The three-dimensional（3D） visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair ...The three-dimensional（3D） visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair nerve defects and in optimizing the construction of tissue-engineered nerve grafts. However, there remain major technical hurdles in obtaining, registering and interpreting 2D images, as well as in establishing 3D models. Moreover, the 3D models are plagued by poor accuracy and lack of detail and cannot completely reflect the stereoscopic microstructure inside the nerve. To explore and help resolve these key technical problems of 3D reconstruction, in the present study, we designed a novel method based on re-imaging techniques and computer image layer processing technology. A 20-cm ulnar nerve segment from the upper arm of a fresh adult cadaver was used for acetylcholinesterase（ACh E） staining. Then, 2D panoramic images were obtained before and after ACh E staining under the stereomicroscope. Using layer processing techniques in Photoshop, a space transformation method was used to fulfill automatic registration. The contours were outlined, and the 3D rendering of functional fascicular groups in the long-segment ulnar nerve was performed with Amira 4.1 software. The re-imaging technique based on layer processing in Photoshop produced an image that was detailed and accurate. The merging of images was accurate, and the whole procedure was simple and fast. The least square support vector machine was accurate, with an error rate of only 8.25%. The 3D reconstruction directly revealed changes in the fusion of different nerve functional fascicular groups. In conclusion. The technique is fast with satisfactory visual reconstruction.展开更多
A versatile and effective method for incorporating functional groups on the pore wall of three-dimensionally ordered macroporous cross-linked polystyrene（3DOM CLPS） by hydrophilic spacer arm has been investigated.Th...A versatile and effective method for incorporating functional groups on the pore wall of three-dimensionally ordered macroporous cross-linked polystyrene（3DOM CLPS） by hydrophilic spacer arm has been investigated.The 3DOM CLPS with pore size 865 nm was prepared by sacrifice template method.The hydrophilic spacer arm（polyethylene glycol,molecular weight is 600） was grafted to the 3DOM CLPS via nucleophilic substitution reaction.The other side of active hydroxyl can be further converted into a lot of other functional groups.In this report,the chelating ligand 2-mercaptobenzothiazole（MBZ） group was introduced on the end of the PGE chain to evidence the versatile functionalization approach.The functionalized ordered macroporous materials were characterized by FT-IR,element analyzer,SEM.The results reveal that the pores were successfully bonded with 2-mercaptobenzothiazole groups via hydrophilic spacer arms and the original morphology of ordered macroporous materials were remained after functionalization.The MBZ group density is 0.052 mmol/m^2.The functionalized 3DOM CLPS are expected to application as heavy metal ions adsorbent.展开更多
The singular hybrid boundary node method （SHBNM） is proposed for solving three-dimensional problems in linear elasticity. The SHBNM represents a coupling between the hybrid displacement variational formulations and ...The singular hybrid boundary node method （SHBNM） is proposed for solving three-dimensional problems in linear elasticity. The SHBNM represents a coupling between the hybrid displacement variational formulations and moving least squares （MLS） approximation. The main idea is to reduce the dimensionality of the former and keep the meshless advantage of the later. The rigid movement method was employed to solve the hyper-singular integrations. The ＇boundary layer effect＇, which is the main drawback of the original Hybrid BNM, was overcome by an adaptive integration scheme. The source points of the fundamental solution were arranged directly on the boundary. Thus the uncertain scale factor taken in the regular hybrid boundary node method （RHBNM） can be avoided. Numerical examples for some 3D elastic problems were given to show the characteristics. The computation results obtained by the present method are in excellent agreement with the analytical solution. The parameters that influence the performance of this method were studied through the numerical examples.展开更多
