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Optimal orthogonal block designs for threecomponent symmetric general blending models in mixture experiment
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作者 Jiawei Bao Yu Tang 《Statistical Theory and Related Fields》 2026年第1期117-134,共18页
In mixture experiments,the observed response is determined by the relative proportions of the components,consequently rendering the experimental region a simplex.This paper focuses primarily on the optimal designs of ... In mixture experiments,the observed response is determined by the relative proportions of the components,consequently rendering the experimental region a simplex.This paper focuses primarily on the optimal designs of mixture experiments that involve process variables.Prior research has extensively delved into optimal orthogonal block designs for some classic mixture models with process variables.Based on the framework of general blending models,this paper proposes a class of symmetric linear mixture models,which can be regarded as a generalization of many existing ones.Under the orthogonal blocking conditions,orthogonal block designs are devised through Latin squares in the presence of process variables.TheD-,A-,and E-optimality criteria are utilized to obtain optimal designs at the boundary of the simplex in the case of 3 components.As the values of the exponents change,numerically derived optimal design points are presented to illustrate the pattern of their variations,and to verify the consistency of the results with previous research on some specific symmetric general blending models. 展开更多
关键词 Mixture experiments general blending models optimal designs orthogonal Latin squares block designs
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Improved method for modeling discrete segment surfaces in myopia control lens design
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作者 Dewen Cheng Yesheng Wang +4 位作者 Tong Yang Wenbin Wei Yabin Hu Weizhong Lan Yongtian Wang 《Advanced Photonics Nexus》 2026年第1期88-100,共13页
With increasing awareness of myopia control,various preventive methods have been developed.In recent decades,a range of specialized spectacle lenses utilizing optical interventions has been manufactured and widely ado... With increasing awareness of myopia control,various preventive methods have been developed.In recent decades,a range of specialized spectacle lenses utilizing optical interventions has been manufactured and widely adopted for myopia management.However,the underlying optical mechanisms of these lenses remain unclear,and there is a lack of simulation methods for pre-manufacturing analysis.Meanwhile,the structures of these lenses are becoming increasingly complex,even incorporating an aspheric segment array on a curved base.To address these challenges,we have developed an efficient,accurate,and flexible modeling method for simulating such lenses,along with an experimental setup for validation.We provide deeper insights into the optical mechanisms of these lenses and establish a convenient design framework that facilitates the development of optimized lens structures. 展开更多
关键词 optics modeling complex surface description optical design optical property myopia management optical measurement
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Teaching Design and Practical Research of the Food Nutrition and Health Course under the BOPPPS Teaching Model
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作者 Xiaohua HUANG 《Agricultural Biotechnology》 2026年第1期36-38,46,共4页
Guided by the"Healthy China 2030"strategy,improving national nutrition and health literacy has become a core task in public health system development.The National Nutrition Plan(2017-2030)explicitly calls fo... Guided by the"Healthy China 2030"strategy,improving national nutrition and health literacy has become a core task in public health system development.The National Nutrition Plan(2017-2030)explicitly calls for"strengthening the training of nutrition talents"and"promoting nutrition science education".As a key vehicle for this mission,the Food Nutrition and Health course in higher education urgently needs to address bottlenecks in traditional teaching,such as low knowledge application and transfer rates,insufficient student engagement,and ineffective guidance on healthy behaviors.The BOPPPS teaching model,with its structured design(Bridge-in,Objective,Pre-assessment,Participatory Learning,Post-assessment,Summary),effectively promotes the internalization of nutritional knowledge and the transformation into healthy behaviors among students by emphasizing practice-oriented teaching activities.In this study,focusing on this course,an in-depth exploration of curriculum teaching design was conducted based on the BOPPPS instructional model,aiming to deeply integrate the strategic objectives of Healthy China into the curriculum,and promote the transformation of nutritional knowledge into healthy decision-making ability.This study provides new insights for food and nutrition education. 展开更多
关键词 BOPPPS instructional model Food Nutrition and Health Teaching design
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Evaluation of bonded block models as a tool for support design in underground coal mines
