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Longitudinal force in continuously welded rail on long-span tied arch continuous bridge carrying multiple tracks 被引量:20
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作者 闫斌 戴公连 +1 位作者 郭文华 徐庆元 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第5期2001-2006,共6页
Considering arch rib, lateral brace, suspender, girder, pier and track position, the model for the interaction between long-span tied arch continuous bridge and multiple tracks was established by using steel-concrete ... Considering arch rib, lateral brace, suspender, girder, pier and track position, the model for the interaction between long-span tied arch continuous bridge and multiple tracks was established by using steel-concrete composite section beam element to simulate concrete-filled steel tube(CFST) arch rib, using the beam element with rigid arm to simulate the prestressed concrete girder and using nonlinear bar element to simulate longitudinal constraint between track and bridge. Taking a(77+3×156.8+77) m tied arch continuous bridge with four tracks on the Harbin-Qiqihar Passenger Dedicated Line as an example, the arrangement of continuously welded rail(CWR) was explored. The longitudinal force in CWR on the tied arch continuous bridge, the pier top horizontal force and torque due to the unbalance load case, were analyzed under the action of temperature, vertical live load, train braking and wind load.Studies show that, it can significantly reduce track displacement to set the track expansion devices at main span arch springing on both sides; the track stress due to arch temperature variation can reach 40.8 MPa; the track stress, pier top horizontal force and torque are related to the number of loaded tracks and train running direction, and the bending force applied to unloaded track is close to the loaded track, while the braking force applied to unloaded track is 1/4 to 1/2 of the loaded track; the longitudinal force of track due to the wind load is up to 12.4 MPa, which should be considered. 展开更多
关键词 railroad bridge long-span bridge tied arch continuous beam continuously welded rail track-bridge interaction
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Optimum Design of Tied Back Retaining Wall 被引量:1
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作者 Nabeel A. Jasim Ahmed M. Al-Yaqoobi 《Open Journal of Civil Engineering》 2016年第2期139-155,共17页
This paper presents an optimization algorithm for the design of tied back retaining wall which is comprised of the same three basic elements: stem, toe and heel, where the stem is hinged to the base and tied to the he... This paper presents an optimization algorithm for the design of tied back retaining wall which is comprised of the same three basic elements: stem, toe and heel, where the stem is hinged to the base and tied to the heel by multiple tie rods at intervals along the wall. The aim of this study is to find the values of design variables for this suggested type of tied back retaining walls which minimize the cost function subjected to constraints of the problem. The optimum design of such structure is conducted by using one of the nontraditional optimization methods, genetic algorithm (GA). The formulation of the problem is based on the elastic analysis and the ultimate strength method of design as per ACI-318-2011 code. The built-in genetic algorithm optimtool of Matlab program is utilized to optimize the cost function of the wall. The cost of concrete, reinforcing steel, tie steel, formwork, excavation, and backfilling works are included. The considered design variables are the geometric dimensions and the amounts of reinforcement for the base slab and stem slab, as well as the amount of tie steel. The developed program is utilized to perform an extensive parametric study regarding the height of wall, backfill soil properties, and materials properties including concrete, reinforcing steel, and tie steel. The backfill properties are represented by a pressure coefficient, which is a function of the unit weight and the angle of internal friction. Average expressions are calculated for the total cost and optimum dimensions as ratios of the wall height H2 which may be useful for the practical design of walls. 展开更多
