In this paper, we show some recent experimental applications of Brillouin optical time-domain analysis （BOTDA） based sensors for geotechnical monitoring. In particular, how these sensors can be applied to detecting ...In this paper, we show some recent experimental applications of Brillouin optical time-domain analysis （BOTDA） based sensors for geotechnical monitoring. In particular, how these sensors can be applied to detecting early movements of soil slopes by the direct embedding of suitable fiber cables in the ground is presented. Furthermore, the same technology can be used to realize innovative inclinometers, as well as smart foundation anchors.展开更多
Based on chromatographic theory, the moment method and the time-domain fitting analysis were applied to measure and evaluate the adsorption equilibrium constant and mass transfer properties (axial dispersion coefficie...Based on chromatographic theory, the moment method and the time-domain fitting analysis were applied to measure and evaluate the adsorption equilibrium constant and mass transfer properties (axial dispersion coefficient and effective intra-particle diffusivity) for toluene and p-dichlorobenzene on silica gel adsorbent in the subcritical and supercritical CO2. An apparatus based on supercritical fluid chromatography was established and the experiments were performed at temperatures of 298.15-318.15 K and pressures of 7.5-17.8 MPa. The two methods have been compared. The results show that for the systems studied here the moment method can give reasonable values for both adsorption equilibrium constant and mass transfer properties, but the time-domain analysis only can obtain the adsorption equilibrium constant. The dependence of adsorption equilibrium constant and mass transfer properties on temperature and pressure was investigated.展开更多
Based on the modified scale boundary finite element method and continued fraction solution,a high-order doubly asymptotic transmitting boundary(DATB)is derived and extended to the simulation of vector wave propagation...Based on the modified scale boundary finite element method and continued fraction solution,a high-order doubly asymptotic transmitting boundary(DATB)is derived and extended to the simulation of vector wave propagation in complex layered soils.The high-order DATB converges rapidly to the exact solution throughout the entire frequency range and its formulation is local in the time domain,possessing high accuracy and good efficiency.Combining with finite element method,a coupled model is constructed for time-domain analysis of underground station-layered soil interaction.The coupled model is divided into the near and far field by the truncated boundary,of which the near field is modelled by FEM while the far field is modelled by the high-order DATB.The coupled model is implemented in an open source finite element software,OpenSees,in which the DATB is employed as a super element.Numerical examples demonstrate that results of the coupled model are stable,accurate and efficient compared with those of the extended mesh model and the viscous-spring boundary model.Besides,it has also shown the fitness for long-time seismic response analysis of underground station-layered soil interaction.Therefore,it is believed that the coupled model could provide a new approach for seismic analysis of underground station-layered soil interaction and could be further developed for engineering.展开更多
Problems experienced during Floating Production, Storage and Offioading （FPSO） tandem offloading operations were investigated. The aim of this research was to improve the reliability of such systems, and it needed a...Problems experienced during Floating Production, Storage and Offioading （FPSO） tandem offloading operations were investigated. The aim of this research was to improve the reliability of such systems, and it needed a means to assess them. Time-domain simulation and analysis of offioading systems was performed using the multi-body mooring software ARIANE 7.0. Hydrodynamic interaction between the vessels was considered. The responses of the offioading system in different loading cases, different parameters of offioading hawsers and the effects of challenging environmental conditions were calculated. There was a focus on the problems of relative motion between the two bodies and its effects on the intensity of hawser forces. Minimum relative distance, maximum relative headings and maximum tension in the hawsers of offloading systems were obtained by time-domain analysis. The time-domain analysis was effective and comparative study can be used to optimize parameters of the system and extend operating limits.展开更多