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作者 Sankhaneel Sinha Gabriel Walton 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第3期1755-1767,共13页
The failure and collapse of coal pillar ribs represent a significant hazard in the mining industry,with the associated risk of fatalities and injuries anticipated to rise as mining operations advance to greater depths... The failure and collapse of coal pillar ribs represent a significant hazard in the mining industry,with the associated risk of fatalities and injuries anticipated to rise as mining operations advance to greater depths.The development of support guidelines through an enhanced understanding of pillar damage and rock–support interaction mechanisms is crucial to resolving this issue.Bonded block models(BBMs)represent a convenient tool for this purpose,as they can reasonably reproduce the rock fracturing process;however,it is not known to what extent this modeling technique can be applied to simulate pillar failure mechanisms and support interaction in anisotropic rock masses,such as coal.To bridge this gap in research,hypothetical coal pillar BBMs of different width-to-height ratios were developed and calibrated to match Mark–Bieniawski's pillar strength equation,along with a few other attributes from the literature(stress levels at the edge of pillars and the transition from brittle to strain-hardening behavior with increasing width-to-height ratio).Elongated blocks were employed to capture the anisotropic behavior of coal mass.With the reliability of the model established,a few different support patterns were evaluated to ensure that the outputs are broadly consistent with expectations.Finally,simulations of roadway development and additional mining activities were completed considering geo-mining conditions representative of underground coal mines in the USA.The good consistency between model response and expected behaviors per field observation demonstrates the potential of BBMs to be used as a support design tool. 展开更多
关键词 Bonded block model(BBM) Ground control Coal mining Anisotropic rock Support design
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A Decade of Soft Robotic Manipulators:Advances in Design,Modeling,Control,and Emerging Challenges
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作者 Elsayed Atif Aner Omar M.Shehata +1 位作者 Mohammed Ibrahim Awad Nancy E.ElHady 《Journal of Bionic Engineering》 2026年第1期55-98,共44页
Soft robotic manipulators represent a rapidly evolving field characterized by inherent compliance,adaptability,and safe interactions within unstructured environments.Over the past decade(2015-2025),significant advance... Soft robotic manipulators represent a rapidly evolving field characterized by inherent compliance,adaptability,and safe interactions within unstructured environments.Over the past decade(2015-2025),significant advancements have trans-formed their capabilities through novel designs inspired by biological systems,advanced modeling frameworks,sophisti-cated control strategies,and integration into diverse real-world applications.Recent innovations in multifunctional mate-rials and emerging actuation technologies have markedly expanded manipulator performance,reliability,and dexterity.Concurrently,developments in modeling have progressed from simplified geometric methods toward highly accurate physics-based and hybrid data-driven approaches,substantially improving real-time prediction and controllability.Coupled with these developments,adaptive and robust control strategies-including learning-based techniques-have enabled unprec-edented autonomy and precision in challenging application domains such as Minimally Invasive Surgery(MIS),precision agriculture,deep-sea exploration,disaster recovery,and space missions.Despite these remarkable strides,key challenges remain,notably regarding scalability,long-term material durability,robust integrated sensing,and standardized evaluation procedures.This review comprehensively synthesizes recent advances,critically evaluates state-of-the-art methodologies,and systematically identifies existing gaps to provide a clear roadmap and targeted research directions,guiding future developments toward the broader adoption and optimal utilization of soft robotic manipulators. 展开更多
关键词 Soft robotics Continuum manipulators Compliant actuation Smart functional materials modeling and control Bio-inspired design
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Automatic gating and riser system design and defect control for K4169 superalloy guide blade casting based on parametric 3D modeling-simulation integrated system
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作者 Le-chuan Li Ya-jun Yin +4 位作者 Bing-zheng Fan Guo-yan Shui Xiao-yuan Ji Jian-xin Zhou Lei Jin 《China Foundry》 2026年第1期20-30,共11页
Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical si... Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical simulation plays a significant role in quantitatively evaluating current processes and making targeted improvements,but its limitations lie in the inability to dynamically reflect the formation outcomes of castings under varying process conditions,making real-time adjustments to gating and riser designs challenging.In this study,an automated design model for gating and riser systems based on integrated parametric 3D modeling-simulation framework is proposed,which enhances the flexibility and usability of evaluating the casting process by simulation.Firstly,geometric feature extraction technology is employed to obtain the geometric information of the target casting.Based on this information,an automated design framework for gating and riser systems is established,incorporating multiple structural parameters for real-time process control.Subsequently,the simulation results for various structural parameters are analyzed,and the influence of these parameters on casting formation is thoroughly investigated.Finally,the optimal design scheme is generated and validated through experimental verification.Simulation analysis and experimental results show that using a larger gate neck(24 mm in side length) and external risers promotes a more uniform temperature distribution and a more stable flow state,effectively eliminating shrinkage cavities and enhancing process yield by 15%. 展开更多
关键词 numerical simulation automatic design investment casting parametric 3D modeling gating and riser system
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Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions 被引量:1
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作者 Chentong GAO Huiyu SUN +1 位作者 Jianping GU W.M.HUANG 《Applied Mathematics and Mechanics(English Edition)》 2025年第1期123-138,共16页
Currently,there are a limited number of dynamic models available for braided composite plates with large overall motions,despite the incorporation of three-dimensional(3D)braided composites into rotating blade compone... Currently,there are a limited number of dynamic models available for braided composite plates with large overall motions,despite the incorporation of three-dimensional(3D)braided composites into rotating blade components.In this paper,a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established.Based on Kirchhoff's plate assumptions,the displacement variables of the plate are expressed.By incorporating the braiding directions into the constitutive equation of the braided composites,the dynamic model of the plate considering braiding directions is obtained.The effects of the speeds,braiding directions,and braided angles on the responses of the plate with fixed-axis rotation and translational motion,respectively,are investigated.This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions.It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications. 展开更多
关键词 three-dimensional(3D)braided composite braiding direction composite thin plate large overall motion dynamic model
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Three-Dimensional Prospectivity Modeling of Jinshan Ag-Au Deposit,Southern China by Weights-of-Evidence
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作者 Fan Xiao Qiuming Cheng +1 位作者 Weisheng Hou Frederik P.Agterberg 《Journal of Earth Science》 2025年第5期2038-2057,共20页
To comprehensively utilize the valuable geological map,exploration profile,borehole,and geochemical logging data and the knowledge on the formation of the Jinshan Ag-Au deposit for forecasting the exploration targets ... To comprehensively utilize the valuable geological map,exploration profile,borehole,and geochemical logging data and the knowledge on the formation of the Jinshan Ag-Au deposit for forecasting the exploration targets of concealed ore bodies,three-dimensional Mineral Prospectivity Modeling(MPM)of the deposit has been conducted using the weights-of-evidence(WofE)method.Conditional independence between evidence layers was tested,and the outline results using the prediction-volume(P-V)and Student's t-statistic methods for delineating favorable mineralization areas from continuous posterior probability map were critically compared.Four exploration targets delineated ultimately by the Student's t-statistic method for the discovery of minable ore bodies in each of the target areas were discussed in detail.The main conclusions include:(1)three-dimensional modeling of a deposit using multi-source reconnaissance data is useful for MPM in interpreting their relationships with known ore bodies;(2)WofE modeling can be used as a straightforward tool for integrating deposit model and reconnaissance data in MPM;(3)the Student's t-statistic method is more applicable in binarizing the continuous prospectivity map for exploration targeting than the PV approach;and(4)two target areas within high potential to find undiscovered ore bodies were diagnosed to guide future near-mine exploration activities of the Jinshan deposit. 展开更多
关键词 three-dimensional modeling mineral prospectivity mapping exploration targeting WEIGHTS-OF-EVIDENCE C-V fractal model Jinshan Ag-Au deposit mineral deposits economic geology
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Mixed integer programming modeling for the satellite three-dimensional component assignment and layout optimization problem
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作者 Yufeng XIA Xianqi CHEN +3 位作者 Zhijia LIU Weien ZHOU Wen YAO Zhongneng ZHANG 《Chinese Journal of Aeronautics》 2025年第6期427-447,共21页
