BACKGROUND Mechanical ventilation can lead to the severe impairment of the metabolic pathway of alveolar surfactants,inactivating alveolar surfactants and significantly reducing lung-chest compliance.The cardiopulmona...BACKGROUND Mechanical ventilation can lead to the severe impairment of the metabolic pathway of alveolar surfactants,inactivating alveolar surfactants and significantly reducing lung-chest compliance.The cardiopulmonary function of elderly patients usually reduced to a certain extent,and there are lung complications after surgical anesthesia,just like lung barotrauma caused by mechanical ventilation,atelectasis and postoperative hypoxemia.AIM To investigate the effects of different positive end expiratory pressures(PEEPs)and tidal volumes(VTs)on respiratory function,the degree of the inflammatory response and hemodynamic indexes in patients undergoing surgery under general anesthesia.METHODS A total of 120 patients undergoing surgery for gastric or colon cancer under general anesthesia in Xinghua People's Hospital from January 2017 to January 2021 were randomly divided into Group A and Group B,with 60 cases in each group.The ventilation mode in Group A was VT(6.0 mL/kg)+PEEP(5.0 cmH_(2)O),while that in Group B was VT(6.0 mL/kg)+PEEP(8.0 cmH_(2)O).Blood gas parameters,respiratory mechanical parameters,inflammatory response indicators,hemodynamic indicators and related complications were compared between the two groups.RESULTS There were no significant differences in PaCO_(2),PaO_(2),oxygen or the examined indexes at T0 between group A and group B(P>0.05).The measured PaO_(2) value of patients in group A at T3 was higher than that in group B,and the difference was significant(P<0.05).There were no significant differences in peak airway pressure(P_(peak)),mean airway pressure or dynamic pulmonary compliance(Cdyn)at T0 between group A and group B(P>0.05).The measured P_(peak) value of patients in group A at T1 was higher than that in group B,and the difference was significant(P<0.05).The measured Cdyn value at T1 and T2 was greater than that in group B(P<0.05).Before surgery,there were no significant differences in tumor necrosis factor-α(TNF-α),interleukin(IL)-6 or IL-10 between group A and group B(P>0.05).After 4 h,the measured values of TNF-αand IL-6 in group A were lower than those in group B,and the differences were significant(P<0.05).The IL-10 Level in group A was higher than that in group B(P<0.05).At T0,there were no significant differences in cardiac output,cardiac index(CI),stroke volume index(SVI)or mean arterial pressure between group A and group B(P>0.05).The measured values of CI and SVI at T2 in patients in group A were higher than those in group B,and the differences were significant(P<0.05).CONCLUSION For patients undergoing surgery for gastric or colon cancer under general anesthesia,the VT(6.0 mL/kg)+PEEP(5.0 cmH_(2)O)regimen was more effective than the VT(6.0 mL/kg)+PEEP(8.0 cmH_(2)O)regimen in protecting the lung function and ventilatory function of patients,and it had better effects on maintaining hemodynamic stability and reducing inflammatory reactions.展开更多
BACKGROUND： This study aimed to observe the effect of recruitment maneuver （RM） and post-RM ventilation at different tidal volume on lung vascular diastole endothelial function in rats with acute lung injury （ALI...BACKGROUND： This study aimed to observe the effect of recruitment maneuver （RM） and post-RM ventilation at different tidal volume on lung vascular diastole endothelial function in rats with acute lung injury （ALI）.METHODS： A ALl rat model was produced by intravenous infusion of lipopolysaccharide （6 mg/ kg）. Twenty-five rats were randomly divided into five groups： control group （n=5）, ALl group （n=5）, low tidal volume group （LV group, VT 6 mL/kg, n=5）, sustained inflation （SI） with low tidal volume group （SI＋LV group, VT 6 mL/kg, n=5）, and SI with moderate tidal volume group （SI＋MV group, VT 12 mL/ kg, n=5）. RM was performed with SI, airway pressure 30 cmH2O for 30 seconds, and positive end- expiratory pressure （PEEP） was set to 5 cmH2O. Lung tissue was taken after 5 hours of mechanical ventilation. Mean arterial blood pressure （MAP） was monitored during the experiment. Endothelin-1 （ET-1）, endothelial nitricoxide synthase （eNOS）, Ach-induced endothelium-dependent relaxation response of isolated pulmonary artery rings were determined at 5 hours. RESULTS：LPS increased ET-1 level, decreased the expression of eNOS in lung tissue, impaired the Ach-induced endothelium-dependent relaxation response in the pulmonary artery, without obvious effect on systemic hemodynamics. SI＋LV significantly reduced LPS-induced elevation of ET-1 level, increased the expression of eNOS, significantly improved endothelial dysfunction, and improved the dysfunction of endothelium-dependent relaxation in the pulmonary artery. CONCLUSIONS：RM with a high or low tidal volume ventilation could improve the lung vascular endothelial function of rats with acute lung injury, and RM with low tidal volume ventilation could lower significantly the injury of lung vascular endothelial diastole function in rats with acute lung injury.展开更多
To validate the accuracy and consistency of respiratory inductive plethysmography (RIP) in measuring tidal volume after an overnight sleep, tidal volumes of 18 patients with suspected sleep disordered breathing and 8...To validate the accuracy and consistency of respiratory inductive plethysmography (RIP) in measuring tidal volume after an overnight sleep, tidal volumes of 18 patients with suspected sleep disordered breathing and 8 normal volunteers were measured simultaneously with RIP (V TRIP ) and with an ultrasonic airflow meter (V TUFM ) before and after an unstrained overnight sleep on supine and lateral decubitus. The bias of the V TRIP was expressed as (V TRIP V TUFM )/ V TUFM ·100 %, limits of agreement between V TRIP and V TUFM was measured by averaged bias ±2 s . Results showed that in normal subjects, the bias of RIP before and after overnight sleep was precise and consistent in both supine (0.7 % and -1.6 %) and lateral decubitus (3.7 % and -0.56 %). In these patients, the bias of RIP before and after sleep in supine also remained small (1.9 % and 1.7 %), but it became larger in lateral decubitus (24.5 % and 20.4 %) and 11.5 % exceeded the limits of agreement observed in the evening. The patients′ body mass indices (BMI) were higher than those of normal subjects (median 34.2 vs. 27.8 kg/m 2). Pooled data showed that the bias of V TRIP in the morning on lateral decubitus but not on supine was correlated to BMI (Spearman R=0.32, n =52, P =0.02). Thus, we were led to conclude that the accuracy of V TRIP overnight was precise and consistent in normal subjects, but the deviation of V TRIP measured on lateral decubitus in patients especially in those with excessive obesity was greater, thus, the method should not be used for quantitative determination.展开更多