Strong hydrodynamic interactions during the side-by-side offloading operation between floating liquefied natural gas(FLNG) and liquefied natural gas carrier(LNGC) can induce high risks of collision. The weather vane e...Strong hydrodynamic interactions during the side-by-side offloading operation between floating liquefied natural gas(FLNG) and liquefied natural gas carrier(LNGC) can induce high risks of collision. The weather vane effect of a single-point mooring system normally results in the satisfactory hydrodynamic performance of the side-by-side configuration in head seas. Nevertheless, the changes in wave directions in real sea conditions can significantly influence the relative motions. This article studies the relative motions of the side-by-side system by using the theoretical analysis method and the numerical calculation method. Based on the three-dimensional potential theory modified by artificial damping-lid method, the frequency-domain hydrodynamic coefficients can be improved to calculate the retardation functions for the multi-body problem. An in-house code is then developed to perform the time-domain simulation of two vessels, through which the relative motions are subsequently obtained. A range of oblique waves are chosen for the extensive calculation of relative motions between the two vessels, which are further analyzed in terms of the phase shift of motion responses induced by specific resonant wave patterns. Investigation results show that wave directions have a significant influence on the relative sway, roll, and yaw motions. Under the circumstance that the absolute phase shift between the roll motions of two vessels approaches 180°, stronger relative motions are induced when LNGC is on the weather side.Moreover, the gap water resonances at high frequencies tend to cause the dangerous opposed oscillation of two vessels in the sway and yaw modes, whereas FLNG reduces the gap water resonances and relative motions when located on the weather side.展开更多
The reduced weight and improved efficiency of modern aeronautical structures result in a decreasing separation of frequency ranges of rigid and elastic modes.Particularly,a high-aspect-ratio flexible flying wing is pr...The reduced weight and improved efficiency of modern aeronautical structures result in a decreasing separation of frequency ranges of rigid and elastic modes.Particularly,a high-aspect-ratio flexible flying wing is prone to body freedomflutter(BFF),which is a result of coupling of the rigid body short-periodmodewith 1st wing bendingmode.Accurate prediction of the BFF characteristics is helpful to reflect the attitude changes of the vehicle intuitively and design the active flutter suppression control law.Instead of using the rigid body mode,this work simulates the rigid bodymotion of the model by using the six-degree-of-freedom(6DOF)equation.A dynamicmesh generation strategy particularly suitable for BFF simulation of free flying aircraft is developed.An accurate Computational Fluid Dynamics/Computational Structural Dynamics/six-degree-of-freedom equation(CFD/CSD/6DOF)-based BFF prediction method is proposed.Firstly,the time-domain CFD/CSD method is used to calculate the static equilibrium state of the model.Based on this state,the CFD/CSD/6DOF equation is solved in time domain to evaluate the structural response of themodel.Then combinedwith the variable stiffnessmethod,the critical flutter point of the model is obtained.This method is applied to the BFF calculation of a flyingwing model.The calculation results of the BFF characteristics of the model agree well with those fromthe modalmethod andNastran software.Finally,the method is used to analyze the influence factors of BFF.The analysis results show that the flutter speed can be improved by either releasing plunge constraint or moving the center ofmass forward or increasing the pitch inertia.展开更多
Aiming at the problem of high requirement for the signal generator in the Brillouin optical time-domain analysis(BOTDA)system,a quarter of the Brillouin frequency shift(BFS)of modulation is proposed to reduce the requ...Aiming at the problem of high requirement for the signal generator in the Brillouin optical time-domain analysis(BOTDA)system,a quarter of the Brillouin frequency shift(BFS)of modulation is proposed to reduce the required bandwidth of the sensing system.A functional model for solving the intensity of each-order sideband of the output light of electro-optic modulator(EOM)is proposed and applied,so the spectrum with suppressed the carrier and the first-order sidebands while maximizing the second-order sidebands is obtained.Compared with the latest scheme,the intensity of the second-order sidebands is increased by 21.1%based on this functional model.In the experiment,the second-order upper sideband and the second-order lower sideband are used as continuous wave(CW)probe light and pump pulse light,respectively,which ultimately reduces the required bandwidth of radio frequency(RF)signal sources to a quarter of the BFS(reduced from~11 GHz to~2.75 GHz),and the frequency sweep range is also reduced to a quarter of the original.展开更多
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'...Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.展开更多
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A...The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
AIM:To explore the causal relationship between several possible behavioral factors and high myopia(HM)using multivariable Mendelian randomization(MVMR)approach and to find the mediators among them with mediation analy...AIM:To explore the causal relationship between several possible behavioral factors and high myopia(HM)using multivariable Mendelian randomization(MVMR)approach and to find the mediators among them with mediation analysis.METHODS:The causal effects of several behavioral factors,including screen time,education time,time spent outdoors,and physical activity,on the risk of HM using univariable Mendelian randomization(MR)and MVMR analyses were first assessed.Genome-wide association study summary statistics of serum metabolites were also used in mediation analysis to determine the extent to which serum metabolites mediate the effects of behavioral factors on HM.RESULTS:MR analyses