A series of related electrophysiology phenomena can be caused by the occurrence of interpolated ventricular premature contraction.In our recent three-dimensional Lorenz R-R scatter plot research,we found that atrioven...A series of related electrophysiology phenomena can be caused by the occurrence of interpolated ventricular premature contraction.In our recent three-dimensional Lorenz R-R scatter plot research,we found that atrioventricular node double path caused by interpolated ventricular premature contraction imprints a specifi c pattern on three-dimensional Lorenz plots generated from 24-hour Holter recordings.We found two independent subclusters separated from the interpolated premature beat precluster,the interpolated premature beat cluster,and the interpolated premature beat postcluster,respectively.Combined with use of the trajectory tracking function and the leap phenomenon,our results reveal the presence of the atrioventricular node double conduction path.展开更多
BACKGROUND Accumulating studies indicated that maintain nuclei homeostasis was deemed to the protective factors for the occurrence of cancer.Thus,high-mobility group box 1(HMGB1)might influence the risk and poorer pro...BACKGROUND Accumulating studies indicated that maintain nuclei homeostasis was deemed to the protective factors for the occurrence of cancer.Thus,high-mobility group box 1(HMGB1)might influence the risk and poorer prognoses of colorectal cancer(CRC).AIM This study was designed to investigate whether HMGB1 polymorphisms influence the risk and lymph node metastasis(LNM)of CRC.METHODS Firstly,we designed an investigation with 1003 CRC patients and 1303 cancer-free controls to observe whether HMGB1 rs1412125 T>C and rs1045411 C>T SNPs could influence the risk of cancer.Subsequently,we carried out a correlation-analysis to assess whether these SNPs could alter the risk of LNM.RESULTS The current investigation suggested a relationship of HMGB1 rs1412125 SNP with the increased susceptibility of CRC.In a subgroup analysis,our findings suggested that this SNP could enhance an occurrence of CRC in≥61 years,non-drinker and body mass index<24 kg/m2 subgroups.However,we found that there was null association between HMGB1 rs1412125 SNP and LNM,even in different CRC region.These observations were confirmed by calculating the power value(more than 0.8).The association of HMGB1 rs1045411 C>T SNP with CRC risk and LNM was not found in any compare.CONCLUSION This study highlights a possible association between HMGB1 rs1412125 polymorphism and the increased risk of CRC.In the future,more studies should be conducted to explore HMGB1 rs1412125 polymorphism in relation to CRC development.展开更多
Two reported three-dimensional covalent organic frameworks(3D-COFs),COF-300 and COF-301,which have hierarchical porous structures and large pore volumes,were synthesized and employed as host materials for lithium-sulf...Two reported three-dimensional covalent organic frameworks(3D-COFs),COF-300 and COF-301,which have hierarchical porous structures and large pore volumes,were synthesized and employed as host materials for lithium-sulfur batteries.Owing to possessing excellent porosities as well as abundant hydroxyl groups in the pore walls,COF-301 can not only trap lithium polysulfides(PSs)via physical adsorption inside the pores,but also capture PSs by chemical interactions to relieve the shuttle effect.Interestingly,it is the first time that 3D-COFs were utilized as host materials for lithium-sulfur batteries as well as hydroxyl groups were introduced into COFs for improving the battery performance.As a result,COF-301@S as cathode material could reserve the capacity of 411.6 mA·h·g^-1 after 500 cycles with only 0.081%fading per cycle at 0.5 C,exhibiting better battery performance compared with COF-300@S.This study not only expands the applications of 3D-COFs but also provides a new route for designing lithium-sulfur batteries.展开更多
