Polychlorinated naphthalenes(PCNs)comprise 75 congeners,with varying concentrations and major congeners across different populations.Recent studies have found a relationship between PCNs and thyroid hormone levels,sug...Polychlorinated naphthalenes(PCNs)comprise 75 congeners,with varying concentrations and major congeners across different populations.Recent studies have found a relationship between PCNs and thyroid hormone levels,suggesting they may interfere with thyroid function.Investigating the con-centrations of PCNs in individuals with thyroid dysfunction helps identify the predominant congeners and enables targeted analysis of their interference with thyroid function.In this study,serum con-centrations of PCNs from 55 adults with thyroid dysfunction were measured.PCN-13,-15,17/25/26,20,23,and 24/14 detected at over 70%,and PCN-23 and-24/14 being the major congeners.No significant difference in PCN concentrations was found between males and females,but the concen-trations of PCN-23 and-24/14 increased with age.Logistic regression and QGC models revealed a sig-nificant association between PCN-23 and thyroid dysfunction,while mediation analysis indicated PCN-23 affects physiological processes involving the BRAF 600E gene,which influences normal thyroid function.Molecular docking results showed that all six PCNs impacted thyroid hormone metabolism and receptor binding,with PCN-23 binding more effectively to TBG and disrupting thyroid hormone transport compared to PCN-24/14.Future studies should focus on the concentrations of trichlorinated PCNs,particularly PCN-23,in the human body and their relationship with thyroid function.展开更多
文摘Polychlorinated naphthalenes(PCNs)comprise 75 congeners,with varying concentrations and major congeners across different populations.Recent studies have found a relationship between PCNs and thyroid hormone levels,suggesting they may interfere with thyroid function.Investigating the con-centrations of PCNs in individuals with thyroid dysfunction helps identify the predominant congeners and enables targeted analysis of their interference with thyroid function.In this study,serum con-centrations of PCNs from 55 adults with thyroid dysfunction were measured.PCN-13,-15,17/25/26,20,23,and 24/14 detected at over 70%,and PCN-23 and-24/14 being the major congeners.No significant difference in PCN concentrations was found between males and females,but the concen-trations of PCN-23 and-24/14 increased with age.Logistic regression and QGC models revealed a sig-nificant association between PCN-23 and thyroid dysfunction,while mediation analysis indicated PCN-23 affects physiological processes involving the BRAF 600E gene,which influences normal thyroid function.Molecular docking results showed that all six PCNs impacted thyroid hormone metabolism and receptor binding,with PCN-23 binding more effectively to TBG and disrupting thyroid hormone transport compared to PCN-24/14.Future studies should focus on the concentrations of trichlorinated PCNs,particularly PCN-23,in the human body and their relationship with thyroid function.
