Borehole-to-surface electrical imaging （BSEI） uses a line source and a point source to generate a stable electric field in the ground. In order to study the surface potential of anomalies, three-dimensional forward ...Borehole-to-surface electrical imaging （BSEI） uses a line source and a point source to generate a stable electric field in the ground. In order to study the surface potential of anomalies, three-dimensional forward modeling of point and line sources was conducted by using the finite-difference method and the incomplete Cholesky conjugate gradient （ICCG） method. Then, the damping least square method was used in the 3D inversion of the formation resistivity data. Several geological models were considered in the forward modeling and inversion. The forward modeling results suggest that the potentials generated by the two sources have different surface signatures. The inversion data suggest that the low- resistivity anomaly is outlined better than the high-resistivity anomaly. Moreover, when the point source is under the anomaly, the resistivity anomaly boundaries are better outlined than when using a line source.展开更多
Achieving high-resolution intracranial imaging in a safe and portable manner is critical for the diagnosis of intracranial diseases,preoperative planning of craniotomies and intraoperative management during craniotomy...Achieving high-resolution intracranial imaging in a safe and portable manner is critical for the diagnosis of intracranial diseases,preoperative planning of craniotomies and intraoperative management during craniotomy procedures.Adaptive waveform inversion(AWI),a variant of full waveform inversion(FWI),has shown potential in intracranial ultrasound imaging.However,the robustness of AWI is affected by the parameterization of the Gaussian penalty matrix and the challenges posed by transcranial scenarios.Conventional AWI struggles to produce accurate images in these cases,limiting its application in critical medical settings.To address these issues,we propose a stabilized adaptive waveform inversion(SAWI)method,which introduces a user-defined zero-lag position for theWiener filter.Numerical experiments demonstrate that SAWI can achieve accurate imaging under Gaussian penalty matrix parameter settings where AWI fails,perform successful transcranial imaging in configurations where AWI cannot,and maintain the same imaging accuracy as AWI.The advantage of this method is that it achieves these advancements without modifying the AWI framework or increasing computational costs,which helps to promote the application of AWI in medical fields,particularly in transcranial scenarios.展开更多
BACKGROUND Hepatobiliary surgery is complex and requires a thorough understanding of the liver’s anatomy,biliary system,and vasculature.Traditional imaging methods such as computed tomography(CT)and magnetic resonanc...BACKGROUND Hepatobiliary surgery is complex and requires a thorough understanding of the liver’s anatomy,biliary system,and vasculature.Traditional imaging methods such as computed tomography(CT)and magnetic resonance imaging(MRI),although helpful,fail to provide three-dimensional(3D)relationships of these structures,which are critical for planning and executing complicated surgeries.AIM To explore the use of 3D imaging and virtual surgical planning(VSP)technologies to improve surgical accuracy,reduce complications,and enhance patient recovery in hepatobiliary surgeries.METHODS A comprehensive review of studies published between 2017 and 2024 was conducted through PubMed,Scopus,Google Scholar,and Web of Science.Studies selected focused on 3D imaging and VSP applications in hepatobiliary surgery,assessing surgical precision,complications,and patient outcomes.Thirty studies,including randomized controlled trials,cohort studies,and case reports,were included in the final analysis.RESULTS Various 3D imaging modalities,including multidetector CT,MRI,and 3D rotational angiography,provide high-resolution views of the liver’s vascular and biliary anatomy.VSP allows surgeons to simulate complex surgeries,improving preoperative planning and reducing complications like bleeding and bile leaks.Several studies have demonstrated improved surgical precision,reduced complications,and faster recovery times when 3D imaging and VSP were used in complex surgeries.CONCLUSION 3D imaging and VSP technologies significantly enhance the accuracy and outcomes of hepatobiliary surgeries by providing individualized preoperative planning.While promising,further research,particularly randomized controlled trials,is needed to standardize protocols and evaluate long-term efficacy.展开更多
BACKGROUND Back pain and sciatica are common complaints that often require imaging for accurate diagnosis and management.Conventional lumbar magnetic resonance imaging(MRI)protocols typically include sagittal and axia...BACKGROUND Back pain and sciatica are common complaints that often require imaging for accurate diagnosis and management.Conventional lumbar magnetic resonance imaging(MRI)protocols typically include sagittal and axial T1 and T2 sequences;however,these may miss certain pathologies.The addition of coronal short tau inversion recovery(STIR)sequences offers the potential to enhance the detection of both spinal and extra-spinal abnormalities,thereby improving clinical decisionmaking and patient outcomes.AIM To evaluate the impact of adding coronal STIR sequences to routine lumbar MRI in diagnosing back pain and sciatica.METHODS We prospectively analyzed data from patients aged 6 and older presenting with back pain or sciatica who underwent lumbar spine MRI at our institution.The standardized MRI protocol utilized included sagittal and axial T1 and T2 sequences,complemented by a coronal STIR sequence.Data on structural abnormalities were collected,reviewed,and analyzed using counts,percentages,and Fisher's exact test for categorical variables.RESULTS Our cohort comprised 274 patients(115 males,159 females;mean age 44.91 years).Notably,39 patients exhibited abnormalities across all sequences,while 72.63%showed normal findings on the coronal STIR sequence.Importantly,30.29%of cases were diagnosed as normal without the coronal STIR,and 36 patients with normal T1 and T2 sequences presented abnormalities on the coronal STIR.The coronal STIR sequence successfully identified 26 spinal and 10 non-spinal pathologies,including 17 cases of sacroiliitis,with a significant association(P<0.0001)between sacroiliitis diagnosis and abnormalities visible solely on this sequence.CONCLUSION Integrating coronal STIR into routine lumbar MRI enhances detection of hidden spinal and extra-spinal pathologies,improves patient management,and offers a cost-effective,practical upgrade with significant diagnostic and clinical value.展开更多
Conventional artificial neural networks used to solve electrical resistivity imaging （ERI） inversion problem suffer from overfitting and local minima. To solve these problems, we propose to use a pruning Bayesian ne...Conventional artificial neural networks used to solve electrical resistivity imaging （ERI） inversion problem suffer from overfitting and local minima. To solve these problems, we propose to use a pruning Bayesian neural network （PBNN） nonlinear inversion method and a sample design method based on the K-medoids clustering algorithm. In the sample design method, the training samples of the neural network are designed according to the prior information provided by the K-medoids clustering results; thus, the training process of the neural network is well guided. The proposed PBNN, based on Bayesian regularization, is used to select the hidden layer structure by assessing the effect of each hidden neuron to the inversion results. Then, the hyperparameter αk, which is based on the generalized mean, is chosen to guide the pruning process according to the prior distribution of the training samples under the small-sample condition. The proposed algorithm is more efficient than other common adaptive regularization methods in geophysics. The inversion of synthetic data and field data suggests that the proposed method suppresses the noise in the neural network training stage and enhances the generalization. The inversion results with the proposed method are better than those of the BPNN, RBFNN, and RRBFNN inversion methods as well as the conventional least squares inversion.展开更多