Based on the working of Lighthill and Hunt et al., in the present paper the author has established the topological rules adapting to analysing the skin-friction lines and the section streamlines in cascades. These rul...Based on the working of Lighthill and Hunt et al., in the present paper the author has established the topological rules adapting to analysing the skin-friction lines and the section streamlines in cascades. These rules are (1) for a rotor cascade without shroud band, the total number of nodal points equals that the saddle points on the skin-friction line vector fields in eachpitch range; (2) for an annular or straight cascade with no-clearances at blade ends, the total number of saddle points is two more than that of nodal points on the skin-friction line fields in a pitch; (3) the total number of saddles in the secondary flow fields on cross-sections in cascade is one less than that of nodes; (4) in the section streamline vector fields on a meridian surface penetrating a flow passage, and on leading and trailing edge sections, the total number of nodes is equal to that of saddles; (5) on the streamline vector fields of a blade-to-blade surface, the total number of nodes is one less than that of saddles.展开更多
Two hundred cates of nasopharyngeal carcinoma (NPC) admitted to this department from Feb. 1985 to May. 1988 were analysed according to the CT scanning and clinical findings of the primary lesions prior to radiotherapy...Two hundred cates of nasopharyngeal carcinoma (NPC) admitted to this department from Feb. 1985 to May. 1988 were analysed according to the CT scanning and clinical findings of the primary lesions prior to radiotherapy. The results showed that involvement of parapharyngeal space was very common in NPC, about 80% (160/200 cases) ; particularly unilateral or bilateral retro-styloid spaces, about 69.5% (139/200 cases). It was proposed that patients with NPC had a high Incidence of ipsilateral cervical node metastasis. Contralateral cervical node metastasis was rare. The development of cervical node metastasto in NPC has two modes: one Is direct Infiltration of the retro-stylold space by the lesion; the other Is along the nasopharyngeal lymphatic rete. The data also showed that patients with NPC who presented symptoms of Ⅸ- Ⅲ cranial nerve paralyses always had ipsilateral or bilateral retro- styloid space Infiltrations.展开更多
Many physical systems can be successfully modelled using equations that admit the soliton solutions.In addition,equations with soliton solutions have a significant mathematical structure.In this paper,we study and ana...Many physical systems can be successfully modelled using equations that admit the soliton solutions.In addition,equations with soliton solutions have a significant mathematical structure.In this paper,we study and analyze a three-dimensional soliton equation,which has applications in plasma physics and other nonlinear sciences such as fluid mechanics,atomic physics,biophysics,nonlinear optics,classical and quantum fields theories.Indeed,solitons and solitary waves have been observed in numerous situations and often dominate long-time behaviour.We perform symmetry reductions of the equation via the use of Lie group theory and then obtain analytic solutions through this technique for the very first time.Direct integration of the resulting ordinary differential equation is done which gives new analytic travelling wave solutions that consist of rational function,elliptic functions,elementary trigonometric and hyperbolic functions solutions of the equation.Besides,various solitonic solutions are secured with the use of a polynomial complete discriminant system and elementary integral technique.These solutions comprise dark soliton,doubly-periodic soliton,trigonometric soliton,explosive/blowup and singular solitons.We further exhibit the dynamics of the solutions with pictorial representations and discuss them.In conclusion,we contemplate conserved quantities for the equation under study via the standard multiplier approach in conjunction with the homotopy integral formula.We state here categorically and emphatically that all results found in this study as far as we know have not been earlier obtained and so are new.展开更多
功能超网络广泛地应用于脑疾病诊断和分类研究中,而现有的关于超网络创建的研究缺乏解释分组效应的能力或者仅考虑到脑区间组级的信息,这样构建的脑功能超网络会丢失一些有用的连接或包含一些虚假的信息,因此,考虑到脑区间的组结构问题...功能超网络广泛地应用于脑疾病诊断和分类研究中,而现有的关于超网络创建的研究缺乏解释分组效应的能力或者仅考虑到脑区间组级的信息,这样构建的脑功能超网络会丢失一些有用的连接或包含一些虚假的信息,因此,考虑到脑区间的组结构问题,引入sparse group Lasso(sgLasso)方法进一步改善超网络的创建。首先,利用sgLasso方法进行超网络创建;然后,引入两组超网络特有的属性指标进行特征提取以及特征选择,这些指标分别是基于单一节点的聚类系数和基于一对节点的聚类系数;最后,将特征选择后得到的两组有显著差异的特征通过多核学习进行特征融合和分类。实验结果表明,所提方法经过多特征融合取得了87.88%的分类准确率。该结果表明为了改善脑功能超网络的创建,需要考虑到组信息,但不能逼迫使用整组信息,可以适当地对组结构进行扩展。展开更多