Since the success of ARMA study in 2000,small tidal volume(Vt,4-8 mL/predicted body weight[PBW])is recommended in acute respiratory distress syndrome(ARDS)guidelines.[1,2]The ultra-protective strategy,further reducing...Since the success of ARMA study in 2000,small tidal volume(Vt,4-8 mL/predicted body weight[PBW])is recommended in acute respiratory distress syndrome(ARDS)guidelines.[1,2]The ultra-protective strategy,further reducing Vt to 3-4 mL/PBW with/without extracorporeal carbon dioxide removal(ECCO_(2)R)with the aim to reduce the excess tidal lung strain and stress,is an appealing alternative for severe ARDS patients.展开更多
This study presents an inversion method to recover the tidal flow velocity using tidal signals extracted from geomagnetic satellite dataset.By integrating the latest Earth conductivity profile and the Earth's magn...This study presents an inversion method to recover the tidal flow velocity using tidal signals extracted from geomagnetic satellite dataset.By integrating the latest Earth conductivity profile and the Earth's magnetic field model,the limited memory quasi-Newton method(L-BFGS)is used to directly invert seawater flow velocities.We used the radial component of the induced magnetic field as the observed data,constructed an L_(2)-norm-based data misfit term using theoretical response and observed data,and applied smoothness constraints to the ocean flow velocity.The results agree well with the widely used HAMTIDE model in low-and mid-latitude regions,which is attributed to Macao Science Satellite-1's(MSS-1)unique low-inclination orbit of full coverage in these areas.These findings underscore MSS-1's potential to advance research on tidal-induced magnetic fields and their applications in ocean dynamics studies.展开更多
Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents followi...Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents following land reclamation.Tidal equa-tions are analytically solved using infinite series,deriving expressions for tidal levels and currents in narrow bays with varying topog-raphy.Tidal levels,influenced by topographic variations,are characterized by amplitude and phase lag of their complex amplitude.These levels demonstrate high sensitivity to longitudinal slope variations but remain relatively stable under lateral slope changes.Un-der constant topographic slopes,even minor changes in bay length can drastically modify amplitude and phase lag,highlighting the sensitivity of tidal dynamics to geometric alterations.Tidal velocity notably increases with steeper longitudinal slopes and modestly rises with elevated lateral slopes.However,changes in longitudinal and lateral slopes do not considerably alter flow patterns.While external forces predominantly regulate tidal velocity with negligible effects on flow patterns,endogenous resistance influences veloci-ty but minimally impacts flow structure.These findings enhance the understanding of tidal responses to geometric and topographic changes,providing valuable guidance for land reclamation projects and coastal management strategies.展开更多
The floating horizontal-axis tidal turbine(FHATT)stands out as the most commercially viable tidal energy device.This paper reviews recent literature on FHATT and summarizes experimental and computational fluid dynamic...The floating horizontal-axis tidal turbine(FHATT)stands out as the most commercially viable tidal energy device.This paper reviews recent literature on FHATT and summarizes experimental and computational fluid dynamics(CFD)methods employed in FHATT research.Based on this foundation,the coupling effects of wave and platform motion(pitch/roll)on FHATT hydrodynamic performance were investigated through flume experiments and CFD simulations.The variations of the power coefficient(C_(P))and thrust coefficient(C_(T))are analyzed under different platform motion periods,amplitudes,wave periods,and wave heights.The results demonstrate that under the coupling of waves and pitch motion,C_(P),C_(T)exhibit dual-frequency oscillations based on the pitch period,with oscillation amplitudes increasing with both pitch frequency(wave frequency)and pitch amplitude(wave height).Within the working conditions of this study,the maximum mean output power under the coupling of pitch motion and waves increases by 26.1%.The maximum fluctuation amplitude of C_(P)reaches 349.8%.When waves and roll motion are coupled,wave parameters dominate,while the influence of roll motion can be ignored.Moreover,the hydrodynamic fluctuations induced by waves and platform motion can couple with each other.This coupling effect not only amplifies the fluctuation amplitude of hydrodynamic coefficients but also has the potential to offset each other.These findings provide insights into the structural design and system control of FHATT,serving as valuable references for FHATT development.展开更多
Arsenic(As)pollution in coastal wetlands has been receiving growing attention.However,the exact mechanism of As mobility driven by tidal action is still not completely understood.The results reveal that lower total As...Arsenic(As)pollution in coastal wetlands has been receiving growing attention.However,the exact mechanism of As mobility driven by tidal action is still not completely understood.The results reveal that lower total As concentrations in solution were observed in the flood-ebb treatment(FE),with the highest concentration being 7.1μg/L,and As(V)was the predominant species.However,elevated levels of total As in solution were found in the flooded treatment(FL),with a maximum value of 14.5μg/L after 30 days,and As(III)was the predominant form.The results of dissolved organicmatter(DOM)suggest that in the early to mid-stages of the incubation,fulvic acid-like substances might be utilized by microorganisms as electron donors or shuttle bodies,facilitating the reductive release of As/Fe from sediments.Both flood-ebb and flooded treatments promoted the transformation of crystalline iron hydrous oxides-bound As into residual forms.However,prolonged flooded conditions more readily facilitated the formation of specific adsorption forms of As and the reduction of crystalline iron hydrous oxides-bound As,increasing As mobility.In addition,the flood-ebb tides have been found to increase the diversity ofmicrobial populations.The main microbial genera in the flood-ebb treatment included Salinimicrobium,Erythrobacter,Yangia,Sulfitobacter,and Marinobacter.Bacillus,Psychrobacter,and Yangia showed a significant correlation with As(V).In flooded treatment,Bacillus,Pseudomonas,and Geothermobacter played a major role in the reduction and release of As.This study significantly contributes to the current understanding of how As behaves in diverse natural environments.展开更多