indicated that both increased time spent outdoors and a higher frequency of moderate physical activity significantly reduced the risk of HM.Further MVMR analysis confirmed that moderate physical activity independently contributed to a lower risk of HM.Additionally,MR analyses identified 13 serum metabolites significantly associated with HM,of which 12 were lipids and one was an amino acid derivative.Mediation analysis revealed that six lipid metabolites mediated the protective effects of moderate physical activity on HM,with the highest mediation proportion observed for 1-(1-enyl-palmitoyl)-GPC(p-16:0;30.83%).CONCLUSION:This study suggests that in addition to outdoor time,moderate physical activity habits may have an independent protective effect against HM and pointed to lipid metabolites as priority targets for the prevention due to low physical activity.These results emphasize the importance of physical activity and metabolic health in HM and underscore the need for further study of these complex associations.展开更多
AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 ...AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countries/regions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation.展开更多
With soaring work frequency and decreasing feature sizes, VLSI circuits with RLC parasitic components are more like analog circuits and should be carefully analyzed in physical design. However, the number of extracted...With soaring work frequency and decreasing feature sizes, VLSI circuits with RLC parasitic components are more like analog circuits and should be carefully analyzed in physical design. However, the number of extracted RLC components is typically too large to be analyzed efficiently by using present analog circuit simulators like SPICE. In order to speedup the simulations without error penalty, this paper proposes a novel methodology to compress the time-descritized circuits resulted from numerical integration approximation at every time step. The main contribution of the methodology is the efficient structure-level compression of DC circuits containing many current sources, which is an important complement to present circuit analysis theory. The methodology consists of the following parts： 1） An approach is proposed to delete all intermediate nodes of RL branches. 2） An efficient approach is proposed to compress and back-solve parallel and serial branches so that it is error-free and of linear complexity to analyze circuits of tree topology. 3） The Y to πtransformation method is used to error-free reduce and back-solve the intermediate nodes of ladder circuits with the linear complexity. Thus, the whole simulation method is very accurate and of linear complexity to analyze circuits of chain topology. Based on the methodology, we propose several novel algorithms for efficiently solving RLC-model transient power/ground （P/G） networks. Among them, EQU-ADI algorithm of linear-complexity is proposed to solve RLC P/G networks with mesh-tree or mesh-chain topologies. Experimental results show that the proposed method is at least two orders of magnitude faster than SPICE while it can scale linearly in both time- and memory-complexity to solve very large P/G networks.展开更多
The vibration and sound radiation of a submerged spherical shell are studied in the time-domain by Laplace transform method, where a CW pulse force acts at the apex of the shell. The numerical results for the case of ...The vibration and sound radiation of a submerged spherical shell are studied in the time-domain by Laplace transform method, where a CW pulse force acts at the apex of the shell. The numerical results for the case of long pulse show that the different vibrational modes and the resonant or beat radiated sound are excited for different carrier-frequencies, but litle sound is radiated for some vibrational modes. For the case of short pulse the waveforms of the pulse become widened and deformed, when the pulse propagates between apexes of the shell. Then, the Doubly Asymptotic Approximations (DAA2) and Kirchhoff's Retarded Potential Formulate (KRPF)are used to solve the same problem. It is shown that the results of DAA2 and KRPF method have a good agreement with the results of Laplace transform method.展开更多
The hydroelastic behavior of a moored oil storage vessel subjected to arbitrary time-dependent external loads,which include wind,waves,and currents with different incident directions,is investigated with the time-doma...The hydroelastic behavior of a moored oil storage vessel subjected to arbitrary time-dependent external loads,which include wind,waves,and currents with different incident directions,is investigated with the time-domain modal expansion method.First,the water boundary integral equations on the body surface of a quarter model,which can be obtained via the free-surface Green’s function method,are established.Then,the time-dependent elastic deflection of the moored oil storage vessel is expressed by a superposition of modal functions and corresponding modal amplitudes,and a Galerkin scheme is applied to derive the linear system of equations for the modal amplitudes.The second-order linear differential equations for modal amplitudes are solved via the fourth-order Runge−Kutta method.The present model is validated against existing frequency domain results for a truncated cylinder and a VLFS.Numerical calculations for the moored oil storage vessel are then conducted to obtain the time series of various modal amplitudes and elastic displacements of the measurement points and the corresponding spectra with different incident directions.展开更多
