotic response if the tissue damage is extensive,repetitive,or if the wound-healing process becomes dysregulated,(5)This irreversible fibrotic response leads to several adverse outcomes,including irreversible scarring,disruption of tissue architecture,organ dysfunction,and ultimately,organ failure and death.(6)Chronic liver diseases,kidney disorders,interstitial lung disease,and heart failure are representative examples.(7.8)The incidence of pulmonary fibrosis has risen globally,particularly following the COVID-19 pandemic.