A numerical investigation on the effectiveness of the actuator disc method in producing the interactions of multiple tidal stream devices via the 3D-RANS finite element model Telemac3D is explored. The methodology for...A numerical investigation on the effectiveness of the actuator disc method in producing the interactions of multiple tidal stream devices via the 3D-RANS finite element model Telemac3D is explored. The methodology for the implementation of the source term to represent an array of 20 m rotor diameter turbines deployed in an idealized channel is reviewed and discussed in detail. Flow interactions between multiple turbines are investigated for a single row arrangement with only two turbines and a two row arrangement containing three turbines. The results demonstrate that the non-hydrostatic solver shows better agreement when validated against published experimental data. Notably,the mesh density at the device location can strongly influence the simulated thrust from the disc. Although the actuator disc model can generally replicate the wake interactions well, the results indicate that it cannot accurately characterize the flow for regions with high turbulences. While a model setup with the largest lateral spacing(1.5D) demonstrates excellent agreement with the experimental data, the 0.5D model(smallest gap) deviates by up to 25%. These findings demonstrate the effectiveness of the applied source term in reproducing the wake profile, which is comparable with the published data, and highlight the inherent nature of the RANS and actuator disc models.展开更多
Sepsis management has significantly improved over the past decades,with intensivists playing a pivotal role in its identification and treatment.[1,2]However,resource constraints in large tertiary hospitals in China li...Sepsis management has significantly improved over the past decades,with intensivists playing a pivotal role in its identification and treatment.[1,2]However,resource constraints in large tertiary hospitals in China limit patient admissions,leading to overcrowding in the emergency departments(EDs)with critically ill patients.[3]This highlights the urgent need for enhanced risk stratification and optimized sepsis management in emergency settings.展开更多
A floating horizontal-axis tidal current turbine(HATT)is an underwater power generation device where cavitation inevitably occurs on blade surfaces,severely affecting a turbine’s lifespan.Under wave action,these floa...A floating horizontal-axis tidal current turbine(HATT)is an underwater power generation device where cavitation inevitably occurs on blade surfaces,severely affecting a turbine’s lifespan.Under wave action,these floating turbines exhibit six degrees of freedom motion,potentially intensifying the cavitation on the blade surfaces.This study selects three types of oscillatory motions from the six degrees of freedom:roll,yaw,and pitch.Computational fluid dynamics(CFD)methods are used for numerical calculations,and transient simulations of multiphase flow are conducted on the basis of the Reynolds-Averaged Navier-Stokes(RANS)model.Research has revealed strong correlations between flow velocity,the blade tip speed ratio,and cavitation.During oscillatory motion,the motion period and amplitude also significantly impact cavitation.In roll motion,the cavitation rate can increase by up to 59%with decreasing period,whereas in pitch and yaw motions,the increases are 7.57 times and 36%larger,respectively.With an increase in amplitude during roll motion,the cavitation rate can increase by up to 1.08 times,whereas in pitch and yaw motions,the increases are 3.49 times and 45%,respectively.The cavitation rate on the blade surfaces is the highest in pitch motion,followed by roll and yaw motions.展开更多
Ecological water supplement projects have been implemented in many coastal wetlands,influencing saltmarsh vegetation restoration by altering tidal creek development.To clarify the effectiveness of ecological water sup...Ecological water supplement projects have been implemented in many coastal wetlands,influencing saltmarsh vegetation restoration by altering tidal creek development.To clarify the effectiveness of ecological water supplement on tidal creek development and saltmarsh vegetation restoration,time series of high-resolution remote sensing images from2000 to 2021 were used to extract and analyze tidal creeks and saltmarsh vegetation in the Diaokou Estuary Reserve.The results are summarized as follows:(1)All tidal creek indices,except curvature,exhibited a significant linear increase with time,while curvature initially decreased and increased afterwards.The 5-year cumulative ecological water supplement volume was significantly positively correlated(R^(2)>0.7)with all tidal creek indices.(2)During the same period,most landscape pattern metrics of Phragmites australis increased,while those of Tamarix chinensis initially increased and then declined.Although the class area(CA)of Suaeda salsa increased with time,its perimeter-area fractal dimension(PAFRAC)and aggregation index(AI)fluctuated.(3)The CA of P.australis and S.salsa was significantly positively correlated with most tidal creek indices except curvature,while that of T.chinensis showed no significant correlation with any tidal creek index.Moreover,the AI and PAFRAC of P.australis were significantly positively correlated with fractal dimension,frequency/curvature of tidal creeks,respectively,while those of S.salsa and T.chinensis exhibited no significant correlation.In summary,the ecological water supplement project enhanced tidal creek development in coastal wetlands,promoting the restoration of P.australis and S.salsa,while having little impact on the restoration of T.chinensis.展开更多
Mechanical ventilation, a crucial therapy to acute respiratory distress syndrome （ARDS）,could exacerbate lung injury, and even result in ventilator-induced lung injury （VILI） if misused in some condition1. Over-ac...Mechanical ventilation, a crucial therapy to acute respiratory distress syndrome （ARDS）,could exacerbate lung injury, and even result in ventilator-induced lung injury （VILI） if misused in some condition1. Over-activating inflammatory cells and expanding inflammatory responses, which are induced by infection, are fundamental reasons for ARDS. Among them,展开更多
Background High positive end-expiratory pressure （PEEP） and low tidal volume （VT） ventilation is thought to be a protective ventilation strategy. It is hypothesized that the stabilization of collapsible alveoli du...Background High positive end-expiratory pressure （PEEP） and low tidal volume （VT） ventilation is thought to be a protective ventilation strategy. It is hypothesized that the stabilization of collapsible alveoli during expiration contributes to lung protection. However, this hypothesis came from analysis of indirect indices like the analysis of the pressure-volume curve of the lung. The purpose of this study was to investigate isolated healthy and injured rat lungs by means of alveolar microscopy, in which combination of PEEP and VT is beneficial with respect to alveolar stability （I-E%）. Methods Alveolar stability was investigated in isolated, non-perfused mechanically ventilated rat lungs. Injured lungs were compared with normal lungs. For both groups three PEEP settings （5, 10, 20 cmH20） were combined with three VT settings （6, 10, 15 ml/kg） resulting in nine PEEP-VT combinations per group. Analysis was performed by alveolar microscopy. Results In normal lungs alveolar stability persisted in all PEEP-VT combinations （I-E% （3.2±11.0）%）. There was no significant difference using different settings （P 〉0.01）. In contrast, alveoli in injured lungs were extremely instable at PEEP levels of 5 cmH20 （mean I-E% 100%） and 10 cmH2O （mean I-E% （30.7±16.8）%）; only at a PEEP of 20 cmH20 were alveoli stabilized （mean I-E% of （0.2±9.3）%）. Conclusions In isolated healthy lungs alveolar stability is almost unaffected by different settings of PEEP and VT. In isolated injured lungs only a high PEEP level of 20 cmH2O resulted in stabilized alveoli whereas lower PEEP levels are associated with alveolar instability.展开更多