This research proposes a novel three-dimensional gravity inversion based on sparse recovery in compress sensing. Zero norm is selected as the objective function, which is then iteratively solved by the approximate zer...This research proposes a novel three-dimensional gravity inversion based on sparse recovery in compress sensing. Zero norm is selected as the objective function, which is then iteratively solved by the approximate zero norm solution. The inversion approach mainly employs forward modeling; a depth weight function is introduced into the objective function of the zero norms. Sparse inversion results are obtained by the corresponding optimal mathematical method. To achieve the practical geophysical and geological significance of the results, penalty function is applied to constrain the density values. Results obtained by proposed provide clear boundary depth and density contrast distribution information. The method's accuracy, validity, and reliability are verified by comparing its results with those of synthetic models. To further explain its reliability, a practical gravity data is obtained for a region in Texas, USA is applied. Inversion results for this region are compared with those of previous studies, including a research of logging data in the same area. The depth of salt dome obtained by the inversion method is 4.2 km, which is in good agreement with the 4.4 km value from the logging data. From this, the practicality of the inversion method is also validated.展开更多
Funded by The National Key Research and Development Program of China,China Deep Exploration(Sinoprobe)and The China Geological Suvery Project on 2009–2019,a large scale magnetotelluric sounding(MT)survey grid(Fig.1)h...Funded by The National Key Research and Development Program of China,China Deep Exploration(Sinoprobe)and The China Geological Suvery Project on 2009–2019,a large scale magnetotelluric sounding(MT)survey grid(Fig.1)has covered whole south China.展开更多
Perianal abscess is a common disease in anorectal surgery. If the diagnosis is not clear and the cure is thoroughly cleared, the recurrence and spread of anal fistula will cause life-long pain. Objective: To investiga...Perianal abscess is a common disease in anorectal surgery. If the diagnosis is not clear and the cure is thoroughly cleared, the recurrence and spread of anal fistula will cause life-long pain. Objective: To investigate the application of 3.0T MRI 3D CUBE T2WI lipid suppression sequence in the diagnosis of perianal abscess. Methods: Thirty-six patients with perianal abscess confirmed by operation were examined with 2D T2WI and 3D CUBE T2WI lipid suppression sequences before operation. Two imaging techniques were evaluated to show the types of perianal abscess, the number of abscesses, the number of internal orifices of abscess, and the number of fistula branches with anal fistula in abscess. Results: Among 36 cases of perianal abscess, there were 5 cases of anal subcutaneous abscess, 12 cases of ischiorectal space abscess (8 cases complicated with anal fistula), 6 cases of posterior anal space abscess, 5 cases of anal sphincter abscess (3 cases complicated with anal fistula), 2 cases of high intermuscular abscess, 2 cases of rectal submucosal abscess, 3 cases of complex abscess (3 cases complicated with anal fistula), 1 case of misdiagnosis, 2D T2WI lipid suppression sequence and 3D CUBE T2WI suppression. The accuracy of lipid sequence abscess typing was 80.6% (29/36) and 88.9% (32/36), respectively, with no significant difference (P > 0.05). Thirty-six patients were surgically diagnosed as having 32 internal orifices, 68.8% (22/32) and 93.8% (30/32) of 2D T2WI and 3D CUBE T2WI lipid-suppressing sequences, respectively, with significant difference (P Conclusion: 3D CUBE T2WI lipid suppression sequence is superior to 2D T2WI lipid suppression sequence in the classification of perianal abscess, the number of internal orifices of abscess and the number of fistula branches of abscess complicated with anal fistula. It can also determine the number of internal orifices of abscess complicated with anal fistula, the number of fistula branches, the shape of primary and branch fistula and the relationship among pelvic floor muscle tissues. It can provide more accurate images for preoperative and intraoperative clinical surgery.展开更多
Late gadolinium enhancement(LGE) cardiovascular magnetic resonance(CMR) is the gold standard for imaging myocardial viability.An important application of LGE CMR is the assessment of the location and extent of the myo...Late gadolinium enhancement(LGE) cardiovascular magnetic resonance(CMR) is the gold standard for imaging myocardial viability.An important application of LGE CMR is the assessment of the location and extent of the myocardial scar in patients with ventricular tachycardia(VT), which allows for more accurate identification of the ablation targets.However, a large percentage of patients with VT have cardiac implantable electronic devices(CIEDs), which is a relative contraindication for cardiac magnetic resonance imaging due to safety and image artifact concerns.Previous studies showed that these patients can be safely scanned on 1.5 T scanners provided that an adequate imaging protocol is adopted.Nevertheless, imaging patients with a CIED result in metal artifacts due to the strong frequency off-resonance effects near the device; therefore, the spins in the surrounding myocardium are not completely inverted, and thus give rise to hyperintensity artifacts.These artifacts obscure the myocardial scar tissue and limit the ability to study the correlation between the myocardial scar structure and the electro-anatomical map during catheter ablation.In this study, we developed a modified inversion recovery technique to alleviate the CIED-induced metal artifacts and improve the diagnostic image quality of LGE images in patients with CIEDs without increasing scan time or requiring additional hardware.The developed technique was tested in phantom experiments and in vivo scans, which showed its capability for suppressing the hyperintensity artifacts without compromising myocardium nulling in the resulting LGE images.展开更多
The gravity inversion is to restore genetic density distribution of the underground target to be explored for explaining the internal structure and distribution of the Earth.In this paper,we propose a new 3D gravity i...The gravity inversion is to restore genetic density distribution of the underground target to be explored for explaining the internal structure and distribution of the Earth.In this paper,we propose a new 3D gravity inversion method based on 3D U-Net++.Compared with two-dimensional gravity inversion,three-dimensional(3D)gravity inversion can more precisely describe the density distribution of underground space.However,conventional 3D gravity inversion method input is two-dimensional,the input and output of the network proposed in our method are three-dimensional.In the training stage,we design a large number of diversifi ed simulation model-data pairs by using the random walk method to improve the generalization ability of the network.In the test phase,we verify the network performance by using the model-data pairs generated by the simulation.To further illustrate the eff ectiveness of the algorithm,we apply the method to the inversion of the San Nicolas mining area,and the inversion results are basically consistent with the borehole measurement results.Moreover,the results of the 3D U-Net++inversion and the 3D U-Net inversion are compared.The density models of the 3D U-Net++inversion have higher resolution,more concentrated inversion results,and a clearer boundary of the density model.展开更多