关键词 Retaining Walls tied Back Wall OPTIMIZATION Optimtool Genetic Algorithm
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EDT Method for Multiple Labelled Objects Subject to Tied Distances
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作者 Andre Marasca Andre Backes +2 位作者 Fabio Favarim Marcelo Teixeira Dalcimar Casanova 《International Journal of Automation and computing》 EI CSCD 2021年第3期468-479,共12页
The success of new scientific areas can be assessed by their potential for contributing to new theoretical approaches aligned with real-world applications.The Euclidean distance transform(EDT)has fared well in both ca... The success of new scientific areas can be assessed by their potential for contributing to new theoretical approaches aligned with real-world applications.The Euclidean distance transform(EDT)has fared well in both cases,providing a sound theoretical basis for a number of applications,such as median axis transform,fractal analysis,skeletonization,and Voronoi diagrams.Despite its wide applicability,the discrete form of the EDT includes interesting properties that have not yet been fully exploited in the literature.In this paper,we are particularly interested in the properties of 1)working with multiple objects/labels;and 2)identifying and counting equidistant pixels/voxels from certain points of interest.In some domains(such as dataset classification,texture,and complexity analysis),the result of applying the EDT transform with different objects,and their respective tied distances,may compromise the performance.In this sense,we propose an efficient modification in the method presented in[1],which leads to a novel approach for computing the distance transform in a space with multiple objects,and for counting equidistant pixels/voxels. 展开更多
关键词 Euclidean distance transform(EDT) multiple-labelled objects tied distances fractal analysis texture analysis
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Effect of Maize/Haricot Bean Intercropping on Soil Fertility Improvement under Different Tied Ridges and Planting Methods, Southeast Ethiopia
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作者 Siraj Beshir Jemal Abdulkerim 《Journal of Geoscience and Environment Protection》 2017年第8期63-70,共8页
Mono cropping is the dominant factor influencing plant nutrient uptake and loss of soil quality in Ethiopia whereas intercropping of cereal/legume has positive environmental qualities. Likewise drought and moisture st... Mono cropping is the dominant factor influencing plant nutrient uptake and loss of soil quality in Ethiopia whereas intercropping of cereal/legume has positive environmental qualities. Likewise drought and moisture stress condition is widely expanding from all direction to the center of the country. Therefore, the objective of this research was to evaluate influence of planting methods, tied ridge and cropping system on different soil chemical properties in case of Madda Walabu district, Southeast Ethiopia. It was undertaken at Bidire from March 2016 to January, 2017. In this experiment, one maize variety (Melkassa 2) and one haricot bean variety (Nasir) were used. Treatments include open end and closed end tied ridge;sole cropping and intercropping;and in furrow, on ridge and flat bed planting. Each treatment has been triplicate and the experiment plots were laid out in randomized complete block design. Intercropping of maize-haricot bean with tied ridge and planting methods were highly influenced soil pH, exchangeable potassium, available phosphorous, soil organic matter and total soil nitrogen. Generally, the use of intercropping and closed end tied ridge in combination with in furrow planting significantly increased (p0.05) soil fertility in the system, which could be promising for sustainable improvement of crop production and productivity for semi arid areas of Bale zone. 展开更多