The finite volume method （FVM） has many advantages in 2-D shallow water numerical simulation. In this study, the finite volume method is used with unstructured triangular grids to simulate the tidal currents. The Ro...The finite volume method （FVM） has many advantages in 2-D shallow water numerical simulation. In this study, the finite volume method is used with unstructured triangular grids to simulate the tidal currents. The Roe scheme is applied in the calculation of the intercell numerical flux, and the MUSCL method is introduced to improve its accuracy. The time integral is a two-step scheme of forecast and revision. For the verification of the present method, the Stoker＇s problem is calculated and the result is compared with the mathematically analytic solutions. The comparison indicates that the method is feasible. A sea area of a port is used as an example to test the method established here. The result shows that the present computational method is satisfactory, and it could be applied to the engineering fields.展开更多
A depth-averaged 2-D numerical model for unsteady tidal flow in estuaries is established by use of the finite volume WENO scheme which maintains both uniform high order accuracy and an essentially non-oscillatory shoc...A depth-averaged 2-D numerical model for unsteady tidal flow in estuaries is established by use of the finite volume WENO scheme which maintains both uniform high order accuracy and an essentially non-oscillatory shock transition on unstructured triangular grid. The third order TVD Range-Kutta method is used for time discretization. The model has been firstly tested against four cases： 1） tidal forcing, 2） seiche oscillation, 3） wind setup in a closed bay, and 4） onedimensional dam-break water flow. The results obtained in the present study compare well with those obtained from the corresponding analytic solutions idealized for the above four cases. The model is then applied to the simulation of tidal circulation in the Yangpu Bay, and detailed model calibration and verification have been conducted with measured tidal current in the spring tide, middle tide, and neap tide. The overall performance of the model is in qualitative agreement with the data observed in 2005, and it can be used to calculate the flow in estuaries and coastal waters.展开更多
1.Introduction La Croix et al.(2019)attempt to interpret the depositional position of the Lower Cretaceous McMurray Formation"A Valley"deposits using the tidally-influenced Fraser River in British Columbia a...1.Introduction La Croix et al.(2019)attempt to interpret the depositional position of the Lower Cretaceous McMurray Formation"A Valley"deposits using the tidally-influenced Fraser River in British Columbia as a modern analogue.Analysis of a portion of seven cores from three study areas(South,Central,and North)positioned along a 145-km basinward transect suggests that observed sedimentological and ichnological trends are indicative of a time-equivalent fluvial-tidal transition(FTT)zone within the"A Valley".展开更多
Coastal wetlands are hotspots for nitrogen(N)cycling,and crab burrowing is known to transform N in intertidal marsh soils.However,the underlying mechanisms remain unclear.This study conducted field experiments and use...Coastal wetlands are hotspots for nitrogen(N)cycling,and crab burrowing is known to transform N in intertidal marsh soils.However,the underlying mechanisms remain unclear.This study conducted field experiments and used indoor control test devices to investigate the seasonal response of nitrogen to crab disturbance at the sediment-water interface in coastal tidal flat wetlands.The results showed that crab disturbance exhibited significant seasonality with large seasonal differences in cave density and depth.Due to crab disturbance,nitrogen fuxes at the sediment-water interface were much greater in the box with crabs than in the box without crabs.In summer,NH-N showed a positive flux from the sediment to the overlying water,but NO2-N and NOg-N showed positive fluxes from the sediment to the overlying water only in early stages.In winter,NH-N showed a positive flux from the sediment to the overlying water,but NO-N and NO,-N both exhibited positive and negative fluxes.These results indicated that the presence of crab burrows can cause the aerobic layer to move downward by approximately 8-15 cm in summer and directly promote nitrification at the sediment surface.展开更多
To address the mooring issues of floating photovoltaic systems in areas with large tidal variations,three mooring schemes were designed and compared in this paper:anchor chain,anchor chain with added weights,and ancho...To address the mooring issues of floating photovoltaic systems in areas with large tidal variations,three mooring schemes were designed and compared in this paper:anchor chain,anchor chain with added weights,and anchor chain with Superflex.The model was established via the numerical simulation tool Orcaflex,which considers the combined effects of wind,waves,and currents.A time-domain coupled dynamic analysis was conducted on the performance of the three mooring schemes under various tidal conditions to determine the mooring cable tension and platform motion response.Furthermore,the mooring system with an anchor chain and Superflex was optimized,with a focus on analyzing the effects of the Superflex length,the diameter of the anchor chains,and the mooring radius.The mooring system with the anchor chain and Superflex exhibits more controllable and stable mooring performance in areas with large tidal variations,so that it more effectively maintains the required mooring tension level.These findings not only provide a reference for the feasibility and optimization design of photovoltaic systems in areas with large tidal variations but also offer valuable experience for the sustainable application of clean energy under specific environmental conditions.展开更多