The nearly analytic discrete(NAD)method is a kind of finite difference method with advantages of high accuracy and stability.Previous studies have investigated the NAD method for simulating wave propagation in the tim...The nearly analytic discrete(NAD)method is a kind of finite difference method with advantages of high accuracy and stability.Previous studies have investigated the NAD method for simulating wave propagation in the time-domain.This study applies the NAD method to solving three-dimensional(3D)acoustic wave equations in the frequency-domain.This forward modeling approach is then used as the“engine”for implementing 3D frequency-domain full waveform inversion(FWI).In the numerical modeling experiments,synthetic examples are first given to show the superiority of the NAD method in forward modeling compared with traditional finite difference methods.Synthetic 3D frequency-domain FWI experiments are then carried out to examine the effectiveness of the proposed methods.The inversion results show that the NAD method is more suitable than traditional methods,in terms of computational cost and stability,for 3D frequency-domain FWI,and represents an effective approach for inversion of subsurface model structures.展开更多
The diagnosis of the recurrent optic neuritis is commonly established clinically,and sometimes it could be challenging because the involved optic nerve does not always show significant enhancement on conventional cont...The diagnosis of the recurrent optic neuritis is commonly established clinically,and sometimes it could be challenging because the involved optic nerve does not always show significant enhancement on conventional contrast enhanced-T1 weighted imaging（CE-T1W1）.In this paper,we reported a middle-aged female with early diagnosis of recurrent optic neuritis using contrast-enhanced T2 fluid-attenuated inversion recovery imaging（CET2FLAIR）.The involved optic nerve presented evident enhancement on CE-T2FLAIR and no enhancement on CE-T1W1.This case suggested that the CE-T2FLAIR may be a useful diagnostic tool specifically for the recurrent optic neuritis in clinical practice.展开更多
The main challenge in bone ultrasound imaging is the large acoustic impedance contrast and sound velocity differences between the bone and surrounding soft tissue. It is difficult for conventional pulse-echo modalitie...The main challenge in bone ultrasound imaging is the large acoustic impedance contrast and sound velocity differences between the bone and surrounding soft tissue. It is difficult for conventional pulse-echo modalities to give accurate ultrasound images for irregular bone boundaries and microstructures using uniform sound velocity assumption rather than getting a prior knowledge of sound speed. To overcome these limitations, this paper proposed a frequency-domain fullwaveform inversion(FDFWI) algorithm for bone quantitative imaging utilizing ultrasonic computed tomography(USCT).The forward model was calculated in the frequency domain by solving the full-wave equation. The inverse problem was solved iteratively from low to high discrete frequency components via minimizing a cost function between the modeled and measured data. A quasi-Newton method called the limited-memory Broyden–Fletcher–Goldfarb–Shanno algorithm(L-BFGS) was utilized in the optimization process. Then, bone images were obtained based on the estimation of the velocity and density. The performance of the proposed method was verified by numerical examples, from tubular bone phantom to single distal fibula model, and finally with a distal tibia-fibula pair model. Compared with the high-resolution peripheral quantitative computed tomography(HR-p QCT), the proposed FDFWI can also clearly and accurately presented the wavelength scaled pores and trabeculae in bone images. The results proved that the FDFWI is capable of reconstructing high-resolution ultrasound bone images with sub-millimeter resolution. The parametric bone images may have the potential for the diagnosis of bone disease.展开更多
The recently introduced real-time three-dimensional color Doppler flow imaging （RT-3D CDFI） technique provides a quick and accurate calculation of regurgitant jet volume （RJV） and fraction. In order to evaluate RT...The recently introduced real-time three-dimensional color Doppler flow imaging （RT-3D CDFI） technique provides a quick and accurate calculation of regurgitant jet volume （RJV） and fraction. In order to evaluate RT-3D CDFI in the noninvasive assessment of aortic RJV and regurgitant jet fraction （RJF） in patients with isolated aortic regurgitation, real-time three-dimensional echocardiographic studies were performed on 23 patients with isolated aortic regurgitation to obtain LV end-diastolic volumes （LVEDV）, end-systolic volumes （LVESV） and RJV, and then RJF could be calculated. The regurgitant volume （RV） and regurgitant fraction （RF） calculated by two-dimensional pulsed Doppler （2D-PD） method served as reference values. The results showed that aortic RJV measured by the RT-3D CDFI method showed a good correlation with the 2D-PD measurements （r= 0.93, Y=0.89X＋ 3.9, SEE= 8.6 mL, P〈0.001 ）; the mean （SD） difference between the two methods was - 1.5 （9.8） mL. % RJF estimated by the RT-3D CDFI method was also correlated well with the values obtained by the 2D-PD method （r=0.88, Y=0.71X＋ 14.8, SEE= 6.4 %, P〈0. 001）; the mean （SD） difference between the two methods was -1.2 （7.9） %. It was suggested that the newly developed RT-3D CDFI technique was feasible in the majority of patients. In patients with eccentric aortic regurgitation, this new modality provides additional information to that obtained from the two-dimensional examination, which overcomes the inherent limitations of two-dimensional echocardiography by depicting the full extent of the jet trajectory. In addition, the RT-3D CDFI method is quick and accurate in calculating RJV and RJF.展开更多
Summary： This study sought to evaluate the contribution of two-dimensional ultrasound （2D-US） and three-dimensional skeletal imaging ultrasound （3D-SUIS） in the prenatal diagnosis of sirenomelia. Be- tween Septem...Summary： This study sought to evaluate the contribution of two-dimensional ultrasound （2D-US） and three-dimensional skeletal imaging ultrasound （3D-SUIS） in the prenatal diagnosis of sirenomelia. Be- tween September 2010 and April 2014, a prospective study was conducted in a single referral center using 3D-SU1S performed after 2D-US in 10 cases of sirenomelia. Diagnostic accuracy and detailed findings were compared with postnatal three-dimensional helical computed tomography （3D-HCT）, radiological findings and autopsy. Pregnancy was terminated in all 10 sirenomelia cases, including 9 singletons and I conjoined twin pregnancy, for a total of 5 males and 5 females. These cases of sirenomelia were deter- mined by autopsy and/or chromosomal examination. Initial 2D-US showed that there were 10 cases of oligohydranmios, bilateral renal agenesis, bladder agenesis, single umbilical artery, fusion of the lower limbs and spinal abnormalities; 8 cases of dipus or monopus; 2 cases of apus; and 8 cases of cardiac abnormalities. Subsequent 3D-SUIS showed that there were 9 cases of scoliosis, l0 cases of sacrococ- cygeal vertebra dysplasia, 3 cases of hemivertebra, 1 case of vertebral fusion, 3 cases of spina bifida, and 5 cases of rib abnormalities. 3D-SUIS identified significantly more skeletal abnormalities than did 2D-US, and its accuracy was 79.5% （70/88） compared with 3D-HCT and radiography. 3D-SUIS seems to be a useful complementary method to 2D-US and may improve the accuracy of identifying prenatal skeletal abnormalities related to sirenomelia.展开更多
Computed tomography has been proven to be useful for non-destructive inspection of structures and materials. We build a three-dimensional imaging system with the photonically generated incoherent noise source and the ...Computed tomography has been proven to be useful for non-destructive inspection of structures and materials. We build a three-dimensional imaging system with the photonically generated incoherent noise source and the Schottky barrier diode detector in the terahertz frequency band （90–140GHz）. Based on the computed tomography technique, the three-dimensional image of a ceramic sample is reconstructed successfully by stacking the slices at different heights. The imaging results not only indicate the ability of terahertz wave in the non-invasive sensing and non-destructive inspection applications, but also prove the effectiveness and superiority of the uni-traveling-carrier photodiode as a terahertz source in the imaging applications.展开更多
