BACKGROUND Diabetic nephropathy(DN),affecting half of diabetic patients and contributing significantly to end-stage kidney disease,poses a substantial medical challenge requiring dialysis or transplantation.The nuance...BACKGROUND Diabetic nephropathy(DN),affecting half of diabetic patients and contributing significantly to end-stage kidney disease,poses a substantial medical challenge requiring dialysis or transplantation.The nuanced onset and clinical progression of kidney disease in diabetes involve consistent renal function decline and persistent albuminuria.AIM To investigate Tiliroside's(Til)protective effect against diabetic nephropathy(DN)in rats under diabetic conditions.METHODS Five groups of six rats each were included in this study:Rats treated with DMSO by intraperitoneal injection as controls,those treated with STZ by intraperitoneal injection,those treated with STZ+Til(25 mg/kg body weight[bwt])or Til(50 mg/kg bwt),and those treated with anti-diabetic medication glibenclamide(600μg/kg bwt).Biochemical markers,fasting blood glucose,food intake,kidney weight,antioxidant enzymes,inflammatory and fibrotic markers,and renal injury were monitored in different groups.Molecular docking analysis was performed to identify the interactions between Til and its targeted biomarkers.RESULTS Til significantly reduced biochemical markers,fasting blood glucose,food intake,and kidney weight and elevated antioxidant enzymes in diabetic rats.It also mitigated inflammatory and fibrotic markers,lessened renal injury,and displayed inhibitory potential against crucial markers associated with DN as demonstrated by molecular docking analysis.CONCLUSION These findings suggest Til's potential as a therapeutic agent for DN treatment,highlighting its promise for future drug development.展开更多
Background and objectives:Several studies have suggested that rose hip extracts have anti-obesity potential.Conventional medicines treating obesity are followed by multiple adverse side effects and is very cost full t...Background and objectives:Several studies have suggested that rose hip extracts have anti-obesity potential.Conventional medicines treating obesity are followed by multiple adverse side effects and is very cost full to society.This makes the investigation of herbal remedies with anti-obesity effects potential highly relevant.This systematic review aims to shed light on the results of existing literature reports on the correlation between the intake of rose hip extracts and anti-obesity effects.Methods:A systematic literature search of PubMed and Web of Science was made to localize relevant experimental literature.Nine articles met the inclusion criteria,including one in vitro study,seven in vivo animal studies,and one human trial with preobese subjects.All nine articles are objectively reviewed in this systematic review.Results:Eight out of nine articles,including the article on humans,presented significant anti-obesity effects.Though some limitations of the studies were found,including the human trial,seven possible metabolic mechanisms are suggested as the underlying cause of the significant effects.Conclusions:Based on the findings of this review,rose hip extracts containing tiliroside found in the seeds have the potential to become a new herbal remedy with anti-obesity effects.Nevertheless,more research is needed to assess the effectiveness and optimal dosage of the rose hip treatment and to elucidate the underlying mechanisms of the effects.展开更多
基金the Ethical Committee of Shanxi Bethune Hospital(Approval No.YXLL-2023-222).
文摘BACKGROUND Diabetic nephropathy(DN),affecting half of diabetic patients and contributing significantly to end-stage kidney disease,poses a substantial medical challenge requiring dialysis or transplantation.The nuanced onset and clinical progression of kidney disease in diabetes involve consistent renal function decline and persistent albuminuria.AIM To investigate Tiliroside's(Til)protective effect against diabetic nephropathy(DN)in rats under diabetic conditions.METHODS Five groups of six rats each were included in this study:Rats treated with DMSO by intraperitoneal injection as controls,those treated with STZ by intraperitoneal injection,those treated with STZ+Til(25 mg/kg body weight[bwt])or Til(50 mg/kg bwt),and those treated with anti-diabetic medication glibenclamide(600μg/kg bwt).Biochemical markers,fasting blood glucose,food intake,kidney weight,antioxidant enzymes,inflammatory and fibrotic markers,and renal injury were monitored in different groups.Molecular docking analysis was performed to identify the interactions between Til and its targeted biomarkers.RESULTS Til significantly reduced biochemical markers,fasting blood glucose,food intake,and kidney weight and elevated antioxidant enzymes in diabetic rats.It also mitigated inflammatory and fibrotic markers,lessened renal injury,and displayed inhibitory potential against crucial markers associated with DN as demonstrated by molecular docking analysis.CONCLUSION These findings suggest Til's potential as a therapeutic agent for DN treatment,highlighting its promise for future drug development.
文摘Background and objectives:Several studies have suggested that rose hip extracts have anti-obesity potential.Conventional medicines treating obesity are followed by multiple adverse side effects and is very cost full to society.This makes the investigation of herbal remedies with anti-obesity effects potential highly relevant.This systematic review aims to shed light on the results of existing literature reports on the correlation between the intake of rose hip extracts and anti-obesity effects.Methods:A systematic literature search of PubMed and Web of Science was made to localize relevant experimental literature.Nine articles met the inclusion criteria,including one in vitro study,seven in vivo animal studies,and one human trial with preobese subjects.All nine articles are objectively reviewed in this systematic review.Results:Eight out of nine articles,including the article on humans,presented significant anti-obesity effects.Though some limitations of the studies were found,including the human trial,seven possible metabolic mechanisms are suggested as the underlying cause of the significant effects.Conclusions:Based on the findings of this review,rose hip extracts containing tiliroside found in the seeds have the potential to become a new herbal remedy with anti-obesity effects.Nevertheless,more research is needed to assess the effectiveness and optimal dosage of the rose hip treatment and to elucidate the underlying mechanisms of the effects.