An improved on-demand multicast routing protocol(ODMRP), node classification on-demand multicast routing protocol(NC-ODMRP), which is based on node classification in mobile ad hoc networks was proposed. NC-ODMRP class...An improved on-demand multicast routing protocol(ODMRP), node classification on-demand multicast routing protocol(NC-ODMRP), which is based on node classification in mobile ad hoc networks was proposed. NC-ODMRP classifies nodes into such three categories as ordinary node, forwarding group(FG) node, neighbor node of FG node according to their history forwarding information. The categories are distinguished with different weights by a weight table in the nodes. NC-ODMRP chooses the node with the highest weight as an FG node during the setup of forwarding group, which reduces a lot of redundant FG nodes by sharing more FG nodes between different sender and receiver pairs. The simulation results show that NC-ODMRP can reduce more than 20% FG number of ODMRP, thus enhances nearly 14% data forwarding efficiency and 12% energy consumption efficiency when the number of multicast senders is more than 5.展开更多
Nowadays, new paradigm of enterprise organization i s constantly changing due to the emergence of the global marketplace, the rise of information technology, and the emphasis of the social developments. This re quires...Nowadays, new paradigm of enterprise organization i s constantly changing due to the emergence of the global marketplace, the rise of information technology, and the emphasis of the social developments. This re quires a more flexible form of organization that are more adaptable to rapid cha nges in business environment such as autonomous work groups (AWGs) in order to achieve higher productivity and effectiveness. AWGs are work units responsib le for the production of goods and the provision of services. They involve team members in making decisions that are traditionally the responsibility of the sup ervisors and managers (Cohen & Bailey, 1997). Team members of AWGs are allowed t o self-regulate their behavior on jobs such as task assignments, methods for ca rrying out the work, and scheduling of activities etc. (Cohen & Ledford, 1994). For example, Motorola achieved a high organizational performance due to the succ essful implementation of AWGs in quality management (Piczak & Hauser, 1996). Xer ox also reported their operational successes based on the team-oriented work gr oups (Wageman, 1997). In recent years many organizations have replaced the traditional layers of manag ement with autonomous team-based work arrangements. Surveys indicated that the adoption of AWGs has soared in responding to the competitive business challenges . Many enterprises are making a deliberate effort to use AWGs to carry out work and operational processes as an alternative for hierarchical approaches (Lawler et al., 1995). There is a growing body of evidence that AWGs are more effective than traditionally managed groups and they contributes to organizational perform ance, such as improvement in operational performance, productivity, quality, cos t savings, employee attitude and behavior, and employee satisfaction (e.g. Pears on, 1992; Cohen & Ledford, 1994; Seers et al. 1995). Given the complexity and cognitive nature of team-based organizations, the mech anisms that the enterprises use in the development of the increasingly sophistic ated models, which can contribute to the effective functioning of AWGs, are extr emely important. The process of developing effective AWGs enables enterprises to inherent built-in intelligence of the organizations so that they will be more able to accommodate to external pressures and changes. The context of this paper is the construction of a dynamics framework and a stra tegic path for autonomous work groups in the technology-oriented manufacturing organization re-design. The framework is a conceptual one drawn from the litera ture survey. The importance of studying autonomous work groups for today’s manuf acturing organizations is claimed. Based on the General System Theory (GST), the characterization of AWGs is addressed. Three-dimensional domains such as t echnical content, service content, and relationship content are identified. A st rategic path is proposed to guide the organizations how the development of AWGs progresses at different levels of maturity that are associated with organization al effectiveness and performance. The utility of the model for AWGs is expected to provide technology-oriented organizations with a strategic path to achieve h igher organizational performance.展开更多