The change of the confined aquifer level reflects the pore pressure change,and the pore pressure change of the aquifer is closely related to the aquifer pressure. This paper uses the tidal response of the well water l...The change of the confined aquifer level reflects the pore pressure change,and the pore pressure change of the aquifer is closely related to the aquifer pressure. This paper uses the tidal response of the well water level data in the North China region to calculate the tidal factor of each well and extract the effective water trend information. Then,the volumetric strain of an existing confined aquifer well in the North China region is inverted,and the contour maps are plotted on a half-year scale from 2009 to 2012. Results show that it can reflect the state of stress and strain in deep crust to a certain extent in the North China region.展开更多
文摘BACKGROUND Mechanical ventilation can lead to the severe impairment of the metabolic pathway of alveolar surfactants,inactivating alveolar surfactants and significantly reducing lung-chest compliance.The cardiopulmonary function of elderly patients usually reduced to a certain extent,and there are lung complications after surgical anesthesia,just like lung barotrauma caused by mechanical ventilation,atelectasis and postoperative hypoxemia.AIM To investigate the effects of different positive end expiratory pressures(PEEPs)and tidal volumes(VTs)on respiratory function,the degree of the inflammatory response and hemodynamic indexes in patients undergoing surgery under general anesthesia.METHODS A total of 120 patients undergoing surgery for gastric or colon cancer under general anesthesia in Xinghua People's Hospital from January 2017 to January 2021 were randomly divided into Group A and Group B,with 60 cases in each group.The ventilation mode in Group A was VT(6.0 mL/kg)+PEEP(5.0 cmH_(2)O),while that in Group B was VT(6.0 mL/kg)+PEEP(8.0 cmH_(2)O).Blood gas parameters,respiratory mechanical parameters,inflammatory response indicators,hemodynamic indicators and related complications were compared between the two groups.RESULTS There were no significant differences in PaCO_(2),PaO_(2),oxygen or the examined indexes at T0 between group A and group B(P>0.05).The measured PaO_(2) value of patients in group A at T3 was higher than that in group B,and the difference was significant(P<0.05).There were no significant differences in peak airway pressure(P_(peak)),mean airway pressure or dynamic pulmonary compliance(Cdyn)at T0 between group A and group B(P>0.05).The measured P_(peak) value of patients in group A at T1 was higher than that in group B,and the difference was significant(P<0.05).The measured Cdyn value at T1 and T2 was greater than that in group B(P<0.05).Before surgery,there were no significant differences in tumor necrosis factor-α(TNF-α),interleukin(IL)-6 or IL-10 between group A and group B(P>0.05).After 4 h,the measured values of TNF-αand IL-6 in group A were lower than those in group B,and the differences were significant(P<0.05).The IL-10 Level in group A was higher than that in group B(P<0.05).At T0,there were no significant differences in cardiac output,cardiac index(CI),stroke volume index(SVI)or mean arterial pressure between group A and group B(P>0.05).The measured values of CI and SVI at T2 in patients in group A were higher than those in group B,and the differences were significant(P<0.05).CONCLUSION For patients undergoing surgery for gastric or colon cancer under general anesthesia,the VT(6.0 mL/kg)+PEEP(5.0 cmH_(2)O)regimen was more effective than the VT(6.0 mL/kg)+PEEP(8.0 cmH_(2)O)regimen in protecting the lung function and ventilatory function of patients,and it had better effects on maintaining hemodynamic stability and reducing inflammatory reactions.
文摘BACKGROUND： This study aimed to observe the effect of recruitment maneuver （RM） and post-RM ventilation at different tidal volume on lung vascular diastole endothelial function in rats with acute lung injury （ALI）.METHODS： A ALl rat model was produced by intravenous infusion of lipopolysaccharide （6 mg/ kg）. Twenty-five rats were randomly divided into five groups： control group （n=5）, ALl group （n=5）, low tidal volume group （LV group, VT 6 mL/kg, n=5）, sustained inflation （SI） with low tidal volume group （SI＋LV group, VT 6 mL/kg, n=5）, and SI with moderate tidal volume group （SI＋MV group, VT 12 mL/ kg, n=5）. RM was performed with SI, airway pressure 30 cmH2O for 30 seconds, and positive end- expiratory pressure （PEEP） was set to 5 cmH2O. Lung tissue was taken after 5 hours of mechanical ventilation. Mean arterial blood pressure （MAP） was monitored during the experiment. Endothelin-1 （ET-1）, endothelial nitricoxide synthase （eNOS）, Ach-induced endothelium-dependent relaxation response of isolated pulmonary artery rings were determined at 5 hours. RESULTS：LPS increased ET-1 level, decreased the expression of eNOS in lung tissue, impaired the Ach-induced endothelium-dependent relaxation response in the pulmonary artery, without obvious effect on systemic hemodynamics. SI＋LV significantly reduced LPS-induced elevation of ET-1 level, increased the expression of eNOS, significantly improved endothelial dysfunction, and improved the dysfunction of endothelium-dependent relaxation in the pulmonary artery. CONCLUSIONS：RM with a high or low tidal volume ventilation could improve the lung vascular endothelial function of rats with acute lung injury, and RM with low tidal volume ventilation could lower significantly the injury of lung vascular endothelial diastole function in rats with acute lung injury.
文摘To validate the accuracy and consistency of respiratory inductive plethysmography (RIP) in measuring tidal volume after an overnight sleep, tidal volumes of 18 patients with suspected sleep disordered breathing and 8 normal volunteers were measured simultaneously with RIP (V TRIP ) and with an ultrasonic airflow meter (V TUFM ) before and after an unstrained overnight sleep on supine and lateral decubitus. The bias of the V TRIP was expressed as (V TRIP V TUFM )/ V TUFM ·100 %, limits of agreement between V TRIP and V TUFM was measured by averaged bias ±2 s . Results showed that in normal subjects, the bias of RIP before and after overnight sleep was precise and consistent in both supine (0.7 % and -1.6 %) and lateral decubitus (3.7 % and -0.56 %). In these patients, the bias of RIP before and after sleep in supine also remained small (1.9 % and 1.7 %), but it became larger in lateral decubitus (24.5 % and 20.4 %) and 11.5 % exceeded the limits of agreement observed in the evening. The patients′ body mass indices (BMI) were higher than those of normal subjects (median 34.2 vs. 27.8 kg/m 2). Pooled data showed that the bias of V TRIP in the morning on lateral decubitus but not on supine was correlated to BMI (Spearman R=0.32, n =52, P =0.02). Thus, we were led to conclude that the accuracy of V TRIP overnight was precise and consistent in normal subjects, but the deviation of V TRIP measured on lateral decubitus in patients especially in those with excessive obesity was greater, thus, the method should not be used for quantitative determination.