关键词 tied Ridge INTERCROPPING PLANTING Methods
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Increasing the Efficiency of Grid Tied Micro Wind Turbines in Low Wind Speed Regimes
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作者 Kshitij Tiwari Tirumalachetty Harinarayana 《Smart Grid and Renewable Energy》 2014年第10期249-257,共9页
Major problem with grid tied micro wind turbine is synchronization and wind variability. Due to this problem the stability of available grid gets reduced. The stability can be achieved by output power control of the t... Major problem with grid tied micro wind turbine is synchronization and wind variability. Due to this problem the stability of available grid gets reduced. The stability can be achieved by output power control of the turbine. Major part of many countries like India, the annual mean wind speed is not high. The rated wind speed of turbine remain around 11 m/s and cut in is around 3.5 m/s. Due to this problem we aimed to develop a sustainable wind energy system that can provide stable power supply even at the locations of low wind speed of 2 - 4 m/s. To address this issue, a momentary impulse or external torque to the rotor by external motor is one of the good options to maintain the momentum of blades and thus provide stability for sufficient time. Various theoretical calculations and experiments are conducted on the above method. This would increase the output power and also the efficiency of wind turbine. We show that Return-On-Investment will be high as compared with other grid connected turbines. Our proposed concept in the present study, if implemented properly, can help the installation of number of wind turbines even at domestic level. It also makes the consumers energy independent and promotes the use of wind as a source of energy and may enter as a rooftop energy supply system similar to solar. 展开更多
关键词 GRID tied Rooftop MICRO WIND TURBINE Small External DC Motor WIND Variability Tip-Speed Ratio (TSR) STABILIZED GRID Supply
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Innovative Design and Development of Simplysupported Tied Arch of Beijing-Shanghai HSR
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作者 WU Mengchang WEN Wangqing XU Sanping 《Chinese Railways》 2022年第2期60-68,共9页
Simply-supported tied arch is a zero-thrust arch bridge with clear structural force,large stiffness,low height,beautiful appearance and economic efficiency.In Xuzhou-Shanghai section of Beijing-Shanghai HSR,the simply... Simply-supported tied arch is a zero-thrust arch bridge with clear structural force,large stiffness,low height,beautiful appearance and economic efficiency.In Xuzhou-Shanghai section of Beijing-Shanghai HSR,the simply-supported tied arch is systematically studied and widely applied for the first time.A total of 21 simplysupported tied arch bridges with the spans of 96 m,112 m and 128 m respectively are constructed for the route.The simply-supported tied arch is an external static and internal super-static parallel arch or basket arch of Nielsen system in structure;single-box,threechamber and equal-height prestressed concrete box girder is adopted for the tie beam;dumbbell steel pipe concrete section is adopted for the arch rib;PES(FD)low-stress anticorrosion cable body is adopted for the suspender.The rational structural form is determined by comparative study on the key technical parameters such as the layout form of suspender,rise-span ratio and arch axis alignment.This paper summarizes the optimization of simplysupported tied arch structure and looks forward to the development of bridge structure. 展开更多