BACKGROUND Neurovascular compression(NVC) is the main cause of primary trigeminal neuralgia(TN) and hemifacial spasm(HFS). Microvascular decompression(MVD) is an effective surgical method for the treatment of TN and H...BACKGROUND Neurovascular compression(NVC) is the main cause of primary trigeminal neuralgia(TN) and hemifacial spasm(HFS). Microvascular decompression(MVD) is an effective surgical method for the treatment of TN and HFS caused by NVC. The judgement of NVC is a critical step in the preoperative evaluation of MVD, which is related to the effect of MVD treatment. Magnetic resonance imaging(MRI) technology has been used to detect NVC prior to MVD for several years. Among many MRI sequences, three-dimensional time-of-flight magnetic resonance angiography(3D TOF MRA) is the most widely used. However, 3D TOF MRA has some shortcomings in detecting NVC. Therefore, 3D TOF MRA combined with high resolution T2-weighted imaging(HR T2WI) is considered to be a more effective method to detect NVC.AIM To determine the value of 3D TOF MRA combined with HR T2WI in the judgment of NVC, and thus to assess its value in the preoperative evaluation of MVD.METHODS Related studies published from inception to September 2022 based on PubMed, Embase, Web of Science, and the Cochrane Library were retrieved. Studies that investigated 3D TOF MRA combined with HR T2WI to judge NVC in patients with TN or HFS were included according to the inclusion criteria. Studies without complete data or not relevant to the research topics were excluded. The Quality Assessment of Diagnostic Accuracy Studies checklist was used to assess the quality of included studies. The publication bias of the included literature was examined by Deeks’ test. An exact binomial rendition of the bivariate mixed-effects regression model was used to synthesize data. Data analysis was performed using the MIDAS module of statistical software Stata 16.0. Two independent investigators extracted patient and study characteristics, and discrepancies were resolved by consensus. Individual and pooled sensitivities and specificities were calculated. The I_(2) statistic and Q test were used to test heterogeneity. The study was registered on the website of PROSERO(registration No. CRD42022357158).RESULTS Our search identified 595 articles, of which 12(including 855 patients) fulfilled the inclusion criteria. Bivariate analysis showed that the pooled sensitivity and specificity of 3D TOF MRA combined with HR T2WI for detecting NVC were 0.96 [95% confidence interval(CI): 0.92-0.98] and 0.92(95%CI: 0.74-0.98), respectively. The pooled positive likelihood ratio was 12.4(95%CI: 3.2-47.8), pooled negative likelihood ratio was 0.04(95%CI: 0.02-0.09), and pooled diagnostic odds ratio was 283(95%CI: 50-1620). The area under the receiver operating characteristic curve was 0.98(95%CI: 0.97-0.99). The studies showed no substantial heterogeneity(I2 = 0, Q = 0.001 P = 0.50).CONCLUSION Our results suggest that 3D TOF MRA combined with HR T2WI has excellent sensitivity and specificity for judging NVC in patients with TN or HFS. This method can be used as an effective tool for preoperative evaluation of MVD.展开更多
With regard to problems in conventional synthetic aperture radar （SAR）, such as imaging distortion, beam limitation and failure in acquiring three-dimensional （3-D） information, a downward-looking 3-D imaging meth...With regard to problems in conventional synthetic aperture radar （SAR）, such as imaging distortion, beam limitation and failure in acquiring three-dimensional （3-D） information, a downward-looking 3-D imaging method based on frequency modulated continuous wave （FMCW） and digital beamforming （DBF） technology for airborne SAR is presented in this study. Downward-looking 3-D SAR signal model is established first, followed by introduction of virtual antenna optimization factor and discussion of equivalent-phase-center compensation. Then, compensation method is provided according to reside video phase （RVP） and slope term for FMCW SAR. As multiple receiving antennas are applied to downward-looking 3-D imaging SAR, range cell migration correction （RCMC） turns to be more complex, and corrective measures are proposed. In addition, DBF technology is applied in realizing cross-track resolution. Finally, to validate the proposed method, magnitude of slice, peak sidelobe ratio （PSLR）, integrated sidelobe ratio （ISLR） and two-dimensional （2-D） contour plot of impulse response function （IRF） of point target in three dimensions are demonstrated. Satisfactory performances are shown by simulation results.展开更多
Conventional fabrication methods lack the ability to control both macro- and micro-structures of generated scaffolds. Three-dimensional printing is a solid free-form fabrication method that provides novel ways to crea...Conventional fabrication methods lack the ability to control both macro- and micro-structures of generated scaffolds. Three-dimensional printing is a solid free-form fabrication method that provides novel ways to create customized scaffolds with high precision and accuracy. In this study, an electrically controlled cortical impactor was used to induce randomized brain tissue defects. The overall shape of scaffolds was designed using rat-specific anatomical data obtained from magnetic resonance imaging, and the internal structure was created by computer- aided design. As the result of limitations arising from insufficient resolution of the manufacturing process, we magnified the size of the cavity model prototype five-fold to successfully fabricate customized collagen-chitosan scaffolds using three-dimensional printing. Results demonstrated that scaffolds have three-dimensional porous structures, high porosity, highly specific surface areas, pore connectivity and good internal characteristics. Neural stem cells co-cultured with scaffolds showed good viability, indicating good biocompatibility and biodegradability. This technique may be a promising new strategy for regenerating complex damaged brain tissues, and helps pave the way toward personalized medicine.展开更多
Large field-of-view（FoV） three-dimensional（3 D） photon-counting imaging is demonstrated with a single-pixel single-photon detector based on a Geiger-mode Si-avalanche photodiode. By removing the collecting lens（C...Large field-of-view（FoV） three-dimensional（3 D） photon-counting imaging is demonstrated with a single-pixel single-photon detector based on a Geiger-mode Si-avalanche photodiode. By removing the collecting lens（CL）before the detector, the FoV is expanded to ±10°. Thanks to the high detection efficiency, the signal-to-noise ratio of the imaging system is as high as 7.8 dB even without the CL when the average output laser pulse energy is about 0.45 pJ/pulse for imaging the targets at a distance of 5 m. A 3 D image overlaid with the reflectivity data is obtained according to the photon-counting time-of-flight measurement and the return photon intensity.展开更多
基金sponsored by the National Major Project(No.2016ZX05014-001)the National Natural Science Foundation of China(No.41172130 and U1403191)the Fundamental Research Funds for the Central Universities(No.2-9-2015-209)
文摘Borehole-to-surface electrical imaging （BSEI） uses a line source and a point source to generate a stable electric field in the ground. In order to study the surface potential of anomalies, three-dimensional forward modeling of point and line sources was conducted by using the finite-difference method and the incomplete Cholesky conjugate gradient （ICCG） method. Then, the damping least square method was used in the 3D inversion of the formation resistivity data. Several geological models were considered in the forward modeling and inversion. The forward modeling results suggest that the potentials generated by the two sources have different surface signatures. The inversion data suggest that the low- resistivity anomaly is outlined better than the high-resistivity anomaly. Moreover, when the point source is under the anomaly, the resistivity anomaly boundaries are better outlined than when using a line source.
