Objective:To study the trauma and bone metabolism after internal absorbable screw and metal screw fixation treatment of tibia-fibula fracture. Methods:78 patients with tibia-fibula fracture who received internal fixat...Objective:To study the trauma and bone metabolism after internal absorbable screw and metal screw fixation treatment of tibia-fibula fracture. Methods:78 patients with tibia-fibula fracture who received internal fixation surgery in our hospital between May 2013 and October 2015 were selected and randomly divided into absorbable group and metal group (n=39) who accepted internal absorbable screw fixation and internal metal screw fixation respectively. 3 d after operation, serum was collected to determine the levels of inflammatory factors, pain mediators, stress hormones and bone metabolism indexes. Results: Serum inflammatory mediators procalcitonin (PCT), Resistin, C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α), pain mediators substance P (SP), prostaglandin E2 (PGE2) and NPY, stress hormones norepinephrine (NE), epinephrine (E) and cortisol (Cor) as well as bone resorption marker molecules C-terminal telopeptides of type I collagen (CTX-I) and C-terminal telopeptides of type II collagen (CTX-II) levels of absorbable group were significantly lower than those of metal group (P<0.05) while bone formation marker molecules N-MID osteocalcin (N-MID) and N-terminal propeptide of procollagen type I (PINP) levels were significantly higher than those of metal group (P<0.05). Conclusions:The trauma degree of internal absorbable screw fixation treatment of tibia-fibula fracture is weaker than that of internal metal screw fixation, and the bone metabolism activity is better than that of internal metal screw fixation.展开更多
目的探究自制三联式乙醇冰袋联合中药外敷对胫腓骨骨折患者早期肿胀的临床效果。方法进行回顾性研究,将60例胫腓骨骨折患者分为对照组及观察组,各30例。对照组运用传统冰敷,观察组运用自制三联式乙醇冰袋冰敷联合中药外敷。观察两组患...目的探究自制三联式乙醇冰袋联合中药外敷对胫腓骨骨折患者早期肿胀的临床效果。方法进行回顾性研究,将60例胫腓骨骨折患者分为对照组及观察组,各30例。对照组运用传统冰敷,观察组运用自制三联式乙醇冰袋冰敷联合中药外敷。观察两组患者伤后24 h、48 h的骨折部位肿胀评分,疼痛程度数字评定量表(NRS)评分以及住院时间、治疗满意度、护理满意度,以评价临床疗效。结果观察组住院时间少于对照组(P<0.05)。与对照组相比,观察组伤后48 h NRS评分、骨折部位肿胀评分均显著下降(P<0.05)。观察组治疗满意度90.00%(27/30)高于对照组的66.67%(20/30)(P<0.05),治疗总有效率90.00%(27/30)高于对照组的66.67%(20/30)(P<0.05)。结论自制三联式乙醇冰袋联合中药外敷用于胫腓骨骨折患者可早期消除患肢肿胀,减轻患者疼痛,缩短住院时间,临床疗效显著,值得推广应用。展开更多
目的分析西溪骨折方对胫腓骨骨折术后患者预后及血清Ⅰ型胶原羧基端肽β特殊序列(Type I collagen carboxy terminal peptideβspecial sequence,β-CTX)、骨胶原交联(Crosslaps)的影响。方法纳入2016年6月—2021年3月收治的110例胫腓...目的分析西溪骨折方对胫腓骨骨折术后患者预后及血清Ⅰ型胶原羧基端肽β特殊序列(Type I collagen carboxy terminal peptideβspecial sequence,β-CTX)、骨胶原交联(Crosslaps)的影响。方法纳入2016年6月—2021年3月收治的110例胫腓骨骨折患者,使用简单随机法分为联合组和对照组各55例,两组均接受切开复位内固定治疗,联合组加用西溪骨折方。评估两组术前、术后7 d疼痛评分、压痛、肿胀度以及血清β-CTX、Crosslaps变化,和术后7 d、术后4周美国特种外科医院(Hospital for special surgery,HSS)膝关节功能评分、膝关节活动度(Range of motion,ROM)变化,比较两组骨折愈合时间,并于术后4周使用Johner-Wruh胫骨干骨折评估标准评估两组预后。结果两组术后7 d疼痛评分、压痛、肿胀度均较术前下降,血清β-CTX、Crosslaps均较术前升高,联合组术后7 d疼痛评分、压痛、肿胀度均低于对照组,血清β-CTX、Crosslaps均高于对照组(P<0.05)。两组术后4周HSS评分、ROM均较术后7 d升高,联合组术后4周HSS评分、ROM均高于对照组(P<0.05)。联合组骨折愈合时间为(15.14±2.63)周,低于对照组的(16.88±3.15)周(t=3.145,P=0.002)。联合组术后4周恢复优良率为94.55%(52/55),较对照组的81.82%(45/55)更高(P<0.05)。联合组、对照组术后并发症发生率分别为7.27%(4/55)、10.91%(6/55),组间比较差异无统计学意义(P>0.05)。结论在切开复位内固定治疗的基础上,加用西溪骨折方能够减轻患者疼痛、改善骨代谢,对于促进患者膝关节功能早期康复具有积极作用,且不会导致术后并发症风险上升。展开更多
