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纳米TiO_2:C薄膜涂层的生物相容性评价 被引量:1
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作者 麦理想 张晟 +3 位作者 谢永建 谢彬 王大为 张志光 《中国组织工程研究》 CAS CSCD 2013年第8期1404-1410,共7页
背景:前期实验采用溶胶-凝胶法在纯钛片表面制备了纳米TiO2:C薄膜涂层。目的:评估纳米TiO2:C薄膜涂层的生物相容性。方法:①溶血实验:取新西兰大白兔静脉血,分别加到TiO2-生理盐水、TiO2:C-生理盐水、蒸馏水和生理盐水中。②细胞毒性实... 背景:前期实验采用溶胶-凝胶法在纯钛片表面制备了纳米TiO2:C薄膜涂层。目的:评估纳米TiO2:C薄膜涂层的生物相容性。方法:①溶血实验:取新西兰大白兔静脉血,分别加到TiO2-生理盐水、TiO2:C-生理盐水、蒸馏水和生理盐水中。②细胞毒性实验:将TiO2:C浸提液加入对数生长期的L929细胞培养基中。③短期全身毒性实验:将60只BALB/C小白鼠随机分为3组,分别灌胃给予TiO2浸提液、TiO2:C浸提液及生理盐水。④口腔黏膜刺激实验:将牙胶圆片与TiO2:C纳米薄膜涂片分别缝合固定于仓地鼠颊黏膜上。结果与结论:纳米TiO2:C涂层未引起急性溶血,毒性等级为0-1级,未对细胞产生明显毒性,细胞周期未见明显异常;TiO2:C浸提液对小鼠无短期全身毒性;对仓鼠口腔黏膜无刺激性。表明纳米TiO2:C薄膜涂层具有良好的生物安全性。 展开更多
关键词 生物材料 纳米生物材料 材料生物相容性 纳米二氧化钛 C 细胞毒性 生物相容性 涂层 国家自然科学基金 生物材料图片文章
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Damage Characteristics of TiD_2 Films Irradiated by a Mixed Pulsed Beam of Titanium and Hydrogen Ions
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作者 刘猛 何铁 +3 位作者 言杰 柯建林 林菊芳 卢彪 《Plasma Science and Technology》 SCIE EI CAS CSCD 2016年第7期764-767,共4页
Titanium deuteride is an important nuclear material used in the field of nuclear technology, and further research is needed into TiD2 films irradiated by pulsed ion beams of the vacuum arc discharge with hydrogen. In ... Titanium deuteride is an important nuclear material used in the field of nuclear technology, and further research is needed into TiD2 films irradiated by pulsed ion beams of the vacuum arc discharge with hydrogen. In the current study, these irradiated TiD2 films have been investigated using scanning electronic microscopy and slow positron annihilation techniques. Both the thermal effect and irradiation defects of TiD2 films were studied, following their irradiation with mixed pulsed ion beams of titanium and hydrogen ions. It is found that the thermal effect is trivial on the irradiated surfaces, and the dominant effect is irradiation defects which can be enhanced by repetitive shots and is characterized by the inner diffusion of irradiation defects. 展开更多
关键词 vacuum arc discharge at hydrogen tid2 film irradiation defect slow positron annihilation
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