Guided waves are generally considered as a powerful approach for crack detection in structures,which are commonly investigated using the finite element method(FEM).However,the traditional FEM has many disadvantages in...Guided waves are generally considered as a powerful approach for crack detection in structures,which are commonly investigated using the finite element method(FEM).However,the traditional FEM has many disadvantages in solving wave propagation due to the strict requirement of mesh density.To tackle this issue,this paper proposes an efficient time-domain spectral finite element method(SFEM)to analyze wave propagation in cracked structures,in which the breathing crack is modeled by definiiig the spectral gap element.Moreover,novel orthogonal polynomials and Gauss-Lobatto-Legendre quadrature rules are adopted to construct the spectral element.Meanwhile,a separable hard contact is utilized to simulate the breathing behavior.Finally,a comparison of the numerical results between the FEM and the SFEM is conducted to demonstrate the high efficiency and accuracy of the proposed method.Based on the developed SFEM,the nonlinear features of waves and influence of the incident mode are also studied in detail,which provides a helpful guide for a physical understanding of the wave propagation behavior in structures with breathing cracks.展开更多
The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable energy.Solar ener...The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable energy.Solar energy,among the various renewable sources,is particularly appealing due to its abundant availability.However,the efficiency of commercial solar photovoltaic(PV)modules is hindered by several factors,notably their conversion efficiency,which averages around 19%.This efficiency can further decline to 10%–16%due to temperature increases during peak sunlight hours.This study investigates the cooling of PV modules by applying water to their front surface through Computational fluid dynamics(CFD).The study aimed to determine the optimal conditions for cooling the PV module by analyzing the interplay between water film thickness,Reynolds number,and their effects on temperature reduction and heat transfer.The CFD analysis revealed that the most effective cooling condition occurred with a 5 mm thick water film and a Reynolds number of 10.These specific parameters were found to maximize the heat transfer and temperature reduction efficiency.This finding is crucial for the development of practical and efficient cooling systems for PV modules,potentially leading to improved performance and longevity of solar panels.Alternative cooling fluids or advanced cooling techniques that might offer even better efficiency or practical benefits.展开更多
The SKP1 gene is an important component of the SCF(SKP1-Cullin1-F-box)complex and serves as a bridge connecting the F-box and Cullin1genes(F-box-SKP1-Cullin1).The pattern of S-RNase being ubiquitously labelled by the ...The SKP1 gene is an important component of the SCF(SKP1-Cullin1-F-box)complex and serves as a bridge connecting the F-box and Cullin1genes(F-box-SKP1-Cullin1).The pattern of S-RNase being ubiquitously labelled by the SCF complex and degraded by the 26S protease accounts for the bulk of the available self-incompatibility studies.In this study,15 ClSKP1s from the‘Xiangshui'lemon genome and ubiquitome exist in the same SKP1 conserved domain(CD)as SKP1s in other species.The q PCR results showed that SKP1-6 and SKP1-14 have tissue expression patterns specific for expression in pollen.In addition,SKP1-6 and SKP1-14 in the stigma,style and ovary were significantly upregulated after self-pollination compared to those after cross-pollination.A subcellular location showed that SKP1-6 and SKP1-14 were located in the nucleus.In addition,yeast two-hybrid(Y2H)assays,bimolecular fluorescence complementation(BiFC)and luciferase complementation imaging(LCI)assays showed that SKP1-6 interacted with F-box1,F-box33,F-box34,F-box17,F-box19,Cullin1-2 and 26S proteasome subunit 4 homolog A(26S PS4HA).SKP1-14 interacted with F-box17,F-box19,F-box35,Cullin1-2 and 26S PS4HA.The interaction of Cullin1-2 and the F-box with SKP1 as a bridge was verified by a yeast three-hybrid experiment.The ability of S3-RNase to inhibit pollen and pollen tube growth and development was assessed using in vitro pollen co-culture experiments with recombinant S3-RNase proteins.Overall,this study provides important experimental evidence and theoretical basis for understanding the mechanism of self-incompatibility in plants by revealing the key role of the SCF complex in‘Xiangshui'lemon,which is bridged by ClSKP1-6,in self-incompatibility.The results of this study are of great significance for the future indepth exploration of the molecular mechanism of the SCF complex and its wide application in the self-incompatibility of plants.展开更多
文摘In this paper, we show some recent experimental applications of Brillouin optical time-domain analysis （BOTDA） based sensors for geotechnical monitoring. In particular, how these sensors can be applied to detecting early movements of soil slopes by the direct embedding of suitable fiber cables in the ground is presented. Furthermore, the same technology can be used to realize innovative inclinometers, as well as smart foundation anchors.