Objective: Exploring the clinical signification of high-mobility group box 1 protein(HMGB1) expression in infiltrating ductal carcinoma(IDC) breast tissue. Methods: The expression of HMGB1 protein in IDC breast tissue...Objective: Exploring the clinical signification of high-mobility group box 1 protein(HMGB1) expression in infiltrating ductal carcinoma(IDC) breast tissue. Methods: The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor 2(HER-2) were also analyzed. Results: Fortysix cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 expression(76.67%), statistical significance was observed between HMGB1 expression with clinical staging(P < 0.01), lymph node metastasis(P < 0.01), breast cancer ER(P < 0.05) and HER-2(P < 0.05), however same conclusion can not be drawn between HMGB1 with either size of tumour or PR expression(P > 0.05) in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion: It's promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis.展开更多
基金supported by the National Natural Science Foundation of China,No.30571913a grant from the Science and Technology Project of Guangdong Province of China,No.2013B010404019+1 种基金the Natural Science Foundation of Guangdong Province of China,No.9151008901000006the Medical Scientific Research Foundation of Guangdong Province of China,No.A2009173
文摘The three-dimensional（3D） visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair nerve defects and in optimizing the construction of tissue-engineered nerve grafts. However, there remain major technical hurdles in obtaining, registering and interpreting 2D images, as well as in establishing 3D models. Moreover, the 3D models are plagued by poor accuracy and lack of detail and cannot completely reflect the stereoscopic microstructure inside the nerve. To explore and help resolve these key technical problems of 3D reconstruction, in the present study, we designed a novel method based on re-imaging techniques and computer image layer processing technology. A 20-cm ulnar nerve segment from the upper arm of a fresh adult cadaver was used for acetylcholinesterase（ACh E） staining. Then, 2D panoramic images were obtained before and after ACh E staining under the stereomicroscope. Using layer processing techniques in Photoshop, a space transformation method was used to fulfill automatic registration. The contours were outlined, and the 3D rendering of functional fascicular groups in the long-segment ulnar nerve was performed with Amira 4.1 software. The re-imaging technique based on layer processing in Photoshop produced an image that was detailed and accurate. The merging of images was accurate, and the whole procedure was simple and fast. The least square support vector machine was accurate, with an error rate of only 8.25%. The 3D reconstruction directly revealed changes in the fusion of different nerve functional fascicular groups. In conclusion. The technique is fast with satisfactory visual reconstruction.
基金supported by National Natural Science Funds for Young Scholar(No.50903027)the Natural Science Foundation of Hebei Province(No.E2010000058)Education Department Science Research Plan of Hebei Province(No.2007307).
文摘A versatile and effective method for incorporating functional groups on the pore wall of three-dimensionally ordered macroporous cross-linked polystyrene（3DOM CLPS） by hydrophilic spacer arm has been investigated.The 3DOM CLPS with pore size 865 nm was prepared by sacrifice template method.The hydrophilic spacer arm（polyethylene glycol,molecular weight is 600） was grafted to the 3DOM CLPS via nucleophilic substitution reaction.The other side of active hydroxyl can be further converted into a lot of other functional groups.In this report,the chelating ligand 2-mercaptobenzothiazole（MBZ） group was introduced on the end of the PGE chain to evidence the versatile functionalization approach.The functionalized ordered macroporous materials were characterized by FT-IR,element analyzer,SEM.The results reveal that the pores were successfully bonded with 2-mercaptobenzothiazole groups via hydrophilic spacer arms and the original morphology of ordered macroporous materials were remained after functionalization.The MBZ group density is 0.052 mmol/m^2.The functionalized 3DOM CLPS are expected to application as heavy metal ions adsorbent.