文摘Objective:To study the trauma and bone metabolism after internal absorbable screw and metal screw fixation treatment of tibia-fibula fracture. Methods:78 patients with tibia-fibula fracture who received internal fixation surgery in our hospital between May 2013 and October 2015 were selected and randomly divided into absorbable group and metal group (n=39) who accepted internal absorbable screw fixation and internal metal screw fixation respectively. 3 d after operation, serum was collected to determine the levels of inflammatory factors, pain mediators, stress hormones and bone metabolism indexes. Results: Serum inflammatory mediators procalcitonin (PCT), Resistin, C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α), pain mediators substance P (SP), prostaglandin E2 (PGE2) and NPY, stress hormones norepinephrine (NE), epinephrine (E) and cortisol (Cor) as well as bone resorption marker molecules C-terminal telopeptides of type I collagen (CTX-I) and C-terminal telopeptides of type II collagen (CTX-II) levels of absorbable group were significantly lower than those of metal group (P<0.05) while bone formation marker molecules N-MID osteocalcin (N-MID) and N-terminal propeptide of procollagen type I (PINP) levels were significantly higher than those of metal group (P<0.05). Conclusions:The trauma degree of internal absorbable screw fixation treatment of tibia-fibula fracture is weaker than that of internal metal screw fixation, and the bone metabolism activity is better than that of internal metal screw fixation.
文摘目的探究自制三联式乙醇冰袋联合中药外敷对胫腓骨骨折患者早期肿胀的临床效果。方法进行回顾性研究,将60例胫腓骨骨折患者分为对照组及观察组,各30例。对照组运用传统冰敷,观察组运用自制三联式乙醇冰袋冰敷联合中药外敷。观察两组患者伤后24 h、48 h的骨折部位肿胀评分,疼痛程度数字评定量表(NRS)评分以及住院时间、治疗满意度、护理满意度,以评价临床疗效。结果观察组住院时间少于对照组(P<0.05)。与对照组相比,观察组伤后48 h NRS评分、骨折部位肿胀评分均显著下降(P<0.05)。观察组治疗满意度90.00%(27/30)高于对照组的66.67%(20/30)(P<0.05),治疗总有效率90.00%(27/30)高于对照组的66.67%(20/30)(P<0.05)。结论自制三联式乙醇冰袋联合中药外敷用于胫腓骨骨折患者可早期消除患肢肿胀,减轻患者疼痛,缩短住院时间,临床疗效显著,值得推广应用。
文摘目的分析西溪骨折方对胫腓骨骨折术后患者预后及血清Ⅰ型胶原羧基端肽β特殊序列(Type I collagen carboxy terminal peptideβspecial sequence,β-CTX)、骨胶原交联(Crosslaps)的影响。方法纳入2016年6月—2021年3月收治的110例胫腓骨骨折患者,使用简单随机法分为联合组和对照组各55例,两组均接受切开复位内固定治疗,联合组加用西溪骨折方。评估两组术前、术后7 d疼痛评分、压痛、肿胀度以及血清β-CTX、Crosslaps变化,和术后7 d、术后4周美国特种外科医院(Hospital for special surgery,HSS)膝关节功能评分、膝关节活动度(Range of motion,ROM)变化,比较两组骨折愈合时间,并于术后4周使用Johner-Wruh胫骨干骨折评估标准评估两组预后。结果两组术后7 d疼痛评分、压痛、肿胀度均较术前下降,血清β-CTX、Crosslaps均较术前升高,联合组术后7 d疼痛评分、压痛、肿胀度均低于对照组,血清β-CTX、Crosslaps均高于对照组(P<0.05)。两组术后4周HSS评分、ROM均较术后7 d升高,联合组术后4周HSS评分、ROM均高于对照组(P<0.05)。联合组骨折愈合时间为(15.14±2.63)周,低于对照组的(16.88±3.15)周(t=3.145,P=0.002)。联合组术后4周恢复优良率为94.55%(52/55),较对照组的81.82%(45/55)更高(P<0.05)。联合组、对照组术后并发症发生率分别为7.27%(4/55)、10.91%(6/55),组间比较差异无统计学意义(P>0.05)。结论在切开复位内固定治疗的基础上,加用西溪骨折方能够减轻患者疼痛、改善骨代谢,对于促进患者膝关节功能早期康复具有积极作用,且不会导致术后并发症风险上升。