关键词 Beijing-Shanghai HSR simply-supported tied arch tie beam arch rib SUSPENDER arch foot cross bracing key technical parameters
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Tie Someone Down/Tied Down
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作者 维拉 《语言教育》 1999年第1期89-,共1页
“The holidays are over,”Mother smiled.“New classesstart tomorrow,so get to bed early.From now on your studiesare going to tie you down.”Penelope groaned.“Gee,we’re
关键词 Tie Someone Down/tied Down
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CNPC and Agip Tied in Close Cooperation
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作者 Zhao Ying(International Cooperation Bureau, CNPC) 《China Oil & Gas》 CAS 1998年第1期46-46,共1页
关键词 CNPC and Agip tied in Close Cooperation
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Analysis on Construction Technology of Reinforced Concrete Tied Arch Bridge
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作者 Zhongyu Wang 《Journal of World Architecture》 2021年第6期67-71,共5页
Bridge construction has received a lot of attention as transportation continues to improve.Reinforced concrete linked arch bridges are a common bridge style in today’s bridge construction.This type of bridge not only... Bridge construction has received a lot of attention as transportation continues to improve.Reinforced concrete linked arch bridges are a common bridge style in today’s bridge construction.This type of bridge not only has a basic and generous shape,but it is also incredibly easy to construct,resulting in significant material and construction cost savings.This article analyzes the construction technology of a reinforced concrete linked arch bridge in order to achieve good construction and application.It is hoped that this analysis can provide a scientific reference for the guarantee of the construction quality and subsequent application effect of this kind of bridge. 展开更多
关键词 Reinforced concrete tied arch bridge Construction technology
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Analysis of Key Technologies in the Design of Small and Medium Span Basket Type Steel Box Tied Arch Bridge
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作者 Zhongyu Wang 《Journal of World Architecture》 2021年第4期49-55,共7页
In order to ensure the construction quality and safety of small and medium span basket type steel box tied arch bridge,this paper takes a practical project as an example to analyze the key technologies in its design p... In order to ensure the construction quality and safety of small and medium span basket type steel box tied arch bridge,this paper takes a practical project as an example to analyze the key technologies in its design process.It is hoped that this analysis can provide corresponding reference for the design and construction of this kind of arch bridge. 展开更多
关键词 Medium and small span Basket type steel box tie arch bridge Arch Bridge Design Key technology
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Evaluation of series-parallel-cross-tied PV array configuration performance with maximum power point tracking techniques under partial shading conditions 被引量:1
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作者 Dharani Kumar Narne T.A.Ramesh Kumar RamaKoteswaraRao Alla 《Clean Energy》 EI CSCD 2023年第3期620-634,共15页