基金Supported by research grant 02KJB530002 from Jiangsu Provincial Committee of Education.
文摘Based on chromatographic theory, the moment method and the time-domain fitting analysis were applied to measure and evaluate the adsorption equilibrium constant and mass transfer properties (axial dispersion coefficient and effective intra-particle diffusivity) for toluene and p-dichlorobenzene on silica gel adsorbent in the subcritical and supercritical CO2. An apparatus based on supercritical fluid chromatography was established and the experiments were performed at temperatures of 298.15-318.15 K and pressures of 7.5-17.8 MPa. The two methods have been compared. The results show that for the systems studied here the moment method can give reasonable values for both adsorption equilibrium constant and mass transfer properties, but the time-domain analysis only can obtain the adsorption equilibrium constant. The dependence of adsorption equilibrium constant and mass transfer properties on temperature and pressure was investigated.
基金This research investigation was supported by the National Natural Science Foundation of China(Grant No.51678248 and Grant No.51878296)the Fundamental Research Funds for the Central Universities.And sincere thanks also to State Key Lab of Subtropical Building Science,South China University of Technology under Grant No.2017KB15 and the Open Research Fund of State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin under Grant No.IWHRSKL-KF201818.
文摘Based on the modified scale boundary finite element method and continued fraction solution,a high-order doubly asymptotic transmitting boundary(DATB)is derived and extended to the simulation of vector wave propagation in complex layered soils.The high-order DATB converges rapidly to the exact solution throughout the entire frequency range and its formulation is local in the time domain,possessing high accuracy and good efficiency.Combining with finite element method,a coupled model is constructed for time-domain analysis of underground station-layered soil interaction.The coupled model is divided into the near and far field by the truncated boundary,of which the near field is modelled by FEM while the far field is modelled by the high-order DATB.The coupled model is implemented in an open source finite element software,OpenSees,in which the DATB is employed as a super element.Numerical examples demonstrate that results of the coupled model are stable,accurate and efficient compared with those of the extended mesh model and the viscous-spring boundary model.Besides,it has also shown the fitness for long-time seismic response analysis of underground station-layered soil interaction.Therefore,it is believed that the coupled model could provide a new approach for seismic analysis of underground station-layered soil interaction and could be further developed for engineering.
基金Supported by China National 111 Project foundation from the State Administration of Foreign Experts Affairs of Chinathe Ministry of Education of China under Grant No.B07019
文摘Problems experienced during Floating Production, Storage and Offioading （FPSO） tandem offloading operations were investigated. The aim of this research was to improve the reliability of such systems, and it needed a means to assess them. Time-domain simulation and analysis of offioading systems was performed using the multi-body mooring software ARIANE 7.0. Hydrodynamic interaction between the vessels was considered. The responses of the offioading system in different loading cases, different parameters of offioading hawsers and the effects of challenging environmental conditions were calculated. There was a focus on the problems of relative motion between the two bodies and its effects on the intensity of hawser forces. Minimum relative distance, maximum relative headings and maximum tension in the hawsers of offloading systems were obtained by time-domain analysis. The time-domain analysis was effective and comparative study can be used to optimize parameters of the system and extend operating limits.