基金supported by National Natural Science Foundation of China(Grant number:82241050,81870060).
文摘Since the success of ARMA study in 2000,small tidal volume(Vt,4-8 mL/predicted body weight[PBW])is recommended in acute respiratory distress syndrome(ARDS)guidelines.[1,2]The ultra-protective strategy,further reducing Vt to 3-4 mL/PBW with/without extracorporeal carbon dioxide removal(ECCO_(2)R)with the aim to reduce the excess tidal lung strain and stress,is an appealing alternative for severe ARDS patients.
基金financially supported by the National Natural Science Foundation of China(42250102,42250101)the Macao Foundation。
文摘This study presents an inversion method to recover the tidal flow velocity using tidal signals extracted from geomagnetic satellite dataset.By integrating the latest Earth conductivity profile and the Earth's magnetic field model,the limited memory quasi-Newton method(L-BFGS)is used to directly invert seawater flow velocities.We used the radial component of the induced magnetic field as the observed data,constructed an L_(2)-norm-based data misfit term using theoretical response and observed data,and applied smoothness constraints to the ocean flow velocity.The results agree well with the widely used HAMTIDE model in low-and mid-latitude regions,which is attributed to Macao Science Satellite-1's(MSS-1)unique low-inclination orbit of full coverage in these areas.These findings underscore MSS-1's potential to advance research on tidal-induced magnetic fields and their applications in ocean dynamics studies.
基金supported by the National Natural Sci-ence Foundation of China(No.U2106204)the Shanxi Water Conservancy Science and Technology Re-search and Extension Project(No.2023ZF19).
文摘Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents following land reclamation.Tidal equa-tions are analytically solved using infinite series,deriving expressions for tidal levels and currents in narrow bays with varying topog-raphy.Tidal levels,influenced by topographic variations,are characterized by amplitude and phase lag of their complex amplitude.These levels demonstrate high sensitivity to longitudinal slope variations but remain relatively stable under lateral slope changes.Un-der constant topographic slopes,even minor changes in bay length can drastically modify amplitude and phase lag,highlighting the sensitivity of tidal dynamics to geometric alterations.Tidal velocity notably increases with steeper longitudinal slopes and modestly rises with elevated lateral slopes.However,changes in longitudinal and lateral slopes do not considerably alter flow patterns.While external forces predominantly regulate tidal velocity with negligible effects on flow patterns,endogenous resistance influences veloci-ty but minimally impacts flow structure.These findings enhance the understanding of tidal responses to geometric and topographic changes,providing valuable guidance for land reclamation projects and coastal management strategies.
基金supported by the National Natural Science Foundation of China(Grant No.U1706227)supported by the R&D Program of Beijing Municipal Education Commission(Grant No.KZ20231001720)the Open Fund Project of Key Laboratory of Ocean Observation Technology,MNR(Grant No.2022klootA03).
文摘The floating horizontal-axis tidal turbine(FHATT)stands out as the most commercially viable tidal energy device.This paper reviews recent literature on FHATT and summarizes experimental and computational fluid dynamics(CFD)methods employed in FHATT research.Based on this foundation,the coupling effects of wave and platform motion(pitch/roll)on FHATT hydrodynamic performance were investigated through flume experiments and CFD simulations.The variations of the power coefficient(C_(P))and thrust coefficient(C_(T))are analyzed under different platform motion periods,amplitudes,wave periods,and wave heights.The results demonstrate that under the coupling of waves and pitch motion,C_(P),C_(T)exhibit dual-frequency oscillations based on the pitch period,with oscillation amplitudes increasing with both pitch frequency(wave frequency)and pitch amplitude(wave height).Within the working conditions of this study,the maximum mean output power under the coupling of pitch motion and waves increases by 26.1%.The maximum fluctuation amplitude of C_(P)reaches 349.8%.When waves and roll motion are coupled,wave parameters dominate,while the influence of roll motion can be ignored.Moreover,the hydrodynamic fluctuations induced by waves and platform motion can couple with each other.This coupling effect not only amplifies the fluctuation amplitude of hydrodynamic coefficients but also has the potential to offset each other.These findings provide insights into the structural design and system control of FHATT,serving as valuable references for FHATT development.
基金supported by the National Natural Science Foundation of China(No.41977283)the Qing Lan Project of Jiangsu Province of China.
文摘Arsenic(As)pollution in coastal wetlands has been receiving growing attention.However,the exact mechanism of As mobility driven by tidal action is still not completely understood.The results reveal that lower total As concentrations in solution were observed in the flood-ebb treatment(FE),with the highest concentration being 7.1μg/L,and As(V)was the predominant species.However,elevated levels of total As in solution were found in the flooded treatment(FL),with a maximum value of 14.5μg/L after 30 days,and As(III)was the predominant form.The results of dissolved organicmatter(DOM)suggest that in the early to mid-stages of the incubation,fulvic acid-like substances might be utilized by microorganisms as electron donors or shuttle bodies,facilitating the reductive release of As/Fe from sediments.Both flood-ebb and flooded treatments promoted the transformation of crystalline iron hydrous oxides-bound As into residual forms.However,prolonged flooded conditions more readily facilitated the formation of specific adsorption forms of As and the reduction of crystalline iron hydrous oxides-bound As,increasing As mobility.In addition,the flood-ebb tides have been found to increase the diversity ofmicrobial populations.The main microbial genera in the flood-ebb treatment included Salinimicrobium,Erythrobacter,Yangia,Sulfitobacter,and Marinobacter.Bacillus,Psychrobacter,and Yangia showed a significant correlation with As(V).In flooded treatment,Bacillus,Pseudomonas,and Geothermobacter played a major role in the reduction and release of As.This study significantly contributes to the current understanding of how As behaves in diverse natural environments.