Tracking the maximum power point is a critical issue with solar systems.The power output of the solar panel varies due to variations in irradiance and temperature.Nonuniform irradiation due to partial shading conditio... Tracking the maximum power point is a critical issue with solar systems.The power output of the solar panel varies due to variations in irradiance and temperature.Nonuniform irradiation due to partial shading conditions has a direct impact on the characteristics of photovoltaic(PV)systems.To build a diversity of maximum power point tracking algorithms in solar PV systems,this work focuses on perturb and observe,incremental conductance,and fuzzy logic control methodologies.The suggested fuzzy logic control method outperformed the conventional incremental conductance and perturb and observe algorithms with a collection of 49 rules.This paper presents a novel series-parallel-cross-tied PV array configuration with a developed fuzzy methodology.To comment on the performance of a proposed system under various partial shading conditions,a series-parallel PV array configuration has been considered.The simulation result demonstrates that the fuzzy method has a percentage improvement in the global maximum power point tracking efficiency of 24.85%when compared to the perturb and observe method and a 65.5%improvement when compared to the incremental conductance method under long wide partial shading conditions.In the case of the middle partial shading condition,the fuzzy method has a percentage improvement in the global maximum power point tracking efficiency of 12.4%compared to the perturb and observe method and a 60.7%improvement compared to the incremental conductance method. 展开更多
关键词 Maximum Power Point Tracking Partial shading Fuzzy Logic Controller Series Parallel-Cross tied PV array configuration Series-Parallel PV array configuration
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Cat Virus Tied to SARS from New York Times 被引量:1
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作者 林妮 《当代外语研究》 2003年第6期2-3,共2页
选注者言:5月24日世界卫生组织解除了香港和广州的旅游警告,同一天,香港和深圳的科学家联合声明在野生动物masked palm civets(果子狸)身上发现了与人类SARS病毒一致的病原体,人类对SARS的战斗胜利越来越近!想起5月的《科技英语学习》... 选注者言:5月24日世界卫生组织解除了香港和广州的旅游警告,同一天,香港和深圳的科学家联合声明在野生动物masked palm civets(果子狸)身上发现了与人类SARS病毒一致的病原体,人类对SARS的战斗胜利越来越近!想起5月的《科技英语学习》上第一篇文章中的一句话…the Canadian are telling them(Chinese in China Town),you dirty Chinese,you eat everything,that’S why 展开更多
关键词 野生动物 果子狸 Cat Virus tied to SARS from New York Times
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Should Home Buying Be Tied to Hukou?
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《Beijing Review》 2011年第13期46-47,共2页
Responding to the recent frenetic rise in house prices,the Central Government in January announced eight new
关键词 Should Home Buying Be tied to Hukou BE
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African Trees May Be Tied to Lemurs' Fate
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作者 John Roach 李晟 《当代外语研究》 2004年第11期4-5,共2页
在非洲的马达加斯加,有些树木的果实只能被狐猴(lemur)吞食,因此狐猴成了这些树木种子的唯一传播者,这些树木的命运也因此而与狐猴紧紧联系在了一起。
关键词 African Trees May Be tied to Lemurs BE
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Sleep Deprivation Tied to Shifts in Hunger Hormones
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作者 Sarah Graham 肖红岭 《当代外语研究》 2005年第2期6-5,共2页
睡眠与健康的密切关系是人们早已熟知的生活常识。然而,每天起早贪黑也能变胖?美国科学家最近研究发现:睡眠减少会使刺激食欲的激素(hormones)分泌增多,抑制食欲的激素分泌减少,从而引起进食,使人变胖。这是否让您耳目一新呢?
关键词 Sleep Deprivation tied to Shifts in Hunger Hormones
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基于Ang-Tie2/VEGF信号轴探讨益景汤对糖尿病微血管异常的干预机制
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作者 任秉仪 刘光辉 +2 位作者 柯小清 潘铭东 郑永征 《亚太传统医药》 2025年第9期24-28,共5页
目的:基于血管生成素(Ang)-内膜内皮酪氨酸激酶(Tie2)信号通路/血管内皮生长因子(VEGF)信号轴探讨益景汤对糖尿病微血管异常的干预机制。方法:采用12周龄雄性SPF级大鼠40只(Wistar大鼠10只,GK自发糖尿病大鼠30只),Wistar大鼠为正常组,30... 目的:基于血管生成素(Ang)-内膜内皮酪氨酸激酶(Tie2)信号通路/血管内皮生长因子(VEGF)信号轴探讨益景汤对糖尿病微血管异常的干预机制。方法:采用12周龄雄性SPF级大鼠40只(Wistar大鼠10只,GK自发糖尿病大鼠30只),Wistar大鼠为正常组,30只GK大鼠随机分为模型组、西药组(羟苯磺酸钙组)和中药组(益景汤组),每组10只。正常组和模型组予以PBS缓冲液灌胃;西药组予以羟苯磺酸钙片156 mg/(kg·d),采用PBS缓冲液稀释灌胃;益景汤组予以益景汤水煎液,按方剂饮片合剂量10.71 g/(kg·d)灌胃,qd。以上处理持续12周。治疗结束后处死全部大鼠,摘除眼球,取视网膜组织,RT-PCR检测Ang1、Ang2、Tie1、Tie2、VEGF、CⅣ、Occludin因子的mRNA表达;Western Blot检测Ang2、Tie2、VEGF、CⅣ、Occludin因子相关的蛋白表达。结果:模型组Ang1、Tie2、Occludin mRNA表达量较正常组明显下降,而Ang2、Tie1、VEGF及CⅣ的mRNA表达量均较正常组明显上升,差异均具有统计学意义(P<0.05);西药组和中药组Ang1、Tie2、Occludin mRNA表达量较模型组明显升高,而Ang2、Tie1、VEGF及CⅣmRNA表达量均较模型组下降,差异均具有统计学意义(P<0.05)。模型组Ang2、VEGF、CⅣ蛋白表达较正常组升高,Tie2、Occludin蛋白表达较正常组降低,差异均具有统计学意义(P<0.05);西药组和中药组Ang2、VEGF、CⅣ蛋白表达较模型组明显降低,Tie2、Occludin蛋白表达均较模型组升高,差异均具有统计学意义(P<0.05)。结论:益景汤可通过抑制Ang2、VEGF、CⅣ的异常表达,激活Tie2及Occludin蛋白的高表达,减轻糖尿病早期微血管损害,修复iBRB功能。 展开更多