基金supported by the National Natural Science Foundation of China(Grant No.82151302)the National High Level Hospital Clinical Research Funding(Grant No.2022-PUMCH-B-113)+1 种基金the National High Level Hospital Clinical Research Funding(Grant No.2022-PUMCH-A-019)the CAMS Innovation Fund for Medical Sciences(Grant No.2021-12M-1-014).
文摘Achieving high-resolution intracranial imaging in a safe and portable manner is critical for the diagnosis of intracranial diseases,preoperative planning of craniotomies and intraoperative management during craniotomy procedures.Adaptive waveform inversion(AWI),a variant of full waveform inversion(FWI),has shown potential in intracranial ultrasound imaging.However,the robustness of AWI is affected by the parameterization of the Gaussian penalty matrix and the challenges posed by transcranial scenarios.Conventional AWI struggles to produce accurate images in these cases,limiting its application in critical medical settings.To address these issues,we propose a stabilized adaptive waveform inversion(SAWI)method,which introduces a user-defined zero-lag position for theWiener filter.Numerical experiments demonstrate that SAWI can achieve accurate imaging under Gaussian penalty matrix parameter settings where AWI fails,perform successful transcranial imaging in configurations where AWI cannot,and maintain the same imaging accuracy as AWI.The advantage of this method is that it achieves these advancements without modifying the AWI framework or increasing computational costs,which helps to promote the application of AWI in medical fields,particularly in transcranial scenarios.
文摘BACKGROUND Hepatobiliary surgery is complex and requires a thorough understanding of the liver’s anatomy,biliary system,and vasculature.Traditional imaging methods such as computed tomography(CT)and magnetic resonance imaging(MRI),although helpful,fail to provide three-dimensional(3D)relationships of these structures,which are critical for planning and executing complicated surgeries.AIM To explore the use of 3D imaging and virtual surgical planning(VSP)technologies to improve surgical accuracy,reduce complications,and enhance patient recovery in hepatobiliary surgeries.METHODS A comprehensive review of studies published between 2017 and 2024 was conducted through PubMed,Scopus,Google Scholar,and Web of Science.Studies selected focused on 3D imaging and VSP applications in hepatobiliary surgery,assessing surgical precision,complications,and patient outcomes.Thirty studies,including randomized controlled trials,cohort studies,and case reports,were included in the final analysis.RESULTS Various 3D imaging modalities,including multidetector CT,MRI,and 3D rotational angiography,provide high-resolution views of the liver’s vascular and biliary anatomy.VSP allows surgeons to simulate complex surgeries,improving preoperative planning and reducing complications like bleeding and bile leaks.Several studies have demonstrated improved surgical precision,reduced complications,and faster recovery times when 3D imaging and VSP were used in complex surgeries.CONCLUSION 3D imaging and VSP technologies significantly enhance the accuracy and outcomes of hepatobiliary surgeries by providing individualized preoperative planning.While promising,further research,particularly randomized controlled trials,is needed to standardize protocols and evaluate long-term efficacy.
文摘BACKGROUND Back pain and sciatica are common complaints that often require imaging for accurate diagnosis and management.Conventional lumbar magnetic resonance imaging(MRI)protocols typically include sagittal and axial T1 and T2 sequences;however,these may miss certain pathologies.The addition of coronal short tau inversion recovery(STIR)sequences offers the potential to enhance the detection of both spinal and extra-spinal abnormalities,thereby improving clinical decisionmaking and patient outcomes.AIM To evaluate the impact of adding coronal STIR sequences to routine lumbar MRI in diagnosing back pain and sciatica.METHODS We prospectively analyzed data from patients aged 6 and older presenting with back pain or sciatica who underwent lumbar spine MRI at our institution.The standardized MRI protocol utilized included sagittal and axial T1 and T2 sequences,complemented by a coronal STIR sequence.Data on structural abnormalities were collected,reviewed,and analyzed using counts,percentages,and Fisher's exact test for categorical variables.RESULTS Our cohort comprised 274 patients(115 males,159 females;mean age 44.91 years).Notably,39 patients exhibited abnormalities across all sequences,while 72.63%showed normal findings on the coronal STIR sequence.Importantly,30.29%of cases were diagnosed as normal without the coronal STIR,and 36 patients with normal T1 and T2 sequences presented abnormalities on the coronal STIR.The coronal STIR sequence successfully identified 26 spinal and 10 non-spinal pathologies,including 17 cases of sacroiliitis,with a significant association(P<0.0001)between sacroiliitis diagnosis and abnormalities visible solely on this sequence.CONCLUSION Integrating coronal STIR into routine lumbar MRI enhances detection of hidden spinal and extra-spinal pathologies,improves patient management,and offers a cost-effective,practical upgrade with significant diagnostic and clinical value.
基金supported by the National Natural Science Foundation of China(Grant No.41374118)the Research Fund for the Higher Education Doctoral Program of China(Grant No.20120162110015)+3 种基金the China Postdoctoral Science Foundation(Grant No.2015M580700)the Hunan Provincial Natural Science Foundation,the China(Grant No.2016JJ3086)the Hunan Provincial Science and Technology Program,China(Grant No.2015JC3067)the Scientific Research Fund of Hunan Provincial Education Department,China(Grant No.15B138)
文摘Conventional artificial neural networks used to solve electrical resistivity imaging （ERI） inversion problem suffer from overfitting and local minima. To solve these problems, we propose to use a pruning Bayesian neural network （PBNN） nonlinear inversion method and a sample design method based on the K-medoids clustering algorithm. In the sample design method, the training samples of the neural network are designed according to the prior information provided by the K-medoids clustering results; thus, the training process of the neural network is well guided. The proposed PBNN, based on Bayesian regularization, is used to select the hidden layer structure by assessing the effect of each hidden neuron to the inversion results. Then, the hyperparameter αk, which is based on the generalized mean, is chosen to guide the pruning process according to the prior distribution of the training samples under the small-sample condition. The proposed algorithm is more efficient than other common adaptive regularization methods in geophysics. The inversion of synthetic data and field data suggests that the proposed method suppresses the noise in the neural network training stage and enhances the generalization. The inversion results with the proposed method are better than those of the BPNN, RBFNN, and RRBFNN inversion methods as well as the conventional least squares inversion.