基金supported by the China National Scientific and Technology Major Project(2016ZX05028-002-004)
文摘Strong hydrodynamic interactions during the side-by-side offloading operation between floating liquefied natural gas(FLNG) and liquefied natural gas carrier(LNGC) can induce high risks of collision. The weather vane effect of a single-point mooring system normally results in the satisfactory hydrodynamic performance of the side-by-side configuration in head seas. Nevertheless, the changes in wave directions in real sea conditions can significantly influence the relative motions. This article studies the relative motions of the side-by-side system by using the theoretical analysis method and the numerical calculation method. Based on the three-dimensional potential theory modified by artificial damping-lid method, the frequency-domain hydrodynamic coefficients can be improved to calculate the retardation functions for the multi-body problem. An in-house code is then developed to perform the time-domain simulation of two vessels, through which the relative motions are subsequently obtained. A range of oblique waves are chosen for the extensive calculation of relative motions between the two vessels, which are further analyzed in terms of the phase shift of motion responses induced by specific resonant wave patterns. Investigation results show that wave directions have a significant influence on the relative sway, roll, and yaw motions. Under the circumstance that the absolute phase shift between the roll motions of two vessels approaches 180°, stronger relative motions are induced when LNGC is on the weather side.Moreover, the gap water resonances at high frequencies tend to cause the dangerous opposed oscillation of two vessels in the sway and yaw modes, whereas FLNG reduces the gap water resonances and relative motions when located on the weather side.
基金This work was supported by the National Natural Science Foundation of China(No.11872212)and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘The reduced weight and improved efficiency of modern aeronautical structures result in a decreasing separation of frequency ranges of rigid and elastic modes.Particularly,a high-aspect-ratio flexible flying wing is prone to body freedomflutter(BFF),which is a result of coupling of the rigid body short-periodmodewith 1st wing bendingmode.Accurate prediction of the BFF characteristics is helpful to reflect the attitude changes of the vehicle intuitively and design the active flutter suppression control law.Instead of using the rigid body mode,this work simulates the rigid bodymotion of the model by using the six-degree-of-freedom(6DOF)equation.A dynamicmesh generation strategy particularly suitable for BFF simulation of free flying aircraft is developed.An accurate Computational Fluid Dynamics/Computational Structural Dynamics/six-degree-of-freedom equation(CFD/CSD/6DOF)-based BFF prediction method is proposed.Firstly,the time-domain CFD/CSD method is used to calculate the static equilibrium state of the model.Based on this state,the CFD/CSD/6DOF equation is solved in time domain to evaluate the structural response of themodel.Then combinedwith the variable stiffnessmethod,the critical flutter point of the model is obtained.This method is applied to the BFF calculation of a flyingwing model.The calculation results of the BFF characteristics of the model agree well with those fromthe modalmethod andNastran software.Finally,the method is used to analyze the influence factors of BFF.The analysis results show that the flutter speed can be improved by either releasing plunge constraint or moving the center ofmass forward or increasing the pitch inertia.
文摘Aiming at the problem of high requirement for the signal generator in the Brillouin optical time-domain analysis(BOTDA)system,a quarter of the Brillouin frequency shift(BFS)of modulation is proposed to reduce the required bandwidth of the sensing system.A functional model for solving the intensity of each-order sideband of the output light of electro-optic modulator(EOM)is proposed and applied,so the spectrum with suppressed the carrier and the first-order sidebands while maximizing the second-order sidebands is obtained.Compared with the latest scheme,the intensity of the second-order sidebands is increased by 21.1%based on this functional model.In the experiment,the second-order upper sideband and the second-order lower sideband are used as continuous wave(CW)probe light and pump pulse light,respectively,which ultimately reduces the required bandwidth of radio frequency(RF)signal sources to a quarter of the BFS(reduced from~11 GHz to~2.75 GHz),and the frequency sweep range is also reduced to a quarter of the original.
文摘Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.
基金supported by Qingdao Key Medical and Health Discipline ProjectThe Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
文摘Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金financially supported by the National Natural Science Foundation of China(Nos.52034002 and U2202254)the Fundamental Research Funds for the Central Universities,China(No.FRF-TT-19-001)。
文摘The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
基金Supported by the Central High Level Hospital Clinical Research Funding(No.BJ-2024-089).
文摘AIM:To explore the causal relationship between several possible behavioral factors and high myopia(HM)using multivariable Mendelian randomization(MVMR)approach and to find the mediators among them with mediation analysis.METHODS:The causal effects of several behavioral factors,including screen time,education time,time spent outdoors,and physical activity,on the risk of HM using univariable Mendelian randomization(MR)and MVMR analyses were first assessed.Genome-wide association study summary statistics of serum metabolites were also used in mediation analysis to determine the extent to which serum metabolites mediate the effects of behavioral factors on HM.RESULTS:MR analyses indicated that both increased time spent outdoors and a higher frequency of moderate physical activity significantly reduced the risk of HM.Further MVMR analysis confirmed that moderate physical activity independently contributed to a lower risk of HM.Additionally,MR analyses identified 13 serum metabolites significantly associated with HM,of which 12 were lipids and one was an amino acid derivative.Mediation analysis revealed that six lipid metabolites mediated the protective effects of moderate physical activity on HM,with the highest mediation proportion observed for 1-(1-enyl-palmitoyl)-GPC(p-16:0;30.83%).CONCLUSION:This study suggests that in addition to outdoor time,moderate physical activity habits may have an independent protective effect against HM and pointed to lipid metabolites as priority targets for the prevention due to low physical activity.These results emphasize the importance of physical activity and metabolic health in HM and underscore the need for further study of these complex associations.