基金Project supported by the Program of the Key Laboratory of Rock and Soil Mechanics of Chinese Academy of Sciences (No.Z110507)
文摘The singular hybrid boundary node method （SHBNM） is proposed for solving three-dimensional problems in linear elasticity. The SHBNM represents a coupling between the hybrid displacement variational formulations and moving least squares （MLS） approximation. The main idea is to reduce the dimensionality of the former and keep the meshless advantage of the later. The rigid movement method was employed to solve the hyper-singular integrations. The ＇boundary layer effect＇, which is the main drawback of the original Hybrid BNM, was overcome by an adaptive integration scheme. The source points of the fundamental solution were arranged directly on the boundary. Thus the uncertain scale factor taken in the regular hybrid boundary node method （RHBNM） can be avoided. Numerical examples for some 3D elastic problems were given to show the characteristics. The computation results obtained by the present method are in excellent agreement with the analytical solution. The parameters that influence the performance of this method were studied through the numerical examples.
文摘A series of related electrophysiology phenomena can be caused by the occurrence of interpolated ventricular premature contraction.In our recent three-dimensional Lorenz R-R scatter plot research,we found that atrioventricular node double path caused by interpolated ventricular premature contraction imprints a specifi c pattern on three-dimensional Lorenz plots generated from 24-hour Holter recordings.We found two independent subclusters separated from the interpolated premature beat precluster,the interpolated premature beat cluster,and the interpolated premature beat postcluster,respectively.Combined with use of the trajectory tracking function and the leap phenomenon,our results reveal the presence of the atrioventricular node double conduction path.
基金Supported by the Major Project of Changzhou Science and Technology Bureau,No.CJ20220255.
文摘BACKGROUND Accumulating studies indicated that maintain nuclei homeostasis was deemed to the protective factors for the occurrence of cancer.Thus,high-mobility group box 1(HMGB1)might influence the risk and poorer prognoses of colorectal cancer(CRC).AIM This study was designed to investigate whether HMGB1 polymorphisms influence the risk and lymph node metastasis(LNM)of CRC.METHODS Firstly,we designed an investigation with 1003 CRC patients and 1303 cancer-free controls to observe whether HMGB1 rs1412125 T>C and rs1045411 C>T SNPs could influence the risk of cancer.Subsequently,we carried out a correlation-analysis to assess whether these SNPs could alter the risk of LNM.RESULTS The current investigation suggested a relationship of HMGB1 rs1412125 SNP with the increased susceptibility of CRC.In a subgroup analysis,our findings suggested that this SNP could enhance an occurrence of CRC in≥61 years,non-drinker and body mass index<24 kg/m2 subgroups.However,we found that there was null association between HMGB1 rs1412125 SNP and LNM,even in different CRC region.These observations were confirmed by calculating the power value(more than 0.8).The association of HMGB1 rs1045411 C>T SNP with CRC risk and LNM was not found in any compare.CONCLUSION This study highlights a possible association between HMGB1 rs1412125 polymorphism and the increased risk of CRC.In the future,more studies should be conducted to explore HMGB1 rs1412125 polymorphism in relation to CRC development.
基金supported by the National Natural Science Foundation of China(Nos.21674026,21574032,51573125,51573147,51803149,51973155,and 51633007(the State Key Program))the Sino-German Center for Research Promotion(No.GZ1286)the Chinese Academy of Sciences(No.121D11KYSB20170031).
文摘Two reported three-dimensional covalent organic frameworks(3D-COFs),COF-300 and COF-301,which have hierarchical porous structures and large pore volumes,were synthesized and employed as host materials for lithium-sulfur batteries.Owing to possessing excellent porosities as well as abundant hydroxyl groups in the pore walls,COF-301 can not only trap lithium polysulfides(PSs)via physical adsorption inside the pores,but also capture PSs by chemical interactions to relieve the shuttle effect.Interestingly,it is the first time that 3D-COFs were utilized as host materials for lithium-sulfur batteries as well as hydroxyl groups were introduced into COFs for improving the battery performance.As a result,COF-301@S as cathode material could reserve the capacity of 411.6 mA·h·g^-1 after 500 cycles with only 0.081%fading per cycle at 0.5 C,exhibiting better battery performance compared with COF-300@S.This study not only expands the applications of 3D-COFs but also provides a new route for designing lithium-sulfur batteries.