基金supported by the Development of airborne gravity gradiometer(No.2017YFC0601601)open subject of Key Laboratory of Petroleum Resources Research,Institute of Geology and Geophysics,Chinese Academy of Sciences(No.KLOR2018-8)
文摘This research proposes a novel three-dimensional gravity inversion based on sparse recovery in compress sensing. Zero norm is selected as the objective function, which is then iteratively solved by the approximate zero norm solution. The inversion approach mainly employs forward modeling; a depth weight function is introduced into the objective function of the zero norms. Sparse inversion results are obtained by the corresponding optimal mathematical method. To achieve the practical geophysical and geological significance of the results, penalty function is applied to constrain the density values. Results obtained by proposed provide clear boundary depth and density contrast distribution information. The method's accuracy, validity, and reliability are verified by comparing its results with those of synthetic models. To further explain its reliability, a practical gravity data is obtained for a region in Texas, USA is applied. Inversion results for this region are compared with those of previous studies, including a research of logging data in the same area. The depth of salt dome obtained by the inversion method is 4.2 km, which is in good agreement with the 4.4 km value from the logging data. From this, the practicality of the inversion method is also validated.
基金co-supported by the China Geological Survey Project(DD20190012 and DD20160082)
文摘Funded by The National Key Research and Development Program of China,China Deep Exploration(Sinoprobe)and The China Geological Suvery Project on 2009–2019,a large scale magnetotelluric sounding(MT)survey grid(Fig.1)has covered whole south China.
文摘Perianal abscess is a common disease in anorectal surgery. If the diagnosis is not clear and the cure is thoroughly cleared, the recurrence and spread of anal fistula will cause life-long pain. Objective: To investigate the application of 3.0T MRI 3D CUBE T2WI lipid suppression sequence in the diagnosis of perianal abscess. Methods: Thirty-six patients with perianal abscess confirmed by operation were examined with 2D T2WI and 3D CUBE T2WI lipid suppression sequences before operation. Two imaging techniques were evaluated to show the types of perianal abscess, the number of abscesses, the number of internal orifices of abscess, and the number of fistula branches with anal fistula in abscess. Results: Among 36 cases of perianal abscess, there were 5 cases of anal subcutaneous abscess, 12 cases of ischiorectal space abscess (8 cases complicated with anal fistula), 6 cases of posterior anal space abscess, 5 cases of anal sphincter abscess (3 cases complicated with anal fistula), 2 cases of high intermuscular abscess, 2 cases of rectal submucosal abscess, 3 cases of complex abscess (3 cases complicated with anal fistula), 1 case of misdiagnosis, 2D T2WI lipid suppression sequence and 3D CUBE T2WI suppression. The accuracy of lipid sequence abscess typing was 80.6% (29/36) and 88.9% (32/36), respectively, with no significant difference (P > 0.05). Thirty-six patients were surgically diagnosed as having 32 internal orifices, 68.8% (22/32) and 93.8% (30/32) of 2D T2WI and 3D CUBE T2WI lipid-suppressing sequences, respectively, with significant difference (P Conclusion: 3D CUBE T2WI lipid suppression sequence is superior to 2D T2WI lipid suppression sequence in the classification of perianal abscess, the number of internal orifices of abscess and the number of fistula branches of abscess complicated with anal fistula. It can also determine the number of internal orifices of abscess complicated with anal fistula, the number of fistula branches, the shape of primary and branch fistula and the relationship among pelvic floor muscle tissues. It can provide more accurate images for preoperative and intraoperative clinical surgery.
文摘Late gadolinium enhancement(LGE) cardiovascular magnetic resonance(CMR) is the gold standard for imaging myocardial viability.An important application of LGE CMR is the assessment of the location and extent of the myocardial scar in patients with ventricular tachycardia(VT), which allows for more accurate identification of the ablation targets.However, a large percentage of patients with VT have cardiac implantable electronic devices(CIEDs), which is a relative contraindication for cardiac magnetic resonance imaging due to safety and image artifact concerns.Previous studies showed that these patients can be safely scanned on 1.5 T scanners provided that an adequate imaging protocol is adopted.Nevertheless, imaging patients with a CIED result in metal artifacts due to the strong frequency off-resonance effects near the device; therefore, the spins in the surrounding myocardium are not completely inverted, and thus give rise to hyperintensity artifacts.These artifacts obscure the myocardial scar tissue and limit the ability to study the correlation between the myocardial scar structure and the electro-anatomical map during catheter ablation.In this study, we developed a modified inversion recovery technique to alleviate the CIED-induced metal artifacts and improve the diagnostic image quality of LGE images in patients with CIEDs without increasing scan time or requiring additional hardware.The developed technique was tested in phantom experiments and in vivo scans, which showed its capability for suppressing the hyperintensity artifacts without compromising myocardium nulling in the resulting LGE images.
基金supported by the Key Laboratory of Geological Survey and Evaluation of Ministry of Education (China University of Geosciences)(No. GLAB2020ZR13)
文摘The gravity inversion is to restore genetic density distribution of the underground target to be explored for explaining the internal structure and distribution of the Earth.In this paper,we propose a new 3D gravity inversion method based on 3D U-Net++.Compared with two-dimensional gravity inversion,three-dimensional(3D)gravity inversion can more precisely describe the density distribution of underground space.However,conventional 3D gravity inversion method input is two-dimensional,the input and output of the network proposed in our method are three-dimensional.In the training stage,we design a large number of diversifi ed simulation model-data pairs by using the random walk method to improve the generalization ability of the network.In the test phase,we verify the network performance by using the model-data pairs generated by the simulation.To further illustrate the eff ectiveness of the algorithm,we apply the method to the inversion of the San Nicolas mining area,and the inversion results are basically consistent with the borehole measurement results.Moreover,the results of the 3D U-Net++inversion and the 3D U-Net inversion are compared.The density models of the 3D U-Net++inversion have higher resolution,more concentrated inversion results,and a clearer boundary of the density model.
基金supported by the Joint Fund of Seismological Science(Grant No.U1839206)the National R&D Program on Monitoring,Early Warning and Prevention of Major Natural Disaster(Grant No.2017YFC1500301)+2 种基金supported by IGGCAS Research Start-up Funds(Grant No.E0515402)National Natural Science Foundation of China(Grant No.E1115401)supported by National Natural Science Foundation of China(Grant No.11971258).