Satellite Component Layout Optimization(SCLO) is crucial in satellite system design.This paper proposes a novel Satellite Three-Dimensional Component Assignment and Layout Optimization(3D-SCALO) problem tailored to en... Satellite Component Layout Optimization(SCLO) is crucial in satellite system design.This paper proposes a novel Satellite Three-Dimensional Component Assignment and Layout Optimization(3D-SCALO) problem tailored to engineering requirements, aiming to optimize satellite heat dissipation while considering constraints on static stability, 3D geometric relationships between components, and special component positions. The 3D-SCALO problem is a challenging bilevel combinatorial optimization task, involving the optimization of discrete component assignment variables in the outer layer and continuous component position variables in the inner layer,with both influencing each other. To address this issue, first, a Mixed Integer Programming(MIP) model is proposed, which reformulates the original bilevel problem into a single-level optimization problem, enabling the exploration of a more comprehensive optimization space while avoiding iterative nested optimization. Then, to model the 3D geometric relationships between components within the MIP framework, a linearized 3D Phi-function method is proposed, which handles non-overlapping and safety distance constraints between cuboid components in an explicit and effective way. Subsequently, the Finite-Rectangle Method(FRM) is proposed to manage 3D geometric constraints for complex-shaped components by approximating them with a finite set of cuboids, extending the applicability of the geometric modeling approach. Finally, the feasibility and effectiveness of the proposed MIP model are demonstrated through two numerical examples"and a real-world engineering case, which confirms its suitability for complex-shaped components and real engineering applications. 展开更多
关键词 Mixed integer programming modeling three-dimensional component assignment Layout optimization Phi-function Finite-rectangle method
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The detection of keratoconus using a three-dimensional corneal model derived from anterior segment optical coherence tomography
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作者 Sang Ngoc Tran Isa S.K.Mohammed +1 位作者 Zeshan Tariq Wuqaas M.Munir 《Annals of Eye Science》 2025年第3期73-82,共10页
Background:Traditional imaging approaches to keratoconus(KCN)have thus far failed to produce a standardized approach for diagnosis.While many diagnostic modalities and metrics exist,none have proven robust enough to b... Background:Traditional imaging approaches to keratoconus(KCN)have thus far failed to produce a standardized approach for diagnosis.While many diagnostic modalities and metrics exist,none have proven robust enough to be considered a gold standard.This study aims to introduce novel metrics to differentiate between KCN and healthy corneas using three-dimensional(3D)measurements of surface area and volume.Methods:This retrospective observational study examined KCN patients along with healthy control patients between the ages of 20 and 79 years old at the University of Maryland,Baltimore.The selected patients underwent a nine-line raster scan anterior segment optical coherence tomography(AS-OCT).ImageJ was used to determine the central 6 mm of each image and each corneal image was then divided into six 1 mm segments.Free-D software was then used to render the nine different images into a 3D model to calculate corneal surface area and volume.A two-tailed Mann-Whitney test was used to assess statistical significance when comparing these subsets.Results:Thirty-three eyes with KCN,along with 33 healthy control,were enrolled.There were statistically significant differences between the healthy and KCN groups in the metric of anterior corneal surface area(13.927 vs.13.991 mm^(2),P=0.046),posterior corneal surface area(14.045 vs.14.173 mm^(2),P<0.001),and volume(8.430 vs.7.773 mm3,P<0.001)within the central 6 mm.Conclusions:3D corneal models derived from AS-OCT can be used to measure anterior corneal surface area,posterior corneal surface area,and corneal volume.All three parameters are statistically different between corneas with KCN and healthy corneas.Further study and application of these parameters may yield new methodologies for the detection of KCN. 展开更多
关键词 CORNEA ECTASIA keratoconus(KCN) anterior segment optical coherence tomography(AS-OCT) three-dimensional model(3D model)
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Three-Dimensional Model Classification Based on VIT-GE and Voting Mechanism
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作者 Fang Yuan Xueyao Gao Chunxiang Zhang 《Computers, Materials & Continua》 2025年第12期5037-5055,共19页
