Hypercoagulability observed in patients with inflammatory bowel diseases (IBD) may lead to thromboembolic events (TE), which affect the venous and arterial systems alike and are an important factor in patients�...Hypercoagulability observed in patients with inflammatory bowel diseases (IBD) may lead to thromboembolic events (TE), which affect the venous and arterial systems alike and are an important factor in patients’ morbidity and mortality. The risk of TE in IBD patients has been demonstrated to be approximately three-fold higher as compared to the general population. The pathogenesis of thrombosis in IBD patients is multifactorial and not fully explained. The most commonly listed factors include genetic and immune abnormalities, disequilibrium between procoagulant and anticoagulant factors, although recently, the role of endothelial damage as an IBD-triggering factor is underlined. Several studies report that the levels of some coagulation enzymes, including fibrinogen, factors V, VII, VIII, active factor XI, tissue factor, prothrombin fragment 1 + 2 and the thrombin-antithrombin complex, are altered in IBD patients. It has been demonstrated that there is a significant decrease of tissue plasminogen activator level, a marked increase of plasminogen activator inhibitor type 1 and thrombin-activable fibrinolysis inhibitor, a significantly lower level of antithrombin III and tissue factor pathway inhibitor. IBD patients have been also observed to produce an increased amount of various anticoagulant antibodies. Hyperhomocysteinemia, which is a potential risk factor for TE was also observed in some IBD patients. Further studies are necessary to assess the role of coagulation abnormalities in IBD etiology and to determine indications for thromboprophylactic treatment in patients at high risk of developing TE.展开更多
目的对局部麻醉和脊椎麻醉在膝关节镜手术中的应用效果及安全性进行分析和比较。方法在我院2015年8月~2017年1月期间收治的膝关节镜手术患者中选取100例作为研究对象,根据随机双盲原则将患者平均分为观察组和对照组两组,每组50例,观察...目的对局部麻醉和脊椎麻醉在膝关节镜手术中的应用效果及安全性进行分析和比较。方法在我院2015年8月~2017年1月期间收治的膝关节镜手术患者中选取100例作为研究对象,根据随机双盲原则将患者平均分为观察组和对照组两组,每组50例,观察组患者接受局部麻醉,对照组患者接受脊椎麻醉,比较两组患者手术效果及手术安全性。结果观察组患者术后不同时点的VAS评分均显著低于对照组患者(P<0.05);此外,相较于对照组患者,观察组患者麻醉总满意率更高、术后不良反应总发生率更低(94.00% vs 72.00%、4.00% vs 24.00%,P<0.05)。结论在膝关节镜手术中,局部麻醉的应用效果及安全性优于脊椎麻醉,可显著降低患者术后疼痛感、减少不良反应,推荐使用。展开更多
Brain-computer interfaces rely on electrodes to record neural activity,but most existing electrodes remain fixed once implanted,limiting their sampling range and often triggering immune responses that degrade signal q...Brain-computer interfaces rely on electrodes to record neural activity,but most existing electrodes remain fixed once implanted,limiting their sampling range and often triggering immune responses that degrade signal quality over time.As reported in a Nature paper(doi:10.1038/s41586-025-09344-w)on September 17,researchers from the Shenzhen Institutes of Advanced Technology(SIAT),Chinese Academy of Sciences,and Donghua University have now developed NeuroWorm-a soft,movable fiber electrode that can navigate through tissues while continuously recording high-quality signals.展开更多
文摘Hypercoagulability observed in patients with inflammatory bowel diseases (IBD) may lead to thromboembolic events (TE), which affect the venous and arterial systems alike and are an important factor in patients’ morbidity and mortality. The risk of TE in IBD patients has been demonstrated to be approximately three-fold higher as compared to the general population. The pathogenesis of thrombosis in IBD patients is multifactorial and not fully explained. The most commonly listed factors include genetic and immune abnormalities, disequilibrium between procoagulant and anticoagulant factors, although recently, the role of endothelial damage as an IBD-triggering factor is underlined. Several studies report that the levels of some coagulation enzymes, including fibrinogen, factors V, VII, VIII, active factor XI, tissue factor, prothrombin fragment 1 + 2 and the thrombin-antithrombin complex, are altered in IBD patients. It has been demonstrated that there is a significant decrease of tissue plasminogen activator level, a marked increase of plasminogen activator inhibitor type 1 and thrombin-activable fibrinolysis inhibitor, a significantly lower level of antithrombin III and tissue factor pathway inhibitor. IBD patients have been also observed to produce an increased amount of various anticoagulant antibodies. Hyperhomocysteinemia, which is a potential risk factor for TE was also observed in some IBD patients. Further studies are necessary to assess the role of coagulation abnormalities in IBD etiology and to determine indications for thromboprophylactic treatment in patients at high risk of developing TE.
文摘目的对局部麻醉和脊椎麻醉在膝关节镜手术中的应用效果及安全性进行分析和比较。方法在我院2015年8月~2017年1月期间收治的膝关节镜手术患者中选取100例作为研究对象,根据随机双盲原则将患者平均分为观察组和对照组两组,每组50例,观察组患者接受局部麻醉,对照组患者接受脊椎麻醉,比较两组患者手术效果及手术安全性。结果观察组患者术后不同时点的VAS评分均显著低于对照组患者(P<0.05);此外,相较于对照组患者,观察组患者麻醉总满意率更高、术后不良反应总发生率更低(94.00% vs 72.00%、4.00% vs 24.00%,P<0.05)。结论在膝关节镜手术中,局部麻醉的应用效果及安全性优于脊椎麻醉,可显著降低患者术后疼痛感、减少不良反应,推荐使用。
文摘Brain-computer interfaces rely on electrodes to record neural activity,but most existing electrodes remain fixed once implanted,limiting their sampling range and often triggering immune responses that degrade signal quality over time.As reported in a Nature paper(doi:10.1038/s41586-025-09344-w)on September 17,researchers from the Shenzhen Institutes of Advanced Technology(SIAT),Chinese Academy of Sciences,and Donghua University have now developed NeuroWorm-a soft,movable fiber electrode that can navigate through tissues while continuously recording high-quality signals.