基金Supported by National Natural Science Foundation of China(No.82020108006,No.81730025).
文摘AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countries/regions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation.
基金supported by the National Natural Science Foundation of China(Grant No.60476014)the State"973"Key Basic Research Program(Grant No.2005CB321604)the UC Senate Research Fund.
文摘With soaring work frequency and decreasing feature sizes, VLSI circuits with RLC parasitic components are more like analog circuits and should be carefully analyzed in physical design. However, the number of extracted RLC components is typically too large to be analyzed efficiently by using present analog circuit simulators like SPICE. In order to speedup the simulations without error penalty, this paper proposes a novel methodology to compress the time-descritized circuits resulted from numerical integration approximation at every time step. The main contribution of the methodology is the efficient structure-level compression of DC circuits containing many current sources, which is an important complement to present circuit analysis theory. The methodology consists of the following parts： 1） An approach is proposed to delete all intermediate nodes of RL branches. 2） An efficient approach is proposed to compress and back-solve parallel and serial branches so that it is error-free and of linear complexity to analyze circuits of tree topology. 3） The Y to πtransformation method is used to error-free reduce and back-solve the intermediate nodes of ladder circuits with the linear complexity. Thus, the whole simulation method is very accurate and of linear complexity to analyze circuits of chain topology. Based on the methodology, we propose several novel algorithms for efficiently solving RLC-model transient power/ground （P/G） networks. Among them, EQU-ADI algorithm of linear-complexity is proposed to solve RLC P/G networks with mesh-tree or mesh-chain topologies. Experimental results show that the proposed method is at least two orders of magnitude faster than SPICE while it can scale linearly in both time- and memory-complexity to solve very large P/G networks.
文摘The vibration and sound radiation of a submerged spherical shell are studied in the time-domain by Laplace transform method, where a CW pulse force acts at the apex of the shell. The numerical results for the case of long pulse show that the different vibrational modes and the resonant or beat radiated sound are excited for different carrier-frequencies, but litle sound is radiated for some vibrational modes. For the case of short pulse the waveforms of the pulse become widened and deformed, when the pulse propagates between apexes of the shell. Then, the Doubly Asymptotic Approximations (DAA2) and Kirchhoff's Retarded Potential Formulate (KRPF)are used to solve the same problem. It is shown that the results of DAA2 and KRPF method have a good agreement with the results of Laplace transform method.
基金financially supported by the Department of Natural Resources of Guangdong Province(Grant No.[2024]31)the National Natural Science Foundation of China(Grant No.52071145)+1 种基金the Natural Science Foundation of Guangdong Province,China(Grant No.2022B1515020071)the Fundamental Research Funds for the Central Universities(Grant No.2023ZYGXZR029).
文摘The hydroelastic behavior of a moored oil storage vessel subjected to arbitrary time-dependent external loads,which include wind,waves,and currents with different incident directions,is investigated with the time-domain modal expansion method.First,the water boundary integral equations on the body surface of a quarter model,which can be obtained via the free-surface Green’s function method,are established.Then,the time-dependent elastic deflection of the moored oil storage vessel is expressed by a superposition of modal functions and corresponding modal amplitudes,and a Galerkin scheme is applied to derive the linear system of equations for the modal amplitudes.The second-order linear differential equations for modal amplitudes are solved via the fourth-order Runge−Kutta method.The present model is validated against existing frequency domain results for a truncated cylinder and a VLFS.Numerical calculations for the moored oil storage vessel are then conducted to obtain the time series of various modal amplitudes and elastic displacements of the measurement points and the corresponding spectra with different incident directions.