文摘The nearly analytic discrete(NAD)method is a kind of finite difference method with advantages of high accuracy and stability.Previous studies have investigated the NAD method for simulating wave propagation in the time-domain.This study applies the NAD method to solving three-dimensional(3D)acoustic wave equations in the frequency-domain.This forward modeling approach is then used as the“engine”for implementing 3D frequency-domain full waveform inversion(FWI).In the numerical modeling experiments,synthetic examples are first given to show the superiority of the NAD method in forward modeling compared with traditional finite difference methods.Synthetic 3D frequency-domain FWI experiments are then carried out to examine the effectiveness of the proposed methods.The inversion results show that the NAD method is more suitable than traditional methods,in terms of computational cost and stability,for 3D frequency-domain FWI,and represents an effective approach for inversion of subsurface model structures.
文摘The diagnosis of the recurrent optic neuritis is commonly established clinically,and sometimes it could be challenging because the involved optic nerve does not always show significant enhancement on conventional contrast enhanced-T1 weighted imaging（CE-T1W1）.In this paper,we reported a middle-aged female with early diagnosis of recurrent optic neuritis using contrast-enhanced T2 fluid-attenuated inversion recovery imaging（CET2FLAIR）.The involved optic nerve presented evident enhancement on CE-T2FLAIR and no enhancement on CE-T1W1.This case suggested that the CE-T2FLAIR may be a useful diagnostic tool specifically for the recurrent optic neuritis in clinical practice.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11827808,11874289,and 11804056)the National Science Fund for Distinguished Young Scholars of China(Grant No.11525416)+3 种基金Shanghai Municipal Science and Technology Major Project,China(Grant No.2017SHZDZX01)Shanghai Talent Development Fund(Grant No.2018112)State Key Laboratory of ASIC and System Project(Grant No.2018MS004)China Postdoctoral Science Foundation(Grant No.2019M661334)。
文摘The main challenge in bone ultrasound imaging is the large acoustic impedance contrast and sound velocity differences between the bone and surrounding soft tissue. It is difficult for conventional pulse-echo modalities to give accurate ultrasound images for irregular bone boundaries and microstructures using uniform sound velocity assumption rather than getting a prior knowledge of sound speed. To overcome these limitations, this paper proposed a frequency-domain fullwaveform inversion(FDFWI) algorithm for bone quantitative imaging utilizing ultrasonic computed tomography(USCT).The forward model was calculated in the frequency domain by solving the full-wave equation. The inverse problem was solved iteratively from low to high discrete frequency components via minimizing a cost function between the modeled and measured data. A quasi-Newton method called the limited-memory Broyden–Fletcher–Goldfarb–Shanno algorithm(L-BFGS) was utilized in the optimization process. Then, bone images were obtained based on the estimation of the velocity and density. The performance of the proposed method was verified by numerical examples, from tubular bone phantom to single distal fibula model, and finally with a distal tibia-fibula pair model. Compared with the high-resolution peripheral quantitative computed tomography(HR-p QCT), the proposed FDFWI can also clearly and accurately presented the wavelength scaled pores and trabeculae in bone images. The results proved that the FDFWI is capable of reconstructing high-resolution ultrasound bone images with sub-millimeter resolution. The parametric bone images may have the potential for the diagnosis of bone disease.
文摘The recently introduced real-time three-dimensional color Doppler flow imaging （RT-3D CDFI） technique provides a quick and accurate calculation of regurgitant jet volume （RJV） and fraction. In order to evaluate RT-3D CDFI in the noninvasive assessment of aortic RJV and regurgitant jet fraction （RJF） in patients with isolated aortic regurgitation, real-time three-dimensional echocardiographic studies were performed on 23 patients with isolated aortic regurgitation to obtain LV end-diastolic volumes （LVEDV）, end-systolic volumes （LVESV） and RJV, and then RJF could be calculated. The regurgitant volume （RV） and regurgitant fraction （RF） calculated by two-dimensional pulsed Doppler （2D-PD） method served as reference values. The results showed that aortic RJV measured by the RT-3D CDFI method showed a good correlation with the 2D-PD measurements （r= 0.93, Y=0.89X＋ 3.9, SEE= 8.6 mL, P〈0.001 ）; the mean （SD） difference between the two methods was - 1.5 （9.8） mL. % RJF estimated by the RT-3D CDFI method was also correlated well with the values obtained by the 2D-PD method （r=0.88, Y=0.71X＋ 14.8, SEE= 6.4 %, P〈0. 001）; the mean （SD） difference between the two methods was -1.2 （7.9） %. It was suggested that the newly developed RT-3D CDFI technique was feasible in the majority of patients. In patients with eccentric aortic regurgitation, this new modality provides additional information to that obtained from the two-dimensional examination, which overcomes the inherent limitations of two-dimensional echocardiography by depicting the full extent of the jet trajectory. In addition, the RT-3D CDFI method is quick and accurate in calculating RJV and RJF.
文摘Summary： This study sought to evaluate the contribution of two-dimensional ultrasound （2D-US） and three-dimensional skeletal imaging ultrasound （3D-SUIS） in the prenatal diagnosis of sirenomelia. Be- tween September 2010 and April 2014, a prospective study was conducted in a single referral center using 3D-SU1S performed after 2D-US in 10 cases of sirenomelia. Diagnostic accuracy and detailed findings were compared with postnatal three-dimensional helical computed tomography （3D-HCT）, radiological findings and autopsy. Pregnancy was terminated in all 10 sirenomelia cases, including 9 singletons and I conjoined twin pregnancy, for a total of 5 males and 5 females. These cases of sirenomelia were deter- mined by autopsy and/or chromosomal examination. Initial 2D-US showed that there were 10 cases of oligohydranmios, bilateral renal agenesis, bladder agenesis, single umbilical artery, fusion of the lower limbs and spinal abnormalities; 8 cases of dipus or monopus; 2 cases of apus; and 8 cases of cardiac abnormalities. Subsequent 3D-SUIS showed that there were 9 cases of scoliosis, l0 cases of sacrococ- cygeal vertebra dysplasia, 3 cases of hemivertebra, 1 case of vertebral fusion, 3 cases of spina bifida, and 5 cases of rib abnormalities. 3D-SUIS identified significantly more skeletal abnormalities than did 2D-US, and its accuracy was 79.5% （70/88） compared with 3D-HCT and radiography. 3D-SUIS seems to be a useful complementary method to 2D-US and may improve the accuracy of identifying prenatal skeletal abnormalities related to sirenomelia.