文摘A numerical investigation on the effectiveness of the actuator disc method in producing the interactions of multiple tidal stream devices via the 3D-RANS finite element model Telemac3D is explored. The methodology for the implementation of the source term to represent an array of 20 m rotor diameter turbines deployed in an idealized channel is reviewed and discussed in detail. Flow interactions between multiple turbines are investigated for a single row arrangement with only two turbines and a two row arrangement containing three turbines. The results demonstrate that the non-hydrostatic solver shows better agreement when validated against published experimental data. Notably,the mesh density at the device location can strongly influence the simulated thrust from the disc. Although the actuator disc model can generally replicate the wake interactions well, the results indicate that it cannot accurately characterize the flow for regions with high turbulences. While a model setup with the largest lateral spacing(1.5D) demonstrates excellent agreement with the experimental data, the 0.5D model(smallest gap) deviates by up to 25%. These findings demonstrate the effectiveness of the applied source term in reproducing the wake profile, which is comparable with the published data, and highlight the inherent nature of the RANS and actuator disc models.
基金supported by grants from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-062,to BD).
文摘Sepsis management has significantly improved over the past decades,with intensivists playing a pivotal role in its identification and treatment.[1,2]However,resource constraints in large tertiary hospitals in China limit patient admissions,leading to overcrowding in the emergency departments(EDs)with critically ill patients.[3]This highlights the urgent need for enhanced risk stratification and optimized sepsis management in emergency settings.
基金supported by the National Natural Science Foundation of China(Grant No.52171261).
文摘A floating horizontal-axis tidal current turbine(HATT)is an underwater power generation device where cavitation inevitably occurs on blade surfaces,severely affecting a turbine’s lifespan.Under wave action,these floating turbines exhibit six degrees of freedom motion,potentially intensifying the cavitation on the blade surfaces.This study selects three types of oscillatory motions from the six degrees of freedom:roll,yaw,and pitch.Computational fluid dynamics(CFD)methods are used for numerical calculations,and transient simulations of multiphase flow are conducted on the basis of the Reynolds-Averaged Navier-Stokes(RANS)model.Research has revealed strong correlations between flow velocity,the blade tip speed ratio,and cavitation.During oscillatory motion,the motion period and amplitude also significantly impact cavitation.In roll motion,the cavitation rate can increase by up to 59%with decreasing period,whereas in pitch and yaw motions,the increases are 7.57 times and 36%larger,respectively.With an increase in amplitude during roll motion,the cavitation rate can increase by up to 1.08 times,whereas in pitch and yaw motions,the increases are 3.49 times and 45%,respectively.The cavitation rate on the blade surfaces is the highest in pitch motion,followed by roll and yaw motions.
基金National Key Research and Development Program of China,No.2022YFC3204302China National Admin-istration of Coal Geology,No.ZMKJ-2021-ZX04。
文摘Ecological water supplement projects have been implemented in many coastal wetlands,influencing saltmarsh vegetation restoration by altering tidal creek development.To clarify the effectiveness of ecological water supplement on tidal creek development and saltmarsh vegetation restoration,time series of high-resolution remote sensing images from2000 to 2021 were used to extract and analyze tidal creeks and saltmarsh vegetation in the Diaokou Estuary Reserve.The results are summarized as follows:(1)All tidal creek indices,except curvature,exhibited a significant linear increase with time,while curvature initially decreased and increased afterwards.The 5-year cumulative ecological water supplement volume was significantly positively correlated(R^(2)>0.7)with all tidal creek indices.(2)During the same period,most landscape pattern metrics of Phragmites australis increased,while those of Tamarix chinensis initially increased and then declined.Although the class area(CA)of Suaeda salsa increased with time,its perimeter-area fractal dimension(PAFRAC)and aggregation index(AI)fluctuated.(3)The CA of P.australis and S.salsa was significantly positively correlated with most tidal creek indices except curvature,while that of T.chinensis showed no significant correlation with any tidal creek index.Moreover,the AI and PAFRAC of P.australis were significantly positively correlated with fractal dimension,frequency/curvature of tidal creeks,respectively,while those of S.salsa and T.chinensis exhibited no significant correlation.In summary,the ecological water supplement project enhanced tidal creek development in coastal wetlands,promoting the restoration of P.australis and S.salsa,while having little impact on the restoration of T.chinensis.
基金THIS WORK WAS SUPPORTED BY GRANTS FROM GREAT TOPIC FOUNDATION OF HEALTH BUREAU JIANGSU PROVINCE, CHINA (NO. H200102), AND SARS SPECIAL FOUNDATION OF SOUTHEAST UNIVERSITY, NANJING, JIANGSU PROVINCE, CHINA (NO. 9290006003).
文摘Mechanical ventilation, a crucial therapy to acute respiratory distress syndrome （ARDS）,could exacerbate lung injury, and even result in ventilator-induced lung injury （VILI） if misused in some condition1. Over-activating inflammatory cells and expanding inflammatory responses, which are induced by infection, are fundamental reasons for ARDS. Among them,
文摘Background High positive end-expiratory pressure （PEEP） and low tidal volume （VT） ventilation is thought to be a protective ventilation strategy. It is hypothesized that the stabilization of collapsible alveoli during expiration contributes to lung protection. However, this hypothesis came from analysis of indirect indices like the analysis of the pressure-volume curve of the lung. The purpose of this study was to investigate isolated healthy and injured rat lungs by means of alveolar microscopy, in which combination of PEEP and VT is beneficial with respect to alveolar stability （I-E%）. Methods Alveolar stability was investigated in isolated, non-perfused mechanically ventilated rat lungs. Injured lungs were compared with normal lungs. For both groups three PEEP settings （5, 10, 20 cmH20） were combined with three VT settings （6, 10, 15 ml/kg） resulting in nine PEEP-VT combinations per group. Analysis was performed by alveolar microscopy. Results In normal lungs alveolar stability persisted in all PEEP-VT combinations （I-E% （3.2±11.0）%）. There was no significant difference using different settings （P 〉0.01）. In contrast, alveoli in injured lungs were extremely instable at PEEP levels of 5 cmH20 （mean I-E% 100%） and 10 cmH2O （mean I-E% （30.7±16.8）%）; only at a PEEP of 20 cmH20 were alveoli stabilized （mean I-E% of （0.2±9.3）%）. Conclusions In isolated healthy lungs alveolar stability is almost unaffected by different settings of PEEP and VT. In isolated injured lungs only a high PEEP level of 20 cmH2O resulted in stabilized alveoli whereas lower PEEP levels are associated with alveolar instability.