基金the National Natural Sclenee Foundation of China(Grant No.51704222)China Pastdoctoral Science Foundation(Grant No.2018M633570)Fundamental Research Funds for the Cemtal Unveritiee(Grant No.3102017090004).
文摘Guided waves are generally considered as a powerful approach for crack detection in structures,which are commonly investigated using the finite element method(FEM).However,the traditional FEM has many disadvantages in solving wave propagation due to the strict requirement of mesh density.To tackle this issue,this paper proposes an efficient time-domain spectral finite element method(SFEM)to analyze wave propagation in cracked structures,in which the breathing crack is modeled by definiiig the spectral gap element.Moreover,novel orthogonal polynomials and Gauss-Lobatto-Legendre quadrature rules are adopted to construct the spectral element.Meanwhile,a separable hard contact is utilized to simulate the breathing behavior.Finally,a comparison of the numerical results between the FEM and the SFEM is conducted to demonstrate the high efficiency and accuracy of the proposed method.Based on the developed SFEM,the nonlinear features of waves and influence of the incident mode are also studied in detail,which provides a helpful guide for a physical understanding of the wave propagation behavior in structures with breathing cracks.
文摘The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable energy.Solar energy,among the various renewable sources,is particularly appealing due to its abundant availability.However,the efficiency of commercial solar photovoltaic(PV)modules is hindered by several factors,notably their conversion efficiency,which averages around 19%.This efficiency can further decline to 10%–16%due to temperature increases during peak sunlight hours.This study investigates the cooling of PV modules by applying water to their front surface through Computational fluid dynamics(CFD).The study aimed to determine the optimal conditions for cooling the PV module by analyzing the interplay between water film thickness,Reynolds number,and their effects on temperature reduction and heat transfer.The CFD analysis revealed that the most effective cooling condition occurred with a 5 mm thick water film and a Reynolds number of 10.These specific parameters were found to maximize the heat transfer and temperature reduction efficiency.This finding is crucial for the development of practical and efficient cooling systems for PV modules,potentially leading to improved performance and longevity of solar panels.Alternative cooling fluids or advanced cooling techniques that might offer even better efficiency or practical benefits.
基金supported by grants from the National Natural Science Foundation of China(Grant No.31960585)Science and Technology Major Project of Guangxi(Grant No.Guike AA22068092)+1 种基金Guangxi Science and Technology Vanguard Special Action Project(Grant No.202204)State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources(Grant Nos.SKLCUSA-a201906,SKLCU-SA-c201901)。
文摘The SKP1 gene is an important component of the SCF(SKP1-Cullin1-F-box)complex and serves as a bridge connecting the F-box and Cullin1genes(F-box-SKP1-Cullin1).The pattern of S-RNase being ubiquitously labelled by the SCF complex and degraded by the 26S protease accounts for the bulk of the available self-incompatibility studies.In this study,15 ClSKP1s from the‘Xiangshui'lemon genome and ubiquitome exist in the same SKP1 conserved domain(CD)as SKP1s in other species.The q PCR results showed that SKP1-6 and SKP1-14 have tissue expression patterns specific for expression in pollen.In addition,SKP1-6 and SKP1-14 in the stigma,style and ovary were significantly upregulated after self-pollination compared to those after cross-pollination.A subcellular location showed that SKP1-6 and SKP1-14 were located in the nucleus.In addition,yeast two-hybrid(Y2H)assays,bimolecular fluorescence complementation(BiFC)and luciferase complementation imaging(LCI)assays showed that SKP1-6 interacted with F-box1,F-box33,F-box34,F-box17,F-box19,Cullin1-2 and 26S proteasome subunit 4 homolog A(26S PS4HA).SKP1-14 interacted with F-box17,F-box19,F-box35,Cullin1-2 and 26S PS4HA.The interaction of Cullin1-2 and the F-box with SKP1 as a bridge was verified by a yeast three-hybrid experiment.The ability of S3-RNase to inhibit pollen and pollen tube growth and development was assessed using in vitro pollen co-culture experiments with recombinant S3-RNase proteins.Overall,this study provides important experimental evidence and theoretical basis for understanding the mechanism of self-incompatibility in plants by revealing the key role of the SCF complex in‘Xiangshui'lemon,which is bridged by ClSKP1-6,in self-incompatibility.The results of this study are of great significance for the future indepth exploration of the molecular mechanism of the SCF complex and its wide application in the self-incompatibility of plants.