关键词 益景汤 糖尿病微血管异常 Ang TIE VEGF CⅣ OCCLUDIN
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面向工程教育的TIE提示语框架的设计与应用研究 被引量:3
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作者 钟柏昌 裴永漫 《电化教育研究》 北大核心 2025年第4期40-48,共9页
工程教育在提高学生的创新能力方面发挥着重要作用,而生成式人工智能(GAI)的教育应用对学生创新能力的培养提出了新的挑战。因此,将GAI引入工程教育需要进行审慎的设计。为此,研究在现有通用GAI提示语框架的基础上,融入发明问题解决理论... 工程教育在提高学生的创新能力方面发挥着重要作用,而生成式人工智能(GAI)的教育应用对学生创新能力的培养提出了新的挑战。因此,将GAI引入工程教育需要进行审慎的设计。为此,研究在现有通用GAI提示语框架的基础上,融入发明问题解决理论(TRIZ理论)和逆向工程方法,构建了面向工程教育的TIE提示语框架。为验证其在工程教育中的有效性,课题组采用实验研究方法,随机选择了两个初中班级进行比较实验。结果表明,与不使用GAI的班级相比,TIE提示语框架的使用能够显著提升学生的创新能力、工程知识水平和工程设计能力,具有较为重要的应用潜力与教育价值。 展开更多
关键词 生成式人工智能 工程教育 TIE提示语框架 TRIZ理论 逆向工程方法
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大直径泥水盾构地表沉降Tie约束模型数值模拟研究 被引量:2
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作者 赫明胜 《建筑机械化》 2025年第4期132-136,共5页
针对泥水盾构开挖越江隧道时经过粉细砂地层易产生较大地表沉降的问题,结合武汉市轨道交通12号线越江隧道工程,建立三维有限元模型进行数值模拟,并引入衬砌与土体刚性连接的Tie约束模型模拟盾构工程实际情况,计算分步开挖下的地表横向... 针对泥水盾构开挖越江隧道时经过粉细砂地层易产生较大地表沉降的问题,结合武汉市轨道交通12号线越江隧道工程,建立三维有限元模型进行数值模拟,并引入衬砌与土体刚性连接的Tie约束模型模拟盾构工程实际情况,计算分步开挖下的地表横向截面沉降结果,与实际监测沉降数据进行对比。结果表明,盾构隧道开挖边线范围内沉降最多,且在隧道开挖隧道轴线正上方出现最大地表沉降,而tie约束计算结果与普通接触约束计算结果相比与实际监测地表沉降结果更相符。 展开更多
关键词 盾构隧道 地表沉降 有限元分析 数值模拟 Tie约束模型
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内皮细胞Tie2-L914F突变引发静脉畸形发病机制的初步研究 被引量:1
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作者 祁雨晨 黄佳栋 +2 位作者 李天一 冷春儒 司亚萌 《口腔医学》 2025年第4期268-274,共7页
目的探究静脉畸形患者TEK受体酪氨酸激酶(TEK receptor tyrosine kinase,Tie2)L914F突变对血管内皮细胞的生物学行为影响及相关信号通路的变化。方法基因测序检测静脉畸形中Tie2-L914F突变情况。运用HE染色及免疫组织化学染色检测该突... 目的探究静脉畸形患者TEK受体酪氨酸激酶(TEK receptor tyrosine kinase,Tie2)L914F突变对血管内皮细胞的生物学行为影响及相关信号通路的变化。方法基因测序检测静脉畸形中Tie2-L914F突变情况。运用HE染色及免疫组织化学染色检测该突变导致的静脉畸形组织中,血小板衍生生长因子亚基B(platelet derived growth factor subunit B,PDGFB)和α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)的表达。将过表达Tie2野生型(Tie2-wild type,Tie2-WT)、Tie2-L914F和Tie2-GFP(green fluorescent protein,GFP)的慢病毒感染人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)。实时荧光定量PCR检测内皮细胞中Tie2的表达水平及蛋白质免疫印迹法检测Flag标签蛋白Tie2蛋白用于验证转染效率。通过CCK-8法、流式细胞术、Transwell迁移实验、Matrigel基质胶成管实验测定细胞的增殖、凋亡、迁移、成管能力,蛋白质免疫印迹法检测蛋白激酶B(protein kinase B,PKB/AKT)、FOXO1及其磷酸化表达水平,ELISA法检测PDGFB表达水平。结果发生L914F位点突变的静脉畸形患者数量约为33.3%。HE及免疫组织化学染色显示:发生Tie2-L914F突变的静脉畸形组织中PDGFB及α-SMA表达显著下调,并与管壁细胞覆盖率下降呈正相关。与表达Tie2-WT内皮细胞比较,表达Tie2-L914F内皮细胞凋亡数明显减少,同时增殖及迁移能力显著增加,成管能力则显著下降。蛋白质免疫印迹及ELISA法显示:表达Tie2-L914F内皮细胞Tie2信号通路下游AKT及FOXO1磷酸化水平显著升高,PDGFB表达水平显著下降。结论在静脉畸形中,Tie2-L914F突变可能通过AKT信号通路下调PDGFB表达,影响血管内皮细胞的生物学行为。 展开更多
关键词 静脉畸形 TEK受体酪氨酸激酶 AKT通路 Tie2-L914F突变
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TIE1的泛癌图谱及其在宫颈癌中的潜在作用机制
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作者 韦洪建 王鑫 +3 位作者 刘芯言 林冰洁 王齐心 史永华 《海南医科大学学报》 北大核心 2025年第11期849-862,共14页
目的:探讨TIE1在人体肿瘤组织中的表达谱及其潜在的临床意义。方法:利用TIMER2、GEPIA2、cBioPortal、UALCAN和STRING等在线网站和数据库,分析不同类型癌症中TIE1的表达与预后、遗传改变、肿瘤免疫及甲基化状态之间的关系。在本研究中,... 目的:探讨TIE1在人体肿瘤组织中的表达谱及其潜在的临床意义。方法:利用TIMER2、GEPIA2、cBioPortal、UALCAN和STRING等在线网站和数据库,分析不同类型癌症中TIE1的表达与预后、遗传改变、肿瘤免疫及甲基化状态之间的关系。在本研究中,使用宫颈癌患者的数据集分析了TIE1表达,并通过富集分析研究了TIE1的分子机制。通过划痕及Transwell侵袭实验进行体外研究,以确定TIE1在宫颈癌细胞中的生物学功能。结果:泛癌分析显示,TIE1在某些肿瘤中表达上调,其表达与癌症患者的预后显著相关。经数据库分析发现TIE1在皮肤黑色素瘤患者中的基因改变频率最高。此外,TIE1的表达与某些肿瘤中的免疫细胞浸润密切相关。在某些类型的肿瘤中,TIE1启动子的甲基化水平显示出显著差异。通过KEGG富集分析发现与TIE1相关的基因在Ras、PI3K-Akt、RAP1和MAPK信号通路中有较高的富集程度。在宫颈癌数据集GO富集分析也表明,这些基因在与外部包裹结构组织、含胶原蛋白的细胞外基质以及与糖胺聚糖结合相关的通路中富集。此外,体外实验的结果进一步证实了TIE1在促进宫颈癌细胞迁移和侵袭方面的作用。结论:TIE1的表达水平与临床预后、基因突变以及肿瘤细胞周围的免疫浸润状态之间存在密切的关联性。本研究为深入理解TIE1在肿瘤发生和发展过程中的作用提供了关键基础数据。 展开更多
关键词 TIE1 生存分析 免疫浸润分析 甲基化分析 富集分析
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