基金This paper was supported bythe Natural Science Foundation of Shandong Province (Grant No.y2004f13)
文摘The finite volume method （FVM） has many advantages in 2-D shallow water numerical simulation. In this study, the finite volume method is used with unstructured triangular grids to simulate the tidal currents. The Roe scheme is applied in the calculation of the intercell numerical flux, and the MUSCL method is introduced to improve its accuracy. The time integral is a two-step scheme of forecast and revision. For the verification of the present method, the Stoker＇s problem is calculated and the result is compared with the mathematically analytic solutions. The comparison indicates that the method is feasible. A sea area of a port is used as an example to test the method established here. The result shows that the present computational method is satisfactory, and it could be applied to the engineering fields.
基金This work was supported by Open Research Fund Programof State Key Laboratory of Water Resources and Hydropow-er Engineering Science ( Grant No. 2005C011)National Natural Science Foundation of China ( Grant No.50479038)
文摘A depth-averaged 2-D numerical model for unsteady tidal flow in estuaries is established by use of the finite volume WENO scheme which maintains both uniform high order accuracy and an essentially non-oscillatory shock transition on unstructured triangular grid. The third order TVD Range-Kutta method is used for time discretization. The model has been firstly tested against four cases： 1） tidal forcing, 2） seiche oscillation, 3） wind setup in a closed bay, and 4） onedimensional dam-break water flow. The results obtained in the present study compare well with those obtained from the corresponding analytic solutions idealized for the above four cases. The model is then applied to the simulation of tidal circulation in the Yangpu Bay, and detailed model calibration and verification have been conducted with measured tidal current in the spring tide, middle tide, and neap tide. The overall performance of the model is in qualitative agreement with the data observed in 2005, and it can be used to calculate the flow in estuaries and coastal waters.
文摘1.Introduction La Croix et al.(2019)attempt to interpret the depositional position of the Lower Cretaceous McMurray Formation"A Valley"deposits using the tidally-influenced Fraser River in British Columbia as a modern analogue.Analysis of a portion of seven cores from three study areas(South,Central,and North)positioned along a 145-km basinward transect suggests that observed sedimentological and ichnological trends are indicative of a time-equivalent fluvial-tidal transition(FTT)zone within the"A Valley".
基金supported by the National Natural Science Foundation of China(Grant No.52271273)the Open Foundation of the Key Laboratory of Ministry of Education for Coastal Disaster and Protection(Grant No.Z202201)。
文摘Coastal wetlands are hotspots for nitrogen(N)cycling,and crab burrowing is known to transform N in intertidal marsh soils.However,the underlying mechanisms remain unclear.This study conducted field experiments and used indoor control test devices to investigate the seasonal response of nitrogen to crab disturbance at the sediment-water interface in coastal tidal flat wetlands.The results showed that crab disturbance exhibited significant seasonality with large seasonal differences in cave density and depth.Due to crab disturbance,nitrogen fuxes at the sediment-water interface were much greater in the box with crabs than in the box without crabs.In summer,NH-N showed a positive flux from the sediment to the overlying water,but NO2-N and NOg-N showed positive fluxes from the sediment to the overlying water only in early stages.In winter,NH-N showed a positive flux from the sediment to the overlying water,but NO-N and NO,-N both exhibited positive and negative fluxes.These results indicated that the presence of crab burrows can cause the aerobic layer to move downward by approximately 8-15 cm in summer and directly promote nitrification at the sediment surface.
基金financially supported by the National Key R&D Program of China(Grant No.2022YFB4200700).
文摘To address the mooring issues of floating photovoltaic systems in areas with large tidal variations,three mooring schemes were designed and compared in this paper:anchor chain,anchor chain with added weights,and anchor chain with Superflex.The model was established via the numerical simulation tool Orcaflex,which considers the combined effects of wind,waves,and currents.A time-domain coupled dynamic analysis was conducted on the performance of the three mooring schemes under various tidal conditions to determine the mooring cable tension and platform motion response.Furthermore,the mooring system with an anchor chain and Superflex was optimized,with a focus on analyzing the effects of the Superflex length,the diameter of the anchor chains,and the mooring radius.The mooring system with the anchor chain and Superflex exhibits more controllable and stable mooring performance in areas with large tidal variations,so that it more effectively maintains the required mooring tension level.These findings not only provide a reference for the feasibility and optimization design of photovoltaic systems in areas with large tidal variations but also offer valuable experience for the sustainable application of clean energy under specific environmental conditions.
基金funded by the 2013 Contract Orientation Tasks of Earthquake Tracing(2013020307)the 2014 Contract Orientation Task of Earthquake Tracing(2014020207)the Spark Program of Earthquake Science and Technology of CEA in 2014(XH14005Y)
文摘The change of the confined aquifer level reflects the pore pressure change,and the pore pressure change of the aquifer is closely related to the aquifer pressure. This paper uses the tidal response of the well water level data in the North China region to calculate the tidal factor of each well and extract the effective water trend information. Then,the volumetric strain of an existing confined aquifer well in the North China region is inverted,and the contour maps are plotted on a half-year scale from 2009 to 2012. Results show that it can reflect the state of stress and strain in deep crust to a certain extent in the North China region.