基金Supported by the Hundred Talents Program of Chinese Academy of Sciencesthe National Basic Research Program of China under Grant No 2014CB339803+2 种基金the Major National Development Project of Scientific Instrument and Equipment under Grant No2011YQ150021the National Natural Science Foundation of China under Grant Nos 61575214,61574155,61404149 and 61404150the Shanghai Municipal Commission of Science and Technology under Grant Nos 14530711300,15560722000 and 15ZR1447500
文摘Computed tomography has been proven to be useful for non-destructive inspection of structures and materials. We build a three-dimensional imaging system with the photonically generated incoherent noise source and the Schottky barrier diode detector in the terahertz frequency band （90–140GHz）. Based on the computed tomography technique, the three-dimensional image of a ceramic sample is reconstructed successfully by stacking the slices at different heights. The imaging results not only indicate the ability of terahertz wave in the non-invasive sensing and non-destructive inspection applications, but also prove the effectiveness and superiority of the uni-traveling-carrier photodiode as a terahertz source in the imaging applications.
基金Supported by the Key Research and Development Plan of Shaanxi Province,No.2021SF-298.
文摘BACKGROUND Neurovascular compression(NVC) is the main cause of primary trigeminal neuralgia(TN) and hemifacial spasm(HFS). Microvascular decompression(MVD) is an effective surgical method for the treatment of TN and HFS caused by NVC. The judgement of NVC is a critical step in the preoperative evaluation of MVD, which is related to the effect of MVD treatment. Magnetic resonance imaging(MRI) technology has been used to detect NVC prior to MVD for several years. Among many MRI sequences, three-dimensional time-of-flight magnetic resonance angiography(3D TOF MRA) is the most widely used. However, 3D TOF MRA has some shortcomings in detecting NVC. Therefore, 3D TOF MRA combined with high resolution T2-weighted imaging(HR T2WI) is considered to be a more effective method to detect NVC.AIM To determine the value of 3D TOF MRA combined with HR T2WI in the judgment of NVC, and thus to assess its value in the preoperative evaluation of MVD.METHODS Related studies published from inception to September 2022 based on PubMed, Embase, Web of Science, and the Cochrane Library were retrieved. Studies that investigated 3D TOF MRA combined with HR T2WI to judge NVC in patients with TN or HFS were included according to the inclusion criteria. Studies without complete data or not relevant to the research topics were excluded. The Quality Assessment of Diagnostic Accuracy Studies checklist was used to assess the quality of included studies. The publication bias of the included literature was examined by Deeks’ test. An exact binomial rendition of the bivariate mixed-effects regression model was used to synthesize data. Data analysis was performed using the MIDAS module of statistical software Stata 16.0. Two independent investigators extracted patient and study characteristics, and discrepancies were resolved by consensus. Individual and pooled sensitivities and specificities were calculated. The I_(2) statistic and Q test were used to test heterogeneity. The study was registered on the website of PROSERO(registration No. CRD42022357158).RESULTS Our search identified 595 articles, of which 12(including 855 patients) fulfilled the inclusion criteria. Bivariate analysis showed that the pooled sensitivity and specificity of 3D TOF MRA combined with HR T2WI for detecting NVC were 0.96 [95% confidence interval(CI): 0.92-0.98] and 0.92(95%CI: 0.74-0.98), respectively. The pooled positive likelihood ratio was 12.4(95%CI: 3.2-47.8), pooled negative likelihood ratio was 0.04(95%CI: 0.02-0.09), and pooled diagnostic odds ratio was 283(95%CI: 50-1620). The area under the receiver operating characteristic curve was 0.98(95%CI: 0.97-0.99). The studies showed no substantial heterogeneity(I2 = 0, Q = 0.001 P = 0.50).CONCLUSION Our results suggest that 3D TOF MRA combined with HR T2WI has excellent sensitivity and specificity for judging NVC in patients with TN or HFS. This method can be used as an effective tool for preoperative evaluation of MVD.
文摘With regard to problems in conventional synthetic aperture radar （SAR）, such as imaging distortion, beam limitation and failure in acquiring three-dimensional （3-D） information, a downward-looking 3-D imaging method based on frequency modulated continuous wave （FMCW） and digital beamforming （DBF） technology for airborne SAR is presented in this study. Downward-looking 3-D SAR signal model is established first, followed by introduction of virtual antenna optimization factor and discussion of equivalent-phase-center compensation. Then, compensation method is provided according to reside video phase （RVP） and slope term for FMCW SAR. As multiple receiving antennas are applied to downward-looking 3-D imaging SAR, range cell migration correction （RCMC） turns to be more complex, and corrective measures are proposed. In addition, DBF technology is applied in realizing cross-track resolution. Finally, to validate the proposed method, magnitude of slice, peak sidelobe ratio （PSLR）, integrated sidelobe ratio （ISLR） and two-dimensional （2-D） contour plot of impulse response function （IRF） of point target in three dimensions are demonstrated. Satisfactory performances are shown by simulation results.
基金supported by the National Natural Science Foundation of China,No.81301050,81401067,81271392,81471275,81541034the Natural Science Foundation of Tianjin City of China,No.14JCQNJC10200,15JCQNJC11100,16JCYBJC27600
文摘Conventional fabrication methods lack the ability to control both macro- and micro-structures of generated scaffolds. Three-dimensional printing is a solid free-form fabrication method that provides novel ways to create customized scaffolds with high precision and accuracy. In this study, an electrically controlled cortical impactor was used to induce randomized brain tissue defects. The overall shape of scaffolds was designed using rat-specific anatomical data obtained from magnetic resonance imaging, and the internal structure was created by computer- aided design. As the result of limitations arising from insufficient resolution of the manufacturing process, we magnified the size of the cavity model prototype five-fold to successfully fabricate customized collagen-chitosan scaffolds using three-dimensional printing. Results demonstrated that scaffolds have three-dimensional porous structures, high porosity, highly specific surface areas, pore connectivity and good internal characteristics. Neural stem cells co-cultured with scaffolds showed good viability, indicating good biocompatibility and biodegradability. This technique may be a promising new strategy for regenerating complex damaged brain tissues, and helps pave the way toward personalized medicine.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11774095,11722431 and 11621404the Shanghai Basic Research Project under Grant No 18JC1412200+2 种基金the National Key R&D Program of China under Grant No2016YFB0400904the Program of Introducing Talents of Discipline to Universities under Grant No B12024the Shanghai International Cooperation Project under Grant No 16520710600
文摘Large field-of-view（FoV） three-dimensional（3 D） photon-counting imaging is demonstrated with a single-pixel single-photon detector based on a Geiger-mode Si-avalanche photodiode. By removing the collecting lens（CL）before the detector, the FoV is expanded to ±10°. Thanks to the high detection efficiency, the signal-to-noise ratio of the imaging system is as high as 7.8 dB even without the CL when the average output laser pulse energy is about 0.45 pJ/pulse for imaging the targets at a distance of 5 m. A 3 D image overlaid with the reflectivity data is obtained according to the photon-counting time-of-flight measurement and the return photon intensity.