3D model classification has emerged as a significant research focus in computer vision.However,traditional convolutional neural networks(CNNs)often struggle to capture global dependencies across both height and width ... 3D model classification has emerged as a significant research focus in computer vision.However,traditional convolutional neural networks(CNNs)often struggle to capture global dependencies across both height and width dimensions simultaneously,leading to limited feature representation capabilities when handling complex visual tasks.To address this challenge,we propose a novel 3D model classification network named ViT-GE(Vision Transformer with Global and Efficient Attention),which integrates Global Grouped Coordinate Attention(GGCA)and Efficient Channel Attention(ECA)mechanisms.Specifically,the Vision Transformer(ViT)is employed to extract comprehensive global features from multi-view inputs using its self-attention mechanism,effectively capturing 3D shape characteristics.To further enhance spatial feature modeling,the GGCA module introduces a grouping strategy and global context interactions.Concurrently,the ECA module strengthens inter-channel information flow,enabling the network to adaptively emphasize key features and improve feature fusion.Finally,a voting mechanism is adopted to enhance classification accuracy,robustness,and stability.Experimental results on the ModelNet10 dataset demonstrate that our method achieves a classification accuracy of 93.50%,validating its effectiveness and superior performance. 展开更多
关键词 3D model voting algorithm visual transformer design space
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Real-time model updating and prediction of three-dimensional timevarying consolidation settlement using machine learning
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作者 Huaming Tian Yu Wang Danni Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第9期5954-5969,共16页
The development of digital twins for geotechnical structures necessitates the real-time updates of threedimensional(3D)virtual models(e.g.numerical finite element method(FEM)model)to accurately predict time-varying ge... The development of digital twins for geotechnical structures necessitates the real-time updates of threedimensional(3D)virtual models(e.g.numerical finite element method(FEM)model)to accurately predict time-varying geotechnical responses(e.g.consolidation settlement)in a 3D spatial domain.However,traditional 3D numerical model updating approaches are computationally prohibitive and therefore difficult to update the 3D responses in real time.To address these challenges,this study proposes a novel machine learning framework called sparse dictionary learning(T-3D-SDL)for real-time updating of time-varying 3D geotechnical responses.In T-3D-SDL,a concerned dataset(e.g.time-varying 3D settlement)is approximated as a linear superposition of dictionary atoms generated from 3D random FEM analyses.Field monitoring data are then used to identify non-trivial atoms and estimate their weights within a Bayesian framework for model updating and prediction.The proposed approach enables the real-time update of temporally varying settlements with a high 3D spatial resolution and quantified uncertainty as field monitoring data evolve.The proposed approach is illustrated using an embankment construction project.The results show that the proposed approach effectively improves settlement predictions along temporal and 3D spatial dimensions,with minimal latency(e.g.within minutes),as monitoring data appear.In addition,the proposed approach requires only a reasonably small number of 3D FEM model evaluations,avoids the use of widely adopted yet often criticized surrogate models,and effectively addresses the limitations(e.g.computational inefficiency)of existing 3D model updating approaches. 展开更多
关键词 Digital twin three-dimensional(3D)finite element method(FEM) Time-varying 3D settlement Real-time model update Sparse dictionary learning(SDL)
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The Design of a Three-Dimensional Physical Modeling System for Real-Time Groundwater Flows 被引量:1
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作者 SHI Feng ZHANG Fawang +5 位作者 CHEN Li HAN Zhantao YAO Hongchao QIAN Long CHEN Liang JIANG Chengchao 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2015年第6期2103-2103,共1页
In the past decades,physical modeling has been widely used in hydrogeology for teaching,studying and exhibition purposes.Most of these models are used to illustrate hydrogeological profiles,but few can depict three-di... In the past decades,physical modeling has been widely used in hydrogeology for teaching,studying and exhibition purposes.Most of these models are used to illustrate hydrogeological profiles,but few can depict three-dimensional groundwater flows,making it impossible to validate groundwater flows simulated by numerical methods with physical modeling. 展开更多
关键词 The design of a three-dimensional Physical modeling System for Real-Time Groundwater Flows
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DEVELOPMENT OF A HYBRID MODEL FOR THREE-DIMENSIONAL GIS 被引量:15
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作者 SHI Wenzhong 《Geo-Spatial Information Science》 2000年第2期6-12,共7页
This paper presents a hybrid model for three-dimensional Geographical Information Systems which is an integration of surface- and volume-based models. The Triangulated Irregular Network (TIN) and octree models are int... This paper presents a hybrid model for three-dimensional Geographical Information Systems which is an integration of surface- and volume-based models. The Triangulated Irregular Network (TIN) and octree models are integrated in this hybrid models. The TIN model works as a surface-based model which mainly serves for surface presentation and visualization. On the other hand, the octree encoding supports volumetric analysis. The designed data structure brings a major advantage in the three-dimensional selective retrieval. This technique increases the efficiency of three-dimensional data operation. 展开更多