文摘Based on the working of Lighthill and Hunt et al., in the present paper the author has established the topological rules adapting to analysing the skin-friction lines and the section streamlines in cascades. These rules are (1) for a rotor cascade without shroud band, the total number of nodal points equals that the saddle points on the skin-friction line vector fields in eachpitch range; (2) for an annular or straight cascade with no-clearances at blade ends, the total number of saddle points is two more than that of nodal points on the skin-friction line fields in a pitch; (3) the total number of saddles in the secondary flow fields on cross-sections in cascade is one less than that of nodes; (4) in the section streamline vector fields on a meridian surface penetrating a flow passage, and on leading and trailing edge sections, the total number of nodes is equal to that of saddles; (5) on the streamline vector fields of a blade-to-blade surface, the total number of nodes is one less than that of saddles.
文摘Two hundred cates of nasopharyngeal carcinoma (NPC) admitted to this department from Feb. 1985 to May. 1988 were analysed according to the CT scanning and clinical findings of the primary lesions prior to radiotherapy. The results showed that involvement of parapharyngeal space was very common in NPC, about 80% (160/200 cases) ; particularly unilateral or bilateral retro-styloid spaces, about 69.5% (139/200 cases). It was proposed that patients with NPC had a high Incidence of ipsilateral cervical node metastasis. Contralateral cervical node metastasis was rare. The development of cervical node metastasto in NPC has two modes: one Is direct Infiltration of the retro-stylold space by the lesion; the other Is along the nasopharyngeal lymphatic rete. The data also showed that patients with NPC who presented symptoms of Ⅸ- Ⅲ cranial nerve paralyses always had ipsilateral or bilateral retro- styloid space Infiltrations.
文摘Many physical systems can be successfully modelled using equations that admit the soliton solutions.In addition,equations with soliton solutions have a significant mathematical structure.In this paper,we study and analyze a three-dimensional soliton equation,which has applications in plasma physics and other nonlinear sciences such as fluid mechanics,atomic physics,biophysics,nonlinear optics,classical and quantum fields theories.Indeed,solitons and solitary waves have been observed in numerous situations and often dominate long-time behaviour.We perform symmetry reductions of the equation via the use of Lie group theory and then obtain analytic solutions through this technique for the very first time.Direct integration of the resulting ordinary differential equation is done which gives new analytic travelling wave solutions that consist of rational function,elliptic functions,elementary trigonometric and hyperbolic functions solutions of the equation.Besides,various solitonic solutions are secured with the use of a polynomial complete discriminant system and elementary integral technique.These solutions comprise dark soliton,doubly-periodic soliton,trigonometric soliton,explosive/blowup and singular solitons.We further exhibit the dynamics of the solutions with pictorial representations and discuss them.In conclusion,we contemplate conserved quantities for the equation under study via the standard multiplier approach in conjunction with the homotopy integral formula.We state here categorically and emphatically that all results found in this study as far as we know have not been earlier obtained and so are new.
文摘功能超网络广泛地应用于脑疾病诊断和分类研究中,而现有的关于超网络创建的研究缺乏解释分组效应的能力或者仅考虑到脑区间组级的信息,这样构建的脑功能超网络会丢失一些有用的连接或包含一些虚假的信息,因此,考虑到脑区间的组结构问题,引入sparse group Lasso(sgLasso)方法进一步改善超网络的创建。首先,利用sgLasso方法进行超网络创建;然后,引入两组超网络特有的属性指标进行特征提取以及特征选择,这些指标分别是基于单一节点的聚类系数和基于一对节点的聚类系数;最后,将特征选择后得到的两组有显著差异的特征通过多核学习进行特征融合和分类。实验结果表明,所提方法经过多特征融合取得了87.88%的分类准确率。该结果表明为了改善脑功能超网络的创建,需要考虑到组信息,但不能逼迫使用整组信息,可以适当地对组结构进行扩展。
基金Project(90304010) supported by the National Natural Science Foundation of China project supported by the NewCentury Excellent Talents in University
文摘An improved on-demand multicast routing protocol(ODMRP), node classification on-demand multicast routing protocol(NC-ODMRP), which is based on node classification in mobile ad hoc networks was proposed. NC-ODMRP classifies nodes into such three categories as ordinary node, forwarding group(FG) node, neighbor node of FG node according to their history forwarding information. The categories are distinguished with different weights by a weight table in the nodes. NC-ODMRP chooses the node with the highest weight as an FG node during the setup of forwarding group, which reduces a lot of redundant FG nodes by sharing more FG nodes between different sender and receiver pairs. The simulation results show that NC-ODMRP can reduce more than 20% FG number of ODMRP, thus enhances nearly 14% data forwarding efficiency and 12% energy consumption efficiency when the number of multicast senders is more than 5.