关键词 hybrid three-dimensional model TIN model octree model GIS
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A three-dimensional semi-implicit unstructured grid finite volume ocean model 被引量:10
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作者 WANG Zhili GENG Yanfen 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2013年第1期68-78,共11页
A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal d... A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal direction and z-level grid in the vertical direction. The three-dimensional model is discretized by the semi-implicit finite-volume method, in that the free-surface and the vertical diffusion are semi-implicit, thereby removing stability limitations associated with the surface gravity wave and vertical diffusion terms. The remaining terms in the momentum equations are discretized explicitly by an integral method. The partial cell method is used for resolving topography, which enables the model to better represent irregular topography. The model has been tested against analytical cases for wind and tidal oscillation circulation, and is applied to simulating the tidal flow in the Bohal Sea. The results are in good agreement both with the analytical solutions and measurement results. 展开更多
关键词 three-dimensional model finite volume unstructured grid SEMI-IMPLICIT z-level grid
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Three-dimensional numerical modeling of gravity anomalies based on Poisson equation in spacewavenumber mixed domain 被引量:6
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作者 Dai Shi-Kun Zhao Dong-Dong +3 位作者 Zhang Qian-Jiang Li Kun Chen Qing-Rui Wang Xu-Long 《Applied Geophysics》 SCIE CSCD 2018年第3期513-523,共11页
In gravity-anomaly-based prospecting, the computational and memory requirements for practical numerical modeling are potentially enormous. Achieving an efficient and precise inversion for gravity anomaly imaging over ... In gravity-anomaly-based prospecting, the computational and memory requirements for practical numerical modeling are potentially enormous. Achieving an efficient and precise inversion for gravity anomaly imaging over large-scale and complex terrain requires additional methods. To this end, we have proposed a new topography-capable By performing a two-dimensional Fourier transform in the horizontal directions, threedimensional partial differential equations in the spatial domain were transformed into a group of independent, one-dimensional differential equations engaged with different wave numbers. These independent differential equations are highly parallel across different wave numbers. differential equations with different wave numbers, and the efficiency of solving fixedbandwidth linear equations was further improved by a chasing method. In a synthetic test, a prism model was used to verify the accuracy and reliability of the proposed algorithm by comparing the numerical solution with the analytical solution. We studied the computational precision and efficiency with and without topography using different Fourier transform methods. The results showed that the Guass-FFT method has higher numerical precision, while the standard FFT method is superior, in terms of computation time, for inversion and quantitative interpretation under complicated terrain. 展开更多
关键词 Topography gravity ANOMALY space-wavenumber mixing DOMAIN three-dimensional NUMERICAL modeling
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Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling 被引量:16
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作者 Nipha Chaicharoenaudomrung Phongsakorn Kunhorm Parinya Noisa 《World Journal of Stem Cells》 SCIE 2019年第12期1065-1083,共19页
Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cel... Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cell characteristics and architectures are closely mimicked by the 3D cell models.Thus,the 3D cell cultures are promising and suitable systems for various proposes,ranging from disease modeling to drug target identification as well as potential therapeutic substances that may transform our lives.This review provides a comprehensive compendium of recent advancements in culturing cells,in particular cancer and stem cells,using 3D culture techniques.The major approaches highlighted here include cell spheroids,hydrogel embedding,bioreactors,scaffolds,and bioprinting.In addition,the progress of employing 3D cell culture systems as a platform for cancer and stem cell research was addressed,and the prominent studies of 3D cell culture systems were discussed. 展开更多
关键词 three-dimensional CULTURES CANCER Stem cells Disease modelING In VITRO screening PLATFORM
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Three-Dimensional Tidal Model and Its Application to Numerical Simulation of Water Quality in Coastal Waters 被引量:7
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作者 Shen Yongming , Li Yucheng and Zhao Wenqian Associate Professor, Department of Civil Engineering, Dalian University of Technology, Dalian 116023 Professor, Department of Civil Engineering, Dalian University of Technology, Dalian 116023 Professor, Department of Civil Engineering, Sichuan Union University, Chengdu 610065 《China Ocean Engineering》 SCIE EI 1994年第4期425-436,共12页
The turbulence mechanism plays an important part in the mixing process and momentum transfer of turbulence. A three-dimensional Prandtl mixing length tidal model has been developed to simulate tidal flows and water qu... The turbulence mechanism plays an important part in the mixing process and momentum transfer of turbulence. A three-dimensional Prandtl mixing length tidal model has been developed to simulate tidal flows and water quality. The eddy viscosities and diffusivities are computed from the Prandtl mixing length model. In order to model the water quality of an estuary or coastal area many interdependent processes need to be simulated. These may be conveniently separated into three main groups: transport and mixing processes, biochemical interaction of water quality variables and the utilization and re-cycling of nutrients by living matter. The model simulates full oxygen and nutrient balance, primary productivity and the transport, reaction mechanism and fate of pollutants over tidal time-scales. The model is applied to numerical simulation of tidal flows and water quality in Dalian Bay. The model has been calibrated against a limited data set of historical water quality observations and in general demonstrates excellent agreement with all available data. 展开更多
关键词 three-dimension tidal flows water quality ECOSYSTEM mixing length model coastal waters
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Microstructure modeling and virtual test of asphalt mixture based on three-dimensional discrete element method 被引量:4
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作者 马涛 张德育 +2 位作者 张垚 赵永利 黄晓明 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第6期1525-1534,共10页
The objective of this work is to model the microstructure of asphalt mixture and build virtual test for asphalt mixture by using Particle Flow Code in three dimensions(PFC^(3D))based on three-dimensional discrete elem... The objective of this work is to model the microstructure of asphalt mixture and build virtual test for asphalt mixture by using Particle Flow Code in three dimensions(PFC^(3D))based on three-dimensional discrete element method.A randomly generating algorithm was proposed to capture the three-dimensional irregular shape of coarse aggregate.And then,modeling algorithm and method for graded aggregates were built.Based on the combination of modeling of coarse aggregates,asphalt mastic and air voids,three-dimensional virtual sample of asphalt mixture was modeled by using PFC^(3D).Virtual tests for penetration test of aggregate and uniaxial creep test of asphalt mixture were built and conducted by using PFC^(3D).By comparison of the testing results between virtual tests and actual laboratory tests,the validity of the microstructure modeling and virtual test built in this study was verified.Additionally,compared with laboratory test,the virtual test is easier to conduct and has less variability.It is proved that microstructure modeling and virtual test based on three-dimensional discrete element method is a promising way to conduct research of asphalt mixture. 展开更多
关键词 asphalt mixture microstructure modeling virtual test discrete element method three-dimensional method
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Three-dimensional land FD-CSEM forward modeling using edge finite-element method 被引量:3
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作者 LIU Jian-xin LIU Peng-mao TONG Xiao-zhong 《Journal of Central South University》 SCIE EI CAS CSCD 2018年第1期131-140,共10页
A modeling tool for simulating three-dimensional land frequency-domain controlled-source electromagnetic surveys,based on a finite-element discretization of the Helmholtz equation for the electric fields,has been deve... A modeling tool for simulating three-dimensional land frequency-domain controlled-source electromagnetic surveys,based on a finite-element discretization of the Helmholtz equation for the electric fields,has been developed.The main difference between our modeling method and those previous works is edge finite-element approach applied to solving the three-dimensional land frequency-domain electromagnetic responses generated by horizontal electric dipole source.Firstly,the edge finite-element equation is formulated through the Galerkin method based on Helmholtz equation of the electric fields.Secondly,in order to check the validity of the modeling code,the numerical results are compared with the analytical solutions for a homogeneous half-space model.Finally,other three models are simulated with three-dimensional electromagnetic responses.The results indicate that the method can be applied for solving three-dimensional electromagnetic responses.The algorithm has been demonstrated,which can be effective to modeling the complex geo-electrical structures.This efficient algorithm will help to study the distribution laws of3-D land frequency-domain controlled-source electromagnetic responses and to setup basis for research of three-dimensional inversion. 展开更多
关键词 three-dimensional model frequency-domain electromagnetic method horizontal electric dipole forward modeling edge finite-element
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