文摘Nowadays, new paradigm of enterprise organization i s constantly changing due to the emergence of the global marketplace, the rise of information technology, and the emphasis of the social developments. This re quires a more flexible form of organization that are more adaptable to rapid cha nges in business environment such as autonomous work groups (AWGs) in order to achieve higher productivity and effectiveness. AWGs are work units responsib le for the production of goods and the provision of services. They involve team members in making decisions that are traditionally the responsibility of the sup ervisors and managers (Cohen & Bailey, 1997). Team members of AWGs are allowed t o self-regulate their behavior on jobs such as task assignments, methods for ca rrying out the work, and scheduling of activities etc. (Cohen & Ledford, 1994). For example, Motorola achieved a high organizational performance due to the succ essful implementation of AWGs in quality management (Piczak & Hauser, 1996). Xer ox also reported their operational successes based on the team-oriented work gr oups (Wageman, 1997). In recent years many organizations have replaced the traditional layers of manag ement with autonomous team-based work arrangements. Surveys indicated that the adoption of AWGs has soared in responding to the competitive business challenges . Many enterprises are making a deliberate effort to use AWGs to carry out work and operational processes as an alternative for hierarchical approaches (Lawler et al., 1995). There is a growing body of evidence that AWGs are more effective than traditionally managed groups and they contributes to organizational perform ance, such as improvement in operational performance, productivity, quality, cos t savings, employee attitude and behavior, and employee satisfaction (e.g. Pears on, 1992; Cohen & Ledford, 1994; Seers et al. 1995). Given the complexity and cognitive nature of team-based organizations, the mech anisms that the enterprises use in the development of the increasingly sophistic ated models, which can contribute to the effective functioning of AWGs, are extr emely important. The process of developing effective AWGs enables enterprises to inherent built-in intelligence of the organizations so that they will be more able to accommodate to external pressures and changes. The context of this paper is the construction of a dynamics framework and a stra tegic path for autonomous work groups in the technology-oriented manufacturing organization re-design. The framework is a conceptual one drawn from the litera ture survey. The importance of studying autonomous work groups for today’s manuf acturing organizations is claimed. Based on the General System Theory (GST), the characterization of AWGs is addressed. Three-dimensional domains such as t echnical content, service content, and relationship content are identified. A st rategic path is proposed to guide the organizations how the development of AWGs progresses at different levels of maturity that are associated with organization al effectiveness and performance. The utility of the model for AWGs is expected to provide technology-oriented organizations with a strategic path to achieve h igher organizational performance.
基金Supported by a grant from the Innovation Foundation of Excellent Intellectuals in Henan Province(No.2109901)
文摘Objective: Exploring the clinical signification of high-mobility group box 1 protein(HMGB1) expression in infiltrating ductal carcinoma(IDC) breast tissue. Methods: The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor 2(HER-2) were also analyzed. Results: Fortysix cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 expression(76.67%), statistical significance was observed between HMGB1 expression with clinical staging(P < 0.01), lymph node metastasis(P < 0.01), breast cancer ER(P < 0.05) and HER-2(P < 0.05), however same conclusion can not be drawn between HMGB1 with either size of tumour or PR expression(P > 0.05) in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion: It's promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis.
